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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RFWD3
Full Name:
E3 ubiquitin-protein ligase RFWD3
Alias:
FLJ10520; ring finger and WD repeat domain 3; RING finger protein 201; RNF201
Type:
Unknown function
Mass (Da):
85094
Number AA:
774
UniProt ID:
Q6PCD5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y8
M
A
H
E
A
M
E
Y
D
V
Q
V
Q
L
N
Site 2
S46
V
P
A
D
V
V
S
S
Q
G
V
P
S
I
L
Site 3
S63
A
P
A
E
V
I
S
S
Q
A
T
P
P
L
L
Site 4
S77
L
Q
P
A
P
Q
L
S
V
D
L
T
E
V
E
Site 5
T90
V
E
V
L
G
E
D
T
V
E
N
I
N
P
R
Site 6
S99
E
N
I
N
P
R
T
S
E
Q
H
R
Q
G
S
Site 7
S106
S
E
Q
H
R
Q
G
S
D
G
N
H
T
I
P
Site 8
T111
Q
G
S
D
G
N
H
T
I
P
A
S
S
L
H
Site 9
S115
G
N
H
T
I
P
A
S
S
L
H
S
M
T
N
Site 10
S116
N
H
T
I
P
A
S
S
L
H
S
M
T
N
F
Site 11
S125
H
S
M
T
N
F
I
S
G
L
Q
R
L
H
G
Site 12
S140
M
L
E
F
L
R
P
S
S
S
N
H
S
V
G
Site 13
S141
L
E
F
L
R
P
S
S
S
N
H
S
V
G
P
Site 14
S142
E
F
L
R
P
S
S
S
N
H
S
V
G
P
M
Site 15
S145
R
P
S
S
S
N
H
S
V
G
P
M
R
T
R
Site 16
T151
H
S
V
G
P
M
R
T
R
R
R
V
S
A
S
Site 17
S156
M
R
T
R
R
R
V
S
A
S
R
R
A
R
A
Site 18
S158
T
R
R
R
V
S
A
S
R
R
A
R
A
G
G
Site 19
S166
R
R
A
R
A
G
G
S
Q
R
T
D
S
A
R
Site 20
S171
G
G
S
Q
R
T
D
S
A
R
L
R
A
P
L
Site 21
Y181
L
R
A
P
L
D
A
Y
F
Q
V
S
R
T
Q
Site 22
T187
A
Y
F
Q
V
S
R
T
Q
P
D
L
P
A
T
Site 23
T194
T
Q
P
D
L
P
A
T
T
Y
D
S
E
T
R
Site 24
Y196
P
D
L
P
A
T
T
Y
D
S
E
T
R
N
P
Site 25
S198
L
P
A
T
T
Y
D
S
E
T
R
N
P
V
S
Site 26
T200
A
T
T
Y
D
S
E
T
R
N
P
V
S
E
E
Site 27
S205
S
E
T
R
N
P
V
S
E
E
L
Q
V
S
S
Site 28
S211
V
S
E
E
L
Q
V
S
S
S
S
D
S
D
S
Site 29
S212
S
E
E
L
Q
V
S
S
S
S
D
S
D
S
D
Site 30
S213
E
E
L
Q
V
S
S
S
S
D
S
D
S
D
S
Site 31
S214
E
L
Q
V
S
S
S
S
D
S
D
S
D
S
S
Site 32
S216
Q
V
S
S
S
S
D
S
D
S
D
S
S
A
E
Site 33
S218
S
S
S
S
D
S
D
S
D
S
S
A
E
Y
G
Site 34
S220
S
S
D
S
D
S
D
S
S
A
E
Y
G
G
V
Site 35
S221
S
D
S
D
S
D
S
S
A
E
Y
G
G
V
V
Site 36
Y224
D
S
D
S
S
A
E
Y
G
G
V
V
D
Q
A
Site 37
T253
V
S
A
E
Q
E
V
T
C
I
D
G
G
K
T
Site 38
T260
T
C
I
D
G
G
K
T
L
P
K
Q
P
S
P
Site 39
S266
K
T
L
P
K
Q
P
S
P
Q
K
S
E
P
L
Site 40
S270
K
Q
P
S
P
Q
K
S
E
P
L
L
P
S
A
Site 41
S276
K
S
E
P
L
L
P
S
A
S
M
D
E
E
E
Site 42
S278
E
P
L
L
P
S
A
S
M
D
E
E
E
G
D
Site 43
S303
N
A
G
D
H
R
L
S
A
L
R
C
G
H
L
Site 44
T318
F
G
Y
R
C
I
S
T
W
L
K
G
Q
V
R
Site 45
S337
C
N
K
K
A
R
H
S
D
I
V
V
L
Y
A
Site 46
T352
R
T
L
R
A
L
D
T
S
E
Q
E
R
M
K
Site 47
S353
T
L
R
A
L
D
T
S
E
Q
E
R
M
K
S
Site 48
S360
S
E
Q
E
R
M
K
S
S
L
L
K
E
Q
M
Site 49
S405
Q
D
L
Q
K
L
T
S
H
Q
S
Q
N
L
Q
Site 50
S408
Q
K
L
T
S
H
Q
S
Q
N
L
Q
Q
P
R
Site 51
S417
N
L
Q
Q
P
R
G
S
Q
A
W
V
L
S
C
Site 52
S423
G
S
Q
A
W
V
L
S
C
S
P
S
S
Q
G
Site 53
S425
Q
A
W
V
L
S
C
S
P
S
S
Q
G
Q
H
Site 54
S427
W
V
L
S
C
S
P
S
S
Q
G
Q
H
K
H
Site 55
S428
V
L
S
C
S
P
S
S
Q
G
Q
H
K
H
K
Site 56
T441
H
K
Y
H
F
Q
K
T
F
T
V
S
Q
A
G
Site 57
T443
Y
H
F
Q
K
T
F
T
V
S
Q
A
G
N
C
Site 58
S472
S
Q
P
S
P
Q
A
S
F
L
P
G
F
G
V
Site 59
S483
G
F
G
V
K
M
L
S
T
A
N
M
K
S
S
Site 60
S489
L
S
T
A
N
M
K
S
S
Q
Y
I
P
M
H
Site 61
S490
S
T
A
N
M
K
S
S
Q
Y
I
P
M
H
G
Site 62
Y492
A
N
M
K
S
S
Q
Y
I
P
M
H
G
K
Q
Site 63
T531
L
T
S
L
E
T
N
T
V
V
Q
T
Y
N
A
Site 64
Y536
T
N
T
V
V
Q
T
Y
N
A
G
R
P
V
W
Site 65
Y567
A
N
G
S
I
L
V
Y
D
V
R
N
T
S
S
Site 66
T572
L
V
Y
D
V
R
N
T
S
S
H
V
Q
E
L
Site 67
S573
V
Y
D
V
R
N
T
S
S
H
V
Q
E
L
V
Site 68
S574
Y
D
V
R
N
T
S
S
H
V
Q
E
L
V
A
Site 69
S590
K
A
R
C
P
L
V
S
L
S
Y
M
P
R
A
Site 70
S599
S
Y
M
P
R
A
A
S
A
A
F
P
Y
G
G
Site 71
S616
A
G
T
L
E
D
A
S
F
W
E
Q
K
M
D
Site 72
T643
G
G
C
I
D
F
Q
T
E
N
S
S
R
H
C
Site 73
S646
I
D
F
Q
T
E
N
S
S
R
H
C
L
V
T
Site 74
T653
S
S
R
H
C
L
V
T
Y
R
P
D
K
N
H
Site 75
Y654
S
R
H
C
L
V
T
Y
R
P
D
K
N
H
T
Site 76
T661
Y
R
P
D
K
N
H
T
T
I
R
S
V
L
M
Site 77
T662
R
P
D
K
N
H
T
T
I
R
S
V
L
M
E
Site 78
S671
R
S
V
L
M
E
M
S
Y
R
L
D
D
T
G
Site 79
Y672
S
V
L
M
E
M
S
Y
R
L
D
D
T
G
N
Site 80
T677
M
S
Y
R
L
D
D
T
G
N
P
I
C
S
C
Site 81
S707
T
K
N
A
I
F
Q
S
P
E
N
D
G
N
I
Site 82
S725
T
G
D
E
A
A
N
S
A
L
L
W
D
A
A
Site 83
S735
L
W
D
A
A
S
G
S
L
L
Q
D
L
Q
T
Site 84
T742
S
L
L
Q
D
L
Q
T
D
Q
P
V
L
D
I
Site 85
S758
P
F
E
V
N
R
N
S
Y
L
A
T
L
T
E
Site 86
Y759
F
E
V
N
R
N
S
Y
L
A
T
L
T
E
K
Site 87
T762
N
R
N
S
Y
L
A
T
L
T
E
K
M
V
H
Site 88
T764
N
S
Y
L
A
T
L
T
E
K
M
V
H
I
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation