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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Actinfilin
Full Name:
Kelch-like protein 17
Alias:
Kelch-like 17; KLH17
Type:
Ubiquitin conjugating system; Actin binding protein
Mass (Da):
69856
Number AA:
642
UniProt ID:
Q6TDP4
International Prot ID:
IPI00418437
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0014069
GO:0045211
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
S
E
R
P
A
G
R
T
Q
S
P
E
H
G
S
Site 2
S14
R
P
A
G
R
T
Q
S
P
E
H
G
S
P
G
Site 3
S19
T
Q
S
P
E
H
G
S
P
G
P
G
P
E
A
Site 4
T42
P
A
P
E
A
E
R
T
R
P
R
Q
A
R
P
Site 5
S61
E
G
A
V
Q
L
L
S
R
E
G
H
S
V
A
Site 6
Y75
A
H
N
S
K
R
H
Y
H
D
A
F
V
A
M
Site 7
S126
A
M
F
T
N
E
M
S
E
S
R
Q
T
H
V
Site 8
S128
F
T
N
E
M
S
E
S
R
Q
T
H
V
T
L
Site 9
T131
E
M
S
E
S
R
Q
T
H
V
T
L
H
D
I
Site 10
T134
E
S
R
Q
T
H
V
T
L
H
D
I
D
P
Q
Site 11
S205
R
G
F
A
D
A
H
S
C
S
D
L
L
K
A
Site 12
S207
F
A
D
A
H
S
C
S
D
L
L
K
A
A
H
Site 13
S246
L
E
L
V
S
S
D
S
L
N
V
P
S
E
E
Site 14
S251
S
D
S
L
N
V
P
S
E
E
E
V
Y
R
A
Site 15
Y256
V
P
S
E
E
E
V
Y
R
A
V
L
S
W
V
Site 16
S261
E
V
Y
R
A
V
L
S
W
V
K
H
D
V
D
Site 17
S287
C
V
R
L
P
L
L
S
R
D
F
L
L
G
H
Site 18
S299
L
G
H
V
D
A
E
S
L
V
R
H
H
P
D
Site 19
T329
E
Q
R
G
V
L
G
T
S
R
T
R
P
R
R
Site 20
T332
G
V
L
G
T
S
R
T
R
P
R
R
C
E
G
Site 21
Y362
I
H
G
D
C
E
A
Y
D
T
R
T
D
R
W
Site 22
S376
W
H
V
V
A
S
M
S
T
R
R
A
R
V
G
Site 23
S401
V
G
G
Y
D
G
T
S
D
L
A
T
V
E
S
Site 24
T405
D
G
T
S
D
L
A
T
V
E
S
Y
D
P
V
Site 25
S408
S
D
L
A
T
V
E
S
Y
D
P
V
T
N
T
Site 26
T413
V
E
S
Y
D
P
V
T
N
T
W
Q
P
E
V
Site 27
T415
S
Y
D
P
V
T
N
T
W
Q
P
E
V
S
M
Site 28
S448
A
G
G
Y
D
G
A
S
C
L
N
S
A
E
R
Site 29
S452
D
G
A
S
C
L
N
S
A
E
R
Y
D
P
L
Site 30
Y456
C
L
N
S
A
E
R
Y
D
P
L
T
G
T
W
Site 31
T460
A
E
R
Y
D
P
L
T
G
T
W
T
S
V
A
Site 32
T464
D
P
L
T
G
T
W
T
S
V
A
A
M
S
T
Site 33
S465
P
L
T
G
T
W
T
S
V
A
A
M
S
T
R
Site 34
S470
W
T
S
V
A
A
M
S
T
R
R
R
Y
V
R
Site 35
T471
T
S
V
A
A
M
S
T
R
R
R
Y
V
R
V
Site 36
Y475
A
M
S
T
R
R
R
Y
V
R
V
A
T
L
D
Site 37
T480
R
R
Y
V
R
V
A
T
L
D
G
N
L
Y
A
Site 38
Y486
A
T
L
D
G
N
L
Y
A
V
G
G
Y
D
S
Site 39
Y491
N
L
Y
A
V
G
G
Y
D
S
S
S
H
L
A
Site 40
S493
Y
A
V
G
G
Y
D
S
S
S
H
L
A
T
V
Site 41
S494
A
V
G
G
Y
D
S
S
S
H
L
A
T
V
E
Site 42
S495
V
G
G
Y
D
S
S
S
H
L
A
T
V
E
K
Site 43
T499
D
S
S
S
H
L
A
T
V
E
K
Y
E
P
Q
Site 44
Y503
H
L
A
T
V
E
K
Y
E
P
Q
V
N
V
W
Site 45
S515
N
V
W
S
P
V
A
S
M
L
S
R
R
S
S
Site 46
S518
S
P
V
A
S
M
L
S
R
R
S
S
A
G
V
Site 47
T541
V
A
G
G
N
D
G
T
S
C
L
N
S
V
E
Site 48
S542
A
G
G
N
D
G
T
S
C
L
N
S
V
E
R
Site 49
S546
D
G
T
S
C
L
N
S
V
E
R
Y
S
P
K
Site 50
Y550
C
L
N
S
V
E
R
Y
S
P
K
A
G
A
W
Site 51
S551
L
N
S
V
E
R
Y
S
P
K
A
G
A
W
E
Site 52
S559
P
K
A
G
A
W
E
S
V
A
P
M
N
I
R
Site 53
S568
A
P
M
N
I
R
R
S
T
H
D
L
V
A
M
Site 54
T569
P
M
N
I
R
R
S
T
H
D
L
V
A
M
D
Site 55
S588
A
V
G
G
N
D
G
S
S
S
L
N
S
I
E
Site 56
S589
V
G
G
N
D
G
S
S
S
L
N
S
I
E
K
Site 57
S590
G
G
N
D
G
S
S
S
L
N
S
I
E
K
Y
Site 58
S593
D
G
S
S
S
L
N
S
I
E
K
Y
N
P
R
Site 59
Y597
S
L
N
S
I
E
K
Y
N
P
R
T
N
K
W
Site 60
S632
L
N
F
P
P
P
S
S
P
T
L
S
V
S
S
Site 61
T634
F
P
P
P
S
S
P
T
L
S
V
S
S
T
S
Site 62
S636
P
P
S
S
P
T
L
S
V
S
S
T
S
L
_
Site 63
S638
S
S
P
T
L
S
V
S
S
T
S
L
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation