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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LLGL2
Full Name:
Lethal(2) giant larvae protein homolog 2
Alias:
HGL; L2GL2; Lethal giant larvae 2; Lethal(2) giant larvae 2
Type:
Cell cycle regulation
Mass (Da):
113448
Number AA:
1020
UniProt ID:
Q6P1M3
International Prot ID:
IPI00641801
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0051301
GO:0006887
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T26
D
L
F
Q
F
N
K
T
V
E
H
G
F
P
H
Site 2
S36
H
G
F
P
H
Q
P
S
A
L
G
Y
S
P
S
Site 3
Y40
H
Q
P
S
A
L
G
Y
S
P
S
L
R
I
L
Site 4
T90
P
G
Q
C
Q
L
V
T
L
L
D
D
N
S
L
Site 5
S101
D
N
S
L
H
L
W
S
L
K
V
K
G
G
A
Site 6
S116
S
E
L
Q
E
D
E
S
F
T
L
R
G
P
P
Site 7
T118
L
Q
E
D
E
S
F
T
L
R
G
P
P
G
A
Site 8
Y145
H
S
S
C
E
L
L
Y
L
G
T
E
S
G
N
Site 9
S170
A
L
E
D
R
T
I
S
S
D
A
V
L
Q
R
Site 10
S171
L
E
D
R
T
I
S
S
D
A
V
L
Q
R
L
Site 11
Y225
L
Q
G
S
R
V
L
Y
H
F
L
S
S
Q
Q
Site 12
S229
R
V
L
Y
H
F
L
S
S
Q
Q
L
E
N
I
Site 13
S247
R
D
G
R
L
L
V
S
C
H
S
D
G
S
Y
Site 14
S253
V
S
C
H
S
D
G
S
Y
C
Q
W
P
V
S
Site 15
Y254
S
C
H
S
D
G
S
Y
C
Q
W
P
V
S
S
Site 16
S260
S
Y
C
Q
W
P
V
S
S
E
A
Q
Q
P
E
Site 17
S261
Y
C
Q
W
P
V
S
S
E
A
Q
Q
P
E
P
Site 18
S271
Q
Q
P
E
P
L
R
S
L
V
P
Y
G
P
F
Site 19
T298
T
R
Q
G
L
P
F
T
I
F
Q
G
G
M
P
Site 20
Y309
G
G
M
P
R
A
S
Y
G
D
R
H
C
I
S
Site 21
T329
Q
Q
T
A
F
D
F
T
S
R
V
I
G
F
T
Site 22
S427
W
P
I
D
G
G
T
S
L
T
P
A
P
P
Q
Site 23
T429
I
D
G
G
T
S
L
T
P
A
P
P
Q
R
D
Site 24
T440
P
Q
R
D
L
L
L
T
G
H
E
D
G
T
V
Site 25
T446
L
T
G
H
E
D
G
T
V
R
F
W
D
A
S
Site 26
T471
S
T
V
R
V
F
L
T
D
T
D
P
N
E
N
Site 27
T473
V
R
V
F
L
T
D
T
D
P
N
E
N
F
S
Site 28
S495
P
P
L
R
K
V
G
S
F
D
P
Y
S
D
D
Site 29
Y499
K
V
G
S
F
D
P
Y
S
D
D
P
R
L
G
Site 30
S500
V
G
S
F
D
P
Y
S
D
D
P
R
L
G
I
Site 31
S568
H
E
R
L
A
A
R
S
G
P
V
R
F
E
P
Site 32
T627
R
Q
V
F
V
K
C
T
L
H
P
S
D
Q
L
Site 33
S631
V
K
C
T
L
H
P
S
D
Q
L
A
L
E
G
Site 34
S641
L
A
L
E
G
P
L
S
R
V
K
S
L
K
K
Site 35
S645
G
P
L
S
R
V
K
S
L
K
K
S
L
R
Q
Site 36
S649
R
V
K
S
L
K
K
S
L
R
Q
S
F
R
R
Site 37
S653
L
K
K
S
L
R
Q
S
F
R
R
M
R
R
S
Site 38
S660
S
F
R
R
M
R
R
S
R
V
S
S
R
K
R
Site 39
S663
R
M
R
R
S
R
V
S
S
R
K
R
H
P
A
Site 40
S664
M
R
R
S
R
V
S
S
R
K
R
H
P
A
G
Site 41
S680
P
G
E
A
Q
E
G
S
A
K
A
E
R
P
G
Site 42
S704
Q
R
K
I
E
A
R
S
A
E
D
S
F
T
G
Site 43
S708
E
A
R
S
A
E
D
S
F
T
G
F
V
R
T
Site 44
T710
R
S
A
E
D
S
F
T
G
F
V
R
T
L
Y
Site 45
T721
R
T
L
Y
F
A
D
T
Y
L
K
D
S
S
R
Site 46
Y722
T
L
Y
F
A
D
T
Y
L
K
D
S
S
R
H
Site 47
S726
A
D
T
Y
L
K
D
S
S
R
H
C
P
S
L
Site 48
S727
D
T
Y
L
K
D
S
S
R
H
C
P
S
L
W
Site 49
S732
D
S
S
R
H
C
P
S
L
W
A
G
T
N
G
Site 50
S800
L
E
V
A
H
D
L
S
K
S
P
D
M
Q
G
Site 51
S802
V
A
H
D
L
S
K
S
P
D
M
Q
G
S
H
Site 52
S808
K
S
P
D
M
Q
G
S
H
Q
L
L
V
V
S
Site 53
T823
E
E
Q
F
K
V
F
T
L
P
K
V
S
A
K
Site 54
S841
K
L
T
A
L
E
G
S
R
V
R
R
V
S
V
Site 55
S847
G
S
R
V
R
R
V
S
V
A
H
F
G
S
R
Site 56
S853
V
S
V
A
H
F
G
S
R
R
A
E
D
Y
G
Site 57
Y859
G
S
R
R
A
E
D
Y
G
E
H
H
L
A
V
Site 58
S888
L
K
P
Q
V
R
Y
S
C
I
R
R
E
D
V
Site 59
Y911
T
K
Y
G
Q
G
F
Y
L
I
S
P
S
E
F
Site 60
S914
G
Q
G
F
Y
L
I
S
P
S
E
F
E
R
F
Site 61
S922
P
S
E
F
E
R
F
S
L
S
T
K
W
L
V
Site 62
S924
E
F
E
R
F
S
L
S
T
K
W
L
V
E
P
Site 63
S937
E
P
R
C
L
V
D
S
A
E
T
K
N
H
R
Site 64
S956
A
G
P
K
K
A
P
S
R
A
R
N
S
G
T
Site 65
S961
A
P
S
R
A
R
N
S
G
T
Q
S
D
G
E
Site 66
T963
S
R
A
R
N
S
G
T
Q
S
D
G
E
E
K
Site 67
S965
A
R
N
S
G
T
Q
S
D
G
E
E
K
Q
P
Site 68
S982
V
M
E
R
A
L
L
S
D
E
R
V
L
K
E
Site 69
T993
V
L
K
E
I
Q
S
T
L
E
G
D
R
G
S
Site 70
S1000
T
L
E
G
D
R
G
S
G
N
W
R
S
H
R
Site 71
S1005
R
G
S
G
N
W
R
S
H
R
A
A
V
G
C
Site 72
S1013
H
R
A
A
V
G
C
S
L
S
N
G
G
A
E
Site 73
S1015
A
A
V
G
C
S
L
S
N
G
G
A
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation