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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDE12
Full Name:
2',5'-phosphodiesterase 12
Alias:
EC 3.1.4.-; Phosphodiesterase 12
Type:
Phosphodiesterase
Mass (Da):
67352
Number AA:
609
UniProt ID:
Q6L8Q7
International Prot ID:
IPI00174390
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0016787
GO:0016787
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
A
A
L
R
V
I
R
T
A
V
E
K
L
S
R
Site 2
S22
R
T
A
V
E
K
L
S
R
A
E
A
G
S
Q
Site 3
S28
L
S
R
A
E
A
G
S
Q
T
A
A
G
A
M
Site 4
T30
R
A
E
A
G
S
Q
T
A
A
G
A
M
E
R
Site 5
S50
V
P
S
E
P
K
L
S
L
S
F
A
L
A
D
Site 6
S52
S
E
P
K
L
S
L
S
F
A
L
A
D
G
S
Site 7
S59
S
F
A
L
A
D
G
S
H
K
N
M
Q
R
D
Site 8
S68
K
N
M
Q
R
D
Q
S
E
P
L
G
R
V
L
Site 9
T80
R
V
L
S
R
I
A
T
N
A
L
K
G
H
A
Site 10
S95
K
A
A
A
A
K
K
S
R
K
S
R
P
N
A
Site 11
S98
A
A
K
K
S
R
K
S
R
P
N
A
S
G
G
Site 12
S103
R
K
S
R
P
N
A
S
G
G
A
A
C
S
G
Site 13
S109
A
S
G
G
A
A
C
S
G
P
G
P
E
P
A
Site 14
Y126
C
E
P
V
V
K
L
Y
Y
R
E
E
A
V
A
Site 15
Y155
L
Q
I
G
D
V
K
Y
K
V
E
R
N
P
P
Site 16
S192
L
E
F
G
D
P
A
S
S
L
F
R
W
Y
K
Site 17
S193
E
F
G
D
P
A
S
S
L
F
R
W
Y
K
E
Site 18
Y198
A
S
S
L
F
R
W
Y
K
E
A
K
P
G
A
Site 19
S214
E
P
E
V
G
V
P
S
S
L
S
P
S
S
P
Site 20
S215
P
E
V
G
V
P
S
S
L
S
P
S
S
P
S
Site 21
S217
V
G
V
P
S
S
L
S
P
S
S
P
S
S
S
Site 22
S219
V
P
S
S
L
S
P
S
S
P
S
S
S
W
T
Site 23
S220
P
S
S
L
S
P
S
S
P
S
S
S
W
T
E
Site 24
S222
S
L
S
P
S
S
P
S
S
S
W
T
E
T
D
Site 25
S223
L
S
P
S
S
P
S
S
S
W
T
E
T
D
V
Site 26
S224
S
P
S
S
P
S
S
S
W
T
E
T
D
V
E
Site 27
T226
S
S
P
S
S
S
W
T
E
T
D
V
E
E
R
Site 28
T228
P
S
S
S
W
T
E
T
D
V
E
E
R
V
Y
Site 29
Y235
T
D
V
E
E
R
V
Y
T
P
S
N
A
D
I
Site 30
T236
D
V
E
E
R
V
Y
T
P
S
N
A
D
I
G
Site 31
S238
E
E
R
V
Y
T
P
S
N
A
D
I
G
L
R
Site 32
T251
L
R
L
K
L
H
C
T
P
G
D
G
Q
R
F
Site 33
S261
D
G
Q
R
F
G
H
S
R
E
L
E
S
V
C
Site 34
S266
G
H
S
R
E
L
E
S
V
C
V
V
E
A
G
Site 35
T278
E
A
G
P
G
T
C
T
F
D
H
R
H
L
Y
Site 36
Y285
T
F
D
H
R
H
L
Y
T
K
K
V
T
E
D
Site 37
T306
S
Y
N
I
L
A
D
T
Y
A
Q
T
E
F
S
Site 38
Y307
Y
N
I
L
A
D
T
Y
A
Q
T
E
F
S
R
Site 39
S313
T
Y
A
Q
T
E
F
S
R
T
V
L
Y
P
Y
Site 40
T315
A
Q
T
E
F
S
R
T
V
L
Y
P
Y
C
A
Site 41
Y318
E
F
S
R
T
V
L
Y
P
Y
C
A
P
Y
A
Site 42
Y320
S
R
T
V
L
Y
P
Y
C
A
P
Y
A
L
E
Site 43
Y330
P
Y
A
L
E
L
D
Y
R
Q
N
L
I
Q
K
Site 44
T384
K
Q
H
E
G
L
A
T
F
Y
R
K
S
K
F
Site 45
S389
L
A
T
F
Y
R
K
S
K
F
S
L
L
S
Q
Site 46
S392
F
Y
R
K
S
K
F
S
L
L
S
Q
H
D
I
Site 47
S395
K
S
K
F
S
L
L
S
Q
H
D
I
S
F
Y
Site 48
S400
L
L
S
Q
H
D
I
S
F
Y
E
A
L
E
S
Site 49
Y402
S
Q
H
D
I
S
F
Y
E
A
L
E
S
D
P
Site 50
S407
S
F
Y
E
A
L
E
S
D
P
L
H
K
E
L
Site 51
S423
E
K
L
V
L
Y
P
S
A
Q
E
K
V
L
Q
Site 52
S438
R
S
S
V
L
Q
V
S
V
L
Q
S
T
K
D
Site 53
S442
L
Q
V
S
V
L
Q
S
T
K
D
S
S
K
R
Site 54
S446
V
L
Q
S
T
K
D
S
S
K
R
I
C
V
A
Site 55
S447
L
Q
S
T
K
D
S
S
K
R
I
C
V
A
N
Site 56
Y465
Y
W
H
P
K
G
G
Y
I
R
L
I
Q
M
A
Site 57
T503
D
F
N
S
T
P
S
T
G
M
Y
H
F
V
I
Site 58
Y506
S
T
P
S
T
G
M
Y
H
F
V
I
N
G
S
Site 59
S523
E
D
H
E
D
W
A
S
N
G
E
E
E
R
C
Site 60
T535
E
R
C
N
M
S
L
T
H
F
F
K
L
K
S
Site 61
S542
T
H
F
F
K
L
K
S
A
C
G
E
P
A
Y
Site 62
Y549
S
A
C
G
E
P
A
Y
T
N
Y
V
G
G
F
Site 63
Y552
G
E
P
A
Y
T
N
Y
V
G
G
F
H
G
C
Site 64
S580
E
Q
V
I
P
L
P
S
H
E
E
V
T
T
H
Site 65
T586
P
S
H
E
E
V
T
T
H
Q
A
L
P
S
V
Site 66
S592
T
T
H
Q
A
L
P
S
V
S
H
P
S
D
H
Site 67
S594
H
Q
A
L
P
S
V
S
H
P
S
D
H
I
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation