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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HYPC
Full Name:
Pre-mRNA-processing factor 40 homolog B
Alias:
Huntingtin yeast partner C;Huntingtin-interacting protein C
Type:
Uncharacterized protein
Mass (Da):
99358
Number AA:
871
UniProt ID:
Q6NWY9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016607
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0006397
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S25
P
M
G
L
P
P
M
S
Q
R
P
P
A
I
P
Site 2
S86
P
G
A
D
T
A
S
S
A
V
A
G
T
G
P
Site 3
S99
G
P
P
R
A
L
W
S
E
H
V
A
P
D
G
Site 4
Y109
V
A
P
D
G
R
I
Y
Y
Y
N
A
D
D
K
Site 5
Y110
A
P
D
G
R
I
Y
Y
Y
N
A
D
D
K
Q
Site 6
Y111
P
D
G
R
I
Y
Y
Y
N
A
D
D
K
Q
S
Site 7
S118
Y
N
A
D
D
K
Q
S
V
W
E
K
P
S
V
Site 8
S124
Q
S
V
W
E
K
P
S
V
L
K
S
K
A
E
Site 9
S128
E
K
P
S
V
L
K
S
K
A
E
L
L
L
S
Site 10
S135
S
K
A
E
L
L
L
S
Q
C
P
W
K
E
Y
Site 11
Y142
S
Q
C
P
W
K
E
Y
K
S
D
T
G
K
P
Site 12
T146
W
K
E
Y
K
S
D
T
G
K
P
Y
Y
Y
N
Site 13
Y150
K
S
D
T
G
K
P
Y
Y
Y
N
N
Q
S
K
Site 14
Y151
S
D
T
G
K
P
Y
Y
Y
N
N
Q
S
K
E
Site 15
Y152
D
T
G
K
P
Y
Y
Y
N
N
Q
S
K
E
S
Site 16
T162
Q
S
K
E
S
R
W
T
R
P
K
D
L
D
D
Site 17
T189
Q
Q
Q
Q
L
P
Q
T
L
Q
P
Q
P
P
Q
Site 18
S223
L
E
P
E
P
G
G
S
E
D
C
D
V
L
E
Site 19
S248
Q
Q
L
E
E
G
P
S
S
S
G
Q
H
Q
P
Site 20
S249
Q
L
E
E
G
P
S
S
S
G
Q
H
Q
P
Q
Site 21
S262
P
Q
Q
E
E
E
E
S
K
P
E
P
E
R
S
Site 22
S269
S
K
P
E
P
E
R
S
G
L
S
W
S
N
R
Site 23
S272
E
P
E
R
S
G
L
S
W
S
N
R
E
K
A
Site 24
S274
E
R
S
G
L
S
W
S
N
R
E
K
A
K
Q
Site 25
T307
Q
A
M
K
M
V
V
T
D
P
R
Y
S
A
L
Site 26
Y311
M
V
V
T
D
P
R
Y
S
A
L
P
K
L
S
Site 27
S312
V
V
T
D
P
R
Y
S
A
L
P
K
L
S
E
Site 28
S318
Y
S
A
L
P
K
L
S
E
K
K
Q
A
F
N
Site 29
T349
R
A
K
E
A
K
Q
T
L
Q
H
F
L
E
Q
Site 30
T361
L
E
Q
H
E
R
M
T
S
T
T
R
Y
R
R
Site 31
S362
E
Q
H
E
R
M
T
S
T
T
R
Y
R
R
A
Site 32
T364
H
E
R
M
T
S
T
T
R
Y
R
R
A
E
Q
Site 33
Y366
R
M
T
S
T
T
R
Y
R
R
A
E
Q
T
F
Site 34
T372
R
Y
R
R
A
E
Q
T
F
G
E
L
E
V
W
Site 35
Y391
E
R
D
R
K
E
V
Y
D
D
V
L
F
F
L
Site 36
S419
R
N
I
Q
A
L
K
S
I
L
D
G
M
S
S
Site 37
S425
K
S
I
L
D
G
M
S
S
V
N
F
Q
T
T
Site 38
S426
S
I
L
D
G
M
S
S
V
N
F
Q
T
T
W
Site 39
T432
S
S
V
N
F
Q
T
T
W
S
Q
A
Q
Q
Y
Site 40
Y439
T
W
S
Q
A
Q
Q
Y
L
M
D
N
P
S
F
Site 41
T499
K
N
R
E
A
F
Q
T
F
L
D
E
L
H
E
Site 42
T507
F
L
D
E
L
H
E
T
G
Q
L
H
S
M
S
Site 43
T525
E
L
Y
P
A
V
S
T
D
V
R
F
A
N
M
Site 44
S538
N
M
L
G
Q
P
G
S
T
P
L
D
L
F
K
Site 45
Y547
P
L
D
L
F
K
F
Y
V
E
E
L
K
A
R
Site 46
S587
E
D
F
A
H
V
I
S
F
D
K
R
A
A
A
Site 47
T603
D
A
G
N
I
K
L
T
F
N
S
L
L
E
K
Site 48
S661
R
E
R
F
V
C
D
S
A
F
E
Q
I
T
L
Site 49
S670
F
E
Q
I
T
L
E
S
E
R
I
R
L
F
R
Site 50
S710
K
K
H
H
H
K
R
S
H
S
P
S
G
S
E
Site 51
S712
H
H
H
K
R
S
H
S
P
S
G
S
E
S
E
Site 52
S714
H
K
R
S
H
S
P
S
G
S
E
S
E
E
E
Site 53
S716
R
S
H
S
P
S
G
S
E
S
E
E
E
E
L
Site 54
S718
H
S
P
S
G
S
E
S
E
E
E
E
L
P
P
Site 55
S727
E
E
E
L
P
P
P
S
L
R
P
P
K
R
R
Site 56
S739
K
R
R
R
R
N
P
S
E
S
G
S
E
P
S
Site 57
S741
R
R
R
N
P
S
E
S
G
S
E
P
S
S
S
Site 58
S743
R
N
P
S
E
S
G
S
E
P
S
S
S
L
D
Site 59
S747
E
S
G
S
E
P
S
S
S
L
D
S
V
E
S
Site 60
S748
S
G
S
E
P
S
S
S
L
D
S
V
E
S
G
Site 61
S751
E
P
S
S
S
L
D
S
V
E
S
G
G
A
A
Site 62
S754
S
S
L
D
S
V
E
S
G
G
A
A
L
G
G
Site 63
S764
A
A
L
G
G
R
G
S
P
S
S
H
L
L
G
Site 64
S766
L
G
G
R
G
S
P
S
S
H
L
L
G
A
D
Site 65
S767
G
G
R
G
S
P
S
S
H
L
L
G
A
D
H
Site 66
T786
A
K
K
P
K
K
K
T
K
K
R
R
H
K
S
Site 67
S793
T
K
K
R
R
H
K
S
N
S
P
E
S
E
T
Site 68
S795
K
R
R
H
K
S
N
S
P
E
S
E
T
D
P
Site 69
S798
H
K
S
N
S
P
E
S
E
T
D
P
E
E
K
Site 70
T800
S
N
S
P
E
S
E
T
D
P
E
E
K
A
G
Site 71
S832
Q
A
E
L
P
N
R
S
P
G
F
G
I
K
K
Site 72
T842
F
G
I
K
K
E
K
T
G
W
D
T
S
E
S
Site 73
T846
K
E
K
T
G
W
D
T
S
E
S
E
L
S
E
Site 74
S847
E
K
T
G
W
D
T
S
E
S
E
L
S
E
G
Site 75
S849
T
G
W
D
T
S
E
S
E
L
S
E
G
E
L
Site 76
S852
D
T
S
E
S
E
L
S
E
G
E
L
E
R
R
Site 77
T862
E
L
E
R
R
R
R
T
L
L
Q
Q
L
D
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation