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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRRC8B
Full Name:
Leucine-rich repeat-containing protein 8B
Alias:
T-cell activation leucine repeat-rich protein
Type:
Mass (Da):
92390
Number AA:
803
UniProt ID:
Q6P9F7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
K
C
L
A
D
A
Q
S
S
Y
H
I
L
K
P
Site 2
Y17
L
A
D
A
Q
S
S
Y
H
I
L
K
P
W
W
Site 3
S76
P
W
D
I
L
K
A
S
M
N
T
S
S
N
P
Site 4
S80
L
K
A
S
M
N
T
S
S
N
P
G
T
P
L
Site 5
S81
K
A
S
M
N
T
S
S
N
P
G
T
P
L
P
Site 6
T85
N
T
S
S
N
P
G
T
P
L
P
L
P
L
R
Site 7
Y102
N
D
L
H
R
Q
Q
Y
S
Y
I
D
A
V
C
Site 8
Y104
L
H
R
Q
Q
Y
S
Y
I
D
A
V
C
Y
E
Site 9
Y142
C
S
N
F
W
L
H
Y
P
S
T
S
S
R
L
Site 10
S144
N
F
W
L
H
Y
P
S
T
S
S
R
L
E
H
Site 11
T145
F
W
L
H
Y
P
S
T
S
S
R
L
E
H
F
Site 12
T165
K
C
F
D
S
P
W
T
T
R
A
L
S
E
T
Site 13
T166
C
F
D
S
P
W
T
T
R
A
L
S
E
T
V
Site 14
S170
P
W
T
T
R
A
L
S
E
T
V
A
E
Q
S
Site 15
T172
T
T
R
A
L
S
E
T
V
A
E
Q
S
V
R
Site 16
S177
S
E
T
V
A
E
Q
S
V
R
P
L
K
L
S
Site 17
S184
S
V
R
P
L
K
L
S
K
S
K
I
L
L
S
Site 18
S186
R
P
L
K
L
S
K
S
K
I
L
L
S
S
S
Site 19
S191
S
K
S
K
I
L
L
S
S
S
G
C
S
A
D
Site 20
S193
S
K
I
L
L
S
S
S
G
C
S
A
D
I
D
Site 21
S196
L
L
S
S
S
G
C
S
A
D
I
D
S
G
K
Site 22
S201
G
C
S
A
D
I
D
S
G
K
Q
S
L
P
Y
Site 23
S205
D
I
D
S
G
K
Q
S
L
P
Y
P
Q
P
G
Site 24
Y208
S
G
K
Q
S
L
P
Y
P
Q
P
G
L
E
S
Site 25
S215
Y
P
Q
P
G
L
E
S
A
G
I
E
S
P
T
Site 26
S220
L
E
S
A
G
I
E
S
P
T
S
S
V
L
D
Site 27
S223
A
G
I
E
S
P
T
S
S
V
L
D
K
K
E
Site 28
S224
G
I
E
S
P
T
S
S
V
L
D
K
K
E
G
Site 29
Y255
V
E
Q
K
D
I
I
Y
R
V
Y
L
K
Q
I
Site 30
Y299
D
V
Q
A
F
T
G
Y
K
R
Y
Q
C
V
Y
Site 31
Y302
A
F
T
G
Y
K
R
Y
Q
C
V
Y
S
L
A
Site 32
Y306
Y
K
R
Y
Q
C
V
Y
S
L
A
E
I
F
K
Site 33
S307
K
R
Y
Q
C
V
Y
S
L
A
E
I
F
K
V
Site 34
S333
Y
G
L
T
S
S
Y
S
L
W
W
M
L
R
S
Site 35
S346
R
S
S
L
K
Q
Y
S
F
E
A
L
R
E
K
Site 36
S354
F
E
A
L
R
E
K
S
N
Y
S
D
I
P
D
Site 37
Y356
A
L
R
E
K
S
N
Y
S
D
I
P
D
V
K
Site 38
Y376
I
L
H
L
A
D
Q
Y
D
P
L
Y
S
K
R
Site 39
Y380
A
D
Q
Y
D
P
L
Y
S
K
R
F
S
I
F
Site 40
S381
D
Q
Y
D
P
L
Y
S
K
R
F
S
I
F
L
Site 41
S389
K
R
F
S
I
F
L
S
E
V
S
E
N
K
L
Site 42
T406
I
N
L
N
N
E
W
T
V
E
K
L
K
S
K
Site 43
S412
W
T
V
E
K
L
K
S
K
L
V
K
N
A
Q
Site 44
Y471
N
L
K
E
L
R
V
Y
H
S
S
L
V
V
D
Site 45
S473
K
E
L
R
V
Y
H
S
S
L
V
V
D
H
P
Site 46
S474
E
L
R
V
Y
H
S
S
L
V
V
D
H
P
A
Site 47
T497
K
I
L
R
L
K
F
T
E
M
G
K
I
P
R
Site 48
S518
N
L
K
E
L
Y
L
S
G
C
V
L
P
E
Q
Site 49
T528
V
L
P
E
Q
L
S
T
M
Q
L
E
G
F
Q
Site 50
T542
Q
D
L
K
N
L
R
T
L
Y
L
K
S
S
L
Site 51
Y544
L
K
N
L
R
T
L
Y
L
K
S
S
L
S
R
Site 52
S548
R
T
L
Y
L
K
S
S
L
S
R
I
P
Q
V
Site 53
S567
L
P
S
L
Q
K
L
S
L
D
N
E
G
S
K
Site 54
S573
L
S
L
D
N
E
G
S
K
L
V
V
L
N
N
Site 55
S589
K
K
M
V
N
L
K
S
L
E
L
I
S
C
D
Site 56
S603
D
L
E
R
I
P
H
S
I
F
S
L
N
N
L
Site 57
S606
R
I
P
H
S
I
F
S
L
N
N
L
H
E
L
Site 58
T622
L
R
E
N
N
L
K
T
V
E
E
I
I
S
F
Site 59
S628
K
T
V
E
E
I
I
S
F
Q
H
L
Q
N
L
Site 60
S662
L
S
N
L
E
Q
L
S
L
D
H
N
N
I
E
Site 61
Y683
F
L
C
T
K
L
H
Y
L
D
L
S
Y
N
H
Site 62
T692
D
L
S
Y
N
H
L
T
F
I
P
E
E
I
Q
Site 63
Y700
F
I
P
E
E
I
Q
Y
L
S
N
L
Q
Y
F
Site 64
S702
P
E
E
I
Q
Y
L
S
N
L
Q
Y
F
A
V
Site 65
Y706
Q
Y
L
S
N
L
Q
Y
F
A
V
T
N
N
N
Site 66
S741
K
N
S
L
M
N
L
S
P
H
V
G
E
L
S
Site 67
S748
S
P
H
V
G
E
L
S
N
L
T
H
L
E
L
Site 68
T762
L
I
G
N
Y
L
E
T
L
P
P
E
L
E
G
Site 69
S772
P
E
L
E
G
C
Q
S
L
K
R
N
C
L
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation