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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIAA1622
Full Name:
Serine/threonine-protein phosphatase 4 regulatory subunit 4
Alias:
K1622, PP4R4
Type:
Mass (Da):
99452
Number AA:
873
UniProt ID:
Q6NUP7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0008287
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
P
A
A
A
M
D
F
S
Q
N
S
L
F
G
Y
Site 2
Y20
S
Q
N
S
L
F
G
Y
M
E
D
L
Q
E
L
Site 3
S37
I
E
R
P
V
R
R
S
L
K
T
P
E
E
I
Site 4
T40
P
V
R
R
S
L
K
T
P
E
E
I
E
R
L
Site 5
T48
P
E
E
I
E
R
L
T
V
D
E
D
L
S
D
Site 6
S54
L
T
V
D
E
D
L
S
D
I
E
R
A
V
Y
Site 7
Y61
S
D
I
E
R
A
V
Y
L
L
S
A
G
Q
D
Site 8
T89
M
R
Q
N
P
T
E
T
L
R
R
V
L
P
K
Site 9
T147
L
H
L
E
H
R
D
T
G
V
S
N
A
W
L
Site 10
S150
E
H
R
D
T
G
V
S
N
A
W
L
E
T
L
Site 11
S179
E
I
L
N
P
L
V
S
K
A
Q
L
S
Q
T
Site 12
S184
L
V
S
K
A
Q
L
S
Q
T
V
Q
S
R
L
Site 13
T186
S
K
A
Q
L
S
Q
T
V
Q
S
R
L
V
S
Site 14
S189
Q
L
S
Q
T
V
Q
S
R
L
V
S
C
K
I
Site 15
T208
T
N
K
F
D
A
H
T
I
K
R
E
I
L
P
Site 16
Y226
S
L
C
Q
D
V
E
Y
E
V
R
S
C
M
C
Site 17
S260
L
P
E
L
I
E
L
S
R
D
E
G
S
S
V
Site 18
S265
E
L
S
R
D
E
G
S
S
V
R
L
A
A
F
Site 19
S266
L
S
R
D
E
G
S
S
V
R
L
A
A
F
E
Site 20
T284
N
L
L
D
I
F
D
T
D
D
R
S
Q
T
I
Site 21
S288
I
F
D
T
D
D
R
S
Q
T
I
L
P
L
V
Site 22
T290
D
T
D
D
R
S
Q
T
I
L
P
L
V
K
S
Site 23
S302
V
K
S
F
C
E
K
S
F
K
A
D
E
S
I
Site 24
Y325
G
K
L
C
H
G
L
Y
G
I
F
T
P
D
Q
Site 25
T329
H
G
L
Y
G
I
F
T
P
D
Q
H
L
R
F
Site 26
Y370
I
L
E
Q
E
K
K
Y
I
S
V
R
K
N
C
Site 27
S465
P
E
I
L
E
L
M
S
T
G
G
E
S
S
V
Site 28
T466
E
I
L
E
L
M
S
T
G
G
E
S
S
V
Q
Site 29
S471
M
S
T
G
G
E
S
S
V
Q
E
N
K
L
S
Site 30
S478
S
V
Q
E
N
K
L
S
S
L
P
D
L
I
P
Site 31
S479
V
Q
E
N
K
L
S
S
L
P
D
L
I
P
A
Site 32
S497
A
E
Q
R
A
A
A
S
L
K
W
R
T
H
E
Site 33
Y510
H
E
K
L
L
Q
K
Y
A
C
L
P
H
V
I
Site 34
Y523
V
I
S
S
D
Q
I
Y
Y
R
F
L
Q
R
M
Site 35
T536
R
M
F
T
I
M
M
T
N
N
V
L
P
V
Q
Site 36
Y556
T
L
C
I
F
L
R
Y
N
R
K
Q
E
Q
R
Site 37
Y580
Q
L
G
Q
G
K
S
Y
W
N
R
L
R
F
L
Site 38
T589
N
R
L
R
F
L
D
T
C
E
F
I
I
E
I
Site 39
S600
I
I
E
I
F
S
K
S
F
F
C
K
Y
F
F
Site 40
Y605
S
K
S
F
F
C
K
Y
F
F
L
P
A
I
E
Site 41
Y627
N
V
R
M
K
L
C
Y
L
L
P
K
V
K
S
Site 42
S634
Y
L
L
P
K
V
K
S
T
L
K
I
P
A
D
Site 43
S725
Q
N
D
G
R
P
M
S
D
K
M
F
E
K
K
Site 44
T736
F
E
K
K
R
R
D
T
K
T
P
T
Q
S
L
Site 45
T738
K
K
R
R
D
T
K
T
P
T
Q
S
L
P
K
Site 46
S755
P
I
S
V
P
G
P
S
S
V
T
P
S
T
S
Site 47
S756
I
S
V
P
G
P
S
S
V
T
P
S
T
S
K
Site 48
T758
V
P
G
P
S
S
V
T
P
S
T
S
K
E
I
Site 49
S760
G
P
S
S
V
T
P
S
T
S
K
E
I
K
K
Site 50
S762
S
S
V
T
P
S
T
S
K
E
I
K
K
S
K
Site 51
S768
T
S
K
E
I
K
K
S
K
L
I
R
S
Q
S
Site 52
S773
K
K
S
K
L
I
R
S
Q
S
F
N
N
Q
A
Site 53
S775
S
K
L
I
R
S
Q
S
F
N
N
Q
A
F
H
Site 54
Y785
N
Q
A
F
H
A
K
Y
G
N
L
E
K
C
A
Site 55
S793
G
N
L
E
K
C
A
S
K
S
S
T
T
G
Y
Site 56
S795
L
E
K
C
A
S
K
S
S
T
T
G
Y
T
T
Site 57
S796
E
K
C
A
S
K
S
S
T
T
G
Y
T
T
S
Site 58
T797
K
C
A
S
K
S
S
T
T
G
Y
T
T
S
V
Site 59
Y800
S
K
S
S
T
T
G
Y
T
T
S
V
S
G
L
Site 60
T801
K
S
S
T
T
G
Y
T
T
S
V
S
G
L
G
Site 61
T802
S
S
T
T
G
Y
T
T
S
V
S
G
L
G
K
Site 62
S803
S
T
T
G
Y
T
T
S
V
S
G
L
G
K
T
Site 63
S805
T
G
Y
T
T
S
V
S
G
L
G
K
T
S
V
Site 64
S814
L
G
K
T
S
V
L
S
L
A
D
D
S
F
R
Site 65
S819
V
L
S
L
A
D
D
S
F
R
T
R
N
A
S
Site 66
S826
S
F
R
T
R
N
A
S
S
V
P
S
S
F
S
Site 67
S827
F
R
T
R
N
A
S
S
V
P
S
S
F
S
P
Site 68
S830
R
N
A
S
S
V
P
S
S
F
S
P
N
T
P
Site 69
S831
N
A
S
S
V
P
S
S
F
S
P
N
T
P
L
Site 70
S833
S
S
V
P
S
S
F
S
P
N
T
P
L
P
S
Site 71
T836
P
S
S
F
S
P
N
T
P
L
P
S
T
S
R
Site 72
S840
S
P
N
T
P
L
P
S
T
S
R
G
T
G
N
Site 73
T841
P
N
T
P
L
P
S
T
S
R
G
T
G
N
S
Site 74
T845
L
P
S
T
S
R
G
T
G
N
S
V
D
P
K
Site 75
S848
T
S
R
G
T
G
N
S
V
D
P
K
S
S
G
Site 76
S853
G
N
S
V
D
P
K
S
S
G
S
K
D
T
Q
Site 77
S854
N
S
V
D
P
K
S
S
G
S
K
D
T
Q
P
Site 78
S856
V
D
P
K
S
S
G
S
K
D
T
Q
P
R
K
Site 79
T859
K
S
S
G
S
K
D
T
Q
P
R
K
A
T
L
Site 80
T865
D
T
Q
P
R
K
A
T
L
K
S
R
K
S
N
Site 81
S868
P
R
K
A
T
L
K
S
R
K
S
N
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation