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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SCAND3
Full Name:
SCAN domain-containing protein 3
Alias:
Protein ZNF452
Type:
Mass (Da):
151666
Number AA:
1325
UniProt ID:
Q6R2W3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T33
K
V
K
E
E
D
H
T
W
D
Q
E
S
A
L
Site 2
S45
S
A
L
R
R
N
L
S
Y
T
R
E
L
S
R
Site 3
Y46
A
L
R
R
N
L
S
Y
T
R
E
L
S
R
Q
Site 4
T47
L
R
R
N
L
S
Y
T
R
E
L
S
R
Q
R
Site 5
S51
L
S
Y
T
R
E
L
S
R
Q
R
F
R
Q
F
Site 6
Y60
Q
R
F
R
Q
F
C
Y
Q
E
T
P
G
P
R
Site 7
T63
R
Q
F
C
Y
Q
E
T
P
G
P
R
E
A
L
Site 8
S71
P
G
P
R
E
A
L
S
Q
L
R
E
L
C
R
Site 9
S110
I
L
P
E
E
L
Q
S
W
V
R
E
H
N
P
Site 10
S119
V
R
E
H
N
P
E
S
G
E
E
V
V
T
L
Site 11
T125
E
S
G
E
E
V
V
T
L
L
E
D
L
E
R
Site 12
S151
G
T
Y
G
Q
E
V
S
M
E
E
M
I
P
L
Site 13
S160
E
E
M
I
P
L
D
S
A
K
E
S
L
G
T
Site 14
S164
P
L
D
S
A
K
E
S
L
G
T
Q
L
Q
S
Site 15
T167
S
A
K
E
S
L
G
T
Q
L
Q
S
M
E
D
Site 16
S171
S
L
G
T
Q
L
Q
S
M
E
D
R
M
E
C
Site 17
S180
E
D
R
M
E
C
E
S
P
E
P
H
P
L
Q
Site 18
S208
S
M
G
G
D
N
L
S
S
L
D
T
N
E
A
Site 19
S209
M
G
G
D
N
L
S
S
L
D
T
N
E
A
E
Site 20
T212
D
N
L
S
S
L
D
T
N
E
A
E
I
E
P
Site 21
S229
M
R
E
K
F
F
R
S
L
A
R
L
L
E
N
Site 22
S238
A
R
L
L
E
N
K
S
N
N
T
K
I
F
S
Site 23
Y249
K
I
F
S
K
A
K
Y
C
Q
L
I
K
E
V
Site 24
Y270
A
K
K
E
S
V
D
Y
R
R
L
A
R
F
D
Site 25
Y300
G
E
T
D
K
I
R
Y
Y
L
H
S
E
D
L
Site 26
Y301
E
T
D
K
I
R
Y
Y
L
H
S
E
D
L
F
Site 27
S304
K
I
R
Y
Y
L
H
S
E
D
L
F
D
I
L
Site 28
S317
I
L
H
N
T
H
L
S
I
G
H
G
G
R
T
Site 29
Y334
E
K
E
L
Q
A
K
Y
K
N
I
T
K
E
V
Site 30
T364
S
K
L
K
K
V
L
T
S
K
S
I
K
E
V
Site 31
S365
K
L
K
K
V
L
T
S
K
S
I
K
E
V
S
Site 32
S367
K
K
V
L
T
S
K
S
I
K
E
V
S
S
R
Site 33
S372
S
K
S
I
K
E
V
S
S
R
C
Q
V
D
L
Site 34
Y390
Q
L
N
P
D
G
E
Y
R
F
I
L
H
Y
Q
Site 35
Y396
E
Y
R
F
I
L
H
Y
Q
D
L
C
T
K
L
Site 36
T401
L
H
Y
Q
D
L
C
T
K
L
T
F
L
R
S
Site 37
T404
Q
D
L
C
T
K
L
T
F
L
R
S
L
K
S
Site 38
S408
T
K
L
T
F
L
R
S
L
K
S
K
R
P
T
Site 39
S411
T
F
L
R
S
L
K
S
K
R
P
T
E
V
A
Site 40
T415
S
L
K
S
K
R
P
T
E
V
A
H
A
L
L
Site 41
S436
G
A
P
S
V
L
Q
S
D
N
G
R
E
F
S
Site 42
S443
S
D
N
G
R
E
F
S
S
Q
V
V
S
E
L
Site 43
S444
D
N
G
R
E
F
S
S
Q
V
V
S
E
L
S
Site 44
S448
E
F
S
S
Q
V
V
S
E
L
S
N
I
W
P
Site 45
S451
S
Q
V
V
S
E
L
S
N
I
W
P
E
L
K
Site 46
S464
L
K
I
V
H
G
K
S
Q
T
C
Q
S
Q
S
Site 47
T466
I
V
H
G
K
S
Q
T
C
Q
S
Q
S
S
A
Site 48
S469
G
K
S
Q
T
C
Q
S
Q
S
S
A
E
Q
T
Site 49
S471
S
Q
T
C
Q
S
Q
S
S
A
E
Q
T
E
D
Site 50
T476
S
Q
S
S
A
E
Q
T
E
D
I
R
K
R
I
Site 51
Y510
Q
M
S
Q
N
Q
P
Y
H
R
S
M
Q
Q
T
Site 52
T517
Y
H
R
S
M
Q
Q
T
P
C
E
S
A
F
S
Site 53
S521
M
Q
Q
T
P
C
E
S
A
F
S
S
E
A
K
Site 54
S524
T
P
C
E
S
A
F
S
S
E
A
K
L
G
L
Site 55
S525
P
C
E
S
A
F
S
S
E
A
K
L
G
L
S
Site 56
S532
S
E
A
K
L
G
L
S
H
S
Q
L
T
E
E
Site 57
S534
A
K
L
G
L
S
H
S
Q
L
T
E
E
L
V
Site 58
S543
L
T
E
E
L
V
A
S
L
H
T
E
N
E
L
Site 59
T560
A
D
K
E
L
E
N
T
L
R
A
Q
Y
E
E
Site 60
Y565
E
N
T
L
R
A
Q
Y
E
E
N
I
E
T
G
Site 61
T571
Q
Y
E
E
N
I
E
T
G
T
D
S
S
D
I
Site 62
S575
N
I
E
T
G
T
D
S
S
D
I
E
E
N
L
Site 63
S576
I
E
T
G
T
D
S
S
D
I
E
E
N
L
S
Site 64
S583
S
D
I
E
E
N
L
S
V
T
P
K
V
A
E
Site 65
T585
I
E
E
N
L
S
V
T
P
K
V
A
E
K
S
Site 66
S592
T
P
K
V
A
E
K
S
P
P
E
S
R
L
R
Site 67
S596
A
E
K
S
P
P
E
S
R
L
R
F
L
S
C
Site 68
S602
E
S
R
L
R
F
L
S
C
V
V
C
E
K
E
Site 69
T635
G
V
P
S
Q
H
G
T
E
G
C
G
R
Q
I
Site 70
T643
E
G
C
G
R
Q
I
T
C
S
L
C
Y
E
T
Site 71
S663
K
H
D
E
I
Q
R
S
L
P
V
K
P
S
K
Site 72
S669
R
S
L
P
V
K
P
S
K
M
L
K
P
S
G
Site 73
S675
P
S
K
M
L
K
P
S
G
T
P
F
S
P
D
Site 74
T677
K
M
L
K
P
S
G
T
P
F
S
P
D
K
V
Site 75
S680
K
P
S
G
T
P
F
S
P
D
K
V
G
D
W
Site 76
S705
V
K
K
R
H
A
F
S
E
H
S
S
S
N
K
Site 77
S709
H
A
F
S
E
H
S
S
S
N
K
R
N
V
N
Site 78
S710
A
F
S
E
H
S
S
S
N
K
R
N
V
N
N
Site 79
Y720
R
N
V
N
N
R
S
Y
P
E
E
G
K
T
K
Site 80
T726
S
Y
P
E
E
G
K
T
K
R
V
H
A
S
F
Site 81
S732
K
T
K
R
V
H
A
S
F
T
R
K
Y
D
P
Site 82
Y737
H
A
S
F
T
R
K
Y
D
P
S
Y
I
E
F
Site 83
Y741
T
R
K
Y
D
P
S
Y
I
E
F
G
F
V
A
Site 84
Y781
S
K
L
K
R
H
L
Y
S
K
H
K
E
I
S
Site 85
S782
K
L
K
R
H
L
Y
S
K
H
K
E
I
S
S
Site 86
S789
S
K
H
K
E
I
S
S
Q
P
K
E
F
F
E
Site 87
S799
K
E
F
F
E
R
K
S
S
E
L
K
S
Q
P
Site 88
S800
E
F
F
E
R
K
S
S
E
L
K
S
Q
P
K
Site 89
S804
R
K
S
S
E
L
K
S
Q
P
K
Q
V
F
N
Site 90
S818
N
V
S
H
I
N
I
S
A
L
R
A
S
Y
K
Site 91
T835
L
P
V
A
K
S
K
T
P
Y
T
I
A
E
T
Site 92
T838
A
K
S
K
T
P
Y
T
I
A
E
T
L
V
K
Site 93
S870
K
V
A
Q
V
P
L
S
N
D
T
I
A
R
R
Site 94
Y898
E
Q
I
K
L
A
K
Y
F
S
L
Q
L
D
E
Site 95
S900
I
K
L
A
K
Y
F
S
L
Q
L
D
E
C
R
Site 96
S934
I
K
E
E
F
F
F
S
A
S
L
P
T
N
T
Site 97
S936
E
E
F
F
F
S
A
S
L
P
T
N
T
T
S
Site 98
T941
S
A
S
L
P
T
N
T
T
S
S
E
L
Y
E
Site 99
Y947
N
T
T
S
S
E
L
Y
E
A
V
K
N
Y
I
Site 100
T977
S
D
G
A
A
S
M
T
G
K
H
S
E
V
V
Site 101
T985
G
K
H
S
E
V
V
T
Q
I
K
E
L
A
P
Site 102
Y1028
D
I
V
K
I
V
N
Y
I
K
S
N
S
L
N
Site 103
S1031
K
I
V
N
Y
I
K
S
N
S
L
N
S
R
L
Site 104
S1033
V
N
Y
I
K
S
N
S
L
N
S
R
L
F
S
Site 105
S1040
S
L
N
S
R
L
F
S
L
L
C
D
N
M
E
Site 106
S1063
H
A
E
I
R
W
L
S
R
G
K
V
L
S
R
Site 107
S1069
L
S
R
G
K
V
L
S
R
M
F
E
I
R
N
Site 108
Y1126
M
Q
G
K
N
A
T
Y
F
S
M
A
D
K
V
Site 109
S1128
G
K
N
A
T
Y
F
S
M
A
D
K
V
E
G
Site 110
Y1152
N
R
I
S
T
D
C
Y
D
M
F
H
N
L
T
Site 111
Y1192
L
L
E
C
F
E
F
Y
F
P
S
K
E
D
P
Site 112
S1212
W
I
Q
N
P
F
L
S
S
K
D
N
L
N
L
Site 113
T1220
S
K
D
N
L
N
L
T
V
T
L
Q
D
K
L
Site 114
T1222
D
N
L
N
L
T
V
T
L
Q
D
K
L
L
K
Site 115
S1239
T
D
E
G
L
K
I
S
F
E
N
T
A
S
L
Site 116
S1248
E
N
T
A
S
L
P
S
F
W
I
K
A
K
N
Site 117
Y1257
W
I
K
A
K
N
D
Y
P
E
L
A
E
I
A
Site 118
S1285
E
T
G
F
S
T
L
S
V
I
K
T
K
H
R
Site 119
T1289
S
T
L
S
V
I
K
T
K
H
R
N
S
L
N
Site 120
S1294
I
K
T
K
H
R
N
S
L
N
I
H
Y
P
L
Site 121
Y1299
R
N
S
L
N
I
H
Y
P
L
R
V
A
L
S
Site 122
S1306
Y
P
L
R
V
A
L
S
S
I
Q
P
R
L
D
Site 123
S1307
P
L
R
V
A
L
S
S
I
Q
P
R
L
D
K
Site 124
T1316
Q
P
R
L
D
K
L
T
S
K
K
Q
A
H
L
Site 125
S1317
P
R
L
D
K
L
T
S
K
K
Q
A
H
L
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation