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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ATAD2
Full Name:
ATPase family AAA domain-containing protein 2
Alias:
ANCCA; ATPase family, AAA domain containing 2; DKFZp667N1320; EC 3.6.1.3; FLJ39814; MGC29843; MGC5254; PRO2000
Type:
Transcription protein coactivator
Mass (Da):
158554
Number AA:
1390
UniProt ID:
Q6PL18
International Prot ID:
IPI00170548
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042624
GO:0003700
PhosphoSite+
KinaseNET
Biological Process:
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
V
V
L
R
S
S
L
E
L
H
N
H
S
Site 2
S14
S
L
E
L
H
N
H
S
A
A
S
A
T
G
S
Site 3
S17
L
H
N
H
S
A
A
S
A
T
G
S
L
D
L
Site 4
S21
S
A
A
S
A
T
G
S
L
D
L
S
S
D
F
Site 5
S26
T
G
S
L
D
L
S
S
D
F
L
S
L
E
H
Site 6
S30
D
L
S
S
D
F
L
S
L
E
H
I
G
R
R
Site 7
S41
I
G
R
R
R
L
R
S
A
G
A
A
Q
K
K
Site 8
S61
A
K
A
G
D
G
S
S
V
K
E
V
E
T
Y
Site 9
Y68
S
V
K
E
V
E
T
Y
H
R
T
R
A
L
R
Site 10
S76
H
R
T
R
A
L
R
S
L
R
K
D
A
Q
N
Site 11
S84
L
R
K
D
A
Q
N
S
S
D
S
S
F
E
K
Site 12
S85
R
K
D
A
Q
N
S
S
D
S
S
F
E
K
N
Site 13
S88
A
Q
N
S
S
D
S
S
F
E
K
N
V
E
I
Site 14
T106
L
A
N
G
R
H
F
T
R
Q
L
A
R
Q
Q
Site 15
S141
R
A
R
N
I
V
Q
S
T
E
H
L
H
E
D
Site 16
S157
G
D
V
E
V
R
R
S
C
R
I
R
S
R
Y
Site 17
S162
R
R
S
C
R
I
R
S
R
Y
S
G
V
N
Q
Site 18
Y164
S
C
R
I
R
S
R
Y
S
G
V
N
Q
S
M
Site 19
S165
C
R
I
R
S
R
Y
S
G
V
N
Q
S
M
L
Site 20
S170
R
Y
S
G
V
N
Q
S
M
L
F
D
K
L
I
Site 21
Y219
E
E
S
N
L
N
M
Y
T
R
G
K
Q
K
D
Site 22
T234
I
Q
R
T
D
E
E
T
T
D
N
Q
E
G
S
Site 23
S241
T
T
D
N
Q
E
G
S
V
E
S
S
E
E
G
Site 24
S245
Q
E
G
S
V
E
S
S
E
E
G
E
D
Q
E
Site 25
Y295
E
E
N
Q
K
R
Y
Y
L
R
Q
R
K
A
T
Site 26
T302
Y
L
R
Q
R
K
A
T
V
Y
Y
Q
A
P
L
Site 27
Y304
R
Q
R
K
A
T
V
Y
Y
Q
A
P
L
E
K
Site 28
Y305
Q
R
K
A
T
V
Y
Y
Q
A
P
L
E
K
P
Site 29
Y322
Q
R
K
P
N
I
F
Y
S
G
P
A
S
P
A
Site 30
S323
R
K
P
N
I
F
Y
S
G
P
A
S
P
A
R
Site 31
S327
I
F
Y
S
G
P
A
S
P
A
R
P
R
Y
R
Site 32
Y333
A
S
P
A
R
P
R
Y
R
L
S
S
A
G
P
Site 33
S336
A
R
P
R
Y
R
L
S
S
A
G
P
R
S
P
Site 34
S337
R
P
R
Y
R
L
S
S
A
G
P
R
S
P
Y
Site 35
S342
L
S
S
A
G
P
R
S
P
Y
C
K
R
M
N
Site 36
Y344
S
A
G
P
R
S
P
Y
C
K
R
M
N
R
R
Site 37
S357
R
R
R
H
A
I
H
S
S
D
S
T
S
S
S
Site 38
S358
R
R
H
A
I
H
S
S
D
S
T
S
S
S
S
Site 39
S360
H
A
I
H
S
S
D
S
T
S
S
S
S
S
E
Site 40
T361
A
I
H
S
S
D
S
T
S
S
S
S
S
E
D
Site 41
S362
I
H
S
S
D
S
T
S
S
S
S
S
E
D
E
Site 42
S364
S
S
D
S
T
S
S
S
S
S
E
D
E
Q
H
Site 43
S365
S
D
S
T
S
S
S
S
S
E
D
E
Q
H
F
Site 44
S366
D
S
T
S
S
S
S
S
E
D
E
Q
H
F
E
Site 45
S379
F
E
R
R
R
K
R
S
R
N
R
A
I
N
R
Site 46
S410
D
R
M
K
I
G
A
S
L
A
D
V
D
P
M
Site 47
S421
V
D
P
M
Q
L
D
S
S
V
R
F
D
S
V
Site 48
S422
D
P
M
Q
L
D
S
S
V
R
F
D
S
V
G
Site 49
S427
D
S
S
V
R
F
D
S
V
G
G
L
S
N
H
Site 50
Y466
P
P
R
G
C
L
F
Y
G
P
P
G
T
G
K
Site 51
S485
R
A
L
A
N
E
C
S
Q
G
D
K
R
V
A
Site 52
S503
R
K
G
A
D
C
L
S
K
W
V
G
E
S
E
Site 53
S509
L
S
K
W
V
G
E
S
E
R
Q
L
R
L
L
Site 54
Y521
R
L
L
F
D
Q
A
Y
Q
M
R
P
S
I
I
Site 55
S541
D
G
L
A
P
V
R
S
S
R
Q
D
Q
I
H
Site 56
S542
G
L
A
P
V
R
S
S
R
Q
D
Q
I
H
S
Site 57
S549
S
R
Q
D
Q
I
H
S
S
I
V
S
T
L
L
Site 58
S550
R
Q
D
Q
I
H
S
S
I
V
S
T
L
L
A
Site 59
S579
G
A
T
N
R
L
D
S
I
D
P
A
L
R
R
Site 60
S597
F
D
R
E
F
L
F
S
L
P
D
K
E
A
R
Site 61
T622
W
N
P
K
P
L
D
T
F
L
E
E
L
A
E
Site 62
Y655
L
C
A
L
R
R
R
Y
P
Q
I
Y
T
T
S
Site 63
Y659
R
R
R
Y
P
Q
I
Y
T
T
S
E
K
L
Q
Site 64
T660
R
R
Y
P
Q
I
Y
T
T
S
E
K
L
Q
L
Site 65
S670
E
K
L
Q
L
D
L
S
S
I
N
I
S
A
K
Site 66
S671
K
L
Q
L
D
L
S
S
I
N
I
S
A
K
D
Site 67
S690
M
Q
K
M
I
P
A
S
Q
R
A
V
T
S
P
Site 68
T695
P
A
S
Q
R
A
V
T
S
P
G
Q
A
L
S
Site 69
S696
A
S
Q
R
A
V
T
S
P
G
Q
A
L
S
T
Site 70
T734
A
E
F
R
T
N
K
T
L
D
S
D
I
S
C
Site 71
S737
R
T
N
K
T
L
D
S
D
I
S
C
P
L
L
Site 72
S740
K
T
L
D
S
D
I
S
C
P
L
L
E
S
D
Site 73
S746
I
S
C
P
L
L
E
S
D
L
A
Y
S
D
D
Site 74
Y750
L
L
E
S
D
L
A
Y
S
D
D
D
V
P
S
Site 75
S751
L
E
S
D
L
A
Y
S
D
D
D
V
P
S
V
Site 76
S757
Y
S
D
D
D
V
P
S
V
Y
E
N
G
L
S
Site 77
Y759
D
D
D
V
P
S
V
Y
E
N
G
L
S
Q
K
Site 78
S764
S
V
Y
E
N
G
L
S
Q
K
S
S
H
K
A
Site 79
S767
E
N
G
L
S
Q
K
S
S
H
K
A
K
D
N
Site 80
S768
N
G
L
S
Q
K
S
S
H
K
A
K
D
N
F
Site 81
Y786
H
L
N
R
N
A
C
Y
Q
P
M
S
F
R
P
Site 82
S837
L
F
G
V
S
T
T
S
P
E
E
T
C
A
Q
Site 83
T841
S
T
T
S
P
E
E
T
C
A
Q
V
I
R
E
Site 84
S855
E
A
K
R
T
A
P
S
I
V
Y
V
P
H
I
Site 85
S901
A
T
S
D
K
P
H
S
A
L
P
E
E
V
Q
Site 86
Y915
Q
E
L
F
I
R
D
Y
G
E
I
F
N
V
Q
Site 87
S947
Q
A
A
K
P
P
I
S
K
K
K
A
V
L
Q
Site 88
S969
A
P
P
P
E
P
R
S
L
T
A
E
E
V
K
Site 89
T971
P
P
E
P
R
S
L
T
A
E
E
V
K
R
L
Site 90
T985
L
E
E
Q
E
E
D
T
F
R
E
L
R
I
F
Site 91
T997
R
I
F
L
R
N
V
T
H
R
L
A
I
D
K
Site 92
T1010
D
K
R
F
R
V
F
T
K
P
V
D
P
D
E
Site 93
Y1021
D
P
D
E
V
P
D
Y
V
T
V
I
K
Q
P
Site 94
T1023
D
E
V
P
D
Y
V
T
V
I
K
Q
P
M
D
Site 95
S1032
I
K
Q
P
M
D
L
S
S
V
I
S
K
I
D
Site 96
S1033
K
Q
P
M
D
L
S
S
V
I
S
K
I
D
L
Site 97
S1036
M
D
L
S
S
V
I
S
K
I
D
L
H
K
Y
Site 98
Y1043
S
K
I
D
L
H
K
Y
L
T
V
K
D
Y
L
Site 99
T1045
I
D
L
H
K
Y
L
T
V
K
D
Y
L
R
D
Site 100
Y1049
K
Y
L
T
V
K
D
Y
L
R
D
I
D
L
I
Site 101
Y1063
I
C
S
N
A
L
E
Y
N
P
D
R
D
P
G
Site 102
T1084
R
A
C
A
L
R
D
T
A
Y
A
I
I
K
E
Site 103
Y1086
C
A
L
R
D
T
A
Y
A
I
I
K
E
E
L
Site 104
S1107
L
C
E
E
I
Q
E
S
R
K
K
R
G
C
S
Site 105
S1114
S
R
K
K
R
G
C
S
S
S
K
Y
A
P
S
Site 106
S1115
R
K
K
R
G
C
S
S
S
K
Y
A
P
S
Y
Site 107
S1116
K
K
R
G
C
S
S
S
K
Y
A
P
S
Y
Y
Site 108
Y1118
R
G
C
S
S
S
K
Y
A
P
S
Y
Y
H
V
Site 109
S1121
S
S
S
K
Y
A
P
S
Y
Y
H
V
M
P
K
Site 110
Y1122
S
S
K
Y
A
P
S
Y
Y
H
V
M
P
K
Q
Site 111
Y1123
S
K
Y
A
P
S
Y
Y
H
V
M
P
K
Q
N
Site 112
S1139
T
L
V
G
D
K
R
S
D
P
E
Q
N
E
K
Site 113
T1149
E
Q
N
E
K
L
K
T
P
S
T
P
V
A
C
Site 114
S1151
N
E
K
L
K
T
P
S
T
P
V
A
C
S
T
Site 115
T1152
E
K
L
K
T
P
S
T
P
V
A
C
S
T
P
Site 116
S1157
P
S
T
P
V
A
C
S
T
P
A
Q
L
K
R
Site 117
T1158
S
T
P
V
A
C
S
T
P
A
Q
L
K
R
K
Site 118
S1170
K
R
K
I
R
K
K
S
N
W
Y
L
G
T
I
Site 119
S1184
I
K
K
R
R
K
I
S
Q
A
K
D
D
S
Q
Site 120
S1190
I
S
Q
A
K
D
D
S
Q
N
A
I
D
H
K
Site 121
S1200
A
I
D
H
K
I
E
S
D
T
E
E
T
Q
D
Site 122
T1208
D
T
E
E
T
Q
D
T
S
V
D
H
N
E
T
Site 123
S1209
T
E
E
T
Q
D
T
S
V
D
H
N
E
T
G
Site 124
T1218
D
H
N
E
T
G
N
T
G
E
S
S
V
E
E
Site 125
S1222
T
G
N
T
G
E
S
S
V
E
E
N
E
K
Q
Site 126
S1233
N
E
K
Q
Q
N
A
S
E
S
K
L
E
L
R
Site 127
S1243
K
L
E
L
R
N
N
S
N
T
C
N
I
E
N
Site 128
T1245
E
L
R
N
N
S
N
T
C
N
I
E
N
E
L
Site 129
S1255
I
E
N
E
L
E
D
S
R
K
T
T
A
C
T
Site 130
T1258
E
L
E
D
S
R
K
T
T
A
C
T
E
L
R
Site 131
T1259
L
E
D
S
R
K
T
T
A
C
T
E
L
R
D
Site 132
S1275
I
A
C
N
G
D
A
S
S
S
Q
I
I
H
I
Site 133
S1276
A
C
N
G
D
A
S
S
S
Q
I
I
H
I
S
Site 134
S1277
C
N
G
D
A
S
S
S
Q
I
I
H
I
S
D
Site 135
S1283
S
S
Q
I
I
H
I
S
D
E
N
E
G
K
E
Site 136
T1297
E
M
C
V
L
R
M
T
R
A
R
R
S
Q
V
Site 137
S1302
R
M
T
R
A
R
R
S
Q
V
E
Q
Q
Q
L
Site 138
T1339
R
L
K
N
L
L
K
T
V
V
K
K
S
Q
N
Site 139
Y1364
A
V
I
S
Q
C
I
Y
R
H
R
K
D
H
D
Site 140
T1373
H
R
K
D
H
D
K
T
S
L
I
Q
K
M
E
Site 141
S1374
R
K
D
H
D
K
T
S
L
I
Q
K
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E
Q
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Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation