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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CASC1
Full Name:
Cancer susceptibility candidate protein 1
Alias:
Lung adenoma susceptibility 1-like protein
Type:
Mass (Da):
83218
Number AA:
716
UniProt ID:
Q6TDU7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y36
E
E
E
A
R
L
K
Y
E
K
E
E
M
E
R
Site 2
Y73
N
E
E
L
E
E
L
Y
L
L
E
R
C
F
P
Site 3
Y98
L
L
S
Q
W
K
H
Y
I
Q
C
D
G
S
P
Site 4
S104
H
Y
I
Q
C
D
G
S
P
D
P
S
V
A
Q
Site 5
S108
C
D
G
S
P
D
P
S
V
A
Q
E
M
N
T
Site 6
T115
S
V
A
Q
E
M
N
T
F
I
S
L
W
K
E
Site 7
T124
I
S
L
W
K
E
K
T
N
E
T
F
E
E
V
Site 8
T127
W
K
E
K
T
N
E
T
F
E
E
V
I
E
K
Site 9
Y165
Q
D
K
N
I
I
Q
Y
Q
E
S
I
L
Q
L
Site 10
S192
E
I
L
L
K
Q
A
S
T
L
A
D
L
D
S
Site 11
S199
S
T
L
A
D
L
D
S
G
N
M
E
K
V
I
Site 12
Y214
K
D
E
N
V
T
L
Y
V
W
A
N
L
K
K
Site 13
S227
K
K
N
P
R
H
R
S
V
R
F
S
E
T
Q
Site 14
S231
R
H
R
S
V
R
F
S
E
T
Q
I
G
F
E
Site 15
T233
R
S
V
R
F
S
E
T
Q
I
G
F
E
I
P
Site 16
S246
I
P
R
I
L
A
T
S
D
I
A
V
R
L
L
Site 17
Y257
V
R
L
L
H
T
H
Y
D
H
V
S
A
L
H
Site 18
S267
V
S
A
L
H
P
V
S
T
P
S
K
E
Y
T
Site 19
T268
S
A
L
H
P
V
S
T
P
S
K
E
Y
T
S
Site 20
S270
L
H
P
V
S
T
P
S
K
E
Y
T
S
A
V
Site 21
T274
S
T
P
S
K
E
Y
T
S
A
V
T
E
L
V
Site 22
S293
K
N
V
E
K
A
I
S
K
E
V
E
E
E
S
Site 23
S307
S
K
Q
Q
E
R
G
S
H
L
I
Q
E
E
E
Site 24
S329
G
D
I
E
V
K
M
S
S
A
E
E
E
S
E
Site 25
S330
D
I
E
V
K
M
S
S
A
E
E
E
S
E
A
Site 26
S348
E
R
E
M
K
V
L
S
E
T
V
S
A
A
Q
Site 27
S362
Q
L
L
L
V
E
N
S
S
E
K
P
D
F
F
Site 28
S363
L
L
L
V
E
N
S
S
E
K
P
D
F
F
E
Site 29
Y416
L
K
E
G
L
Q
K
Y
T
Y
P
P
E
T
T
Site 30
T417
K
E
G
L
Q
K
Y
T
Y
P
P
E
T
T
E
Site 31
Y418
E
G
L
Q
K
Y
T
Y
P
P
E
T
T
E
E
Site 32
T428
E
T
T
E
E
F
E
T
E
N
A
F
P
P
I
Site 33
T465
A
E
G
K
H
W
R
T
D
G
I
S
N
V
S
Site 34
Y473
D
G
I
S
N
V
S
Y
K
P
K
E
R
L
V
Site 35
T481
K
P
K
E
R
L
V
T
F
S
L
D
T
F
G
Site 36
Y502
D
A
H
I
N
M
P
Y
Q
S
W
E
L
R
P
Site 37
S538
K
E
N
L
C
M
L
S
S
I
K
L
K
D
K
Site 38
S539
E
N
L
C
M
L
S
S
I
K
L
K
D
K
K
Site 39
S549
L
K
D
K
K
H
I
S
I
L
E
G
T
W
M
Site 40
Y581
P
T
R
H
S
H
F
Y
V
I
I
N
N
K
V
Site 41
S659
R
L
K
I
K
E
E
S
E
A
F
S
E
A
L
Site 42
S663
K
E
E
S
E
A
F
S
E
A
L
K
E
E
T
Site 43
T670
S
E
A
L
K
E
E
T
E
F
H
S
T
L
Y
Site 44
T675
E
E
T
E
F
H
S
T
L
Y
H
M
V
K
D
Site 45
Y677
T
E
F
H
S
T
L
Y
H
M
V
K
D
F
A
Site 46
S685
H
M
V
K
D
F
A
S
E
E
A
M
E
K
V
Site 47
S694
E
A
M
E
K
V
R
S
S
N
C
Q
F
V
N
Site 48
S695
A
M
E
K
V
R
S
S
N
C
Q
F
V
N
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation