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Updated November 2019
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Protein Info
Short Name:
MYO7B
Full Name:
Myosin-VIIb
Alias:
myosin VIIB
Type:
Apical cell membrane protein
Mass (Da):
241599
Number AA:
2116
UniProt ID:
Q6PIF6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016324
GO:0016459
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003779
GO:0003774
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
H
V
W
L
E
P
P
S
T
H
K
T
G
V
A
Site 2
T17
V
W
L
E
P
P
S
T
H
K
T
G
V
A
I
Site 3
T20
E
P
P
S
T
H
K
T
G
V
A
I
G
G
I
Site 4
S57
A
E
D
F
G
V
L
S
P
M
H
P
N
S
V
Site 5
S63
L
S
P
M
H
P
N
S
V
Q
G
V
D
D
M
Site 6
Y95
R
Y
Q
Q
H
K
I
Y
T
Y
T
G
S
I
L
Site 7
T96
Y
Q
Q
H
K
I
Y
T
Y
T
G
S
I
L
V
Site 8
Y122
T
L
E
Q
V
Q
L
Y
Y
S
R
H
M
G
E
Site 9
Y123
L
E
Q
V
Q
L
Y
Y
S
R
H
M
G
E
L
Site 10
Y142
F
A
I
A
N
N
C
Y
F
S
M
K
R
N
K
Site 11
S157
R
D
Q
C
C
I
I
S
G
E
S
G
A
G
K
Site 12
T167
S
G
A
G
K
T
E
T
T
K
L
I
L
Q
F
Site 13
S183
A
T
I
S
G
Q
H
S
W
I
E
Q
Q
V
L
Site 14
T204
E
A
F
G
N
A
K
T
I
R
N
D
N
S
S
Site 15
S210
K
T
I
R
N
D
N
S
S
R
F
G
K
Y
I
Site 16
S211
T
I
R
N
D
N
S
S
R
F
G
K
Y
I
D
Site 17
Y216
N
S
S
R
F
G
K
Y
I
D
I
Y
F
N
P
Site 18
Y252
Q
A
P
E
E
R
N
Y
H
I
F
Y
C
M
L
Site 19
S271
A
E
D
K
Q
L
L
S
L
G
T
P
S
E
Y
Site 20
T274
K
Q
L
L
S
L
G
T
P
S
E
Y
H
Y
L
Site 21
Y278
S
L
G
T
P
S
E
Y
H
Y
L
T
M
G
N
Site 22
Y280
G
T
P
S
E
Y
H
Y
L
T
M
G
N
C
T
Site 23
T282
P
S
E
Y
H
Y
L
T
M
G
N
C
T
S
C
Site 24
Y298
G
L
N
D
A
K
D
Y
A
H
I
R
S
A
M
Site 25
S311
A
M
K
I
L
Q
F
S
D
S
E
S
W
D
V
Site 26
S313
K
I
L
Q
F
S
D
S
E
S
W
D
V
I
K
Site 27
S315
L
Q
F
S
D
S
E
S
W
D
V
I
K
L
L
Site 28
S344
V
F
E
N
L
D
A
S
D
V
M
E
T
P
A
Site 29
S385
R
G
E
F
V
T
R
S
L
N
I
A
Q
A
A
Site 30
T420
K
I
N
A
A
I
F
T
P
P
A
Q
D
P
K
Site 31
Y477
F
T
M
E
Q
E
E
Y
R
S
E
N
I
S
W
Site 32
Y486
S
E
N
I
S
W
D
Y
I
H
Y
T
D
N
R
Site 33
Y489
I
S
W
D
Y
I
H
Y
T
D
N
R
P
T
L
Site 34
T495
H
Y
T
D
N
R
P
T
L
D
L
L
A
L
K
Site 35
S508
L
K
P
M
S
I
I
S
L
L
D
E
E
S
R
Site 36
S514
I
S
L
L
D
E
E
S
R
F
P
Q
G
T
D
Site 37
T520
E
S
R
F
P
Q
G
T
D
L
T
M
L
Q
K
Site 38
T523
F
P
Q
G
T
D
L
T
M
L
Q
K
L
N
S
Site 39
S530
T
M
L
Q
K
L
N
S
V
H
A
N
N
K
A
Site 40
Y560
H
F
A
G
E
V
Y
Y
Q
A
E
G
F
L
E
Site 41
S574
E
K
N
R
D
V
L
S
T
D
I
L
T
L
V
Site 42
S583
D
I
L
T
L
V
Y
S
S
K
N
K
F
L
R
Site 43
S584
I
L
T
L
V
Y
S
S
K
N
K
F
L
R
E
Site 44
S619
A
G
N
H
L
F
K
S
A
D
S
N
K
R
P
Site 45
S622
H
L
F
K
S
A
D
S
N
K
R
P
S
T
L
Site 46
S627
A
D
S
N
K
R
P
S
T
L
G
S
Q
F
K
Site 47
T628
D
S
N
K
R
P
S
T
L
G
S
Q
F
K
Q
Site 48
S631
K
R
P
S
T
L
G
S
Q
F
K
Q
S
L
D
Site 49
S636
L
G
S
Q
F
K
Q
S
L
D
Q
L
M
K
I
Site 50
Y660
R
C
I
K
P
N
E
Y
K
K
P
L
L
F
D
Site 51
T683
R
Y
S
G
M
M
E
T
V
H
I
R
K
S
G
Site 52
S689
E
T
V
H
I
R
K
S
G
F
P
I
R
Y
T
Site 53
Y695
K
S
G
F
P
I
R
Y
T
F
E
E
F
S
Q
Site 54
T696
S
G
F
P
I
R
Y
T
F
E
E
F
S
Q
R
Site 55
S701
R
Y
T
F
E
E
F
S
Q
R
F
G
V
L
L
Site 56
T724
Q
G
K
L
R
Q
M
T
L
G
I
T
D
V
W
Site 57
T753
F
L
R
D
H
Q
D
T
L
L
E
V
Q
R
S
Site 58
S760
T
L
L
E
V
Q
R
S
Q
V
L
D
R
A
A
Site 59
Y777
I
Q
K
V
L
R
G
Y
R
Y
R
K
E
F
L
Site 60
Y779
K
V
L
R
G
Y
R
Y
R
K
E
F
L
R
Q
Site 61
T792
R
Q
R
R
A
A
V
T
L
Q
A
W
W
R
G
Site 62
S822
R
L
Q
A
I
A
R
S
Q
P
L
A
R
Q
Y
Site 63
Y829
S
Q
P
L
A
R
Q
Y
Q
A
M
R
Q
R
T
Site 64
T836
Y
Q
A
M
R
Q
R
T
V
Q
L
Q
A
L
C
Site 65
Y846
L
Q
A
L
C
R
G
Y
L
V
R
Q
Q
V
Q
Site 66
S893
I
P
A
E
G
Q
K
S
Q
G
A
L
P
A
K
Site 67
S904
L
P
A
K
K
R
R
S
I
Y
D
T
V
T
D
Site 68
Y906
A
K
K
R
R
S
I
Y
D
T
V
T
D
T
E
Site 69
T908
K
R
R
S
I
Y
D
T
V
T
D
T
E
M
V
Site 70
T910
R
S
I
Y
D
T
V
T
D
T
E
M
V
E
K
Site 71
T912
I
Y
D
T
V
T
D
T
E
M
V
E
K
V
F
Site 72
S934
G
G
Q
E
G
Q
A
S
P
H
F
E
D
L
E
Site 73
S942
P
H
F
E
D
L
E
S
K
T
Q
K
L
L
E
Site 74
Y980
F
P
K
F
A
V
T
Y
F
Q
K
S
A
S
H
Site 75
S984
A
V
T
Y
F
Q
K
S
A
S
H
T
H
I
R
Site 76
T988
F
Q
K
S
A
S
H
T
H
I
R
R
P
L
R
Site 77
Y996
H
I
R
R
P
L
R
Y
P
L
L
Y
H
E
D
Site 78
Y1000
P
L
R
Y
P
L
L
Y
H
E
D
D
T
D
C
Site 79
Y1030
D
L
P
E
P
V
L
Y
A
R
S
S
Q
Q
G
Site 80
S1033
E
P
V
L
Y
A
R
S
S
Q
Q
G
S
S
V
Site 81
S1034
P
V
L
Y
A
R
S
S
Q
Q
G
S
S
V
M
Site 82
S1038
A
R
S
S
Q
Q
G
S
S
V
M
R
Q
I
H
Site 83
S1039
R
S
S
Q
Q
G
S
S
V
M
R
Q
I
H
D
Site 84
T1047
V
M
R
Q
I
H
D
T
L
G
R
E
H
G
A
Site 85
S1060
G
A
Q
V
P
Q
H
S
R
S
A
Q
V
A
S
Site 86
S1062
Q
V
P
Q
H
S
R
S
A
Q
V
A
S
Q
L
Site 87
S1067
S
R
S
A
Q
V
A
S
Q
L
N
I
G
E
E
Site 88
S1088
L
G
A
D
R
P
M
S
N
L
E
K
V
H
F
Site 89
S1105
G
Y
A
I
L
R
P
S
L
R
D
E
I
Y
C
Site 90
Y1111
P
S
L
R
D
E
I
Y
C
Q
I
C
K
Q
L
Site 91
S1119
C
Q
I
C
K
Q
L
S
E
N
F
K
T
S
S
Site 92
T1124
Q
L
S
E
N
F
K
T
S
S
L
A
R
G
W
Site 93
S1126
S
E
N
F
K
T
S
S
L
A
R
G
W
I
L
Site 94
Y1150
P
S
E
R
F
M
K
Y
L
L
N
F
I
G
Q
Site 95
Y1162
I
G
Q
G
P
A
T
Y
G
P
F
C
A
E
R
Site 96
T1173
C
A
E
R
L
R
R
T
Y
A
N
G
V
R
A
Site 97
Y1174
A
E
R
L
R
R
T
Y
A
N
G
V
R
A
E
Site 98
T1184
G
V
R
A
E
P
P
T
W
L
E
L
Q
A
V
Site 99
S1193
L
E
L
Q
A
V
K
S
K
K
H
I
P
I
Q
Site 100
S1215
S
L
T
V
P
V
D
S
A
S
T
S
R
E
M
Site 101
S1217
T
V
P
V
D
S
A
S
T
S
R
E
M
C
M
Site 102
S1219
P
V
D
S
A
S
T
S
R
E
M
C
M
H
I
Site 103
S1233
I
A
H
K
Q
G
L
S
D
H
L
G
F
S
L
Site 104
S1250
A
V
Y
D
K
F
W
S
L
G
S
G
R
D
H
Site 105
S1275
M
A
Q
E
R
G
E
S
Q
R
Q
S
P
W
R
Site 106
S1279
R
G
E
S
Q
R
Q
S
P
W
R
I
Y
F
R
Site 107
Y1284
R
Q
S
P
W
R
I
Y
F
R
K
E
F
F
T
Site 108
S1296
F
F
T
P
W
H
D
S
R
E
D
P
V
S
T
Site 109
S1302
D
S
R
E
D
P
V
S
T
E
L
I
Y
R
Q
Site 110
S1316
Q
V
L
R
G
V
W
S
G
E
Y
S
F
E
K
Site 111
S1320
G
V
W
S
G
E
Y
S
F
E
K
E
E
E
L
Site 112
Y1361
S
C
I
P
H
K
L
Y
R
T
K
P
P
D
R
Site 113
S1371
K
P
P
D
R
W
A
S
L
V
T
A
A
C
A
Site 114
T1383
A
C
A
K
A
P
Y
T
Q
K
Q
V
T
P
L
Site 115
T1388
P
Y
T
Q
K
Q
V
T
P
L
A
V
R
E
Q
Site 116
S1472
G
G
Q
R
L
L
L
S
T
M
H
E
E
Y
E
Site 117
T1473
G
Q
R
L
L
L
S
T
M
H
E
E
Y
E
F
Site 118
Y1478
L
S
T
M
H
E
E
Y
E
F
V
S
P
S
S
Site 119
S1482
H
E
E
Y
E
F
V
S
P
S
S
V
A
I
A
Site 120
T1515
A
L
Q
D
R
K
A
T
D
D
T
T
L
L
A
Site 121
T1518
D
R
K
A
T
D
D
T
T
L
L
A
F
K
K
Site 122
T1519
R
K
A
T
D
D
T
T
L
L
A
F
K
K
G
Site 123
S1540
K
K
Q
G
L
L
A
S
E
N
W
T
L
G
Q
Site 124
T1544
L
L
A
S
E
N
W
T
L
G
Q
N
D
R
T
Site 125
T1551
T
L
G
Q
N
D
R
T
G
K
T
G
L
V
P
Site 126
T1596
A
A
Q
E
G
Q
F
T
E
P
R
P
E
E
P
Site 127
T1610
P
P
K
E
K
L
H
T
L
E
E
F
S
Y
E
Site 128
Y1616
H
T
L
E
E
F
S
Y
E
F
F
R
A
P
E
Site 129
Y1644
A
R
G
H
L
W
A
Y
S
C
E
P
L
R
Q
Site 130
S1645
R
G
H
L
W
A
Y
S
C
E
P
L
R
Q
P
Site 131
Y1681
I
L
R
Y
M
G
D
Y
P
S
R
Q
A
W
P
Site 132
T1689
P
S
R
Q
A
W
P
T
L
E
L
T
D
Q
I
Site 133
Y1711
P
A
L
Q
D
E
V
Y
C
Q
I
L
K
Q
L
Site 134
T1719
C
Q
I
L
K
Q
L
T
H
N
S
N
R
H
S
Site 135
S1722
L
K
Q
L
T
H
N
S
N
R
H
S
E
E
R
Site 136
S1726
T
H
N
S
N
R
H
S
E
E
R
G
W
Q
L
Site 137
T1757
H
A
Q
K
F
I
D
T
R
R
G
K
L
L
A
Site 138
S1768
K
L
L
A
P
D
C
S
R
R
I
Q
K
V
L
Site 139
Y1804
S
R
I
C
H
K
I
Y
F
P
N
D
T
S
E
Site 140
S1827
R
V
R
D
V
C
D
S
I
A
T
R
L
Q
L
Site 141
S1852
K
I
S
D
K
V
I
S
Q
K
E
G
D
F
F
Site 142
S1862
E
G
D
F
F
F
D
S
L
R
E
V
S
D
W
Site 143
S1867
F
D
S
L
R
E
V
S
D
W
V
K
K
N
K
Site 144
T1883
Q
K
E
G
A
P
V
T
L
P
Y
Q
V
Y
F
Site 145
Y1886
G
A
P
V
T
L
P
Y
Q
V
Y
F
M
R
K
Site 146
S1899
R
K
L
W
L
N
I
S
P
G
K
D
V
N
A
Site 147
Y1912
N
A
D
T
I
L
H
Y
H
Q
E
L
P
K
Y
Site 148
Y1919
Y
H
Q
E
L
P
K
Y
L
R
G
F
H
K
C
Site 149
Y1939
I
H
L
A
G
L
I
Y
K
A
Q
F
N
N
D
Site 150
S1948
A
Q
F
N
N
D
R
S
Q
L
A
S
V
P
K
Site 151
S1952
N
D
R
S
Q
L
A
S
V
P
K
I
L
R
E
Site 152
S1970
E
N
L
T
R
L
M
S
S
E
E
W
K
K
S
Site 153
S1977
S
S
E
E
W
K
K
S
I
L
L
A
Y
D
K
Site 154
T1989
Y
D
K
H
K
D
K
T
V
E
E
A
K
V
A
Site 155
T2017
A
F
F
E
V
K
Q
T
S
E
P
S
Y
P
D
Site 156
S2018
F
F
E
V
K
Q
T
S
E
P
S
Y
P
D
V
Site 157
Y2022
K
Q
T
S
E
P
S
Y
P
D
V
I
L
I
A
Site 158
T2047
P
K
T
K
D
L
L
T
T
Y
P
F
T
K
I
Site 159
Y2049
T
K
D
L
L
T
T
Y
P
F
T
K
I
S
S
Site 160
T2052
L
L
T
T
Y
P
F
T
K
I
S
S
W
S
S
Site 161
S2055
T
Y
P
F
T
K
I
S
S
W
S
S
G
S
T
Site 162
S2056
Y
P
F
T
K
I
S
S
W
S
S
G
S
T
Y
Site 163
S2059
T
K
I
S
S
W
S
S
G
S
T
Y
F
H
M
Site 164
S2061
I
S
S
W
S
S
G
S
T
Y
F
H
M
A
L
Site 165
T2062
S
S
W
S
S
G
S
T
Y
F
H
M
A
L
G
Site 166
Y2063
S
W
S
S
G
S
T
Y
F
H
M
A
L
G
S
Site 167
S2070
Y
F
H
M
A
L
G
S
L
G
R
G
S
R
L
Site 168
S2075
L
G
S
L
G
R
G
S
R
L
L
C
E
T
S
Site 169
T2081
G
S
R
L
L
C
E
T
S
L
G
Y
K
M
D
Site 170
S2082
S
R
L
L
C
E
T
S
L
G
Y
K
M
D
D
Site 171
T2092
Y
K
M
D
D
L
L
T
S
Y
V
Q
Q
L
L
Site 172
S2093
K
M
D
D
L
L
T
S
Y
V
Q
Q
L
L
S
Site 173
S2100
S
Y
V
Q
Q
L
L
S
A
M
N
K
Q
R
G
Site 174
S2108
A
M
N
K
Q
R
G
S
K
A
P
A
L
A
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation