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Updated November 2019
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Protein Info
Short Name:
ARHGAP11A
Full Name:
Rho GTPase-activating protein 11A
Alias:
GAP (1-12); KIAA0013; MGC70740; RHGBA; Rho GTPase activating protein 11A
Type:
GTPase activating protein, Rac/Rho
Mass (Da):
113866
Number AA:
1023
UniProt ID:
Q6P4F7
International Prot ID:
IPI00477330
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0008047
GO:0030234
PhosphoSite+
KinaseNET
Biological Process:
GO:0007154
GO:0007165
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T37
C
D
R
R
R
H
E
T
A
A
T
E
I
G
G
Site 2
T40
R
R
H
E
T
A
A
T
E
I
G
G
K
I
F
Site 3
S57
P
F
N
A
L
P
H
S
A
V
P
E
Y
G
H
Site 4
Y62
P
H
S
A
V
P
E
Y
G
H
I
P
S
F
L
Site 5
S89
T
E
G
L
F
R
K
S
G
S
V
I
R
L
K
Site 6
S110
D
H
G
E
G
C
L
S
S
A
P
P
C
D
I
Site 7
S111
H
G
E
G
C
L
S
S
A
P
P
C
D
I
A
Site 8
Y173
H
T
V
H
V
L
R
Y
F
F
N
F
L
R
N
Site 9
S182
F
N
F
L
R
N
V
S
L
R
S
S
E
N
K
Site 10
S186
R
N
V
S
L
R
S
S
E
N
K
M
D
S
S
Site 11
S192
S
S
E
N
K
M
D
S
S
N
L
A
V
I
F
Site 12
S193
S
E
N
K
M
D
S
S
N
L
A
V
I
F
A
Site 13
S215
E
G
H
E
K
M
S
S
N
T
E
K
K
L
R
Site 14
S236
Q
T
L
I
D
Y
A
S
D
I
G
R
V
P
D
Site 15
S263
D
G
L
C
A
T
P
S
L
E
G
F
E
E
G
Site 16
Y272
E
G
F
E
E
G
E
Y
E
T
P
G
E
Y
K
Site 17
T274
F
E
E
G
E
Y
E
T
P
G
E
Y
K
R
K
Site 18
Y278
E
Y
E
T
P
G
E
Y
K
R
K
R
R
Q
S
Site 19
S285
Y
K
R
K
R
R
Q
S
V
G
D
F
V
S
G
Site 20
S291
Q
S
V
G
D
F
V
S
G
A
L
N
K
F
K
Site 21
T302
N
K
F
K
P
N
R
T
P
S
I
T
P
Q
E
Site 22
S304
F
K
P
N
R
T
P
S
I
T
P
Q
E
E
R
Site 23
T306
P
N
R
T
P
S
I
T
P
Q
E
E
R
I
A
Site 24
S316
E
E
R
I
A
Q
L
S
E
S
P
V
I
L
T
Site 25
S318
R
I
A
Q
L
S
E
S
P
V
I
L
T
P
N
Site 26
T323
S
E
S
P
V
I
L
T
P
N
A
K
R
T
L
Site 27
T329
L
T
P
N
A
K
R
T
L
P
V
D
S
S
H
Site 28
S334
K
R
T
L
P
V
D
S
S
H
G
F
S
S
K
Site 29
S335
R
T
L
P
V
D
S
S
H
G
F
S
S
K
K
Site 30
S339
V
D
S
S
H
G
F
S
S
K
K
R
K
S
I
Site 31
S340
D
S
S
H
G
F
S
S
K
K
R
K
S
I
K
Site 32
S345
F
S
S
K
K
R
K
S
I
K
H
N
F
N
F
Site 33
S357
F
N
F
E
L
L
P
S
N
L
F
N
S
S
S
Site 34
S362
L
P
S
N
L
F
N
S
S
S
T
P
V
S
V
Site 35
S363
P
S
N
L
F
N
S
S
S
T
P
V
S
V
H
Site 36
S364
S
N
L
F
N
S
S
S
T
P
V
S
V
H
I
Site 37
T365
N
L
F
N
S
S
S
T
P
V
S
V
H
I
D
Site 38
S368
N
S
S
S
T
P
V
S
V
H
I
D
T
S
S
Site 39
T373
P
V
S
V
H
I
D
T
S
S
E
G
S
S
Q
Site 40
S374
V
S
V
H
I
D
T
S
S
E
G
S
S
Q
S
Site 41
S375
S
V
H
I
D
T
S
S
E
G
S
S
Q
S
S
Site 42
S378
I
D
T
S
S
E
G
S
S
Q
S
S
L
S
P
Site 43
S379
D
T
S
S
E
G
S
S
Q
S
S
L
S
P
V
Site 44
S381
S
S
E
G
S
S
Q
S
S
L
S
P
V
L
I
Site 45
S382
S
E
G
S
S
Q
S
S
L
S
P
V
L
I
G
Site 46
S384
G
S
S
Q
S
S
L
S
P
V
L
I
G
G
N
Site 47
S402
T
A
G
V
P
R
R
S
K
R
I
A
G
K
K
Site 48
S415
K
K
V
C
R
V
E
S
G
K
A
G
C
F
S
Site 49
S422
S
G
K
A
G
C
F
S
P
K
I
S
H
K
E
Site 50
S426
G
C
F
S
P
K
I
S
H
K
E
K
V
R
R
Site 51
S434
H
K
E
K
V
R
R
S
L
R
L
K
F
N
L
Site 52
Y457
G
C
S
G
V
N
R
Y
E
S
V
G
W
R
L
Site 53
S459
S
G
V
N
R
Y
E
S
V
G
W
R
L
A
N
Site 54
S469
W
R
L
A
N
Q
Q
S
L
K
N
R
I
E
S
Site 55
S476
S
L
K
N
R
I
E
S
V
K
T
G
L
L
F
Site 56
T479
N
R
I
E
S
V
K
T
G
L
L
F
S
P
D
Site 57
S484
V
K
T
G
L
L
F
S
P
D
V
D
E
K
L
Site 58
S496
E
K
L
P
K
K
G
S
E
K
I
S
K
S
E
Site 59
S500
K
K
G
S
E
K
I
S
K
S
E
E
T
L
L
Site 60
S502
G
S
E
K
I
S
K
S
E
E
T
L
L
T
P
Site 61
T508
K
S
E
E
T
L
L
T
P
E
R
L
V
G
T
Site 62
T515
T
P
E
R
L
V
G
T
N
Y
R
M
S
W
T
Site 63
Y517
E
R
L
V
G
T
N
Y
R
M
S
W
T
G
P
Site 64
T522
T
N
Y
R
M
S
W
T
G
P
N
N
S
S
F
Site 65
S528
W
T
G
P
N
N
S
S
F
Q
E
V
D
A
N
Site 66
S539
V
D
A
N
E
A
S
S
M
V
E
N
L
E
V
Site 67
S549
E
N
L
E
V
E
N
S
L
E
P
D
I
M
V
Site 68
S559
P
D
I
M
V
E
K
S
P
A
T
S
C
E
L
Site 69
S563
V
E
K
S
P
A
T
S
C
E
L
T
P
S
N
Site 70
T567
P
A
T
S
C
E
L
T
P
S
N
L
N
N
K
Site 71
S569
T
S
C
E
L
T
P
S
N
L
N
N
K
H
N
Site 72
S577
N
L
N
N
K
H
N
S
N
I
T
S
S
P
L
Site 73
T580
N
K
H
N
S
N
I
T
S
S
P
L
S
G
D
Site 74
S581
K
H
N
S
N
I
T
S
S
P
L
S
G
D
E
Site 75
S582
H
N
S
N
I
T
S
S
P
L
S
G
D
E
N
Site 76
S585
N
I
T
S
S
P
L
S
G
D
E
N
N
M
T
Site 77
T592
S
G
D
E
N
N
M
T
K
E
T
L
V
K
V
Site 78
S604
V
K
V
Q
K
A
F
S
E
S
G
S
N
L
H
Site 79
S606
V
Q
K
A
F
S
E
S
G
S
N
L
H
A
L
Site 80
S608
K
A
F
S
E
S
G
S
N
L
H
A
L
M
N
Site 81
S619
A
L
M
N
Q
R
Q
S
S
V
T
N
V
G
K
Site 82
S620
L
M
N
Q
R
Q
S
S
V
T
N
V
G
K
V
Site 83
T622
N
Q
R
Q
S
S
V
T
N
V
G
K
V
K
L
Site 84
T630
N
V
G
K
V
K
L
T
E
P
S
Y
L
E
D
Site 85
Y634
V
K
L
T
E
P
S
Y
L
E
D
S
P
E
E
Site 86
S638
E
P
S
Y
L
E
D
S
P
E
E
N
L
F
E
Site 87
T650
L
F
E
T
N
D
L
T
I
V
E
S
K
E
K
Site 88
S654
N
D
L
T
I
V
E
S
K
E
K
Y
E
H
H
Site 89
Y658
I
V
E
S
K
E
K
Y
E
H
H
T
G
K
G
Site 90
S670
G
K
G
E
K
C
F
S
E
R
D
F
S
P
L
Site 91
S675
C
F
S
E
R
D
F
S
P
L
Q
T
Q
T
F
Site 92
T679
R
D
F
S
P
L
Q
T
Q
T
F
N
R
E
T
Site 93
T681
F
S
P
L
Q
T
Q
T
F
N
R
E
T
T
I
Site 94
T686
T
Q
T
F
N
R
E
T
T
I
K
C
Y
S
T
Site 95
T687
Q
T
F
N
R
E
T
T
I
K
C
Y
S
T
Q
Site 96
Y711
H
S
N
M
P
K
D
Y
L
S
K
Q
E
F
S
Site 97
S713
N
M
P
K
D
Y
L
S
K
Q
E
F
S
S
D
Site 98
S719
L
S
K
Q
E
F
S
S
D
E
E
I
K
K
Q
Site 99
S728
E
E
I
K
K
Q
Q
S
P
K
D
K
L
N
N
Site 100
S762
S
K
D
E
A
R
S
S
F
S
Q
Q
S
T
C
Site 101
S764
D
E
A
R
S
S
F
S
Q
Q
S
T
C
V
V
Site 102
S767
R
S
S
F
S
Q
Q
S
T
C
V
V
T
N
L
Site 103
T768
S
S
F
S
Q
Q
S
T
C
V
V
T
N
L
S
Site 104
S775
T
C
V
V
T
N
L
S
K
P
R
P
M
R
I
Site 105
T794
S
L
E
T
C
E
K
T
V
S
E
S
S
Q
M
Site 106
S796
E
T
C
E
K
T
V
S
E
S
S
Q
M
T
E
Site 107
T802
V
S
E
S
S
Q
M
T
E
H
R
K
V
S
D
Site 108
S829
P
N
R
I
K
V
K
S
P
L
K
F
Q
R
T
Site 109
T836
S
P
L
K
F
Q
R
T
P
V
R
Q
S
V
R
Site 110
S841
Q
R
T
P
V
R
Q
S
V
R
R
I
N
S
L
Site 111
S847
Q
S
V
R
R
I
N
S
L
L
E
Y
S
R
Q
Site 112
Y851
R
I
N
S
L
L
E
Y
S
R
Q
P
T
G
H
Site 113
S852
I
N
S
L
L
E
Y
S
R
Q
P
T
G
H
K
Site 114
T856
L
E
Y
S
R
Q
P
T
G
H
K
L
A
S
L
Site 115
S862
P
T
G
H
K
L
A
S
L
G
D
T
A
S
P
Site 116
T866
K
L
A
S
L
G
D
T
A
S
P
L
V
K
S
Site 117
S868
A
S
L
G
D
T
A
S
P
L
V
K
S
V
S
Site 118
S882
S
C
D
G
A
L
S
S
C
I
E
S
A
S
K
Site 119
S886
A
L
S
S
C
I
E
S
A
S
K
D
S
S
V
Site 120
S888
S
S
C
I
E
S
A
S
K
D
S
S
V
S
C
Site 121
S892
E
S
A
S
K
D
S
S
V
S
C
I
K
S
G
Site 122
S894
A
S
K
D
S
S
V
S
C
I
K
S
G
P
K
Site 123
S898
S
S
V
S
C
I
K
S
G
P
K
E
Q
K
S
Site 124
S905
S
G
P
K
E
Q
K
S
M
S
C
E
E
S
N
Site 125
S907
P
K
E
Q
K
S
M
S
C
E
E
S
N
I
G
Site 126
S911
K
S
M
S
C
E
E
S
N
I
G
A
I
S
K
Site 127
S917
E
S
N
I
G
A
I
S
K
S
S
M
E
L
P
Site 128
S919
N
I
G
A
I
S
K
S
S
M
E
L
P
S
K
Site 129
S925
K
S
S
M
E
L
P
S
K
S
F
L
K
M
R
Site 130
S927
S
M
E
L
P
S
K
S
F
L
K
M
R
K
H
Site 131
S937
K
M
R
K
H
P
D
S
V
N
A
S
L
R
S
Site 132
S941
H
P
D
S
V
N
A
S
L
R
S
T
T
V
Y
Site 133
T945
V
N
A
S
L
R
S
T
T
V
Y
K
Q
K
I
Site 134
T946
N
A
S
L
R
S
T
T
V
Y
K
Q
K
I
L
Site 135
Y948
S
L
R
S
T
T
V
Y
K
Q
K
I
L
S
D
Site 136
T966
K
V
P
L
D
D
L
T
N
H
D
I
V
K
P
Site 137
S994
N
R
V
L
R
R
P
S
E
R
G
R
A
W
Y
Site 138
Y1001
S
E
R
G
R
A
W
Y
K
G
S
P
K
H
P
Site 139
S1004
G
R
A
W
Y
K
G
S
P
K
H
P
I
G
K
Site 140
T1012
P
K
H
P
I
G
K
T
Q
L
L
P
T
S
K
Site 141
S1018
K
T
Q
L
L
P
T
S
K
P
V
D
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation