KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TXNDC11
Full Name:
Thioredoxin domain-containing protein 11
Alias:
EF-hand binding protein 1; EF-hand-binding protein 1; EFP1; Thioredoxin domain containing 11; TXD11
Type:
Unknown function
Mass (Da):
110510
Number AA:
985
UniProt ID:
Q6PKC3
International Prot ID:
IPI00074799
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0045454
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
C
G
G
R
G
G
G
S
S
S
S
E
D
A
E
Site 2
S12
G
G
R
G
G
G
S
S
S
S
E
D
A
E
D
Site 3
S13
G
R
G
G
G
S
S
S
S
E
D
A
E
D
E
Site 4
S14
R
G
G
G
S
S
S
S
E
D
A
E
D
E
G
Site 5
S30
G
G
G
G
P
A
G
S
D
C
L
S
S
S
P
Site 6
S34
P
A
G
S
D
C
L
S
S
S
P
T
L
A
T
Site 7
S36
G
S
D
C
L
S
S
S
P
T
L
A
T
A
S
Site 8
T41
S
S
S
P
T
L
A
T
A
S
S
A
G
R
L
Site 9
S43
S
P
T
L
A
T
A
S
S
A
G
R
L
R
R
Site 10
S44
P
T
L
A
T
A
S
S
A
G
R
L
R
R
G
Site 11
S99
I
P
A
K
P
P
V
S
F
F
S
L
R
S
P
Site 12
S102
K
P
P
V
S
F
F
S
L
R
S
P
V
L
D
Site 13
Y117
L
F
Q
G
Q
L
D
Y
A
E
Y
V
R
R
D
Site 14
Y120
G
Q
L
D
Y
A
E
Y
V
R
R
D
S
E
V
Site 15
Y133
E
V
V
L
L
F
F
Y
A
P
W
C
G
Q
S
Site 16
S152
A
E
I
E
Q
A
A
S
R
L
S
D
Q
V
L
Site 17
Y180
R
K
Q
K
H
F
F
Y
F
P
V
I
Y
L
Y
Site 18
Y196
R
S
F
G
P
I
E
Y
K
G
P
M
S
A
V
Site 19
Y204
K
G
P
M
S
A
V
Y
I
E
K
F
V
R
R
Site 20
Y218
R
V
M
K
P
L
L
Y
I
P
S
Q
S
E
L
Site 21
S221
K
P
L
L
Y
I
P
S
Q
S
E
L
L
D
F
Site 22
Y239
Y
E
P
G
V
L
G
Y
F
E
F
S
G
S
P
Site 23
S243
V
L
G
Y
F
E
F
S
G
S
P
Q
P
P
G
Site 24
S245
G
Y
F
E
F
S
G
S
P
Q
P
P
G
Y
L
Site 25
Y251
G
S
P
Q
P
P
G
Y
L
T
F
F
T
S
A
Site 26
T253
P
Q
P
P
G
Y
L
T
F
F
T
S
A
L
H
Site 27
S268
S
L
K
K
A
L
E
S
T
S
S
P
R
A
L
Site 28
S270
K
K
A
L
E
S
T
S
S
P
R
A
L
V
S
Site 29
S271
K
A
L
E
S
T
S
S
P
R
A
L
V
S
F
Site 30
S277
S
S
P
R
A
L
V
S
F
T
G
E
W
H
L
Site 31
S312
K
H
L
A
K
L
V
S
L
V
H
S
G
S
V
Site 32
S318
V
S
L
V
H
S
G
S
V
Y
L
H
R
H
F
Site 33
Y320
L
V
H
S
G
S
V
Y
L
H
R
H
F
N
T
Site 34
T327
Y
L
H
R
H
F
N
T
S
L
V
F
P
R
E
Site 35
S328
L
H
R
H
F
N
T
S
L
V
F
P
R
E
V
Site 36
Y338
F
P
R
E
V
L
N
Y
T
A
E
N
I
C
K
Site 37
S365
L
R
P
H
G
G
K
S
L
L
L
N
N
E
L
Site 38
T398
H
P
L
I
D
E
I
T
E
V
A
L
E
Y
N
Site 39
Y404
I
T
E
V
A
L
E
Y
N
N
C
H
G
D
Q
Site 40
T444
A
Q
L
P
D
P
P
T
I
T
A
S
P
C
C
Site 41
T446
L
P
D
P
P
T
I
T
A
S
P
C
C
N
T
Site 42
T465
Q
W
H
S
F
S
R
T
H
N
V
C
E
L
C
Site 43
S477
E
L
C
V
N
Q
T
S
G
G
M
K
P
S
S
Site 44
S483
T
S
G
G
M
K
P
S
S
V
S
V
P
Q
C
Site 45
S484
S
G
G
M
K
P
S
S
V
S
V
P
Q
C
S
Site 46
S501
E
M
A
A
A
L
D
S
F
Y
L
K
E
Q
T
Site 47
Y503
A
A
A
L
D
S
F
Y
L
K
E
Q
T
F
Y
Site 48
T508
S
F
Y
L
K
E
Q
T
F
Y
H
V
A
S
D
Site 49
Y510
Y
L
K
E
Q
T
F
Y
H
V
A
S
D
S
I
Site 50
S514
Q
T
F
Y
H
V
A
S
D
S
I
E
C
S
N
Site 51
S520
A
S
D
S
I
E
C
S
N
F
L
T
S
Y
S
Site 52
T524
I
E
C
S
N
F
L
T
S
Y
S
P
F
S
Y
Site 53
Y526
C
S
N
F
L
T
S
Y
S
P
F
S
Y
Y
T
Site 54
S527
S
N
F
L
T
S
Y
S
P
F
S
Y
Y
T
A
Site 55
Y531
T
S
Y
S
P
F
S
Y
Y
T
A
C
C
R
T
Site 56
Y532
S
Y
S
P
F
S
Y
Y
T
A
C
C
R
T
I
Site 57
T538
Y
Y
T
A
C
C
R
T
I
S
R
G
V
S
G
Site 58
S544
R
T
I
S
R
G
V
S
G
F
I
D
S
E
Q
Site 59
S574
K
C
E
V
D
A
P
S
S
V
P
H
I
E
E
Site 60
S575
C
E
V
D
A
P
S
S
V
P
H
I
E
E
N
Site 61
Y584
P
H
I
E
E
N
R
Y
L
F
P
E
V
D
M
Site 62
S593
F
P
E
V
D
M
T
S
T
N
F
T
G
L
S
Site 63
S600
S
T
N
F
T
G
L
S
C
R
T
N
K
T
L
Site 64
T606
L
S
C
R
T
N
K
T
L
N
I
Y
L
L
D
Site 65
Y610
T
N
K
T
L
N
I
Y
L
L
D
S
N
L
F
Site 66
Y620
D
S
N
L
F
W
L
Y
A
E
R
L
G
A
P
Site 67
S628
A
E
R
L
G
A
P
S
S
T
Q
V
K
E
F
Site 68
S629
E
R
L
G
A
P
S
S
T
Q
V
K
E
F
A
Site 69
Y647
D
V
K
E
E
S
H
Y
I
L
D
P
K
Q
A
Site 70
T659
K
Q
A
L
M
K
L
T
L
E
S
F
I
Q
N
Site 71
S668
E
S
F
I
Q
N
F
S
V
L
Y
S
P
L
K
Site 72
S672
Q
N
F
S
V
L
Y
S
P
L
K
R
H
L
I
Site 73
S681
L
K
R
H
L
I
G
S
G
S
A
Q
F
P
S
Site 74
S683
R
H
L
I
G
S
G
S
A
Q
F
P
S
Q
H
Site 75
S688
S
G
S
A
Q
F
P
S
Q
H
L
I
T
E
V
Site 76
T740
A
R
N
L
P
M
D
T
F
T
V
A
R
I
D
Site 77
S749
T
V
A
R
I
D
V
S
Q
N
D
L
P
W
E
Site 78
S776
P
C
N
R
K
D
L
S
V
K
Y
P
E
D
V
Site 79
Y779
R
K
D
L
S
V
K
Y
P
E
D
V
P
I
T
Site 80
S798
L
R
F
I
L
H
H
S
D
P
A
S
S
P
Q
Site 81
S802
L
H
H
S
D
P
A
S
S
P
Q
N
V
A
N
Site 82
S803
H
H
S
D
P
A
S
S
P
Q
N
V
A
N
S
Site 83
S810
S
P
Q
N
V
A
N
S
P
T
K
E
C
L
Q
Site 84
S818
P
T
K
E
C
L
Q
S
E
A
V
L
Q
R
G
Site 85
S828
V
L
Q
R
G
H
I
S
H
L
E
R
E
I
Q
Site 86
S842
Q
K
L
R
A
E
I
S
S
L
Q
R
A
Q
V
Site 87
S843
K
L
R
A
E
I
S
S
L
Q
R
A
Q
V
Q
Site 88
S853
R
A
Q
V
Q
V
E
S
Q
L
S
S
A
R
R
Site 89
S856
V
Q
V
E
S
Q
L
S
S
A
R
R
D
E
H
Site 90
S857
Q
V
E
S
Q
L
S
S
A
R
R
D
E
H
R
Site 91
S877
R
A
L
E
E
Q
H
S
L
L
H
A
H
S
E
Site 92
S883
H
S
L
L
H
A
H
S
E
Q
L
Q
A
L
Y
Site 93
Y890
S
E
Q
L
Q
A
L
Y
E
Q
K
T
R
E
L
Site 94
T916
D
A
S
E
N
L
L
T
E
N
T
W
L
K
I
Site 95
S940
E
G
R
D
G
A
E
S
L
A
A
Q
R
E
V
Site 96
S955
H
P
K
Q
P
E
P
S
A
T
P
Q
L
P
G
Site 97
T957
K
Q
P
E
P
S
A
T
P
Q
L
P
G
S
S
Site 98
S963
A
T
P
Q
L
P
G
S
S
P
P
P
A
N
V
Site 99
S964
T
P
Q
L
P
G
S
S
P
P
P
A
N
V
S
Site 100
S971
S
P
P
P
A
N
V
S
A
T
L
V
S
E
R
Site 101
T973
P
P
A
N
V
S
A
T
L
V
S
E
R
N
K
Site 102
S976
N
V
S
A
T
L
V
S
E
R
N
K
E
N
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation