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Updated November 2019
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Protein Info
Short Name:
NHS
Full Name:
Nance-Horan syndrome protein
Alias:
congenital cataracts and dental anomalies; Nance-Horan syndrome; SCML1
Type:
Uncharacterized protein
Mass (Da):
176700
Number AA:
1630
UniProt ID:
Q6T4R5
International Prot ID:
IPI00375220
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
P
G
P
A
V
D
A
S
G
G
S
A
E
P
P
Site 2
S65
A
R
A
V
P
A
P
S
G
L
P
P
P
P
P
Site 3
T81
L
P
A
P
A
D
Q
T
Q
P
P
H
G
E
A
Site 4
S89
Q
P
P
H
G
E
A
S
V
A
G
E
E
S
T
Site 5
S140
A
R
V
L
R
Q
L
S
D
V
A
R
H
A
C
Site 6
S148
D
V
A
R
H
A
C
S
L
F
Q
E
L
E
S
Site 7
S155
S
L
F
Q
E
L
E
S
D
I
Q
L
T
H
R
Site 8
T160
L
E
S
D
I
Q
L
T
H
R
R
V
W
A
L
Site 9
S179
G
G
V
Q
R
V
L
S
T
L
D
P
K
Q
E
Site 10
S191
K
Q
E
A
V
P
V
S
N
L
D
I
E
S
K
Site 11
S197
V
S
N
L
D
I
E
S
K
L
S
V
Y
Y
R
Site 12
S200
L
D
I
E
S
K
L
S
V
Y
Y
R
A
P
W
Site 13
Y202
I
E
S
K
L
S
V
Y
Y
R
A
P
W
H
Q
Site 14
Y203
E
S
K
L
S
V
Y
Y
R
A
P
W
H
Q
Q
Site 15
T218
R
N
I
F
L
P
A
T
R
P
P
C
V
E
E
Site 16
S233
L
H
R
H
A
R
Q
S
L
Q
A
L
R
R
E
Site 17
S243
A
L
R
R
E
H
R
S
R
S
D
R
R
E
Q
Site 18
S245
R
R
E
H
R
S
R
S
D
R
R
E
Q
R
A
Site 19
S257
Q
R
A
A
A
P
L
S
I
A
A
P
P
L
P
Site 20
Y266
A
A
P
P
L
P
A
Y
P
P
A
H
S
Q
R
Site 21
S271
P
A
Y
P
P
A
H
S
Q
R
R
R
E
F
K
Site 22
S285
K
D
R
H
F
L
T
S
H
P
P
E
D
E
D
Site 23
T293
H
P
P
E
D
E
D
T
D
V
M
L
G
Q
R
Site 24
S310
N
P
I
H
N
I
P
S
T
L
D
K
Q
T
N
Site 25
T311
P
I
H
N
I
P
S
T
L
D
K
Q
T
N
W
Site 26
T326
S
K
A
L
P
L
P
T
P
E
E
K
M
K
Q
Site 27
S361
R
E
A
S
I
R
C
S
L
V
H
S
Q
S
V
Site 28
S365
I
R
C
S
L
V
H
S
Q
S
V
L
Q
R
R
Site 29
S367
C
S
L
V
H
S
Q
S
V
L
Q
R
R
R
K
Site 30
T380
R
K
L
R
R
R
K
T
I
S
G
I
P
R
R
Site 31
S382
L
R
R
R
K
T
I
S
G
I
P
R
R
V
Q
Site 32
S394
R
V
Q
Q
E
I
D
S
D
E
S
P
V
A
R
Site 33
S397
Q
E
I
D
S
D
E
S
P
V
A
R
E
R
N
Site 34
T416
T
N
P
D
P
S
N
T
V
N
R
I
S
G
T
Site 35
S421
S
N
T
V
N
R
I
S
G
T
R
D
S
E
C
Site 36
S426
R
I
S
G
T
R
D
S
E
C
Q
T
E
D
I
Site 37
T430
T
R
D
S
E
C
Q
T
E
D
I
L
I
A
A
Site 38
S439
D
I
L
I
A
A
P
S
R
R
R
I
R
A
Q
Site 39
S450
I
R
A
Q
R
G
Q
S
I
A
A
S
L
S
H
Site 40
S454
R
G
Q
S
I
A
A
S
L
S
H
S
A
G
N
Site 41
S456
Q
S
I
A
A
S
L
S
H
S
A
G
N
I
S
Site 42
S458
I
A
A
S
L
S
H
S
A
G
N
I
S
A
L
Site 43
T474
D
K
G
D
T
M
F
T
P
A
V
S
S
R
T
Site 44
S478
T
M
F
T
P
A
V
S
S
R
T
R
S
R
S
Site 45
S479
M
F
T
P
A
V
S
S
R
T
R
S
R
S
L
Site 46
T481
T
P
A
V
S
S
R
T
R
S
R
S
L
P
R
Site 47
S483
A
V
S
S
R
T
R
S
R
S
L
P
R
E
G
Site 48
S485
S
S
R
T
R
S
R
S
L
P
R
E
G
N
R
Site 49
S505
P
K
V
G
A
K
P
S
A
Y
E
E
G
E
S
Site 50
Y507
V
G
A
K
P
S
A
Y
E
E
G
E
S
F
V
Site 51
S512
S
A
Y
E
E
G
E
S
F
V
G
D
H
E
R
Site 52
T520
F
V
G
D
H
E
R
T
P
N
D
F
S
E
A
Site 53
S525
E
R
T
P
N
D
F
S
E
A
P
S
S
P
S
Site 54
S529
N
D
F
S
E
A
P
S
S
P
S
A
Q
D
H
Site 55
S530
D
F
S
E
A
P
S
S
P
S
A
Q
D
H
Q
Site 56
S545
P
T
L
G
L
A
C
S
Q
H
L
H
S
P
Q
Site 57
S550
A
C
S
Q
H
L
H
S
P
Q
H
K
L
S
E
Site 58
S556
H
S
P
Q
H
K
L
S
E
R
G
R
S
R
L
Site 59
S561
K
L
S
E
R
G
R
S
R
L
S
R
M
A
A
Site 60
S564
E
R
G
R
S
R
L
S
R
M
A
A
D
S
G
Site 61
S570
L
S
R
M
A
A
D
S
G
S
C
D
I
S
S
Site 62
S572
R
M
A
A
D
S
G
S
C
D
I
S
S
N
S
Site 63
S576
D
S
G
S
C
D
I
S
S
N
S
D
T
F
G
Site 64
S577
S
G
S
C
D
I
S
S
N
S
D
T
F
G
S
Site 65
S579
S
C
D
I
S
S
N
S
D
T
F
G
S
P
I
Site 66
T581
D
I
S
S
N
S
D
T
F
G
S
P
I
H
C
Site 67
S584
S
N
S
D
T
F
G
S
P
I
H
C
I
S
T
Site 68
S597
S
T
A
G
V
L
L
S
S
H
M
D
Q
K
D
Site 69
S598
T
A
G
V
L
L
S
S
H
M
D
Q
K
D
D
Site 70
S608
D
Q
K
D
D
H
Q
S
S
S
G
N
W
S
G
Site 71
S609
Q
K
D
D
H
Q
S
S
S
G
N
W
S
G
S
Site 72
S610
K
D
D
H
Q
S
S
S
G
N
W
S
G
S
S
Site 73
S614
Q
S
S
S
G
N
W
S
G
S
S
S
T
C
P
Site 74
S616
S
S
G
N
W
S
G
S
S
S
T
C
P
S
Q
Site 75
S618
G
N
W
S
G
S
S
S
T
C
P
S
Q
T
S
Site 76
S622
G
S
S
S
T
C
P
S
Q
T
S
E
T
I
P
Site 77
S625
S
T
C
P
S
Q
T
S
E
T
I
P
P
A
A
Site 78
S633
E
T
I
P
P
A
A
S
P
P
L
T
G
S
S
Site 79
T637
P
A
A
S
P
P
L
T
G
S
S
H
C
D
S
Site 80
S639
A
S
P
P
L
T
G
S
S
H
C
D
S
E
L
Site 81
S640
S
P
P
L
T
G
S
S
H
C
D
S
E
L
S
Site 82
S644
T
G
S
S
H
C
D
S
E
L
S
L
N
T
A
Site 83
S647
S
H
C
D
S
E
L
S
L
N
T
A
P
H
A
Site 84
S659
P
H
A
N
E
D
A
S
V
F
V
T
E
Q
Y
Site 85
T663
E
D
A
S
V
F
V
T
E
Q
Y
N
D
H
L
Site 86
S680
V
R
G
H
R
A
N
S
F
T
S
T
V
A
D
Site 87
T682
G
H
R
A
N
S
F
T
S
T
V
A
D
L
L
Site 88
T684
R
A
N
S
F
T
S
T
V
A
D
L
L
D
D
Site 89
S695
L
L
D
D
P
N
N
S
N
T
S
D
S
E
W
Site 90
S698
D
P
N
N
S
N
T
S
D
S
E
W
N
Y
L
Site 91
Y704
T
S
D
S
E
W
N
Y
L
H
H
H
H
D
A
Site 92
S718
A
S
C
R
Q
D
F
S
P
E
R
P
K
A
D
Site 93
S726
P
E
R
P
K
A
D
S
L
G
C
P
S
F
T
Site 94
T737
P
S
F
T
S
M
A
T
Y
D
S
F
L
E
K
Site 95
Y738
S
F
T
S
M
A
T
Y
D
S
F
L
E
K
S
Site 96
S740
T
S
M
A
T
Y
D
S
F
L
E
K
S
P
S
Site 97
S745
Y
D
S
F
L
E
K
S
P
S
D
K
A
D
T
Site 98
S747
S
F
L
E
K
S
P
S
D
K
A
D
T
S
S
Site 99
T752
S
P
S
D
K
A
D
T
S
S
H
F
S
V
D
Site 100
S753
P
S
D
K
A
D
T
S
S
H
F
S
V
D
T
Site 101
S754
S
D
K
A
D
T
S
S
H
F
S
V
D
T
E
Site 102
S757
A
D
T
S
S
H
F
S
V
D
T
E
G
Y
Y
Site 103
T760
S
S
H
F
S
V
D
T
E
G
Y
Y
T
S
M
Site 104
Y763
F
S
V
D
T
E
G
Y
Y
T
S
M
H
F
D
Site 105
Y764
S
V
D
T
E
G
Y
Y
T
S
M
H
F
D
C
Site 106
Y779
G
L
K
G
N
K
S
Y
V
C
H
Y
A
A
L
Site 107
Y783
N
K
S
Y
V
C
H
Y
A
A
L
G
P
E
N
Site 108
S797
N
G
Q
G
V
G
A
S
P
G
L
P
D
C
A
Site 109
Y808
P
D
C
A
W
Q
D
Y
L
D
H
K
R
Q
G
Site 110
S818
H
K
R
Q
G
R
P
S
I
S
F
R
K
P
K
Site 111
S820
R
Q
G
R
P
S
I
S
F
R
K
P
K
A
K
Site 112
T829
R
K
P
K
A
K
P
T
P
P
K
R
S
S
S
Site 113
S834
K
P
T
P
P
K
R
S
S
S
L
R
K
S
D
Site 114
S835
P
T
P
P
K
R
S
S
S
L
R
K
S
D
G
Site 115
S836
T
P
P
K
R
S
S
S
L
R
K
S
D
G
N
Site 116
S840
R
S
S
S
L
R
K
S
D
G
N
A
D
I
S
Site 117
S847
S
D
G
N
A
D
I
S
E
K
K
E
P
K
I
Site 118
S855
E
K
K
E
P
K
I
S
S
G
Q
H
L
P
H
Site 119
S856
K
K
E
P
K
I
S
S
G
Q
H
L
P
H
S
Site 120
S863
S
G
Q
H
L
P
H
S
S
R
E
M
K
L
P
Site 121
T876
L
P
L
D
F
A
N
T
P
S
R
M
E
N
A
Site 122
S878
L
D
F
A
N
T
P
S
R
M
E
N
A
N
L
Site 123
S909
K
E
P
Q
L
D
A
S
D
I
P
P
F
K
D
Site 124
Y924
E
V
A
E
S
T
H
Y
A
D
L
W
L
L
N
Site 125
T935
W
L
L
N
D
L
K
T
N
D
P
Y
R
S
L
Site 126
Y939
D
L
K
T
N
D
P
Y
R
S
L
S
N
S
S
Site 127
S941
K
T
N
D
P
Y
R
S
L
S
N
S
S
T
A
Site 128
S943
N
D
P
Y
R
S
L
S
N
S
S
T
A
T
G
Site 129
S945
P
Y
R
S
L
S
N
S
S
T
A
T
G
T
T
Site 130
T947
R
S
L
S
N
S
S
T
A
T
G
T
T
V
I
Site 131
S959
T
V
I
E
C
I
K
S
P
E
S
S
E
S
Q
Site 132
S962
E
C
I
K
S
P
E
S
S
E
S
Q
T
S
Q
Site 133
S963
C
I
K
S
P
E
S
S
E
S
Q
T
S
Q
S
Site 134
S965
K
S
P
E
S
S
E
S
Q
T
S
Q
S
E
S
Site 135
T967
P
E
S
S
E
S
Q
T
S
Q
S
E
S
R
A
Site 136
S968
E
S
S
E
S
Q
T
S
Q
S
E
S
R
A
T
Site 137
S970
S
E
S
Q
T
S
Q
S
E
S
R
A
T
T
P
Site 138
S972
S
Q
T
S
Q
S
E
S
R
A
T
T
P
S
L
Site 139
T975
S
Q
S
E
S
R
A
T
T
P
S
L
P
S
V
Site 140
T976
Q
S
E
S
R
A
T
T
P
S
L
P
S
V
D
Site 141
S978
E
S
R
A
T
T
P
S
L
P
S
V
D
N
E
Site 142
S990
D
N
E
F
K
L
A
S
P
E
K
L
A
G
L
Site 143
S999
E
K
L
A
G
L
A
S
P
S
S
G
Y
S
S
Site 144
S1001
L
A
G
L
A
S
P
S
S
G
Y
S
S
Q
S
Site 145
S1002
A
G
L
A
S
P
S
S
G
Y
S
S
Q
S
E
Site 146
S1005
A
S
P
S
S
G
Y
S
S
Q
S
E
T
P
T
Site 147
S1006
S
P
S
S
G
Y
S
S
Q
S
E
T
P
T
S
Site 148
S1008
S
S
G
Y
S
S
Q
S
E
T
P
T
S
S
F
Site 149
T1010
G
Y
S
S
Q
S
E
T
P
T
S
S
F
P
T
Site 150
T1012
S
S
Q
S
E
T
P
T
S
S
F
P
T
A
F
Site 151
S1013
S
Q
S
E
T
P
T
S
S
F
P
T
A
F
F
Site 152
S1014
Q
S
E
T
P
T
S
S
F
P
T
A
F
F
S
Site 153
S1025
A
F
F
S
G
P
L
S
P
G
G
S
K
R
K
Site 154
S1029
G
P
L
S
P
G
G
S
K
R
K
P
K
V
P
Site 155
S1040
P
K
V
P
E
R
K
S
S
L
Q
Q
P
S
L
Site 156
S1041
K
V
P
E
R
K
S
S
L
Q
Q
P
S
L
K
Site 157
S1046
K
S
S
L
Q
Q
P
S
L
K
D
G
T
I
S
Site 158
T1051
Q
P
S
L
K
D
G
T
I
S
L
S
K
D
L
Site 159
S1053
S
L
K
D
G
T
I
S
L
S
K
D
L
E
L
Site 160
S1055
K
D
G
T
I
S
L
S
K
D
L
E
L
P
I
Site 161
S1071
P
P
T
H
L
D
L
S
A
L
H
N
V
L
N
Site 162
T1097
F
T
H
N
K
Q
N
T
V
G
E
T
L
R
S
Site 163
T1101
K
Q
N
T
V
G
E
T
L
R
S
N
P
P
P
Site 164
S1104
T
V
G
E
T
L
R
S
N
P
P
P
S
L
A
Site 165
S1109
L
R
S
N
P
P
P
S
L
A
I
T
P
T
I
Site 166
S1124
L
K
S
V
N
L
R
S
I
N
K
S
E
E
V
Site 167
S1128
N
L
R
S
I
N
K
S
E
E
V
K
Q
K
E
Site 168
T1139
K
Q
K
E
E
N
N
T
D
L
P
Y
L
E
E
Site 169
Y1143
E
N
N
T
D
L
P
Y
L
E
E
S
T
L
T
Site 170
T1150
Y
L
E
E
S
T
L
T
T
A
A
L
S
P
S
Site 171
T1151
L
E
E
S
T
L
T
T
A
A
L
S
P
S
K
Site 172
S1155
T
L
T
T
A
A
L
S
P
S
K
I
R
P
H
Site 173
S1157
T
T
A
A
L
S
P
S
K
I
R
P
H
T
A
Site 174
T1163
P
S
K
I
R
P
H
T
A
N
K
S
V
S
R
Site 175
S1167
R
P
H
T
A
N
K
S
V
S
R
Q
Y
S
T
Site 176
S1169
H
T
A
N
K
S
V
S
R
Q
Y
S
T
E
D
Site 177
Y1172
N
K
S
V
S
R
Q
Y
S
T
E
D
T
I
L
Site 178
S1173
K
S
V
S
R
Q
Y
S
T
E
D
T
I
L
S
Site 179
T1174
S
V
S
R
Q
Y
S
T
E
D
T
I
L
S
F
Site 180
T1177
R
Q
Y
S
T
E
D
T
I
L
S
F
L
D
S
Site 181
S1180
S
T
E
D
T
I
L
S
F
L
D
S
S
A
V
Site 182
T1201
L
H
L
E
K
N
S
T
F
D
V
K
N
R
C
Site 183
T1212
K
N
R
C
D
P
E
T
I
T
S
A
G
S
S
Site 184
T1214
R
C
D
P
E
T
I
T
S
A
G
S
S
L
L
Site 185
S1215
C
D
P
E
T
I
T
S
A
G
S
S
L
L
D
Site 186
S1223
A
G
S
S
L
L
D
S
N
V
T
K
D
Q
V
Site 187
T1234
K
D
Q
V
R
T
E
T
E
P
I
P
E
N
T
Site 188
T1241
T
E
P
I
P
E
N
T
P
T
K
N
C
A
F
Site 189
T1243
P
I
P
E
N
T
P
T
K
N
C
A
F
P
T
Site 190
S1257
T
E
G
F
Q
R
V
S
A
A
R
P
N
D
L
Site 191
T1278
Y
G
P
G
P
D
E
T
L
E
Q
V
Q
K
A
Site 192
S1298
E
E
V
A
Q
P
E
S
V
D
V
I
T
S
Q
Site 193
S1304
E
S
V
D
V
I
T
S
Q
S
D
S
P
T
R
Site 194
S1306
V
D
V
I
T
S
Q
S
D
S
P
T
R
A
T
Site 195
S1308
V
I
T
S
Q
S
D
S
P
T
R
A
T
D
V
Site 196
T1310
T
S
Q
S
D
S
P
T
R
A
T
D
V
S
N
Site 197
T1313
S
D
S
P
T
R
A
T
D
V
S
N
Q
F
K
Site 198
S1316
P
T
R
A
T
D
V
S
N
Q
F
K
H
Q
F
Site 199
T1335
H
H
D
K
V
P
G
T
I
S
Y
E
S
E
I
Site 200
S1337
D
K
V
P
G
T
I
S
Y
E
S
E
I
T
S
Site 201
Y1338
K
V
P
G
T
I
S
Y
E
S
E
I
T
S
V
Site 202
S1340
P
G
T
I
S
Y
E
S
E
I
T
S
V
N
S
Site 203
T1343
I
S
Y
E
S
E
I
T
S
V
N
S
F
P
E
Site 204
S1344
S
Y
E
S
E
I
T
S
V
N
S
F
P
E
K
Site 205
S1347
S
E
I
T
S
V
N
S
F
P
E
K
C
S
K
Site 206
S1360
S
K
Q
E
N
I
A
S
G
I
S
A
K
S
A
Site 207
S1366
A
S
G
I
S
A
K
S
A
S
D
N
S
K
A
Site 208
S1368
G
I
S
A
K
S
A
S
D
N
S
K
A
E
E
Site 209
S1371
A
K
S
A
S
D
N
S
K
A
E
E
T
Q
G
Site 210
S1384
Q
G
N
V
D
E
A
S
L
K
E
S
S
P
S
Site 211
S1388
D
E
A
S
L
K
E
S
S
P
S
D
D
S
I
Site 212
S1389
E
A
S
L
K
E
S
S
P
S
D
D
S
I
I
Site 213
S1391
S
L
K
E
S
S
P
S
D
D
S
I
I
S
P
Site 214
S1394
E
S
S
P
S
D
D
S
I
I
S
P
L
S
E
Site 215
S1397
P
S
D
D
S
I
I
S
P
L
S
E
D
S
Q
Site 216
S1400
D
S
I
I
S
P
L
S
E
D
S
Q
A
E
A
Site 217
S1403
I
S
P
L
S
E
D
S
Q
A
E
A
E
G
V
Site 218
S1413
E
A
E
G
V
F
V
S
P
N
K
P
R
T
T
Site 219
T1419
V
S
P
N
K
P
R
T
T
E
D
L
F
A
V
Site 220
T1420
S
P
N
K
P
R
T
T
E
D
L
F
A
V
I
Site 221
S1430
L
F
A
V
I
H
R
S
K
R
K
V
L
G
R
Site 222
S1440
K
V
L
G
R
K
D
S
G
D
M
S
V
R
S
Site 223
S1444
R
K
D
S
G
D
M
S
V
R
S
K
S
R
A
Site 224
S1447
S
G
D
M
S
V
R
S
K
S
R
A
P
L
S
Site 225
S1449
D
M
S
V
R
S
K
S
R
A
P
L
S
S
S
Site 226
S1454
S
K
S
R
A
P
L
S
S
S
S
S
S
A
S
Site 227
S1455
K
S
R
A
P
L
S
S
S
S
S
S
A
S
S
Site 228
S1456
S
R
A
P
L
S
S
S
S
S
S
A
S
S
I
Site 229
S1457
R
A
P
L
S
S
S
S
S
S
A
S
S
I
T
Site 230
S1458
A
P
L
S
S
S
S
S
S
A
S
S
I
T
S
Site 231
S1459
P
L
S
S
S
S
S
S
A
S
S
I
T
S
P
Site 232
S1461
S
S
S
S
S
S
A
S
S
I
T
S
P
S
S
Site 233
S1462
S
S
S
S
S
A
S
S
I
T
S
P
S
S
N
Site 234
T1464
S
S
S
A
S
S
I
T
S
P
S
S
N
V
T
Site 235
S1465
S
S
A
S
S
I
T
S
P
S
S
N
V
T
T
Site 236
S1467
A
S
S
I
T
S
P
S
S
N
V
T
T
P
N
Site 237
S1468
S
S
I
T
S
P
S
S
N
V
T
T
P
N
S
Site 238
T1471
T
S
P
S
S
N
V
T
T
P
N
S
Q
R
S
Site 239
T1472
S
P
S
S
N
V
T
T
P
N
S
Q
R
S
P
Site 240
S1475
S
N
V
T
T
P
N
S
Q
R
S
P
G
L
I
Site 241
S1478
T
T
P
N
S
Q
R
S
P
G
L
I
Y
R
N
Site 242
S1489
I
Y
R
N
A
K
K
S
N
T
S
N
E
E
F
Site 243
S1505
L
L
L
L
K
K
G
S
R
S
D
S
S
Y
R
Site 244
S1507
L
L
K
K
G
S
R
S
D
S
S
Y
R
M
S
Site 245
S1509
K
K
G
S
R
S
D
S
S
Y
R
M
S
A
T
Site 246
S1510
K
G
S
R
S
D
S
S
Y
R
M
S
A
T
E
Site 247
Y1511
G
S
R
S
D
S
S
Y
R
M
S
A
T
E
I
Site 248
S1514
S
D
S
S
Y
R
M
S
A
T
E
I
L
K
S
Site 249
S1521
S
A
T
E
I
L
K
S
P
I
L
P
K
P
P
Site 250
T1532
P
K
P
P
G
E
L
T
A
E
S
P
Q
S
T
Site 251
S1535
P
G
E
L
T
A
E
S
P
Q
S
T
D
D
A
Site 252
S1538
L
T
A
E
S
P
Q
S
T
D
D
A
H
Q
G
Site 253
T1539
T
A
E
S
P
Q
S
T
D
D
A
H
Q
G
S
Site 254
S1553
S
Q
G
A
E
A
L
S
P
L
S
P
C
S
P
Site 255
S1556
A
E
A
L
S
P
L
S
P
C
S
P
R
V
N
Site 256
S1559
L
S
P
L
S
P
C
S
P
R
V
N
A
E
G
Site 257
S1569
V
N
A
E
G
F
S
S
K
S
F
A
T
S
A
Site 258
S1571
A
E
G
F
S
S
K
S
F
A
T
S
A
S
A
Site 259
S1575
S
S
K
S
F
A
T
S
A
S
A
R
V
G
R
Site 260
S1577
K
S
F
A
T
S
A
S
A
R
V
G
R
S
R
Site 261
S1583
A
S
A
R
V
G
R
S
R
A
P
P
A
A
S
Site 262
S1590
S
R
A
P
P
A
A
S
S
S
R
Y
S
V
R
Site 263
S1591
R
A
P
P
A
A
S
S
S
R
Y
S
V
R
C
Site 264
S1592
A
P
P
A
A
S
S
S
R
Y
S
V
R
C
R
Site 265
Y1594
P
A
A
S
S
S
R
Y
S
V
R
C
R
L
Y
Site 266
S1595
A
A
S
S
S
R
Y
S
V
R
C
R
L
Y
N
Site 267
Y1601
Y
S
V
R
C
R
L
Y
N
T
P
M
Q
A
I
Site 268
T1603
V
R
C
R
L
Y
N
T
P
M
Q
A
I
S
E
Site 269
S1609
N
T
P
M
Q
A
I
S
E
G
E
T
E
N
S
Site 270
T1613
Q
A
I
S
E
G
E
T
E
N
S
D
G
S
P
Site 271
S1616
S
E
G
E
T
E
N
S
D
G
S
P
H
D
D
Site 272
S1619
E
T
E
N
S
D
G
S
P
H
D
D
R
S
S
Site 273
S1625
G
S
P
H
D
D
R
S
S
Q
S
S
T
_
_
Site 274
S1626
S
P
H
D
D
R
S
S
Q
S
S
T
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation