KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SCYL2
Full Name:
SCY1-like protein 2
Alias:
Coated vesicle-associated kinase of 104 kDa; KIAA1360; SCY1-like protein 2
Type:
Protein-serine kinase, Other group, SCY1 family
Mass (Da):
103709
Number AA:
929
UniProt ID:
Q6P3W7
International Prot ID:
IPI00396218
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0030136
GO:0010008
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004672
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
S
M
L
N
K
L
K
S
T
V
T
K
V
T
A
Site 2
T11
M
L
N
K
L
K
S
T
V
T
K
V
T
A
D
Site 3
T13
N
K
L
K
S
T
V
T
K
V
T
A
D
V
T
Site 4
T29
A
V
M
G
N
P
V
T
R
E
F
D
V
G
R
Site 5
S40
D
V
G
R
H
I
A
S
G
G
N
G
L
A
W
Site 6
S56
I
F
N
G
T
K
K
S
T
K
Q
E
V
A
V
Site 7
T57
F
N
G
T
K
K
S
T
K
Q
E
V
A
V
F
Site 8
Y74
D
K
K
L
I
D
K
Y
Q
K
F
E
K
D
Q
Site 9
S85
E
K
D
Q
I
I
D
S
L
K
R
G
V
Q
Q
Site 10
T94
K
R
G
V
Q
Q
L
T
R
L
R
H
P
R
L
Site 11
T103
L
R
H
P
R
L
L
T
V
Q
H
P
L
E
E
Site 12
S138
G
N
W
E
N
L
P
S
P
I
S
P
D
I
K
Site 13
S141
E
N
L
P
S
P
I
S
P
D
I
K
D
Y
K
Site 14
Y147
I
S
P
D
I
K
D
Y
K
L
Y
D
V
E
T
Site 15
Y150
D
I
K
D
Y
K
L
Y
D
V
E
T
K
Y
G
Site 16
T154
Y
K
L
Y
D
V
E
T
K
Y
G
L
L
Q
V
Site 17
Y156
L
Y
D
V
E
T
K
Y
G
L
L
Q
V
S
E
Site 18
T180
K
M
V
H
G
N
I
T
P
E
N
I
I
L
N
Site 19
S203
G
F
D
F
C
V
S
S
T
N
P
S
E
Q
E
Site 20
S207
C
V
S
S
T
N
P
S
E
Q
E
P
K
F
P
Site 21
S224
E
W
D
P
N
L
P
S
L
C
L
P
N
P
E
Site 22
S242
P
E
Y
I
L
S
V
S
C
E
T
A
S
D
M
Site 23
S247
S
V
S
C
E
T
A
S
D
M
Y
S
L
G
T
Site 24
Y275
E
V
N
K
Q
D
I
Y
K
S
F
S
R
Q
L
Site 25
S277
N
K
Q
D
I
Y
K
S
F
S
R
Q
L
D
Q
Site 26
S279
Q
D
I
Y
K
S
F
S
R
Q
L
D
Q
L
S
Site 27
S286
S
R
Q
L
D
Q
L
S
R
L
G
S
S
S
L
Site 28
S290
D
Q
L
S
R
L
G
S
S
S
L
T
N
I
P
Site 29
S292
L
S
R
L
G
S
S
S
L
T
N
I
P
E
E
Site 30
T294
R
L
G
S
S
S
L
T
N
I
P
E
E
V
R
Site 31
T313
L
L
L
N
V
T
P
T
V
R
P
D
A
D
Q
Site 32
T322
R
P
D
A
D
Q
M
T
K
I
P
F
F
D
D
Site 33
T340
V
T
L
Q
Y
F
D
T
L
F
Q
R
D
N
L
Site 34
S350
Q
R
D
N
L
Q
K
S
Q
F
F
K
G
L
P
Site 35
Y405
E
E
C
T
K
E
E
Y
V
K
L
I
L
P
E
Site 36
T438
Q
K
M
D
L
L
L
T
K
T
P
P
D
E
I
Site 37
T440
M
D
L
L
L
T
K
T
P
P
D
E
I
K
N
Site 38
S448
P
P
D
E
I
K
N
S
V
L
P
M
V
Y
R
Site 39
T555
G
I
Y
K
C
T
F
T
H
K
K
L
G
I
T
Site 40
S604
E
M
L
N
R
L
E
S
E
H
K
T
K
L
E
Site 41
T608
R
L
E
S
E
H
K
T
K
L
E
Q
L
H
I
Site 42
S622
I
M
Q
E
Q
Q
K
S
L
D
I
G
N
Q
M
Site 43
T638
V
S
E
E
M
K
V
T
N
I
G
N
Q
Q
I
Site 44
T658
N
I
G
A
D
L
L
T
G
S
E
S
E
N
K
Site 45
S660
G
A
D
L
L
T
G
S
E
S
E
N
K
E
D
Site 46
S662
D
L
L
T
G
S
E
S
E
N
K
E
D
G
L
Site 47
S677
Q
N
K
H
K
R
A
S
L
T
L
E
E
K
Q
Site 48
T679
K
H
K
R
A
S
L
T
L
E
E
K
Q
K
L
Site 49
S698
E
Q
A
Q
K
L
K
S
Q
Q
P
L
K
P
Q
Site 50
T708
P
L
K
P
Q
V
H
T
P
V
A
T
V
K
Q
Site 51
T720
V
K
Q
T
K
D
L
T
D
T
L
M
D
N
M
Site 52
T722
Q
T
K
D
L
T
D
T
L
M
D
N
M
S
S
Site 53
S732
D
N
M
S
S
L
T
S
L
S
V
S
T
P
K
Site 54
S734
M
S
S
L
T
S
L
S
V
S
T
P
K
S
S
Site 55
S736
S
L
T
S
L
S
V
S
T
P
K
S
S
A
S
Site 56
T737
L
T
S
L
S
V
S
T
P
K
S
S
A
S
S
Site 57
S740
L
S
V
S
T
P
K
S
S
A
S
S
T
F
T
Site 58
S741
S
V
S
T
P
K
S
S
A
S
S
T
F
T
S
Site 59
S743
S
T
P
K
S
S
A
S
S
T
F
T
S
V
P
Site 60
S744
T
P
K
S
S
A
S
S
T
F
T
S
V
P
S
Site 61
T745
P
K
S
S
A
S
S
T
F
T
S
V
P
S
M
Site 62
S759
M
G
I
G
M
M
F
S
T
P
T
D
N
T
K
Site 63
T760
G
I
G
M
M
F
S
T
P
T
D
N
T
K
R
Site 64
T765
F
S
T
P
T
D
N
T
K
R
N
L
T
N
G
Site 65
T770
D
N
T
K
R
N
L
T
N
G
L
N
A
N
M
Site 66
Y795
V
N
T
N
Q
N
F
Y
S
S
P
S
T
V
G
Site 67
S797
T
N
Q
N
F
Y
S
S
P
S
T
V
G
V
T
Site 68
S799
Q
N
F
Y
S
S
P
S
T
V
G
V
T
K
M
Site 69
T800
N
F
Y
S
S
P
S
T
V
G
V
T
K
M
T
Site 70
T835
K
Q
T
Q
Q
R
P
T
D
M
S
A
L
N
N
Site 71
S838
Q
Q
R
P
T
D
M
S
A
L
N
N
L
F
G
Site 72
S857
K
V
S
M
N
Q
L
S
Q
Q
K
P
N
Q
W
Site 73
S874
Q
F
V
P
P
Q
G
S
P
T
M
G
S
S
V
Site 74
T876
V
P
P
Q
G
S
P
T
M
G
S
S
V
M
G
Site 75
S879
Q
G
S
P
T
M
G
S
S
V
M
G
T
Q
M
Site 76
S880
G
S
P
T
M
G
S
S
V
M
G
T
Q
M
N
Site 77
T912
Q
N
F
A
Q
P
P
T
T
M
T
N
S
S
S
Site 78
T913
N
F
A
Q
P
P
T
T
M
T
N
S
S
S
A
Site 79
T915
A
Q
P
P
T
T
M
T
N
S
S
S
A
S
N
Site 80
S917
P
P
T
T
M
T
N
S
S
S
A
S
N
D
L
Site 81
S919
T
T
M
T
N
S
S
S
A
S
N
D
L
K
D
Site 82
S921
M
T
N
S
S
S
A
S
N
D
L
K
D
L
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation