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Updated November 2019
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Protein Info
Short Name:
BRWD3
Full Name:
Bromodomain and WD repeat-containing protein 3
Alias:
BRODL; bromodomain and WD repeat domain containing 3; FLJ38568
Type:
Mass (Da):
203626
Number AA:
1802
UniProt ID:
Q6RI45
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
A
A
A
P
T
Q
I
E
A
E
L
Y
Site 2
Y13
T
Q
I
E
A
E
L
Y
Y
L
I
A
R
F
L
Site 3
S28
Q
S
G
P
C
N
K
S
A
Q
V
L
V
Q
E
Site 4
S56
E
G
K
E
H
R
R
S
F
E
D
L
V
A
A
Site 5
Y71
N
A
H
I
P
P
D
Y
L
L
K
I
C
E
R
Site 6
S90
L
D
K
E
I
P
Q
S
V
P
G
V
Q
T
L
Site 7
S104
L
L
G
V
G
R
Q
S
L
L
R
D
A
K
D
Site 8
S114
R
D
A
K
D
C
K
S
T
L
W
N
G
S
A
Site 9
Y137
P
P
E
L
P
V
N
Y
V
K
P
P
N
V
V
Site 10
T153
I
T
S
A
R
Q
L
T
G
C
S
R
F
G
H
Site 11
Y167
H
I
F
P
S
S
A
Y
Q
H
I
K
M
H
K
Site 12
T197
R
S
G
R
R
I
F
T
G
S
D
D
C
L
V
Site 13
S199
G
R
R
I
F
T
G
S
D
D
C
L
V
K
I
Site 14
T217
D
D
G
R
L
L
A
T
L
R
G
H
S
A
E
Site 15
S222
L
A
T
L
R
G
H
S
A
E
I
S
D
M
A
Site 16
S226
R
G
H
S
A
E
I
S
D
M
A
V
N
Y
E
Site 17
T268
Q
G
H
S
A
S
I
T
S
I
Q
F
C
P
S
Site 18
S269
G
H
S
A
S
I
T
S
I
Q
F
C
P
S
T
Site 19
S275
T
S
I
Q
F
C
P
S
T
K
G
T
N
R
Y
Site 20
T276
S
I
Q
F
C
P
S
T
K
G
T
N
R
Y
L
Site 21
T279
F
C
P
S
T
K
G
T
N
R
Y
L
T
S
T
Site 22
Y282
S
T
K
G
T
N
R
Y
L
T
S
T
G
A
D
Site 23
T284
K
G
T
N
R
Y
L
T
S
T
G
A
D
G
T
Site 24
S285
G
T
N
R
Y
L
T
S
T
G
A
D
G
T
I
Site 25
T286
T
N
R
Y
L
T
S
T
G
A
D
G
T
I
C
Site 26
T312
R
D
R
P
V
K
F
T
E
R
S
R
P
G
V
Site 27
S322
S
R
P
G
V
Q
I
S
C
S
S
F
S
S
G
Site 28
T334
S
S
G
G
M
F
I
T
T
G
S
T
D
H
V
Site 29
S337
G
M
F
I
T
T
G
S
T
D
H
V
I
R
I
Site 30
T338
M
F
I
T
T
G
S
T
D
H
V
I
R
I
Y
Site 31
Y345
T
D
H
V
I
R
I
Y
Y
L
G
S
E
V
P
Site 32
Y346
D
H
V
I
R
I
Y
Y
L
G
S
E
V
P
E
Site 33
S376
Q
F
C
N
N
G
D
S
L
R
F
V
S
G
S
Site 34
S381
G
D
S
L
R
F
V
S
G
S
R
D
G
T
A
Site 35
S383
S
L
R
F
V
S
G
S
R
D
G
T
A
R
I
Site 36
T387
V
S
G
S
R
D
G
T
A
R
I
W
Q
Y
Q
Site 37
T422
P
S
G
E
D
K
I
T
K
L
K
V
T
M
V
Site 38
S462
G
Q
L
L
H
T
L
S
G
H
D
D
E
V
F
Site 39
S483
F
D
Q
R
I
I
L
S
A
G
H
D
G
N
I
Site 40
Y504
R
G
T
K
I
R
N
Y
F
N
M
I
E
G
Q
Site 41
S522
A
V
F
D
C
K
F
S
P
D
G
N
H
F
A
Site 42
Y547
F
G
F
G
C
S
K
Y
Y
E
K
I
P
D
Q
Site 43
Y548
G
F
G
C
S
K
Y
Y
E
K
I
P
D
Q
M
Site 44
T559
P
D
Q
M
F
F
H
T
D
Y
R
P
L
I
R
Site 45
Y561
Q
M
F
F
H
T
D
Y
R
P
L
I
R
D
A
Site 46
Y571
L
I
R
D
A
N
N
Y
V
L
D
E
Q
T
Q
Site 47
Y622
Q
L
I
P
Q
L
G
Y
V
A
N
G
D
G
E
Site 48
Y677
H
L
P
V
N
R
A
Y
S
V
N
G
A
L
R
Site 49
S678
L
P
V
N
R
A
Y
S
V
N
G
A
L
R
S
Site 50
S685
S
V
N
G
A
L
R
S
P
N
M
D
I
S
S
Site 51
S691
R
S
P
N
M
D
I
S
S
S
P
N
I
R
L
Site 52
S692
S
P
N
M
D
I
S
S
S
P
N
I
R
L
R
Site 53
S693
P
N
M
D
I
S
S
S
P
N
I
R
L
R
R
Site 54
S702
N
I
R
L
R
R
H
S
S
Q
I
E
G
V
R
Site 55
S703
I
R
L
R
R
H
S
S
Q
I
E
G
V
R
Q
Site 56
S718
M
H
N
N
A
P
R
S
Q
M
A
T
E
R
D
Site 57
T722
A
P
R
S
Q
M
A
T
E
R
D
L
M
A
W
Site 58
S730
E
R
D
L
M
A
W
S
R
R
V
V
V
N
E
Site 59
T751
R
V
Q
E
E
C
R
T
A
K
G
D
I
E
I
Site 60
S759
A
K
G
D
I
E
I
S
L
Y
T
V
E
K
K
Site 61
Y761
G
D
I
E
I
S
L
Y
T
V
E
K
K
K
K
Site 62
Y771
E
K
K
K
K
P
S
Y
T
T
Q
R
N
D
Y
Site 63
Y778
Y
T
T
Q
R
N
D
Y
E
P
S
C
G
R
S
Site 64
S781
Q
R
N
D
Y
E
P
S
C
G
R
S
L
R
R
Site 65
S785
Y
E
P
S
C
G
R
S
L
R
R
T
Q
R
K
Site 66
T789
C
G
R
S
L
R
R
T
Q
R
K
R
Q
H
T
Site 67
T796
T
Q
R
K
R
Q
H
T
Y
Q
T
R
S
N
I
Site 68
Y797
Q
R
K
R
Q
H
T
Y
Q
T
R
S
N
I
E
Site 69
S807
R
S
N
I
E
H
N
S
Q
A
S
C
Q
N
S
Site 70
S814
S
Q
A
S
C
Q
N
S
G
V
Q
E
D
S
D
Site 71
S820
N
S
G
V
Q
E
D
S
D
S
S
S
E
E
D
Site 72
S822
G
V
Q
E
D
S
D
S
S
S
E
E
D
E
T
Site 73
S824
Q
E
D
S
D
S
S
S
E
E
D
E
T
V
G
Site 74
T829
S
S
S
E
E
D
E
T
V
G
T
S
D
A
S
Site 75
T832
E
E
D
E
T
V
G
T
S
D
A
S
V
E
D
Site 76
S836
T
V
G
T
S
D
A
S
V
E
D
P
V
V
E
Site 77
S846
D
P
V
V
E
W
Q
S
E
S
S
S
S
D
S
Site 78
S848
V
V
E
W
Q
S
E
S
S
S
S
D
S
S
S
Site 79
S849
V
E
W
Q
S
E
S
S
S
S
D
S
S
S
E
Site 80
S850
E
W
Q
S
E
S
S
S
S
D
S
S
S
E
Y
Site 81
S851
W
Q
S
E
S
S
S
S
D
S
S
S
E
Y
S
Site 82
S853
S
E
S
S
S
S
D
S
S
S
E
Y
S
D
W
Site 83
S854
E
S
S
S
S
D
S
S
S
E
Y
S
D
W
T
Site 84
S855
S
S
S
S
D
S
S
S
E
Y
S
D
W
T
A
Site 85
Y857
S
S
D
S
S
S
E
Y
S
D
W
T
A
D
A
Site 86
S858
S
D
S
S
S
E
Y
S
D
W
T
A
D
A
G
Site 87
T861
S
S
E
Y
S
D
W
T
A
D
A
G
I
N
L
Site 88
T875
L
Q
P
P
K
R
Q
T
R
Q
T
T
R
K
I
Site 89
T878
P
K
R
Q
T
R
Q
T
T
R
K
I
C
S
S
Site 90
T879
K
R
Q
T
R
Q
T
T
R
K
I
C
S
S
S
Site 91
S884
Q
T
T
R
K
I
C
S
S
S
D
E
E
N
L
Site 92
S885
T
T
R
K
I
C
S
S
S
D
E
E
N
L
K
Site 93
S886
T
R
K
I
C
S
S
S
D
E
E
N
L
K
S
Site 94
S893
S
D
E
E
N
L
K
S
L
E
E
R
Q
K
K
Site 95
S913
K
K
K
G
G
L
V
S
I
A
G
E
P
N
E
Site 96
T931
A
P
Q
W
I
L
D
T
I
P
R
R
S
P
F
Site 97
S936
L
D
T
I
P
R
R
S
P
F
V
P
Q
M
G
Site 98
Y948
Q
M
G
D
E
L
I
Y
F
R
Q
G
H
E
A
Site 99
Y956
F
R
Q
G
H
E
A
Y
V
R
A
V
R
K
S
Site 100
S963
Y
V
R
A
V
R
K
S
K
I
Y
S
V
N
L
Site 101
Y966
A
V
R
K
S
K
I
Y
S
V
N
L
Q
K
Q
Site 102
S967
V
R
K
S
K
I
Y
S
V
N
L
Q
K
Q
P
Site 103
T1016
D
P
I
S
G
K
M
T
G
E
S
F
S
I
K
Site 104
S1019
S
G
K
M
T
G
E
S
F
S
I
K
Y
H
D
Site 105
Y1024
G
E
S
F
S
I
K
Y
H
D
M
P
D
V
I
Site 106
Y1040
F
L
V
L
H
Q
F
Y
N
E
A
K
E
R
N
Site 107
Y1077
Q
Q
P
F
Q
P
E
Y
P
D
S
S
F
Q
C
Site 108
S1080
F
Q
P
E
Y
P
D
S
S
F
Q
C
Y
S
V
Site 109
S1098
N
N
E
R
E
K
M
S
P
W
D
M
E
P
I
Site 110
Y1131
E
E
L
T
A
L
L
Y
K
P
Q
E
G
E
W
Site 111
S1142
E
G
E
W
G
A
H
S
R
D
E
E
C
E
R
Site 112
T1190
A
Y
P
T
D
L
N
T
I
R
R
R
L
E
N
Site 113
Y1200
R
R
L
E
N
R
F
Y
R
R
I
S
A
L
M
Site 114
T1219
Y
I
E
H
N
A
R
T
F
N
E
P
D
S
P
Site 115
S1225
R
T
F
N
E
P
D
S
P
I
V
K
A
A
K
Site 116
S1246
L
R
F
I
G
D
Q
S
C
T
D
I
L
D
T
Site 117
T1253
S
C
T
D
I
L
D
T
Y
N
K
I
K
A
E
Site 118
Y1254
C
T
D
I
L
D
T
Y
N
K
I
K
A
E
E
Site 119
S1264
I
K
A
E
E
R
N
S
T
D
A
E
E
D
T
Site 120
T1265
K
A
E
E
R
N
S
T
D
A
E
E
D
T
E
Site 121
T1271
S
T
D
A
E
E
D
T
E
I
V
D
L
D
S
Site 122
S1278
T
E
I
V
D
L
D
S
D
G
P
G
T
S
S
Site 123
S1284
D
S
D
G
P
G
T
S
S
G
R
R
V
K
C
Site 124
S1285
S
D
G
P
G
T
S
S
G
R
R
V
K
C
R
Site 125
S1297
K
C
R
G
R
R
Q
S
L
K
C
N
P
D
A
Site 126
S1314
K
Q
C
K
E
L
L
S
L
I
Y
E
R
E
D
Site 127
Y1317
K
E
L
L
S
L
I
Y
E
R
E
D
S
E
P
Site 128
S1322
L
I
Y
E
R
E
D
S
E
P
F
R
Q
P
A
Site 129
S1333
R
Q
P
A
D
L
L
S
Y
P
G
H
Q
E
Q
Site 130
Y1334
Q
P
A
D
L
L
S
Y
P
G
H
Q
E
Q
E
Site 131
S1345
Q
E
Q
E
G
E
S
S
E
S
V
V
P
E
R
Site 132
S1347
Q
E
G
E
S
S
E
S
V
V
P
E
R
Q
Q
Site 133
S1357
P
E
R
Q
Q
D
S
S
L
S
E
D
Y
Q
D
Site 134
S1359
R
Q
Q
D
S
S
L
S
E
D
Y
Q
D
V
I
Site 135
Y1362
D
S
S
L
S
E
D
Y
Q
D
V
I
D
T
P
Site 136
T1368
D
Y
Q
D
V
I
D
T
P
V
D
F
S
T
V
Site 137
S1373
I
D
T
P
V
D
F
S
T
V
K
E
T
L
E
Site 138
T1374
D
T
P
V
D
F
S
T
V
K
E
T
L
E
A
Site 139
Y1384
E
T
L
E
A
G
N
Y
G
S
P
L
E
F
Y
Site 140
S1386
L
E
A
G
N
Y
G
S
P
L
E
F
Y
K
D
Site 141
Y1391
Y
G
S
P
L
E
F
Y
K
D
V
R
Q
I
F
Site 142
T1405
F
N
N
S
K
A
Y
T
S
N
K
K
S
R
I
Site 143
S1406
N
N
S
K
A
Y
T
S
N
K
K
S
R
I
Y
Site 144
S1410
A
Y
T
S
N
K
K
S
R
I
Y
S
M
M
L
Site 145
Y1413
S
N
K
K
S
R
I
Y
S
M
M
L
R
L
S
Site 146
S1414
N
K
K
S
R
I
Y
S
M
M
L
R
L
S
A
Site 147
S1432
S
H
I
K
N
I
I
S
E
Y
K
S
A
I
Q
Site 148
S1436
N
I
I
S
E
Y
K
S
A
I
Q
S
Q
K
R
Site 149
S1440
E
Y
K
S
A
I
Q
S
Q
K
R
R
R
P
R
Site 150
Y1448
Q
K
R
R
R
P
R
Y
R
K
R
L
R
S
S
Site 151
S1454
R
Y
R
K
R
L
R
S
S
S
S
S
L
S
S
Site 152
S1455
Y
R
K
R
L
R
S
S
S
S
S
L
S
S
S
Site 153
S1456
R
K
R
L
R
S
S
S
S
S
L
S
S
S
G
Site 154
S1457
K
R
L
R
S
S
S
S
S
L
S
S
S
G
A
Site 155
S1458
R
L
R
S
S
S
S
S
L
S
S
S
G
A
P
Site 156
S1460
R
S
S
S
S
S
L
S
S
S
G
A
P
S
P
Site 157
S1461
S
S
S
S
S
L
S
S
S
G
A
P
S
P
K
Site 158
S1462
S
S
S
S
L
S
S
S
G
A
P
S
P
K
G
Site 159
S1466
L
S
S
S
G
A
P
S
P
K
G
K
Q
K
Q
Site 160
S1485
P
K
N
D
Q
N
T
S
V
S
H
A
R
T
S
Site 161
S1487
N
D
Q
N
T
S
V
S
H
A
R
T
S
S
P
Site 162
T1491
T
S
V
S
H
A
R
T
S
S
P
F
S
S
P
Site 163
S1492
S
V
S
H
A
R
T
S
S
P
F
S
S
P
V
Site 164
S1493
V
S
H
A
R
T
S
S
P
F
S
S
P
V
S
Site 165
S1496
A
R
T
S
S
P
F
S
S
P
V
S
D
A
A
Site 166
S1497
R
T
S
S
P
F
S
S
P
V
S
D
A
A
E
Site 167
S1500
S
P
F
S
S
P
V
S
D
A
A
E
G
L
S
Site 168
Y1509
A
A
E
G
L
S
L
Y
L
L
D
D
E
P
D
Site 169
S1520
D
E
P
D
G
P
F
S
S
S
S
F
G
G
Y
Site 170
S1521
E
P
D
G
P
F
S
S
S
S
F
G
G
Y
S
Site 171
S1522
P
D
G
P
F
S
S
S
S
F
G
G
Y
S
R
Site 172
S1523
D
G
P
F
S
S
S
S
F
G
G
Y
S
R
S
Site 173
Y1527
S
S
S
S
F
G
G
Y
S
R
S
G
N
S
H
Site 174
S1528
S
S
S
F
G
G
Y
S
R
S
G
N
S
H
D
Site 175
S1530
S
F
G
G
Y
S
R
S
G
N
S
H
D
P
G
Site 176
S1541
H
D
P
G
K
A
K
S
F
R
N
R
V
L
P
Site 177
S1554
L
P
V
K
Q
D
H
S
L
D
G
P
L
T
N
Site 178
T1560
H
S
L
D
G
P
L
T
N
G
D
G
R
E
P
Site 179
T1569
G
D
G
R
E
P
R
T
G
I
K
R
K
L
L
Site 180
S1577
G
I
K
R
K
L
L
S
A
S
E
E
D
E
N
Site 181
S1579
K
R
K
L
L
S
A
S
E
E
D
E
N
M
G
Site 182
T1595
E
D
K
E
K
K
E
T
K
E
K
S
H
L
S
Site 183
S1599
K
K
E
T
K
E
K
S
H
L
S
T
S
E
S
Site 184
S1602
T
K
E
K
S
H
L
S
T
S
E
S
G
E
L
Site 185
T1603
K
E
K
S
H
L
S
T
S
E
S
G
E
L
G
Site 186
S1604
E
K
S
H
L
S
T
S
E
S
G
E
L
G
S
Site 187
S1606
S
H
L
S
T
S
E
S
G
E
L
G
S
S
L
Site 188
S1611
S
E
S
G
E
L
G
S
S
L
S
S
E
S
T
Site 189
S1612
E
S
G
E
L
G
S
S
L
S
S
E
S
T
C
Site 190
S1614
G
E
L
G
S
S
L
S
S
E
S
T
C
G
S
Site 191
S1615
E
L
G
S
S
L
S
S
E
S
T
C
G
S
D
Site 192
S1617
G
S
S
L
S
S
E
S
T
C
G
S
D
S
D
Site 193
T1618
S
S
L
S
S
E
S
T
C
G
S
D
S
D
S
Site 194
S1621
S
S
E
S
T
C
G
S
D
S
D
S
E
S
T
Site 195
S1623
E
S
T
C
G
S
D
S
D
S
E
S
T
S
R
Site 196
S1625
T
C
G
S
D
S
D
S
E
S
T
S
R
T
D
Site 197
S1627
G
S
D
S
D
S
E
S
T
S
R
T
D
Q
D
Site 198
S1629
D
S
D
S
E
S
T
S
R
T
D
Q
D
Y
V
Site 199
T1631
D
S
E
S
T
S
R
T
D
Q
D
Y
V
D
G
Site 200
Y1635
T
S
R
T
D
Q
D
Y
V
D
G
D
H
D
Y
Site 201
Y1642
Y
V
D
G
D
H
D
Y
S
K
F
I
Q
T
R
Site 202
T1667
N
G
K
R
N
W
K
T
R
G
T
G
G
R
G
Site 203
T1670
R
N
W
K
T
R
G
T
G
G
R
G
R
W
G
Site 204
S1696
R
G
G
R
G
R
G
S
R
G
R
G
G
G
G
Site 205
T1704
R
G
R
G
G
G
G
T
R
G
R
G
R
G
R
Site 206
S1717
G
R
G
G
R
G
A
S
R
G
A
T
R
A
K
Site 207
T1721
R
G
A
S
R
G
A
T
R
A
K
R
A
R
I
Site 208
T1735
I
A
D
D
E
F
D
T
M
F
S
G
R
F
S
Site 209
S1738
D
E
F
D
T
M
F
S
G
R
F
S
R
L
P
Site 210
S1742
T
M
F
S
G
R
F
S
R
L
P
R
I
K
T
Site 211
T1749
S
R
L
P
R
I
K
T
R
N
Q
G
R
R
T
Site 212
T1756
T
R
N
Q
G
R
R
T
V
L
Y
N
D
D
S
Site 213
Y1759
Q
G
R
R
T
V
L
Y
N
D
D
S
D
N
D
Site 214
S1763
T
V
L
Y
N
D
D
S
D
N
D
N
F
V
S
Site 215
S1770
S
D
N
D
N
F
V
S
T
E
D
P
L
N
L
Site 216
S1780
D
P
L
N
L
G
T
S
R
S
G
R
V
R
K
Site 217
S1782
L
N
L
G
T
S
R
S
G
R
V
R
K
M
T
Site 218
T1789
S
G
R
V
R
K
M
T
E
K
A
R
V
S
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation