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Updated November 2019
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Protein Info
Short Name:
NIPBL
Full Name:
Nipped-B-like protein
Alias:
Delangin; DKFZp434L1319; FLJ11203; FLJ12597; FLJ13354; FLJ13648; IDN3; Nipped-B; Nipped-B-like; SCC2; SCC2 homolog; Sister chromatid cohesion 2
Type:
DNA binding protein
Mass (Da):
316051
Number AA:
2804
UniProt ID:
Q6KC79
International Prot ID:
IPI00436632
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0032116
Uniprot
OncoNet
Molecular Function:
GO:0008022
PhosphoSite+
KinaseNET
Biological Process:
GO:0034088
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
L
N
Q
L
P
L
P
S
P
L
P
A
T
T
T
Site 2
S63
C
R
D
D
N
L
V
S
Q
L
V
H
S
L
N
Site 3
S68
L
V
S
Q
L
V
H
S
L
N
Q
V
S
T
D
Site 4
S73
V
H
S
L
N
Q
V
S
T
D
H
I
E
L
K
Site 5
T74
H
S
L
N
Q
V
S
T
D
H
I
E
L
K
D
Site 6
S85
E
L
K
D
N
L
G
S
D
D
P
E
G
D
I
Site 7
S103
L
Q
A
V
L
A
R
S
P
N
V
F
R
E
K
Site 8
S111
P
N
V
F
R
E
K
S
M
Q
N
R
Y
V
Q
Site 9
Y116
E
K
S
M
Q
N
R
Y
V
Q
S
G
M
M
M
Site 10
S124
V
Q
S
G
M
M
M
S
Q
Y
K
L
S
Q
N
Site 11
Y126
S
G
M
M
M
S
Q
Y
K
L
S
Q
N
S
M
Site 12
S129
M
M
S
Q
Y
K
L
S
Q
N
S
M
H
S
S
Site 13
S132
Q
Y
K
L
S
Q
N
S
M
H
S
S
P
A
S
Site 14
S135
L
S
Q
N
S
M
H
S
S
P
A
S
S
N
Y
Site 15
S136
S
Q
N
S
M
H
S
S
P
A
S
S
N
Y
Q
Site 16
S139
S
M
H
S
S
P
A
S
S
N
Y
Q
Q
T
T
Site 17
S140
M
H
S
S
P
A
S
S
N
Y
Q
Q
T
T
I
Site 18
Y142
S
S
P
A
S
S
N
Y
Q
Q
T
T
I
S
H
Site 19
T146
S
S
N
Y
Q
Q
T
T
I
S
H
S
P
S
S
Site 20
S148
N
Y
Q
Q
T
T
I
S
H
S
P
S
S
R
F
Site 21
S150
Q
Q
T
T
I
S
H
S
P
S
S
R
F
V
P
Site 22
S152
T
T
I
S
H
S
P
S
S
R
F
V
P
P
Q
Site 23
S153
T
I
S
H
S
P
S
S
R
F
V
P
P
Q
T
Site 24
T160
S
R
F
V
P
P
Q
T
S
S
G
N
R
F
M
Site 25
S161
R
F
V
P
P
Q
T
S
S
G
N
R
F
M
P
Site 26
S162
F
V
P
P
Q
T
S
S
G
N
R
F
M
P
Q
Site 27
S172
R
F
M
P
Q
Q
N
S
P
V
P
S
P
Y
A
Site 28
S176
Q
Q
N
S
P
V
P
S
P
Y
A
P
Q
S
P
Site 29
Y178
N
S
P
V
P
S
P
Y
A
P
Q
S
P
A
G
Site 30
S182
P
S
P
Y
A
P
Q
S
P
A
G
Y
M
P
Y
Site 31
Y186
A
P
Q
S
P
A
G
Y
M
P
Y
S
H
P
S
Site 32
Y189
S
P
A
G
Y
M
P
Y
S
H
P
S
S
Y
T
Site 33
S190
P
A
G
Y
M
P
Y
S
H
P
S
S
Y
T
T
Site 34
T197
S
H
P
S
S
Y
T
T
H
P
Q
M
Q
Q
A
Site 35
S205
H
P
Q
M
Q
Q
A
S
V
S
S
P
I
V
A
Site 36
S208
M
Q
Q
A
S
V
S
S
P
I
V
A
G
G
L
Site 37
S224
N
I
H
D
N
K
V
S
G
P
L
S
G
N
S
Site 38
S228
N
K
V
S
G
P
L
S
G
N
S
A
N
H
H
Site 39
S243
A
D
N
P
R
H
G
S
S
E
D
Y
L
H
M
Site 40
S244
D
N
P
R
H
G
S
S
E
D
Y
L
H
M
V
Site 41
Y247
R
H
G
S
S
E
D
Y
L
H
M
V
H
R
L
Site 42
S255
L
H
M
V
H
R
L
S
S
D
D
G
D
S
S
Site 43
S256
H
M
V
H
R
L
S
S
D
D
G
D
S
S
T
Site 44
S261
L
S
S
D
D
G
D
S
S
T
M
R
N
A
A
Site 45
S262
S
S
D
D
G
D
S
S
T
M
R
N
A
A
S
Site 46
T263
S
D
D
G
D
S
S
T
M
R
N
A
A
S
F
Site 47
S269
S
T
M
R
N
A
A
S
F
P
L
R
S
P
Q
Site 48
S274
A
A
S
F
P
L
R
S
P
Q
P
V
C
S
P
Site 49
S280
R
S
P
Q
P
V
C
S
P
A
G
S
E
G
T
Site 50
S284
P
V
C
S
P
A
G
S
E
G
T
P
K
G
S
Site 51
T287
S
P
A
G
S
E
G
T
P
K
G
S
R
P
P
Site 52
S291
S
E
G
T
P
K
G
S
R
P
P
L
I
L
Q
Site 53
S299
R
P
P
L
I
L
Q
S
Q
S
L
P
C
S
S
Site 54
S301
P
L
I
L
Q
S
Q
S
L
P
C
S
S
P
R
Site 55
S305
Q
S
Q
S
L
P
C
S
S
P
R
D
V
P
P
Site 56
S306
S
Q
S
L
P
C
S
S
P
R
D
V
P
P
D
Site 57
S318
P
P
D
I
L
L
D
S
P
E
R
K
Q
K
K
Site 58
S339
G
K
D
E
K
E
Q
S
E
K
A
A
M
Y
D
Site 59
Y345
Q
S
E
K
A
A
M
Y
D
I
I
S
S
P
S
Site 60
S349
A
A
M
Y
D
I
I
S
S
P
S
K
D
S
T
Site 61
S350
A
M
Y
D
I
I
S
S
P
S
K
D
S
T
K
Site 62
S355
I
S
S
P
S
K
D
S
T
K
L
T
L
R
L
Site 63
T356
S
S
P
S
K
D
S
T
K
L
T
L
R
L
S
Site 64
T359
S
K
D
S
T
K
L
T
L
R
L
S
R
V
R
Site 65
S363
T
K
L
T
L
R
L
S
R
V
R
S
S
D
M
Site 66
S367
L
R
L
S
R
V
R
S
S
D
M
D
Q
Q
E
Site 67
S368
R
L
S
R
V
R
S
S
D
M
D
Q
Q
E
D
Site 68
S378
D
Q
Q
E
D
M
I
S
G
V
E
N
S
N
V
Site 69
S383
M
I
S
G
V
E
N
S
N
V
S
E
N
D
I
Site 70
Y396
D
I
P
F
N
V
Q
Y
P
G
Q
T
S
K
T
Site 71
S401
V
Q
Y
P
G
Q
T
S
K
T
P
I
T
P
Q
Site 72
T403
Y
P
G
Q
T
S
K
T
P
I
T
P
Q
D
I
Site 73
T406
Q
T
S
K
T
P
I
T
P
Q
D
I
N
R
P
Site 74
S421
L
N
A
A
Q
C
L
S
Q
Q
E
Q
T
A
F
Site 75
S442
P
V
L
Q
Q
N
T
S
V
A
A
K
Q
P
Q
Site 76
Y466
I
S
Q
Q
G
P
I
Y
D
E
V
E
L
D
A
Site 77
S484
I
E
R
I
E
R
E
S
A
I
E
R
E
R
F
Site 78
S492
A
I
E
R
E
R
F
S
K
E
V
Q
D
K
D
Site 79
S509
L
K
K
R
K
Q
D
S
Y
P
Q
E
A
G
G
Site 80
Y510
K
K
R
K
Q
D
S
Y
P
Q
E
A
G
G
A
Site 81
S525
T
G
G
N
R
P
A
S
Q
E
T
G
S
T
G
Site 82
S530
P
A
S
Q
E
T
G
S
T
G
N
G
S
R
P
Site 83
T531
A
S
Q
E
T
G
S
T
G
N
G
S
R
P
A
Site 84
S535
T
G
S
T
G
N
G
S
R
P
A
L
M
V
S
Site 85
S553
H
Q
A
G
R
V
D
S
Q
A
S
I
T
Q
D
Site 86
S556
G
R
V
D
S
Q
A
S
I
T
Q
D
S
D
S
Site 87
T558
V
D
S
Q
A
S
I
T
Q
D
S
D
S
I
K
Site 88
S561
Q
A
S
I
T
Q
D
S
D
S
I
K
K
P
E
Site 89
S563
S
I
T
Q
D
S
D
S
I
K
K
P
E
E
I
Site 90
S588
L
Q
E
D
I
V
G
S
L
K
S
T
P
E
N
Site 91
S591
D
I
V
G
S
L
K
S
T
P
E
N
H
P
E
Site 92
T592
I
V
G
S
L
K
S
T
P
E
N
H
P
E
T
Site 93
T599
T
P
E
N
H
P
E
T
P
K
K
K
S
D
P
Site 94
S604
P
E
T
P
K
K
K
S
D
P
E
L
S
K
S
Site 95
S609
K
K
S
D
P
E
L
S
K
S
E
M
K
Q
S
Site 96
S611
S
D
P
E
L
S
K
S
E
M
K
Q
S
E
S
Site 97
S616
S
K
S
E
M
K
Q
S
E
S
R
L
A
E
S
Site 98
S618
S
E
M
K
Q
S
E
S
R
L
A
E
S
K
P
Site 99
S635
N
R
L
V
E
T
K
S
S
E
N
K
L
E
T
Site 100
S636
R
L
V
E
T
K
S
S
E
N
K
L
E
T
K
Site 101
T646
K
L
E
T
K
V
E
T
Q
T
E
E
L
K
Q
Site 102
T659
K
Q
N
E
S
R
T
T
E
C
K
Q
N
E
S
Site 103
S679
K
Q
N
E
N
R
L
S
D
T
K
P
N
D
N
Site 104
S693
N
K
Q
N
N
G
R
S
E
T
T
K
S
R
P
Site 105
T695
Q
N
N
G
R
S
E
T
T
K
S
R
P
E
T
Site 106
S698
G
R
S
E
T
T
K
S
R
P
E
T
P
K
Q
Site 107
T702
T
T
K
S
R
P
E
T
P
K
Q
K
G
E
S
Site 108
S709
T
P
K
Q
K
G
E
S
R
P
E
T
P
K
Q
Site 109
T713
K
G
E
S
R
P
E
T
P
K
Q
K
S
D
G
Site 110
S718
P
E
T
P
K
Q
K
S
D
G
H
P
E
T
P
Site 111
T724
K
S
D
G
H
P
E
T
P
K
Q
K
G
D
G
Site 112
T735
K
G
D
G
R
P
E
T
P
K
Q
K
G
E
S
Site 113
T746
K
G
E
S
R
P
E
T
P
K
Q
K
N
E
G
Site 114
T757
K
N
E
G
R
P
E
T
P
K
H
R
H
D
N
Site 115
S768
R
H
D
N
R
R
D
S
G
K
P
S
T
E
K
Site 116
S772
R
R
D
S
G
K
P
S
T
E
K
K
P
E
V
Site 117
T786
V
S
K
H
K
Q
D
T
K
S
D
S
P
R
L
Site 118
S788
K
H
K
Q
D
T
K
S
D
S
P
R
L
K
S
Site 119
S790
K
Q
D
T
K
S
D
S
P
R
L
K
S
E
R
Site 120
S795
S
D
S
P
R
L
K
S
E
R
A
E
A
L
K
Site 121
S809
K
Q
R
P
D
G
R
S
V
S
E
S
L
R
R
Site 122
S811
R
P
D
G
R
S
V
S
E
S
L
R
R
D
H
Site 123
S813
D
G
R
S
V
S
E
S
L
R
R
D
H
D
N
Site 124
S824
D
H
D
N
K
Q
K
S
D
D
R
G
E
S
E
Site 125
S830
K
S
D
D
R
G
E
S
E
R
H
R
G
D
Q
Site 126
S838
E
R
H
R
G
D
Q
S
R
V
R
R
P
E
T
Site 127
T845
S
R
V
R
R
P
E
T
L
R
S
S
S
R
N
Site 128
S848
R
R
P
E
T
L
R
S
S
S
R
N
E
H
G
Site 129
S849
R
P
E
T
L
R
S
S
S
R
N
E
H
G
I
Site 130
S850
P
E
T
L
R
S
S
S
R
N
E
H
G
I
K
Site 131
S858
R
N
E
H
G
I
K
S
D
S
S
K
T
D
K
Site 132
S861
H
G
I
K
S
D
S
S
K
T
D
K
L
E
R
Site 133
S874
E
R
K
H
R
H
E
S
G
D
S
R
E
R
P
Site 134
S877
H
R
H
E
S
G
D
S
R
E
R
P
S
S
G
Site 135
S882
G
D
S
R
E
R
P
S
S
G
E
Q
K
S
R
Site 136
S883
D
S
R
E
R
P
S
S
G
E
Q
K
S
R
P
Site 137
S888
P
S
S
G
E
Q
K
S
R
P
D
S
P
R
V
Site 138
S892
E
Q
K
S
R
P
D
S
P
R
V
K
Q
G
D
Site 139
S900
P
R
V
K
Q
G
D
S
N
K
S
R
S
D
K
Site 140
S903
K
Q
G
D
S
N
K
S
R
S
D
K
L
G
F
Site 141
S905
G
D
S
N
K
S
R
S
D
K
L
G
F
K
S
Site 142
S912
S
D
K
L
G
F
K
S
P
T
S
K
D
D
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S
E
D
D
I
N
Site 295
S2515
D
S
D
S
D
S
D
S
E
D
D
I
N
S
V
Site 296
S2521
D
S
E
D
D
I
N
S
V
M
K
C
L
P
E
Site 297
S2560
L
K
N
L
C
G
F
S
D
S
K
I
Q
K
Y
Site 298
S2562
N
L
C
G
F
S
D
S
K
I
Q
K
Y
S
P
Site 299
Y2567
S
D
S
K
I
Q
K
Y
S
P
S
E
S
A
K
Site 300
S2568
D
S
K
I
Q
K
Y
S
P
S
E
S
A
K
V
Site 301
S2570
K
I
Q
K
Y
S
P
S
E
S
A
K
V
Y
D
Site 302
S2572
Q
K
Y
S
P
S
E
S
A
K
V
Y
D
K
A
Site 303
Y2576
P
S
E
S
A
K
V
Y
D
K
A
I
N
R
K
Site 304
T2584
D
K
A
I
N
R
K
T
G
V
H
F
H
P
K
Site 305
S2599
Q
T
L
D
F
L
R
S
D
M
A
N
S
K
I
Site 306
S2613
I
T
E
E
V
K
R
S
I
V
K
Q
Y
L
D
Site 307
Y2618
K
R
S
I
V
K
Q
Y
L
D
F
K
L
L
M
Site 308
S2640
E
E
E
E
G
E
V
S
A
S
T
N
A
R
N
Site 309
S2642
E
E
G
E
V
S
A
S
T
N
A
R
N
K
A
Site 310
T2651
N
A
R
N
K
A
I
T
S
L
L
G
G
G
S
Site 311
S2652
A
R
N
K
A
I
T
S
L
L
G
G
G
S
P
Site 312
S2658
T
S
L
L
G
G
G
S
P
K
N
N
T
A
A
Site 313
T2663
G
G
S
P
K
N
N
T
A
A
E
T
E
D
D
Site 314
T2667
K
N
N
T
A
A
E
T
E
D
D
E
S
D
G
Site 315
S2672
A
E
T
E
D
D
E
S
D
G
E
D
R
G
G
Site 316
T2681
G
E
D
R
G
G
G
T
S
G
S
L
R
R
S
Site 317
S2682
E
D
R
G
G
G
T
S
G
S
L
R
R
S
K
Site 318
S2684
R
G
G
G
T
S
G
S
L
R
R
S
K
R
N
Site 319
S2688
T
S
G
S
L
R
R
S
K
R
N
S
D
S
T
Site 320
S2692
L
R
R
S
K
R
N
S
D
S
T
E
L
A
A
Site 321
T2695
S
K
R
N
S
D
S
T
E
L
A
A
Q
M
N
Site 322
Y2718
I
A
I
C
C
P
K
Y
K
D
R
P
Q
I
A
Site 323
T2731
I
A
R
V
V
Q
K
T
S
S
G
F
S
V
Q
Site 324
S2736
Q
K
T
S
S
G
F
S
V
Q
W
M
A
G
S
Site 325
S2743
S
V
Q
W
M
A
G
S
Y
S
G
S
W
T
E
Site 326
S2747
M
A
G
S
Y
S
G
S
W
T
E
A
K
R
R
Site 327
T2749
G
S
Y
S
G
S
W
T
E
A
K
R
R
D
G
Site 328
T2765
K
L
V
P
W
V
D
T
I
K
E
S
D
I
I
Site 329
Y2773
I
K
E
S
D
I
I
Y
K
K
I
A
L
T
S
Site 330
Y2796
V
Q
T
L
R
S
L
Y
A
A
K
D
G
T
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation