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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KNL2
Full Name:
Kinetochore-associated protein KNL-2 homolog
Alias:
chromosome 14 open reading frame 106; CV106; FLJ11186; HSA242977; KIAA1903; MIS18BP1
Type:
DNA binding protein
Mass (Da):
129085
Number AA:
1132
UniProt ID:
Q6P0N0
International Prot ID:
IPI00104907
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000775
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007067
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
P
L
K
H
S
R
I
Y
L
P
P
E
A
S
S
Site 2
S18
I
Y
L
P
P
E
A
S
S
Q
R
R
N
L
P
Site 3
S19
Y
L
P
P
E
A
S
S
Q
R
R
N
L
P
M
Site 4
Y48
P
V
K
D
L
V
K
Y
Q
N
S
S
L
K
L
Site 5
S52
L
V
K
Y
Q
N
S
S
L
K
L
N
D
H
K
Site 6
T81
I
F
Q
S
T
M
L
T
E
A
T
T
S
N
S
Site 7
T84
S
T
M
L
T
E
A
T
T
S
N
S
S
L
D
Site 8
S86
M
L
T
E
A
T
T
S
N
S
S
L
D
I
S
Site 9
S88
T
E
A
T
T
S
N
S
S
L
D
I
S
A
I
Site 10
S89
E
A
T
T
S
N
S
S
L
D
I
S
A
I
K
Site 11
S93
S
N
S
S
L
D
I
S
A
I
K
P
N
K
D
Site 12
Y108
G
L
K
N
K
A
N
Y
E
S
P
G
K
I
F
Site 13
S110
K
N
K
A
N
Y
E
S
P
G
K
I
F
L
R
Site 14
S131
R
D
K
Q
E
Q
P
S
R
N
S
S
L
L
E
Site 15
S134
Q
E
Q
P
S
R
N
S
S
L
L
E
P
Q
K
Site 16
S135
E
Q
P
S
R
N
S
S
L
L
E
P
Q
K
S
Site 17
S142
S
L
L
E
P
Q
K
S
G
N
N
E
T
F
T
Site 18
T147
Q
K
S
G
N
N
E
T
F
T
P
N
R
V
E
Site 19
T149
S
G
N
N
E
T
F
T
P
N
R
V
E
K
K
Site 20
T161
E
K
K
K
L
Q
H
T
Y
L
C
E
E
K
E
Site 21
Y162
K
K
K
L
Q
H
T
Y
L
C
E
E
K
E
N
Site 22
S172
E
E
K
E
N
N
K
S
F
Q
S
D
D
S
S
Site 23
S175
E
N
N
K
S
F
Q
S
D
D
S
S
L
R
A
Site 24
S178
K
S
F
Q
S
D
D
S
S
L
R
A
S
V
Q
Site 25
S179
S
F
Q
S
D
D
S
S
L
R
A
S
V
Q
G
Site 26
S183
D
D
S
S
L
R
A
S
V
Q
G
V
P
L
E
Site 27
S191
V
Q
G
V
P
L
E
S
S
N
N
D
I
F
L
Site 28
S192
Q
G
V
P
L
E
S
S
N
N
D
I
F
L
P
Site 29
T218
K
A
P
L
H
N
L
T
Y
E
L
P
T
L
N
Site 30
Y219
A
P
L
H
N
L
T
Y
E
L
P
T
L
N
Q
Site 31
T240
A
V
E
A
R
N
K
T
L
T
R
A
Q
L
A
Site 32
T242
E
A
R
N
K
T
L
T
R
A
Q
L
A
K
Q
Site 33
S256
Q
I
F
H
S
K
E
S
I
V
A
T
T
K
S
Site 34
T260
S
K
E
S
I
V
A
T
T
K
S
K
K
D
T
Site 35
T261
K
E
S
I
V
A
T
T
K
S
K
K
D
T
F
Site 36
S263
S
I
V
A
T
T
K
S
K
K
D
T
F
V
L
Site 37
T267
T
T
K
S
K
K
D
T
F
V
L
E
S
V
D
Site 38
S275
F
V
L
E
S
V
D
S
A
D
E
Q
F
Q
N
Site 39
T283
A
D
E
Q
F
Q
N
T
N
A
E
T
L
S
T
Site 40
S289
N
T
N
A
E
T
L
S
T
N
C
I
P
I
K
Site 41
T290
T
N
A
E
T
L
S
T
N
C
I
P
I
K
N
Site 42
S299
C
I
P
I
K
N
G
S
L
L
M
V
S
D
S
Site 43
S304
N
G
S
L
L
M
V
S
D
S
E
R
T
T
E
Site 44
S306
S
L
L
M
V
S
D
S
E
R
T
T
E
G
T
Site 45
T310
V
S
D
S
E
R
T
T
E
G
T
S
Q
Q
K
Site 46
T325
V
K
E
G
N
G
K
T
V
P
G
E
T
G
L
Site 47
T330
G
K
T
V
P
G
E
T
G
L
P
G
S
M
K
Site 48
S335
G
E
T
G
L
P
G
S
M
K
D
T
C
K
I
Site 49
T346
T
C
K
I
V
L
A
T
P
R
L
H
I
T
I
Site 50
T352
A
T
P
R
L
H
I
T
I
P
R
R
S
K
R
Site 51
S357
H
I
T
I
P
R
R
S
K
R
N
I
S
K
L
Site 52
S362
R
R
S
K
R
N
I
S
K
L
S
P
P
R
I
Site 53
S365
K
R
N
I
S
K
L
S
P
P
R
I
F
Q
T
Site 54
T372
S
P
P
R
I
F
Q
T
V
T
N
G
L
K
K
Site 55
S431
H
N
K
L
R
T
I
S
G
N
V
Y
I
L
K
Site 56
S445
K
G
M
I
D
Q
I
S
M
K
E
A
G
Y
P
Site 57
Y451
I
S
M
K
E
A
G
Y
P
N
Y
L
I
R
K
Site 58
Y454
K
E
A
G
Y
P
N
Y
L
I
R
K
F
M
F
Site 59
T488
G
E
K
N
R
E
K
T
K
Q
K
Q
K
T
G
Site 60
T494
K
T
K
Q
K
Q
K
T
G
R
S
V
R
D
I
Site 61
S497
Q
K
Q
K
T
G
R
S
V
R
D
I
R
K
S
Site 62
S504
S
V
R
D
I
R
K
S
M
K
N
D
A
R
E
Site 63
T516
A
R
E
N
Q
T
D
T
A
Q
R
A
T
T
T
Site 64
T521
T
D
T
A
Q
R
A
T
T
T
Y
D
F
D
C
Site 65
T522
D
T
A
Q
R
A
T
T
T
Y
D
F
D
C
D
Site 66
Y524
A
Q
R
A
T
T
T
Y
D
F
D
C
D
N
L
Site 67
S535
C
D
N
L
E
L
K
S
N
K
H
S
E
S
P
Site 68
S539
E
L
K
S
N
K
H
S
E
S
P
G
A
T
E
Site 69
S541
K
S
N
K
H
S
E
S
P
G
A
T
E
L
N
Site 70
T545
H
S
E
S
P
G
A
T
E
L
N
M
C
H
S
Site 71
T570
P
D
D
Q
V
N
N
T
I
Q
N
G
G
G
D
Site 72
S580
N
G
G
G
D
D
L
S
N
Q
E
L
I
G
K
Site 73
Y590
E
L
I
G
K
K
E
Y
K
M
S
S
K
K
L
Site 74
S593
G
K
K
E
Y
K
M
S
S
K
K
L
K
I
G
Site 75
S594
K
K
E
Y
K
M
S
S
K
K
L
K
I
G
E
Site 76
S610
T
N
E
R
I
I
K
S
Q
K
Q
E
T
T
E
Site 77
S622
T
T
E
E
L
D
V
S
I
D
I
L
T
S
R
Site 78
T627
D
V
S
I
D
I
L
T
S
R
E
Q
F
F
S
Site 79
S628
V
S
I
D
I
L
T
S
R
E
Q
F
F
S
D
Site 80
S634
T
S
R
E
Q
F
F
S
D
E
E
R
K
Y
M
Site 81
Y640
F
S
D
E
E
R
K
Y
M
A
I
N
Q
K
K
Site 82
T653
K
K
A
Y
I
L
V
T
P
L
K
S
R
K
V
Site 83
S671
R
C
M
R
Y
N
L
S
A
G
T
I
K
A
V
Site 84
S690
I
P
E
C
Q
K
K
S
P
I
S
K
S
M
G
Site 85
S693
C
Q
K
K
S
P
I
S
K
S
M
G
T
L
E
Site 86
S695
K
K
S
P
I
S
K
S
M
G
T
L
E
N
T
Site 87
T702
S
M
G
T
L
E
N
T
F
E
G
H
K
S
K
Site 88
T721
C
D
E
R
D
L
L
T
V
N
R
K
I
K
I
Site 89
S729
V
N
R
K
I
K
I
S
N
L
E
K
E
Q
M
Site 90
T738
L
E
K
E
Q
M
L
T
S
D
F
K
K
N
T
Site 91
S739
E
K
E
Q
M
L
T
S
D
F
K
K
N
T
R
Site 92
S761
I
E
N
Q
V
A
M
S
F
Y
K
H
Q
S
S
Site 93
Y763
N
Q
V
A
M
S
F
Y
K
H
Q
S
S
P
D
Site 94
S767
M
S
F
Y
K
H
Q
S
S
P
D
L
S
S
E
Site 95
S768
S
F
Y
K
H
Q
S
S
P
D
L
S
S
E
E
Site 96
S772
H
Q
S
S
P
D
L
S
S
E
E
S
E
T
E
Site 97
S773
Q
S
S
P
D
L
S
S
E
E
S
E
T
E
K
Site 98
S776
P
D
L
S
S
E
E
S
E
T
E
K
E
I
K
Site 99
T778
L
S
S
E
E
S
E
T
E
K
E
I
K
R
K
Site 100
T791
R
K
A
E
V
K
K
T
K
A
G
N
T
K
E
Site 101
S806
A
V
V
H
L
R
K
S
T
R
N
T
S
N
I
Site 102
T807
V
V
H
L
R
K
S
T
R
N
T
S
N
I
P
Site 103
T810
L
R
K
S
T
R
N
T
S
N
I
P
V
I
L
Site 104
S811
R
K
S
T
R
N
T
S
N
I
P
V
I
L
E
Site 105
T821
P
V
I
L
E
P
E
T
E
E
S
E
N
E
F
Site 106
S824
L
E
P
E
T
E
E
S
E
N
E
F
Y
I
K
Site 107
Y829
E
E
S
E
N
E
F
Y
I
K
Q
K
K
A
R
Site 108
S838
K
Q
K
K
A
R
P
S
V
K
E
T
L
Q
K
Site 109
T842
A
R
P
S
V
K
E
T
L
Q
K
S
G
V
R
Site 110
S846
V
K
E
T
L
Q
K
S
G
V
R
K
E
F
P
Site 111
T855
V
R
K
E
F
P
I
T
E
A
V
G
S
D
K
Site 112
S860
P
I
T
E
A
V
G
S
D
K
T
N
R
H
P
Site 113
T863
E
A
V
G
S
D
K
T
N
R
H
P
L
E
C
Site 114
S894
K
L
H
C
A
F
A
S
L
P
K
H
K
P
G
Site 115
S914
A
A
A
V
G
S
R
S
P
E
E
C
Q
R
K
Site 116
Y922
P
E
E
C
Q
R
K
Y
M
E
N
P
R
G
K
Site 117
S931
E
N
P
R
G
K
G
S
Q
K
H
V
T
K
K
Site 118
S991
D
D
H
D
D
F
F
S
T
T
P
L
Q
H
Q
Site 119
T992
D
H
D
D
F
F
S
T
T
P
L
Q
H
Q
R
Site 120
T993
H
D
D
F
F
S
T
T
P
L
Q
H
Q
R
I
Site 121
S1004
H
Q
R
I
L
L
P
S
F
Q
D
S
E
D
D
Site 122
S1008
L
L
P
S
F
Q
D
S
E
D
D
D
D
I
L
Site 123
T1023
P
N
M
D
K
N
P
T
T
P
S
S
V
I
F
Site 124
T1024
N
M
D
K
N
P
T
T
P
S
S
V
I
F
P
Site 125
S1026
D
K
N
P
T
T
P
S
S
V
I
F
P
L
V
Site 126
S1027
K
N
P
T
T
P
S
S
V
I
F
P
L
V
K
Site 127
T1035
V
I
F
P
L
V
K
T
P
Q
C
Q
H
V
S
Site 128
S1042
T
P
Q
C
Q
H
V
S
P
G
M
L
G
S
I
Site 129
S1048
V
S
P
G
M
L
G
S
I
N
R
N
D
C
D
Site 130
Y1057
N
R
N
D
C
D
K
Y
V
F
R
M
Q
K
Y
Site 131
Y1064
Y
V
F
R
M
Q
K
Y
H
K
S
N
G
G
I
Site 132
S1086
K
L
V
E
T
D
F
S
T
P
T
P
R
R
K
Site 133
T1087
L
V
E
T
D
F
S
T
P
T
P
R
R
K
T
Site 134
T1089
E
T
D
F
S
T
P
T
P
R
R
K
T
P
F
Site 135
T1094
T
P
T
P
R
R
K
T
P
F
N
T
D
L
G
Site 136
T1098
R
R
K
T
P
F
N
T
D
L
G
E
N
S
G
Site 137
S1104
N
T
D
L
G
E
N
S
G
I
G
K
L
F
T
Site 138
S1116
L
F
T
N
A
V
E
S
L
D
E
E
E
K
D
Site 139
Y1124
L
D
E
E
E
K
D
Y
Y
F
S
N
S
D
S
Site 140
Y1125
D
E
E
E
K
D
Y
Y
F
S
N
S
D
S
A
Site 141
S1127
E
E
K
D
Y
Y
F
S
N
S
D
S
A
_
_
Site 142
S1129
K
D
Y
Y
F
S
N
S
D
S
A
_
_
_
_
Site 143
S1131
Y
Y
F
S
N
S
D
S
A
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation