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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
WDR59
Full Name:
WD repeat-containing protein 59
Alias:
FLJ12270; WD repeat domain 59; WD repeat protein 59
Type:
Mass (Da):
109793
Number AA:
974
UniProt ID:
Q6PJI9
International Prot ID:
IPI00872889
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
E
F
R
D
S
Q
A
T
A
M
S
V
D
C
L
Site 2
S55
F
E
G
H
R
K
I
S
R
Q
S
K
W
D
I
Site 3
S58
H
R
K
I
S
R
Q
S
K
W
D
I
G
A
V
Site 4
Y76
P
H
D
S
F
A
H
Y
F
A
A
S
S
N
Q
Site 5
S81
A
H
Y
F
A
A
S
S
N
Q
R
V
D
L
Y
Site 6
Y88
S
N
Q
R
V
D
L
Y
K
W
K
D
G
S
G
Site 7
S94
L
Y
K
W
K
D
G
S
G
E
V
G
T
T
L
Site 8
T100
G
S
G
E
V
G
T
T
L
Q
G
H
T
R
V
Site 9
S109
Q
G
H
T
R
V
I
S
D
L
D
W
A
V
F
Site 10
Y131
S
S
V
D
T
Y
I
Y
I
W
D
I
K
D
T
Site 11
T138
Y
I
W
D
I
K
D
T
R
K
P
T
V
A
L
Site 12
S152
L
S
A
V
A
G
A
S
Q
V
K
W
N
K
K
Site 13
S181
I
W
D
K
R
K
P
S
T
A
V
E
Y
L
A
Site 14
Y186
K
P
S
T
A
V
E
Y
L
A
A
H
L
S
K
Site 15
S203
G
L
D
W
H
P
D
S
E
H
I
L
A
T
S
Site 16
S210
S
E
H
I
L
A
T
S
S
Q
D
N
S
V
K
Site 17
S211
E
H
I
L
A
T
S
S
Q
D
N
S
V
K
F
Site 18
S215
A
T
S
S
Q
D
N
S
V
K
F
W
D
Y
R
Site 19
Y221
N
S
V
K
F
W
D
Y
R
Q
P
R
K
Y
L
Site 20
Y227
D
Y
R
Q
P
R
K
Y
L
N
I
L
P
C
Q
Site 21
Y242
V
P
V
W
K
A
R
Y
T
P
F
S
N
G
L
Site 22
T243
P
V
W
K
A
R
Y
T
P
F
S
N
G
L
V
Site 23
S246
K
A
R
Y
T
P
F
S
N
G
L
V
T
V
M
Site 24
S262
P
Q
L
R
R
E
N
S
L
L
L
W
N
V
F
Site 25
T277
D
L
N
T
P
V
H
T
F
V
G
H
D
D
V
Site 26
Y300
Q
K
E
G
S
K
D
Y
Q
L
V
T
W
S
R
Site 27
T304
S
K
D
Y
Q
L
V
T
W
S
R
D
Q
T
L
Site 28
S340
D
E
F
I
E
S
I
S
L
L
P
E
P
E
K
Site 29
T348
L
L
P
E
P
E
K
T
L
H
T
E
D
T
D
Site 30
T354
K
T
L
H
T
E
D
T
D
H
Q
H
T
A
S
Site 31
S361
T
D
H
Q
H
T
A
S
H
G
E
E
E
A
L
Site 32
S382
N
L
L
E
E
R
K
S
D
Q
L
G
L
P
Q
Site 33
T390
D
Q
L
G
L
P
Q
T
L
Q
Q
E
F
S
L
Site 34
S396
Q
T
L
Q
Q
E
F
S
L
I
N
V
Q
I
R
Site 35
T417
D
A
A
D
R
S
C
T
V
S
V
H
C
S
N
Site 36
S419
A
D
R
S
C
T
V
S
V
H
C
S
N
H
R
Site 37
Y437
L
V
K
F
P
A
Q
Y
P
N
N
A
A
P
S
Site 38
T451
S
F
Q
F
I
N
P
T
T
I
T
S
T
M
K
Site 39
S478
Q
K
V
K
R
G
Q
S
C
L
E
P
C
L
R
Site 40
S493
Q
L
V
S
C
L
E
S
F
V
N
Q
E
D
S
Site 41
S500
S
F
V
N
Q
E
D
S
A
S
S
N
P
F
A
Site 42
S502
V
N
Q
E
D
S
A
S
S
N
P
F
A
L
P
Site 43
S511
N
P
F
A
L
P
N
S
V
T
P
P
L
P
T
Site 44
T523
L
P
T
F
A
R
V
T
T
A
Y
G
S
Y
Q
Site 45
T524
P
T
F
A
R
V
T
T
A
Y
G
S
Y
Q
D
Site 46
Y526
F
A
R
V
T
T
A
Y
G
S
Y
Q
D
A
N
Site 47
S540
N
I
P
F
P
R
T
S
G
A
R
F
C
G
A
Site 48
T558
V
Y
F
T
R
P
M
T
M
H
R
A
V
S
P
Site 49
S564
M
T
M
H
R
A
V
S
P
T
E
P
T
P
R
Site 50
T566
M
H
R
A
V
S
P
T
E
P
T
P
R
S
L
Site 51
T569
A
V
S
P
T
E
P
T
P
R
S
L
S
A
L
Site 52
S572
P
T
E
P
T
P
R
S
L
S
A
L
S
A
Y
Site 53
S574
E
P
T
P
R
S
L
S
A
L
S
A
Y
H
T
Site 54
T591
I
A
P
M
K
I
R
T
E
A
P
G
N
L
R
Site 55
Y600
A
P
G
N
L
R
L
Y
S
G
S
P
T
R
S
Site 56
S601
P
G
N
L
R
L
Y
S
G
S
P
T
R
S
E
Site 57
S603
N
L
R
L
Y
S
G
S
P
T
R
S
E
K
E
Site 58
T605
R
L
Y
S
G
S
P
T
R
S
E
K
E
Q
V
Site 59
S607
Y
S
G
S
P
T
R
S
E
K
E
Q
V
S
I
Site 60
S613
R
S
E
K
E
Q
V
S
I
S
S
F
Y
Y
K
Site 61
S616
K
E
Q
V
S
I
S
S
F
Y
Y
K
E
R
K
Site 62
Y619
V
S
I
S
S
F
Y
Y
K
E
R
K
S
R
R
Site 63
S624
F
Y
Y
K
E
R
K
S
R
R
W
K
S
K
R
Site 64
S629
R
K
S
R
R
W
K
S
K
R
E
G
S
D
S
Site 65
S634
W
K
S
K
R
E
G
S
D
S
G
N
R
Q
I
Site 66
S636
S
K
R
E
G
S
D
S
G
N
R
Q
I
K
A
Site 67
S711
D
L
C
L
G
P
K
S
D
P
D
L
E
T
P
Site 68
T717
K
S
D
P
D
L
E
T
P
W
A
R
H
P
F
Site 69
S731
F
G
R
Q
L
L
E
S
L
L
A
H
Y
C
R
Site 70
Y736
L
E
S
L
L
A
H
Y
C
R
L
R
D
V
Q
Site 71
S772
F
G
P
F
P
N
R
S
S
N
L
V
V
S
H
Site 72
S773
G
P
F
P
N
R
S
S
N
L
V
V
S
H
S
Site 73
S778
R
S
S
N
L
V
V
S
H
S
R
Y
P
S
F
Site 74
S780
S
N
L
V
V
S
H
S
R
Y
P
S
F
T
S
Site 75
Y782
L
V
V
S
H
S
R
Y
P
S
F
T
S
S
G
Site 76
S784
V
S
H
S
R
Y
P
S
F
T
S
S
G
S
C
Site 77
T786
H
S
R
Y
P
S
F
T
S
S
G
S
C
S
S
Site 78
S787
S
R
Y
P
S
F
T
S
S
G
S
C
S
S
M
Site 79
S788
R
Y
P
S
F
T
S
S
G
S
C
S
S
M
S
Site 80
S790
P
S
F
T
S
S
G
S
C
S
S
M
S
D
P
Site 81
S792
F
T
S
S
G
S
C
S
S
M
S
D
P
G
L
Site 82
S793
T
S
S
G
S
C
S
S
M
S
D
P
G
L
N
Site 83
S795
S
G
S
C
S
S
M
S
D
P
G
L
N
T
G
Site 84
S815
G
R
E
A
E
H
L
S
S
P
W
G
E
S
S
Site 85
S816
R
E
A
E
H
L
S
S
P
W
G
E
S
S
P
Site 86
S821
L
S
S
P
W
G
E
S
S
P
E
E
L
R
F
Site 87
S822
S
S
P
W
G
E
S
S
P
E
E
L
R
F
G
Site 88
S830
P
E
E
L
R
F
G
S
L
T
Y
S
D
P
R
Site 89
T832
E
L
R
F
G
S
L
T
Y
S
D
P
R
E
R
Site 90
Y833
L
R
F
G
S
L
T
Y
S
D
P
R
E
R
E
Site 91
S834
R
F
G
S
L
T
Y
S
D
P
R
E
R
E
R
Site 92
Y866
F
D
D
F
K
K
C
Y
G
E
I
L
Y
R
W
Site 93
Y871
K
C
Y
G
E
I
L
Y
R
W
G
L
R
E
K
Site 94
S887
A
E
V
L
K
F
V
S
C
P
P
D
P
H
K
Site 95
Y901
K
G
I
E
F
G
V
Y
C
S
H
C
R
S
E
Site 96
T912
C
R
S
E
V
R
G
T
Q
C
A
I
C
K
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation