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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SARM1
Full Name:
Sterile alpha and TIR motif-containing protein 1
Alias:
Sterile alpha and Armadillo repeat protein;Sterile alpha motif domain-containing protein 2;Tir-1 homolog
Type:
Mass (Da):
79388
Number AA:
724
UniProt ID:
Q6SZW1
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
L
C
R
F
F
A
M
S
G
P
R
P
G
A
E
Site 2
S54
G
R
G
P
R
E
V
S
P
G
A
G
T
E
V
Site 3
S77
P
E
L
Q
Q
A
L
S
A
L
K
Q
A
G
G
Site 4
Y213
G
G
L
D
A
V
L
Y
W
C
R
R
T
D
P
Site 5
T218
V
L
Y
W
C
R
R
T
D
P
A
L
L
R
H
Site 6
S290
V
E
R
E
V
E
R
S
G
T
L
A
L
V
E
Site 7
T292
R
E
V
E
R
S
G
T
L
A
L
V
E
P
L
Site 8
S316
A
R
C
L
V
D
A
S
D
T
S
Q
G
R
G
Site 9
S319
L
V
D
A
S
D
T
S
Q
G
R
G
P
D
D
Site 10
S336
R
L
V
P
L
L
D
S
N
R
L
E
A
Q
C
Site 11
S357
C
A
E
A
A
I
K
S
L
Q
G
K
T
K
V
Site 12
T362
I
K
S
L
Q
G
K
T
K
V
F
S
D
I
G
Site 13
S366
Q
G
K
T
K
V
F
S
D
I
G
A
I
Q
S
Site 14
S379
Q
S
L
K
R
L
V
S
Y
S
T
N
G
T
K
Site 15
S381
L
K
R
L
V
S
Y
S
T
N
G
T
K
S
A
Site 16
T385
V
S
Y
S
T
N
G
T
K
S
A
L
A
K
R
Site 17
S387
Y
S
T
N
G
T
K
S
A
L
A
K
R
A
L
Site 18
S408
V
P
R
P
I
L
P
S
V
P
S
W
K
E
A
Site 19
Y429
Q
Q
I
G
F
S
K
Y
C
E
S
F
R
E
Q
Site 20
S432
G
F
S
K
Y
C
E
S
F
R
E
Q
Q
V
D
Site 21
T447
G
D
L
L
L
R
L
T
E
E
E
L
Q
T
D
Site 22
T453
L
T
E
E
E
L
Q
T
D
L
G
M
K
S
G
Site 23
S459
Q
T
D
L
G
M
K
S
G
I
T
R
K
R
F
Site 24
T471
K
R
F
F
R
E
L
T
E
L
K
T
F
A
N
Site 25
T475
R
E
L
T
E
L
K
T
F
A
N
Y
S
T
C
Site 26
S480
L
K
T
F
A
N
Y
S
T
C
D
R
S
N
L
Site 27
S493
N
L
A
D
W
L
G
S
L
D
P
R
F
R
Q
Site 28
Y501
L
D
P
R
F
R
Q
Y
T
Y
G
L
V
S
C
Site 29
T502
D
P
R
F
R
Q
Y
T
Y
G
L
V
S
C
G
Site 30
Y503
P
R
F
R
Q
Y
T
Y
G
L
V
S
C
G
L
Site 31
S513
V
S
C
G
L
D
R
S
L
L
H
R
V
S
E
Site 32
S519
R
S
L
L
H
R
V
S
E
Q
Q
L
L
E
D
Site 33
T540
V
H
R
A
R
I
L
T
A
A
R
E
M
L
H
Site 34
S548
A
A
R
E
M
L
H
S
P
L
P
C
T
G
G
Site 35
T553
L
H
S
P
L
P
C
T
G
G
K
P
S
G
D
Site 36
S558
P
C
T
G
G
K
P
S
G
D
T
P
D
V
F
Site 37
T561
G
G
K
P
S
G
D
T
P
D
V
F
I
S
Y
Site 38
S567
D
T
P
D
V
F
I
S
Y
R
R
N
S
G
S
Site 39
Y568
T
P
D
V
F
I
S
Y
R
R
N
S
G
S
Q
Site 40
S572
F
I
S
Y
R
R
N
S
G
S
Q
L
A
S
L
Site 41
S574
S
Y
R
R
N
S
G
S
Q
L
A
S
L
L
K
Site 42
S578
N
S
G
S
Q
L
A
S
L
L
K
V
H
L
Q
Site 43
T677
E
D
M
Q
A
V
L
T
F
N
G
I
K
W
S
Site 44
Y687
G
I
K
W
S
H
E
Y
Q
E
A
T
I
E
K
Site 45
S703
I
R
F
L
Q
G
R
S
S
R
D
S
S
A
G
Site 46
S704
R
F
L
Q
G
R
S
S
R
D
S
S
A
G
S
Site 47
S707
Q
G
R
S
S
R
D
S
S
A
G
S
D
T
S
Site 48
S708
G
R
S
S
R
D
S
S
A
G
S
D
T
S
L
Site 49
S711
S
R
D
S
S
A
G
S
D
T
S
L
E
G
A
Site 50
S714
S
S
A
G
S
D
T
S
L
E
G
A
A
P
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation