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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NEK5
Full Name:
Serine/threonine-protein kinase Nek5
Alias:
EC 2.7.11.1; MGC75495
Type:
Protein-serine kinase, Other group, NEK family
Mass (Da):
81445
Number AA:
708
UniProt ID:
Q6P3R8
International Prot ID:
IPI00243995
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y19
Q
G
A
F
G
K
A
Y
L
A
K
G
K
S
D
Site 2
S25
A
Y
L
A
K
G
K
S
D
S
K
H
C
V
I
Site 3
S27
L
A
K
G
K
S
D
S
K
H
C
V
I
K
E
Site 4
S48
P
I
Q
E
K
E
A
S
K
K
E
V
I
L
L
Site 5
S69
N
I
V
A
F
F
N
S
F
Q
E
N
G
R
L
Site 6
S101
R
Q
R
G
V
L
F
S
E
D
Q
I
L
G
W
Site 7
S137
K
A
Q
N
I
F
L
S
K
N
G
M
V
A
K
Site 8
T163
N
S
M
E
L
A
R
T
C
I
G
T
P
Y
Y
Site 9
T167
L
A
R
T
C
I
G
T
P
Y
Y
L
S
P
E
Site 10
S172
I
G
T
P
Y
Y
L
S
P
E
I
C
Q
N
K
Site 11
S225
Q
A
H
F
A
P
I
S
P
G
F
S
R
E
L
Site 12
S234
G
F
S
R
E
L
H
S
L
I
S
Q
L
F
Q
Site 13
S237
R
E
L
H
S
L
I
S
Q
L
F
Q
V
S
P
Site 14
S243
I
S
Q
L
F
Q
V
S
P
R
D
R
P
S
I
Site 15
S249
V
S
P
R
D
R
P
S
I
N
S
I
L
K
R
Site 16
S252
R
D
R
P
S
I
N
S
I
L
K
R
P
F
L
Site 17
T268
N
L
I
P
K
Y
L
T
P
E
V
I
Q
E
E
Site 18
S314
Q
G
K
C
P
P
R
S
R
I
S
V
P
I
K
Site 19
S317
C
P
P
R
S
R
I
S
V
P
I
K
R
N
A
Site 20
Y360
A
V
C
G
H
Y
D
Y
Y
Y
A
Q
L
D
M
Site 21
Y361
V
C
G
H
Y
D
Y
Y
Y
A
Q
L
D
M
L
Site 22
Y362
C
G
H
Y
D
Y
Y
Y
A
Q
L
D
M
L
R
Site 23
S376
R
R
R
A
H
K
P
S
Y
H
P
I
P
Q
E
Site 24
Y377
R
R
A
H
K
P
S
Y
H
P
I
P
Q
E
N
Site 25
Y390
E
N
T
G
V
E
D
Y
G
Q
E
T
R
H
G
Site 26
S399
Q
E
T
R
H
G
P
S
P
S
Q
W
P
A
E
Site 27
S401
T
R
H
G
P
S
P
S
Q
W
P
A
E
Y
L
Site 28
Y407
P
S
Q
W
P
A
E
Y
L
Q
R
K
F
E
A
Site 29
Y417
R
K
F
E
A
Q
Q
Y
K
L
K
V
E
K
Q
Site 30
S430
K
Q
L
G
L
R
P
S
S
A
E
P
N
Y
N
Site 31
S431
Q
L
G
L
R
P
S
S
A
E
P
N
Y
N
Q
Site 32
Y436
P
S
S
A
E
P
N
Y
N
Q
R
Q
E
L
R
Site 33
S444
N
Q
R
Q
E
L
R
S
N
G
E
E
P
R
F
Site 34
Y477
L
E
E
I
R
Q
Q
Y
H
N
D
M
K
E
I
Site 35
S496
G
R
E
P
E
E
N
S
K
I
S
H
K
T
Y
Site 36
T502
N
S
K
I
S
H
K
T
Y
L
V
K
K
S
N
Site 37
Y503
S
K
I
S
H
K
T
Y
L
V
K
K
S
N
L
Site 38
S508
K
T
Y
L
V
K
K
S
N
L
P
V
H
Q
D
Site 39
Y573
S
K
N
P
E
Q
K
Y
K
A
K
K
G
V
K
Site 40
S590
I
N
L
D
K
C
I
S
D
E
N
I
L
Q
E
Site 41
T609
D
I
P
N
E
T
L
T
F
E
D
G
M
K
F
Site 42
Y619
D
G
M
K
F
K
E
Y
E
C
V
K
E
H
G
Site 43
Y628
C
V
K
E
H
G
D
Y
T
D
K
A
F
E
K
Site 44
T629
V
K
E
H
G
D
Y
T
D
K
A
F
E
K
L
Site 45
T647
E
A
G
F
S
T
Q
T
V
A
A
V
G
N
R
Site 46
T680
D
I
T
S
T
C
P
T
G
P
D
S
E
S
V
Site 47
S684
T
C
P
T
G
P
D
S
E
S
V
L
S
V
S
Site 48
S686
P
T
G
P
D
S
E
S
V
L
S
V
S
R
Q
Site 49
S689
P
D
S
E
S
V
L
S
V
S
R
Q
E
G
K
Site 50
T697
V
S
R
Q
E
G
K
T
K
D
P
Y
S
P
V
Site 51
Y701
E
G
K
T
K
D
P
Y
S
P
V
L
I
L
M
Site 52
S702
G
K
T
K
D
P
Y
S
P
V
L
I
L
M
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation