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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ALKBH5
Full Name:
Probable alpha-ketoglutarate-dependent dioxygenase ABH5
Alias:
ALKB5; Alkylated DNA repair protein alkB homolog 5: Alkylated DNA repair protein alkB homolog 5; Alkylated repair protein alkB
Type:
DNA repair, Oxidoreductase
Mass (Da):
51409
Number AA:
458
UniProt ID:
Q6P6C2
International Prot ID:
IPI00413659
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
A
A
A
S
G
Y
T
D
L
R
E
Site 2
S16
D
L
R
E
K
L
K
S
M
T
S
R
D
N
Y
Site 3
S19
E
K
L
K
S
M
T
S
R
D
N
Y
K
A
G
Site 4
Y23
S
M
T
S
R
D
N
Y
K
A
G
S
R
E
A
Site 5
Y51
A
A
A
A
A
E
P
Y
P
V
S
G
A
K
R
Site 6
S54
A
A
E
P
Y
P
V
S
G
A
K
R
K
Y
Q
Site 7
Y60
V
S
G
A
K
R
K
Y
Q
E
D
S
D
P
E
Site 8
S64
K
R
K
Y
Q
E
D
S
D
P
E
R
S
D
Y
Site 9
S69
E
D
S
D
P
E
R
S
D
Y
E
E
Q
Q
L
Site 10
Y71
S
D
P
E
R
S
D
Y
E
E
Q
Q
L
Q
K
Site 11
S87
E
E
A
R
K
V
K
S
G
I
R
Q
M
R
L
Site 12
S96
I
R
Q
M
R
L
F
S
Q
D
E
C
A
K
I
Site 13
S112
A
R
I
D
E
V
V
S
R
A
E
K
G
L
Y
Site 14
Y119
S
R
A
E
K
G
L
Y
N
E
H
T
V
D
R
Site 15
T123
K
G
L
Y
N
E
H
T
V
D
R
A
P
L
R
Site 16
Y133
R
A
P
L
R
N
K
Y
F
F
G
E
G
Y
T
Site 17
Y141
F
F
G
E
G
Y
T
Y
G
A
Q
L
Q
K
R
Site 18
Y156
G
P
G
Q
E
R
L
Y
P
P
G
D
V
D
E
Site 19
S240
Q
F
K
P
I
R
V
S
E
P
V
L
S
L
P
Site 20
S245
R
V
S
E
P
V
L
S
L
P
V
R
R
G
S
Site 21
T265
G
Y
A
A
D
E
I
T
H
C
I
R
P
Q
D
Site 22
T294
L
D
A
P
R
L
E
T
K
S
L
S
S
S
V
Site 23
S296
A
P
R
L
E
T
K
S
L
S
S
S
V
L
P
Site 24
S298
R
L
E
T
K
S
L
S
S
S
V
L
P
P
S
Site 25
S299
L
E
T
K
S
L
S
S
S
V
L
P
P
S
Y
Site 26
S300
E
T
K
S
L
S
S
S
V
L
P
P
S
Y
A
Site 27
S305
S
S
S
V
L
P
P
S
Y
A
S
D
R
L
S
Site 28
Y306
S
S
V
L
P
P
S
Y
A
S
D
R
L
S
G
Site 29
S308
V
L
P
P
S
Y
A
S
D
R
L
S
G
N
N
Site 30
S312
S
Y
A
S
D
R
L
S
G
N
N
R
D
P
A
Site 31
S325
P
A
L
K
P
K
R
S
H
R
K
A
D
P
D
Site 32
S350
D
K
E
E
N
R
R
S
V
L
L
P
T
H
R
Site 33
T355
R
R
S
V
L
L
P
T
H
R
R
R
G
S
F
Site 34
S361
P
T
H
R
R
R
G
S
F
S
S
E
N
Y
W
Site 35
S363
H
R
R
R
G
S
F
S
S
E
N
Y
W
R
K
Site 36
S364
R
R
R
G
S
F
S
S
E
N
Y
W
R
K
S
Site 37
Y367
G
S
F
S
S
E
N
Y
W
R
K
S
Y
E
S
Site 38
S371
S
E
N
Y
W
R
K
S
Y
E
S
S
E
D
C
Site 39
Y372
E
N
Y
W
R
K
S
Y
E
S
S
E
D
C
S
Site 40
S374
Y
W
R
K
S
Y
E
S
S
E
D
C
S
E
A
Site 41
S375
W
R
K
S
Y
E
S
S
E
D
C
S
E
A
A
Site 42
S379
Y
E
S
S
E
D
C
S
E
A
A
G
S
P
G
Site 43
S384
D
C
S
E
A
A
G
S
P
G
N
S
G
S
S
Site 44
S388
A
A
G
S
P
G
N
S
G
S
S
L
R
S
C
Site 45
S390
G
S
P
G
N
S
G
S
S
L
R
S
C
P
S
Site 46
S391
S
P
G
N
S
G
S
S
L
R
S
C
P
S
F
Site 47
S394
N
S
G
S
S
L
R
S
C
P
S
F
C
F
E
Site 48
S443
R
I
G
Q
D
L
G
S
H
I
L
G
I
P
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation