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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMED8
Full Name:
Protein TMED8
Alias:
FAM15B; L10; MGC126559; transmembrane emp24 protein transport domain containing 8
Type:
Unknown function
Mass (Da):
35722
Number AA:
325
UniProt ID:
Q6PL24
International Prot ID:
IPI00292812
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
Q
A
A
E
G
P
G
S
W
S
P
T
A
R
P
Site 2
S14
A
E
G
P
G
S
W
S
P
T
A
R
P
G
S
Site 3
T16
G
P
G
S
W
S
P
T
A
R
P
G
S
A
G
Site 4
S21
S
P
T
A
R
P
G
S
A
G
G
V
G
D
C
Site 5
S34
D
C
Q
G
V
E
G
S
Q
A
A
A
S
E
N
Site 6
S39
E
G
S
Q
A
A
A
S
E
N
E
D
L
E
N
Site 7
T49
E
D
L
E
N
K
D
T
S
L
L
A
S
A
T
Site 8
S50
D
L
E
N
K
D
T
S
L
L
A
S
A
T
D
Site 9
S54
K
D
T
S
L
L
A
S
A
T
D
P
E
P
C
Site 10
T56
T
S
L
L
A
S
A
T
D
P
E
P
C
S
S
Site 11
S62
A
T
D
P
E
P
C
S
S
P
H
R
P
Q
M
Site 12
S63
T
D
P
E
P
C
S
S
P
H
R
P
Q
M
V
Site 13
S71
P
H
R
P
Q
M
V
S
P
V
S
K
D
A
T
Site 14
S74
P
Q
M
V
S
P
V
S
K
D
A
T
E
D
L
Site 15
T78
S
P
V
S
K
D
A
T
E
D
L
R
K
A
T
Site 16
T85
T
E
D
L
R
K
A
T
G
P
L
E
A
Q
A
Site 17
Y113
V
L
N
E
M
A
K
Y
Q
V
P
Q
R
S
G
Site 18
S153
L
G
D
H
R
K
V
S
P
P
L
M
A
P
P
Site 19
S173
A
K
V
K
E
F
K
S
K
L
G
K
E
K
N
Site 20
S181
K
L
G
K
E
K
N
S
R
L
V
V
K
R
G
Site 21
T192
V
K
R
G
E
V
V
T
I
R
V
P
T
H
P
Site 22
T197
V
V
T
I
R
V
P
T
H
P
E
G
K
R
V
Site 23
Y213
W
E
F
A
T
D
D
Y
D
I
G
F
G
V
Y
Site 24
T229
D
W
T
P
V
T
S
T
D
I
T
V
Q
V
S
Site 25
T232
P
V
T
S
T
D
I
T
V
Q
V
S
D
S
S
Site 26
S236
T
D
I
T
V
Q
V
S
D
S
S
D
D
E
D
Site 27
S238
I
T
V
Q
V
S
D
S
S
D
D
E
D
E
E
Site 28
S265
A
G
D
V
E
R
G
S
R
S
S
L
R
G
R
Site 29
S267
D
V
E
R
G
S
R
S
S
L
R
G
R
Y
G
Site 30
S268
V
E
R
G
S
R
S
S
L
R
G
R
Y
G
E
Site 31
Y273
R
S
S
L
R
G
R
Y
G
E
V
M
P
V
Y
Site 32
Y280
Y
G
E
V
M
P
V
Y
R
R
D
S
H
R
D
Site 33
S284
M
P
V
Y
R
R
D
S
H
R
D
V
Q
A
G
Site 34
S292
H
R
D
V
Q
A
G
S
H
D
Y
P
G
E
G
Site 35
Y295
V
Q
A
G
S
H
D
Y
P
G
E
G
I
Y
L
Site 36
Y301
D
Y
P
G
E
G
I
Y
L
L
K
F
D
N
S
Site 37
S308
Y
L
L
K
F
D
N
S
Y
S
L
L
R
N
K
Site 38
Y309
L
L
K
F
D
N
S
Y
S
L
L
R
N
K
T
Site 39
S310
L
K
F
D
N
S
Y
S
L
L
R
N
K
T
L
Site 40
Y318
L
L
R
N
K
T
L
Y
F
H
I
Y
Y
T
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation