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Updated November 2019
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Protein Info
Short Name:
HISPPD2A
Full Name:
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1
Alias:
EC 2.7.4.21; EC 2.7.4.24; Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1; IP6K; IPS1; KIAA0377; VIP1
Type:
EC 2.7.4.24; EC 2.7.4.21; Phosphatase (non-protein); Kinase (non-protein)
Mass (Da):
159521
Number AA:
1433
UniProt ID:
Q6PFW1
International Prot ID:
IPI00398511
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003993
GO:0033857
PhosphoSite+
KinaseNET
Biological Process:
GO:0006020
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
W
S
L
T
A
S
E
G
E
S
T
T
A
Site 2
T12
T
A
S
E
G
E
S
T
T
A
H
F
F
L
G
Site 3
T27
A
G
D
E
G
L
G
T
R
G
I
G
M
R
P
Site 4
S37
I
G
M
R
P
E
E
S
D
S
E
L
L
E
D
Site 5
S39
M
R
P
E
E
S
D
S
E
L
L
E
D
E
E
Site 6
S68
A
M
T
K
K
S
K
S
K
P
M
T
Q
I
L
Site 7
T72
K
S
K
S
K
P
M
T
Q
I
L
E
R
L
C
Site 8
S113
H
C
L
I
S
F
H
S
K
G
F
P
L
D
K
Site 9
S125
L
D
K
A
V
A
Y
S
K
L
R
N
P
F
L
Site 10
Y141
N
D
L
A
M
Q
Y
Y
I
Q
D
R
R
E
V
Site 11
Y149
I
Q
D
R
R
E
V
Y
R
I
L
Q
E
E
G
Site 12
Y162
E
G
I
D
L
P
R
Y
A
V
L
N
R
D
P
Site 13
S201
P
F
V
E
K
P
V
S
A
E
D
H
N
V
Y
Site 14
Y208
S
A
E
D
H
N
V
Y
I
Y
Y
P
S
S
A
Site 15
Y210
E
D
H
N
V
Y
I
Y
Y
P
S
S
A
G
G
Site 16
Y211
D
H
N
V
Y
I
Y
Y
P
S
S
A
G
G
G
Site 17
S213
N
V
Y
I
Y
Y
P
S
S
A
G
G
G
S
Q
Site 18
S214
V
Y
I
Y
Y
P
S
S
A
G
G
G
S
Q
R
Site 19
S219
P
S
S
A
G
G
G
S
Q
R
L
F
R
K
I
Site 20
S228
R
L
F
R
K
I
G
S
R
S
S
V
Y
S
P
Site 21
S230
F
R
K
I
G
S
R
S
S
V
Y
S
P
E
S
Site 22
S231
R
K
I
G
S
R
S
S
V
Y
S
P
E
S
S
Site 23
Y233
I
G
S
R
S
S
V
Y
S
P
E
S
S
V
R
Site 24
S234
G
S
R
S
S
V
Y
S
P
E
S
S
V
R
K
Site 25
S237
S
S
V
Y
S
P
E
S
S
V
R
K
T
G
S
Site 26
S238
S
V
Y
S
P
E
S
S
V
R
K
T
G
S
Y
Site 27
T242
P
E
S
S
V
R
K
T
G
S
Y
I
Y
E
E
Site 28
Y245
S
V
R
K
T
G
S
Y
I
Y
E
E
F
M
P
Site 29
Y247
R
K
T
G
S
Y
I
Y
E
E
F
M
P
T
D
Site 30
T253
I
Y
E
E
F
M
P
T
D
G
T
D
V
K
V
Site 31
T256
E
F
M
P
T
D
G
T
D
V
K
V
Y
T
V
Site 32
Y261
D
G
T
D
V
K
V
Y
T
V
G
P
D
Y
A
Site 33
T262
G
T
D
V
K
V
Y
T
V
G
P
D
Y
A
H
Site 34
Y267
V
Y
T
V
G
P
D
Y
A
H
A
E
A
R
K
Site 35
S275
A
H
A
E
A
R
K
S
P
A
L
D
G
K
V
Site 36
S286
D
G
K
V
E
R
D
S
E
G
K
E
I
R
Y
Site 37
Y293
S
E
G
K
E
I
R
Y
P
V
M
L
T
A
M
Site 38
Y346
V
K
N
S
M
K
Y
Y
D
D
C
A
K
I
L
Site 39
S370
P
Q
F
Q
I
P
W
S
I
P
T
E
A
E
D
Site 40
T404
I
I
R
H
G
D
R
T
P
K
Q
K
M
K
M
Site 41
T430
E
K
H
G
G
Y
K
T
G
K
L
K
L
K
R
Site 42
S475
G
K
L
E
Q
L
K
S
V
L
E
M
Y
G
H
Site 43
T493
I
N
R
K
V
Q
L
T
Y
Y
P
H
G
V
K
Site 44
Y495
R
K
V
Q
L
T
Y
Y
P
H
G
V
K
A
S
Site 45
T512
G
Q
D
P
Q
R
E
T
L
A
P
S
L
L
L
Site 46
T528
L
K
W
G
G
E
L
T
P
A
G
R
V
Q
A
Site 47
Y546
G
R
A
F
R
C
M
Y
P
G
G
Q
G
D
Y
Site 48
Y553
Y
P
G
G
Q
G
D
Y
A
G
F
P
G
C
G
Site 49
S566
C
G
L
L
R
L
H
S
T
F
R
H
D
L
K
Site 50
T567
G
L
L
R
L
H
S
T
F
R
H
D
L
K
I
Site 51
Y575
F
R
H
D
L
K
I
Y
A
S
D
E
G
R
V
Site 52
S577
H
D
L
K
I
Y
A
S
D
E
G
R
V
Q
M
Site 53
T585
D
E
G
R
V
Q
M
T
A
A
A
F
A
K
G
Site 54
S619
N
M
N
G
L
L
D
S
D
G
D
S
L
S
S
Site 55
S623
L
L
D
S
D
G
D
S
L
S
S
C
Q
H
R
Site 56
S625
D
S
D
G
D
S
L
S
S
C
Q
H
R
V
K
Site 57
Y650
A
P
F
G
P
E
D
Y
D
Q
L
A
P
T
R
Site 58
T656
D
Y
D
Q
L
A
P
T
R
S
T
S
L
L
N
Site 59
S658
D
Q
L
A
P
T
R
S
T
S
L
L
N
S
M
Site 60
T659
Q
L
A
P
T
R
S
T
S
L
L
N
S
M
T
Site 61
S664
R
S
T
S
L
L
N
S
M
T
I
I
Q
N
P
Site 62
S698
E
R
M
Q
D
P
R
S
V
D
L
Q
L
Y
H
Site 63
Y704
R
S
V
D
L
Q
L
Y
H
S
E
T
L
E
L
Site 64
T708
L
Q
L
Y
H
S
E
T
L
E
L
M
L
Q
R
Site 65
S717
E
L
M
L
Q
R
W
S
K
L
E
R
D
F
R
Site 66
S727
E
R
D
F
R
Q
K
S
G
R
Y
D
I
S
K
Site 67
Y730
F
R
Q
K
S
G
R
Y
D
I
S
K
I
P
D
Site 68
S733
K
S
G
R
Y
D
I
S
K
I
P
D
I
Y
D
Site 69
Y739
I
S
K
I
P
D
I
Y
D
C
V
K
Y
D
V
Site 70
Y744
D
I
Y
D
C
V
K
Y
D
V
Q
H
N
G
S
Site 71
S751
Y
D
V
Q
H
N
G
S
L
G
L
Q
G
T
A
Site 72
S764
T
A
E
L
L
R
L
S
K
A
L
A
D
V
V
Site 73
Y776
D
V
V
I
P
Q
E
Y
G
I
S
R
E
E
K
Site 74
S779
I
P
Q
E
Y
G
I
S
R
E
E
K
L
E
I
Site 75
S810
Q
R
T
H
E
D
E
S
V
N
K
L
H
P
L
Site 76
Y819
N
K
L
H
P
L
C
Y
L
R
Y
S
R
G
V
Site 77
Y822
H
P
L
C
Y
L
R
Y
S
R
G
V
L
S
P
Site 78
S823
P
L
C
Y
L
R
Y
S
R
G
V
L
S
P
G
Site 79
S828
R
Y
S
R
G
V
L
S
P
G
R
H
V
R
T
Site 80
Y838
R
H
V
R
T
R
L
Y
F
T
S
E
S
H
V
Site 81
S841
R
T
R
L
Y
F
T
S
E
S
H
V
H
S
L
Site 82
S843
R
L
Y
F
T
S
E
S
H
V
H
S
L
L
S
Site 83
S847
T
S
E
S
H
V
H
S
L
L
S
V
F
R
Y
Site 84
T861
Y
G
G
L
L
D
E
T
Q
D
A
Q
W
Q
R
Site 85
Y872
Q
W
Q
R
A
L
D
Y
L
S
A
I
S
E
L
Site 86
S874
Q
R
A
L
D
Y
L
S
A
I
S
E
L
N
Y
Site 87
Y890
T
Q
I
V
I
M
L
Y
E
D
N
T
Q
D
P
Site 88
T894
I
M
L
Y
E
D
N
T
Q
D
P
L
S
E
E
Site 89
S899
D
N
T
Q
D
P
L
S
E
E
R
F
H
V
E
Site 90
S921
K
G
V
E
E
E
G
S
A
P
A
G
C
G
F
Site 91
S932
G
C
G
F
R
P
A
S
S
E
N
E
E
M
K
Site 92
S933
C
G
F
R
P
A
S
S
E
N
E
E
M
K
T
Site 93
T940
S
E
N
E
E
M
K
T
N
Q
G
S
M
E
N
Site 94
S944
E
M
K
T
N
Q
G
S
M
E
N
L
C
P
G
Site 95
S954
N
L
C
P
G
K
A
S
D
E
P
D
R
A
L
Site 96
T963
E
P
D
R
A
L
Q
T
S
P
Q
P
P
E
G
Site 97
S964
P
D
R
A
L
Q
T
S
P
Q
P
P
E
G
P
Site 98
S977
G
P
G
L
P
R
R
S
P
L
I
R
N
R
K
Site 99
S987
I
R
N
R
K
A
G
S
M
E
V
L
S
E
T
Site 100
S992
A
G
S
M
E
V
L
S
E
T
S
S
S
R
P
Site 101
T994
S
M
E
V
L
S
E
T
S
S
S
R
P
G
G
Site 102
S995
M
E
V
L
S
E
T
S
S
S
R
P
G
G
Y
Site 103
S996
E
V
L
S
E
T
S
S
S
R
P
G
G
Y
R
Site 104
S997
V
L
S
E
T
S
S
S
R
P
G
G
Y
R
L
Site 105
Y1002
S
S
S
R
P
G
G
Y
R
L
F
S
S
S
R
Site 106
S1006
P
G
G
Y
R
L
F
S
S
S
R
P
P
T
E
Site 107
S1007
G
G
Y
R
L
F
S
S
S
R
P
P
T
E
M
Site 108
S1008
G
Y
R
L
F
S
S
S
R
P
P
T
E
M
K
Site 109
T1012
F
S
S
S
R
P
P
T
E
M
K
Q
S
G
L
Site 110
S1017
P
P
T
E
M
K
Q
S
G
L
G
S
Q
C
T
Site 111
S1021
M
K
Q
S
G
L
G
S
Q
C
T
G
L
F
S
Site 112
S1037
T
V
L
G
G
S
S
S
A
P
N
L
Q
D
Y
Site 113
Y1044
S
A
P
N
L
Q
D
Y
A
R
S
H
G
K
K
Site 114
S1056
G
K
K
L
P
P
A
S
L
K
H
R
D
E
L
Site 115
S1073
V
P
A
V
K
R
F
S
V
S
F
A
K
H
P
Site 116
S1075
A
V
K
R
F
S
V
S
F
A
K
H
P
T
N
Site 117
S1104
E
T
L
H
N
A
L
S
L
R
Q
V
S
E
F
Site 118
S1113
R
Q
V
S
E
F
L
S
R
V
C
Q
R
H
T
Site 119
T1120
S
R
V
C
Q
R
H
T
D
A
Q
A
Q
A
S
Site 120
S1133
A
S
A
A
L
F
D
S
M
H
S
S
Q
A
S
Site 121
S1136
A
L
F
D
S
M
H
S
S
Q
A
S
D
N
P
Site 122
S1137
L
F
D
S
M
H
S
S
Q
A
S
D
N
P
F
Site 123
S1140
S
M
H
S
S
Q
A
S
D
N
P
F
S
P
P
Site 124
S1145
Q
A
S
D
N
P
F
S
P
P
R
T
L
H
S
Site 125
T1149
N
P
F
S
P
P
R
T
L
H
S
P
P
L
Q
Site 126
S1152
S
P
P
R
T
L
H
S
P
P
L
Q
L
Q
Q
Site 127
S1161
P
L
Q
L
Q
Q
R
S
E
K
P
P
W
Y
S
Site 128
Y1167
R
S
E
K
P
P
W
Y
S
S
G
P
S
S
T
Site 129
S1168
S
E
K
P
P
W
Y
S
S
G
P
S
S
T
V
Site 130
S1169
E
K
P
P
W
Y
S
S
G
P
S
S
T
V
S
Site 131
S1172
P
W
Y
S
S
G
P
S
S
T
V
S
S
A
G
Site 132
S1173
W
Y
S
S
G
P
S
S
T
V
S
S
A
G
P
Site 133
T1174
Y
S
S
G
P
S
S
T
V
S
S
A
G
P
S
Site 134
S1176
S
G
P
S
S
T
V
S
S
A
G
P
S
S
P
Site 135
S1177
G
P
S
S
T
V
S
S
A
G
P
S
S
P
T
Site 136
S1181
T
V
S
S
A
G
P
S
S
P
T
T
V
D
G
Site 137
S1182
V
S
S
A
G
P
S
S
P
T
T
V
D
G
N
Site 138
T1185
A
G
P
S
S
P
T
T
V
D
G
N
S
Q
F
Site 139
S1190
P
T
T
V
D
G
N
S
Q
F
G
F
S
D
Q
Site 140
S1195
G
N
S
Q
F
G
F
S
D
Q
P
S
L
N
S
Site 141
S1199
F
G
F
S
D
Q
P
S
L
N
S
H
V
A
E
Site 142
S1202
S
D
Q
P
S
L
N
S
H
V
A
E
E
H
Q
Site 143
T1217
G
L
G
L
L
Q
E
T
P
G
S
G
A
Q
E
Site 144
S1220
L
L
Q
E
T
P
G
S
G
A
Q
E
L
S
I
Site 145
S1226
G
S
G
A
Q
E
L
S
I
E
G
E
Q
E
L
Site 146
S1239
E
L
F
E
P
N
Q
S
P
Q
V
P
P
M
E
Site 147
S1248
Q
V
P
P
M
E
T
S
Q
P
Y
E
E
V
S
Site 148
Y1251
P
M
E
T
S
Q
P
Y
E
E
V
S
Q
P
C
Site 149
S1255
S
Q
P
Y
E
E
V
S
Q
P
C
Q
E
V
P
Site 150
S1265
C
Q
E
V
P
D
I
S
Q
P
C
Q
D
I
S
Site 151
S1272
S
Q
P
C
Q
D
I
S
E
A
L
S
Q
P
C
Site 152
S1276
Q
D
I
S
E
A
L
S
Q
P
C
Q
K
V
P
Site 153
S1307
C
Q
E
V
P
H
I
S
Q
P
C
Q
K
S
S
Site 154
S1314
S
Q
P
C
Q
K
S
S
Q
L
C
Q
K
V
S
Site 155
S1332
C
Q
L
C
L
E
N
S
E
E
V
S
Q
P
C
Site 156
S1336
L
E
N
S
E
E
V
S
Q
P
C
Q
G
V
S
Site 157
S1370
E
T
L
V
E
V
G
S
P
A
E
E
I
P
E
Site 158
Y1383
P
E
E
V
I
Q
P
Y
Q
E
F
S
V
E
V
Site 159
S1398
G
R
L
A
Q
E
T
S
A
I
N
L
L
S
Q
Site 160
S1414
I
P
E
I
D
K
P
S
Q
E
F
P
E
E
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation