PhosphoNET

           
Protein Info 
   
Short Name:  MED27
Full Name:  Mediator of RNA polymerase II transcription subunit 27
Alias:  Cofactor required for Sp1 transcriptional activation subunit 8;Mediator complex subunit 27;P37 TRAP/SMCC/PC2 subunit;Transcriptional coactivator CRSP34
Type: 
Mass (Da):  35432
Number AA:  311
UniProt ID:  Q6P2C8
International Prot ID: 
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:      PhosphoSite+ KinaseNET
Biological Process:      Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S27AIQALRSSVSRVFDC
Site 2S29QALRSSVSRVFDCLK
Site 3S74LNELERLSNLVGKPS
Site 4S81SNLVGKPSENHPLHN
Site 5S89ENHPLHNSGLLSLDP
Site 6S93LHNSGLLSLDPVQDK
Site 7T101LDPVQDKTPLYSQLL
Site 8Y104VQDKTPLYSQLLQAY
Site 9S105QDKTPLYSQLLQAYK
Site 10Y119KWSNKLQYHAGLASG
Site 11S132SGLLNQQSLKRSANQ
Site 12S136NQQSLKRSANQMGVS
Site 13S143SANQMGVSAKRRPKA
Site 14T153RRPKAQPTTLVLPPQ
Site 15T154RPKAQPTTLVLPPQY
Site 16S177DRMFPEMSIHLSRPN
Site 17S181PEMSIHLSRPNGTSA
Site 18T212RSLFIDRTIVKGYNE
Site 19Y222KGYNENVYTEDGKLD
Site 20T223GYNENVYTEDGKLDI
Site 21Y236DIWSKSNYQVFQKVT
Site 22Y253ATTALLHYQLPQMPD
Site 23T295LQDGLPPTWRDFRTL
Site 24T301PTWRDFRTLEAFHDT
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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