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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADAM5P
Full Name:
Putative disintegrin and metalloproteinase domain-containing protein 5
Alias:
Putative transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II
Type:
Mass (Da):
47181
Number AA:
412
UniProt ID:
Q6NVV9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
Q
T
S
I
L
I
K
S
S
C
R
P
Q
F
Q
Site 2
S10
T
S
I
L
I
K
S
S
C
R
P
Q
F
Q
R
Site 3
S42
S
S
A
S
V
I
N
S
Y
D
E
N
D
I
R
Site 4
Y43
S
A
S
V
I
N
S
Y
D
E
N
D
I
R
H
Site 5
S51
D
E
N
D
I
R
H
S
K
P
L
L
V
Q
M
Site 6
Y65
M
D
C
N
Y
N
G
Y
V
A
G
I
P
N
S
Site 7
Y109
S
G
F
I
H
K
I
Y
E
E
K
Y
A
D
T
Site 8
Y113
H
K
I
Y
E
E
K
Y
A
D
T
N
I
L
L
Site 9
T125
I
L
L
E
E
N
D
T
Y
T
W
F
N
S
E
Site 10
Y126
L
L
E
E
N
D
T
Y
T
W
F
N
S
E
Y
Site 11
Y133
Y
T
W
F
N
S
E
Y
Q
V
R
K
S
S
E
Site 12
S138
S
E
Y
Q
V
R
K
S
S
E
K
T
D
F
I
Site 13
S139
E
Y
Q
V
R
K
S
S
E
K
T
D
F
I
K
Site 14
T142
V
R
K
S
S
E
K
T
D
F
I
K
L
F
P
Site 15
Y183
K
E
C
D
F
T
E
Y
C
N
G
D
L
P
Y
Site 16
Y190
Y
C
N
G
D
L
P
Y
C
L
P
D
T
Y
V
Site 17
T195
L
P
Y
C
L
P
D
T
Y
V
R
D
G
E
Y
Site 18
Y196
P
Y
C
L
P
D
T
Y
V
R
D
G
E
Y
C
Site 19
Y202
T
Y
V
R
D
G
E
Y
C
D
S
G
G
A
F
Site 20
S230
D
D
L
I
G
R
G
S
R
G
A
P
V
F
C
Site 21
Y238
R
G
A
P
V
F
C
Y
D
E
I
N
T
R
G
Site 22
S277
W
E
H
R
D
L
I
S
R
P
N
L
S
V
I
Site 23
T292
Y
A
H
V
R
D
Q
T
C
V
S
T
Y
L
P
Site 24
Y297
D
Q
T
C
V
S
T
Y
L
P
R
R
T
P
P
Site 25
T302
S
T
Y
L
P
R
R
T
P
P
P
V
N
S
P
Site 26
S308
R
T
P
P
P
V
N
S
P
I
S
I
T
S
Y
Site 27
S311
P
P
V
N
S
P
I
S
I
T
S
Y
Y
S
A
Site 28
S314
N
S
P
I
S
I
T
S
Y
Y
S
A
E
D
R
Site 29
Y315
S
P
I
S
I
T
S
Y
Y
S
A
E
D
R
D
Site 30
T324
S
A
E
D
R
D
E
T
F
V
Q
D
G
S
M
Site 31
Y383
E
K
G
Y
N
P
P
Y
C
Q
P
K
Q
G
A
Site 32
S393
P
K
Q
G
A
F
G
S
I
D
D
G
H
L
V
Site 33
T403
D
G
H
L
V
P
P
T
E
R
S
Y
M
E
E
Site 34
S406
L
V
P
P
T
E
R
S
Y
M
E
E
G
R
_
Site 35
Y407
V
P
P
T
E
R
S
Y
M
E
E
G
R
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation