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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Rictor
Full Name:
Rapamycin-insensitive companion of mTOR
Alias:
AVO3; KIAA1999; MAVO3; MGC39830; PIA; Pianissimo; RICTR; RPTOR independent companion of MTOR, complex 2
Type:
Adapter/scaffold protein
Mass (Da):
192218
Number AA:
1708
UniProt ID:
Q6R327
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031932
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005085
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0031532
GO:0009790
GO:0032008
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
A
I
G
R
G
R
S
L
K
N
L
R
V
R
Site 2
S21
R
V
R
G
R
N
D
S
G
E
E
N
V
P
L
Site 3
T31
E
N
V
P
L
D
L
T
R
E
P
S
D
N
L
Site 4
S35
L
D
L
T
R
E
P
S
D
N
L
R
E
I
L
Site 5
S52
V
A
R
L
Q
G
V
S
N
M
R
K
L
G
H
Site 6
S115
R
Y
L
I
Q
D
S
S
I
L
Q
K
V
L
K
Site 7
S138
R
C
I
D
I
Q
Q
S
N
E
V
E
R
T
Q
Site 8
T144
Q
S
N
E
V
E
R
T
Q
A
L
R
L
V
R
Site 9
T240
H
L
L
N
H
P
K
T
R
Q
Y
V
R
A
D
Site 10
Y243
N
H
P
K
T
R
Q
Y
V
R
A
D
V
E
L
Site 11
Y257
L
E
R
I
L
A
P
Y
T
D
F
H
Y
R
H
Site 12
T258
E
R
I
L
A
P
Y
T
D
F
H
Y
R
H
S
Site 13
Y262
A
P
Y
T
D
F
H
Y
R
H
S
P
D
T
A
Site 14
S265
T
D
F
H
Y
R
H
S
P
D
T
A
E
G
Q
Site 15
T268
H
Y
R
H
S
P
D
T
A
E
G
Q
L
K
E
Site 16
S284
R
E
A
R
F
L
A
S
K
M
G
I
I
A
T
Site 17
S307
N
L
C
K
P
G
N
S
G
I
Q
S
L
I
G
Site 18
S361
D
P
G
R
F
Q
D
S
W
R
L
S
D
G
F
Site 19
S365
F
Q
D
S
W
R
L
S
D
G
F
V
A
A
E
Site 20
S383
I
L
P
H
R
A
R
S
R
P
D
L
M
D
N
Site 21
T413
E
G
L
V
E
V
I
T
N
S
D
D
H
I
S
Site 22
S415
L
V
E
V
I
T
N
S
D
D
H
I
S
V
R
Site 23
S420
T
N
S
D
D
H
I
S
V
R
A
T
I
L
L
Site 24
T424
D
H
I
S
V
R
A
T
I
L
L
G
E
L
L
Site 25
T436
E
L
L
H
M
A
N
T
I
L
P
H
S
H
S
Site 26
S458
T
L
M
N
M
A
A
S
F
D
I
P
K
E
K
Site 27
S470
K
E
K
R
L
R
A
S
A
A
L
N
C
L
K
Site 28
Y490
K
K
R
G
P
K
P
Y
S
L
H
L
D
H
I
Site 29
S491
K
R
G
P
K
P
Y
S
L
H
L
D
H
I
I
Site 30
Y511
T
H
Q
K
R
D
Q
Y
L
R
V
Q
K
D
I
Site 31
S535
L
L
I
N
L
R
D
S
Q
V
L
Q
H
K
E
Site 32
Y565
P
N
V
N
L
R
N
Y
K
D
E
Q
L
H
R
Site 33
Y579
R
F
V
R
R
L
L
Y
F
Y
K
P
S
S
K
Site 34
Y581
V
R
R
L
L
Y
F
Y
K
P
S
S
K
L
Y
Site 35
S585
L
Y
F
Y
K
P
S
S
K
L
Y
A
N
L
D
Site 36
Y588
Y
K
P
S
S
K
L
Y
A
N
L
D
L
D
F
Site 37
S615
F
T
E
F
L
L
E
S
E
E
D
G
Q
G
Y
Site 38
Y622
S
E
E
D
G
Q
G
Y
L
E
D
L
V
K
D
Site 39
S645
S
G
M
K
P
E
R
S
L
Q
N
N
G
L
L
Site 40
T701
Q
D
H
L
L
K
L
T
V
S
S
L
D
Y
S
Site 41
S703
H
L
L
K
L
T
V
S
S
L
D
Y
S
R
D
Site 42
S704
L
L
K
L
T
V
S
S
L
D
Y
S
R
D
G
Site 43
Y707
L
T
V
S
S
L
D
Y
S
R
D
G
L
A
R
Site 44
S708
T
V
S
S
L
D
Y
S
R
D
G
L
A
R
V
Site 45
Y731
A
T
D
A
C
R
L
Y
A
T
K
H
L
R
V
Site 46
T733
D
A
C
R
L
Y
A
T
K
H
L
R
V
L
L
Site 47
T757
W
G
I
E
L
L
V
T
Q
L
H
D
K
N
K
Site 48
T765
Q
L
H
D
K
N
K
T
I
S
S
E
A
L
D
Site 49
Y817
S
I
P
K
G
F
S
Y
L
N
E
R
G
Y
V
Site 50
Y823
S
Y
L
N
E
R
G
Y
V
A
K
Q
L
E
K
Site 51
Y835
L
E
K
W
H
R
E
Y
N
S
K
Y
V
D
L
Site 52
Y839
H
R
E
Y
N
S
K
Y
V
D
L
I
E
E
Q
Site 53
T852
E
Q
L
N
E
A
L
T
T
Y
R
K
P
V
D
Site 54
T853
Q
L
N
E
A
L
T
T
Y
R
K
P
V
D
G
Site 55
Y854
L
N
E
A
L
T
T
Y
R
K
P
V
D
G
D
Site 56
Y863
K
P
V
D
G
D
N
Y
V
R
R
S
N
Q
R
Site 57
S867
G
D
N
Y
V
R
R
S
N
Q
R
L
Q
R
P
Site 58
Y877
R
L
Q
R
P
H
V
Y
L
P
I
H
L
Y
G
Site 59
T891
G
Q
L
V
H
H
K
T
G
C
H
L
L
E
V
Site 60
T911
E
L
C
R
N
V
R
T
P
D
L
D
K
W
E
Site 61
S1016
E
Q
L
C
N
E
L
S
S
I
P
S
T
L
S
Site 62
S1020
N
E
L
S
S
I
P
S
T
L
S
L
N
S
E
Site 63
T1021
E
L
S
S
I
P
S
T
L
S
L
N
S
E
S
Site 64
S1023
S
S
I
P
S
T
L
S
L
N
S
E
S
T
S
Site 65
S1026
P
S
T
L
S
L
N
S
E
S
T
S
S
R
H
Site 66
S1028
T
L
S
L
N
S
E
S
T
S
S
R
H
N
S
Site 67
T1029
L
S
L
N
S
E
S
T
S
S
R
H
N
S
E
Site 68
S1030
S
L
N
S
E
S
T
S
S
R
H
N
S
E
S
Site 69
S1031
L
N
S
E
S
T
S
S
R
H
N
S
E
S
E
Site 70
S1035
S
T
S
S
R
H
N
S
E
S
E
S
V
P
S
Site 71
S1037
S
S
R
H
N
S
E
S
E
S
V
P
S
S
M
Site 72
S1039
R
H
N
S
E
S
E
S
V
P
S
S
M
F
I
Site 73
S1042
S
E
S
E
S
V
P
S
S
M
F
I
L
E
D
Site 74
S1043
E
S
E
S
V
P
S
S
M
F
I
L
E
D
D
Site 75
S1054
L
E
D
D
R
F
G
S
S
S
T
S
T
F
F
Site 76
S1056
D
D
R
F
G
S
S
S
T
S
T
F
F
L
D
Site 77
S1058
R
F
G
S
S
S
T
S
T
F
F
L
D
I
N
Site 78
T1059
F
G
S
S
S
T
S
T
F
F
L
D
I
N
E
Site 79
T1068
F
L
D
I
N
E
D
T
E
P
T
F
Y
D
R
Site 80
T1071
I
N
E
D
T
E
P
T
F
Y
D
R
S
G
P
Site 81
Y1073
E
D
T
E
P
T
F
Y
D
R
S
G
P
I
K
Site 82
S1084
G
P
I
K
D
K
N
S
F
P
F
F
A
S
S
Site 83
T1103
N
R
I
L
N
S
L
T
L
P
N
K
K
H
R
Site 84
S1111
L
P
N
K
K
H
R
S
S
S
D
P
K
G
G
Site 85
S1112
P
N
K
K
H
R
S
S
S
D
P
K
G
G
K
Site 86
S1113
N
K
K
H
R
S
S
S
D
P
K
G
G
K
L
Site 87
S1121
D
P
K
G
G
K
L
S
S
E
S
K
T
S
N
Site 88
S1122
P
K
G
G
K
L
S
S
E
S
K
T
S
N
R
Site 89
S1124
G
G
K
L
S
S
E
S
K
T
S
N
R
R
I
Site 90
T1126
K
L
S
S
E
S
K
T
S
N
R
R
I
R
T
Site 91
S1127
L
S
S
E
S
K
T
S
N
R
R
I
R
T
L
Site 92
T1133
T
S
N
R
R
I
R
T
L
T
E
P
S
V
D
Site 93
T1135
N
R
R
I
R
T
L
T
E
P
S
V
D
F
N
Site 94
S1138
I
R
T
L
T
E
P
S
V
D
F
N
H
S
D
Site 95
S1144
P
S
V
D
F
N
H
S
D
D
F
T
P
I
S
Site 96
T1148
F
N
H
S
D
D
F
T
P
I
S
T
V
Q
K
Site 97
S1151
S
D
D
F
T
P
I
S
T
V
Q
K
T
L
Q
Site 98
T1152
D
D
F
T
P
I
S
T
V
Q
K
T
L
Q
L
Site 99
T1156
P
I
S
T
V
Q
K
T
L
Q
L
E
T
S
F
Site 100
S1162
K
T
L
Q
L
E
T
S
F
M
G
N
K
H
I
Site 101
T1172
G
N
K
H
I
E
D
T
G
S
T
P
S
I
G
Site 102
S1174
K
H
I
E
D
T
G
S
T
P
S
I
G
E
N
Site 103
T1175
H
I
E
D
T
G
S
T
P
S
I
G
E
N
D
Site 104
S1177
E
D
T
G
S
T
P
S
I
G
E
N
D
L
K
Site 105
T1198
T
E
N
H
R
E
N
T
S
R
E
R
L
V
V
Site 106
S1207
R
E
R
L
V
V
E
S
S
T
S
S
H
M
K
Site 107
S1208
E
R
L
V
V
E
S
S
T
S
S
H
M
K
I
Site 108
S1210
L
V
V
E
S
S
T
S
S
H
M
K
I
R
S
Site 109
S1211
V
V
E
S
S
T
S
S
H
M
K
I
R
S
Q
Site 110
S1217
S
S
H
M
K
I
R
S
Q
S
F
N
T
D
T
Site 111
S1219
H
M
K
I
R
S
Q
S
F
N
T
D
T
T
T
Site 112
T1222
I
R
S
Q
S
F
N
T
D
T
T
T
S
G
I
Site 113
T1224
S
Q
S
F
N
T
D
T
T
T
S
G
I
S
S
Site 114
T1225
Q
S
F
N
T
D
T
T
T
S
G
I
S
S
M
Site 115
T1226
S
F
N
T
D
T
T
T
S
G
I
S
S
M
S
Site 116
S1227
F
N
T
D
T
T
T
S
G
I
S
S
M
S
S
Site 117
S1230
D
T
T
T
S
G
I
S
S
M
S
S
S
P
S
Site 118
S1231
T
T
T
S
G
I
S
S
M
S
S
S
P
S
R
Site 119
S1233
T
S
G
I
S
S
M
S
S
S
P
S
R
E
T
Site 120
S1234
S
G
I
S
S
M
S
S
S
P
S
R
E
T
V
Site 121
S1235
G
I
S
S
M
S
S
S
P
S
R
E
T
V
G
Site 122
S1237
S
S
M
S
S
S
P
S
R
E
T
V
G
V
D
Site 123
T1240
S
S
S
P
S
R
E
T
V
G
V
D
A
T
T
Site 124
T1246
E
T
V
G
V
D
A
T
T
M
D
T
D
C
G
Site 125
T1250
V
D
A
T
T
M
D
T
D
C
G
S
M
S
T
Site 126
S1254
T
M
D
T
D
C
G
S
M
S
T
V
V
S
T
Site 127
S1256
D
T
D
C
G
S
M
S
T
V
V
S
T
K
T
Site 128
S1260
G
S
M
S
T
V
V
S
T
K
T
I
K
T
S
Site 129
T1263
S
T
V
V
S
T
K
T
I
K
T
S
H
Y
L
Site 130
S1267
S
T
K
T
I
K
T
S
H
Y
L
T
P
Q
S
Site 131
Y1269
K
T
I
K
T
S
H
Y
L
T
P
Q
S
N
H
Site 132
T1271
I
K
T
S
H
Y
L
T
P
Q
S
N
H
L
S
Site 133
S1274
S
H
Y
L
T
P
Q
S
N
H
L
S
L
S
K
Site 134
S1278
T
P
Q
S
N
H
L
S
L
S
K
S
N
S
V
Site 135
S1280
Q
S
N
H
L
S
L
S
K
S
N
S
V
S
L
Site 136
S1282
N
H
L
S
L
S
K
S
N
S
V
S
L
V
P
Site 137
S1284
L
S
L
S
K
S
N
S
V
S
L
V
P
P
G
Site 138
S1286
L
S
K
S
N
S
V
S
L
V
P
P
G
S
S
Site 139
S1292
V
S
L
V
P
P
G
S
S
H
T
L
P
R
R
Site 140
S1293
S
L
V
P
P
G
S
S
H
T
L
P
R
R
A
Site 141
T1295
V
P
P
G
S
S
H
T
L
P
R
R
A
Q
S
Site 142
S1302
T
L
P
R
R
A
Q
S
L
K
A
P
S
I
A
Site 143
S1307
A
Q
S
L
K
A
P
S
I
A
T
I
K
S
L
Site 144
S1313
P
S
I
A
T
I
K
S
L
A
D
C
N
F
S
Site 145
S1320
S
L
A
D
C
N
F
S
Y
T
S
S
R
D
A
Site 146
Y1321
L
A
D
C
N
F
S
Y
T
S
S
R
D
A
F
Site 147
S1324
C
N
F
S
Y
T
S
S
R
D
A
F
G
Y
A
Site 148
Y1330
S
S
R
D
A
F
G
Y
A
T
L
K
R
L
Q
Site 149
T1332
R
D
A
F
G
Y
A
T
L
K
R
L
Q
Q
Q
Site 150
S1344
Q
Q
Q
R
M
H
P
S
L
S
H
S
E
A
L
Site 151
S1346
Q
R
M
H
P
S
L
S
H
S
E
A
L
A
S
Site 152
S1348
M
H
P
S
L
S
H
S
E
A
L
A
S
P
A
Site 153
S1353
S
H
S
E
A
L
A
S
P
A
K
D
V
L
F
Site 154
T1361
P
A
K
D
V
L
F
T
D
T
I
T
M
K
A
Site 155
T1363
K
D
V
L
F
T
D
T
I
T
M
K
A
N
S
Site 156
S1370
T
I
T
M
K
A
N
S
F
E
S
R
L
T
P
Site 157
T1376
N
S
F
E
S
R
L
T
P
S
R
F
M
K
A
Site 158
S1385
S
R
F
M
K
A
L
S
Y
A
S
L
D
K
E
Site 159
Y1386
R
F
M
K
A
L
S
Y
A
S
L
D
K
E
D
Site 160
S1388
M
K
A
L
S
Y
A
S
L
D
K
E
D
L
L
Site 161
S1396
L
D
K
E
D
L
L
S
P
I
N
Q
N
T
L
Site 162
T1402
L
S
P
I
N
Q
N
T
L
Q
R
S
S
S
V
Site 163
S1406
N
Q
N
T
L
Q
R
S
S
S
V
R
S
M
V
Site 164
S1407
Q
N
T
L
Q
R
S
S
S
V
R
S
M
V
S
Site 165
S1408
N
T
L
Q
R
S
S
S
V
R
S
M
V
S
S
Site 166
S1411
Q
R
S
S
S
V
R
S
M
V
S
S
A
T
Y
Site 167
S1414
S
S
V
R
S
M
V
S
S
A
T
Y
G
G
S
Site 168
S1415
S
V
R
S
M
V
S
S
A
T
Y
G
G
S
D
Site 169
T1417
R
S
M
V
S
S
A
T
Y
G
G
S
D
D
Y
Site 170
Y1418
S
M
V
S
S
A
T
Y
G
G
S
D
D
Y
I
Site 171
S1421
S
S
A
T
Y
G
G
S
D
D
Y
I
G
L
A
Site 172
Y1444
F
Q
V
K
D
I
P
Y
F
Q
T
K
N
I
P
Site 173
T1447
K
D
I
P
Y
F
Q
T
K
N
I
P
P
H
D
Site 174
S1470
H
D
A
G
G
L
P
S
G
T
G
G
L
V
K
Site 175
T1472
A
G
G
L
P
S
G
T
G
G
L
V
K
N
S
Site 176
S1479
T
G
G
L
V
K
N
S
F
H
L
L
R
Q
Q
Site 177
S1488
H
L
L
R
Q
Q
M
S
L
T
E
I
M
N
S
Site 178
T1490
L
R
Q
Q
M
S
L
T
E
I
M
N
S
I
H
Site 179
S1495
S
L
T
E
I
M
N
S
I
H
S
D
A
S
L
Site 180
S1501
N
S
I
H
S
D
A
S
L
F
L
E
S
T
E
Site 181
T1507
A
S
L
F
L
E
S
T
E
D
T
G
L
Q
E
Site 182
T1510
F
L
E
S
T
E
D
T
G
L
Q
E
H
T
D
Site 183
S1538
F
Q
P
S
N
Q
L
S
A
I
C
S
H
S
D
Site 184
S1542
N
Q
L
S
A
I
C
S
H
S
D
F
Q
D
I
Site 185
Y1551
S
D
F
Q
D
I
P
Y
S
D
W
C
E
Q
T
Site 186
S1568
N
P
L
E
V
V
P
S
K
F
S
G
I
S
G
Site 187
S1571
E
V
V
P
S
K
F
S
G
I
S
G
C
S
D
Site 188
S1574
P
S
K
F
S
G
I
S
G
C
S
D
G
V
S
Site 189
S1577
F
S
G
I
S
G
C
S
D
G
V
S
Q
E
G
Site 190
S1581
S
G
C
S
D
G
V
S
Q
E
G
S
A
S
S
Site 191
S1585
D
G
V
S
Q
E
G
S
A
S
S
T
K
S
T
Site 192
S1587
V
S
Q
E
G
S
A
S
S
T
K
S
T
E
L
Site 193
T1589
Q
E
G
S
A
S
S
T
K
S
T
E
L
L
L
Site 194
S1591
G
S
A
S
S
T
K
S
T
E
L
L
L
G
V
Site 195
T1592
S
A
S
S
T
K
S
T
E
L
L
L
G
V
K
Site 196
T1605
V
K
T
I
P
D
D
T
P
M
C
R
I
L
L
Site 197
S1628
I
N
L
S
S
S
V
S
T
K
C
H
E
T
G
Site 198
T1629
N
L
S
S
S
V
S
T
K
C
H
E
T
G
L
Site 199
Y1643
L
L
T
I
K
E
K
Y
P
Q
T
F
D
D
I
Site 200
T1646
I
K
E
K
Y
P
Q
T
F
D
D
I
C
L
Y
Site 201
S1661
S
E
V
S
H
L
L
S
H
C
T
F
R
L
P
Site 202
T1664
S
H
L
L
S
H
C
T
F
R
L
P
C
R
R
Site 203
T1704
P
K
Q
P
I
V
D
T
S
A
E
S
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation