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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IRGC
Full Name:
Interferon-inducible GTPase 5
Alias:
Immunity-related GTPase cinema 1
Type:
Mass (Da):
50288
Number AA:
463
UniProt ID:
Q6NXR0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
V
P
G
E
E
E
N
T
I
L
M
A
K
E
R
Site 2
T29
E
R
L
E
A
L
R
T
A
F
E
S
G
D
L
Site 3
S33
A
L
R
T
A
F
E
S
G
D
L
P
Q
A
A
Site 4
S41
G
D
L
P
Q
A
A
S
H
L
Q
E
L
L
A
Site 5
S49
H
L
Q
E
L
L
A
S
T
E
S
I
R
L
E
Site 6
T60
I
R
L
E
V
G
V
T
G
E
S
G
A
G
K
Site 7
S63
E
V
G
V
T
G
E
S
G
A
G
K
S
S
L
Site 8
S69
E
S
G
A
G
K
S
S
L
I
N
A
L
R
G
Site 9
T93
L
T
G
V
M
E
T
T
M
Q
P
S
P
Y
P
Site 10
S97
M
E
T
T
M
Q
P
S
P
Y
P
H
P
Q
F
Site 11
Y99
T
T
M
Q
P
S
P
Y
P
H
P
Q
F
P
D
Site 12
T108
H
P
Q
F
P
D
V
T
L
W
D
L
P
G
A
Site 13
S117
W
D
L
P
G
A
G
S
P
G
C
P
A
D
K
Site 14
Y125
P
G
C
P
A
D
K
Y
L
K
Q
V
D
F
S
Site 15
Y164
L
C
Q
G
K
K
F
Y
F
V
R
T
K
V
D
Site 16
T179
E
D
L
A
A
T
R
T
Q
R
P
S
G
F
R
Site 17
S183
A
T
R
T
Q
R
P
S
G
F
R
E
A
A
V
Site 18
S216
D
P
R
I
F
L
V
S
N
L
S
P
A
R
Y
Site 19
Y223
S
N
L
S
P
A
R
Y
D
F
P
T
L
V
S
Site 20
T227
P
A
R
Y
D
F
P
T
L
V
S
T
W
E
H
Site 21
S247
R
R
H
A
G
L
L
S
L
P
D
I
S
L
E
Site 22
S297
D
D
A
L
L
I
H
S
L
R
G
Y
H
R
S
Site 23
Y301
L
I
H
S
L
R
G
Y
H
R
S
F
G
L
D
Site 24
S304
S
L
R
G
Y
H
R
S
F
G
L
D
D
D
S
Site 25
S311
S
F
G
L
D
D
D
S
L
A
K
L
A
E
Q
Site 26
S328
K
Q
A
G
D
L
R
S
V
I
R
S
P
L
A
Site 27
S332
D
L
R
S
V
I
R
S
P
L
A
N
E
V
S
Site 28
S339
S
P
L
A
N
E
V
S
P
E
T
V
L
R
L
Site 29
T342
A
N
E
V
S
P
E
T
V
L
R
L
Y
S
Q
Site 30
Y347
P
E
T
V
L
R
L
Y
S
Q
S
S
D
G
A
Site 31
S348
E
T
V
L
R
L
Y
S
Q
S
S
D
G
A
M
Site 32
S350
V
L
R
L
Y
S
Q
S
S
D
G
A
M
R
V
Site 33
S351
L
R
L
Y
S
Q
S
S
D
G
A
M
R
V
A
Site 34
S414
D
E
P
Q
P
E
V
S
L
E
V
A
S
D
N
Site 35
S428
N
G
V
E
K
G
G
S
G
E
G
G
G
E
E
Site 36
S439
G
G
E
E
A
P
L
S
T
C
R
K
L
G
L
Site 37
T440
G
E
E
A
P
L
S
T
C
R
K
L
G
L
L
Site 38
Y450
K
L
G
L
L
L
K
Y
I
L
D
S
W
K
K
Site 39
S454
L
L
K
Y
I
L
D
S
W
K
K
H
D
S
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation