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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AFTPH
Full Name:
Aftiphilin
Alias:
AFTIN; FLJ20080; FLJ23793; MGC33965; Nbla10388
Type:
Unknown function; Adaptor/scaffold; Vesicle protein
Mass (Da):
102200
Number AA:
937
UniProt ID:
Q6ULP2
International Prot ID:
IPI00329005
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030121
GO:0005829
GO:0030119
Uniprot
OncoNet
Molecular Function:
GO:0030276
GO:0005515
GO:0030276
PhosphoSite+
KinaseNET
Biological Process:
GO:0015031
GO:0015031
GO:0045184
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
E
P
D
I
I
R
M
Y
S
S
S
P
P
P
L
Site 2
S10
P
D
I
I
R
M
Y
S
S
S
P
P
P
L
D
Site 3
S12
I
I
R
M
Y
S
S
S
P
P
P
L
D
N
G
Site 4
T49
V
G
F
V
D
F
D
T
P
D
Y
T
R
P
K
Site 5
Y52
V
D
F
D
T
P
D
Y
T
R
P
K
E
E
F
Site 6
T53
D
F
D
T
P
D
Y
T
R
P
K
E
E
F
V
Site 7
S72
F
M
P
I
H
E
F
S
E
N
V
D
S
L
T
Site 8
S77
E
F
S
E
N
V
D
S
L
T
S
F
K
S
I
Site 9
T79
S
E
N
V
D
S
L
T
S
F
K
S
I
K
N
Site 10
S80
E
N
V
D
S
L
T
S
F
K
S
I
K
N
G
Site 11
S83
D
S
L
T
S
F
K
S
I
K
N
G
N
D
K
Site 12
T93
N
G
N
D
K
D
I
T
A
E
L
S
A
P
V
Site 13
S97
K
D
I
T
A
E
L
S
A
P
V
K
G
Q
S
Site 14
S104
S
A
P
V
K
G
Q
S
D
V
L
L
S
T
T
Site 15
S109
G
Q
S
D
V
L
L
S
T
T
S
K
E
I
I
Site 16
T110
Q
S
D
V
L
L
S
T
T
S
K
E
I
I
S
Site 17
T111
S
D
V
L
L
S
T
T
S
K
E
I
I
S
S
Site 18
S112
D
V
L
L
S
T
T
S
K
E
I
I
S
S
E
Site 19
T123
I
S
S
E
M
L
A
T
S
I
D
G
M
E
R
Site 20
T146
E
Q
R
Q
N
V
G
T
L
E
S
F
S
P
G
Site 21
S149
Q
N
V
G
T
L
E
S
F
S
P
G
D
F
R
Site 22
S151
V
G
T
L
E
S
F
S
P
G
D
F
R
T
N
Site 23
T191
N
G
F
A
V
L
E
T
V
N
P
Q
G
T
D
Site 24
S206
D
L
D
N
V
A
D
S
K
G
R
K
P
L
S
Site 25
S213
S
K
G
R
K
P
L
S
T
H
S
T
E
Y
N
Site 26
T214
K
G
R
K
P
L
S
T
H
S
T
E
Y
N
L
Site 27
S216
R
K
P
L
S
T
H
S
T
E
Y
N
L
D
S
Site 28
T217
K
P
L
S
T
H
S
T
E
Y
N
L
D
S
V
Site 29
S223
S
T
E
Y
N
L
D
S
V
P
S
P
A
E
E
Site 30
S226
Y
N
L
D
S
V
P
S
P
A
E
E
F
A
D
Site 31
T236
E
E
F
A
D
F
A
T
F
S
K
K
E
R
I
Site 32
S284
K
E
V
A
L
G
R
S
L
D
N
K
G
D
T
Site 33
S311
I
V
T
N
R
G
F
S
V
E
K
Q
G
L
P
Site 34
S328
Q
Q
D
E
F
L
Q
S
G
V
Q
S
K
A
W
Site 35
S332
F
L
Q
S
G
V
Q
S
K
A
W
S
L
V
D
Site 36
S336
G
V
Q
S
K
A
W
S
L
V
D
S
A
D
N
Site 37
S340
K
A
W
S
L
V
D
S
A
D
N
S
E
A
I
Site 38
S344
L
V
D
S
A
D
N
S
E
A
I
R
R
E
Q
Site 39
T354
I
R
R
E
Q
C
K
T
E
E
K
L
D
L
L
Site 40
S372
C
A
H
L
C
M
D
S
V
K
T
S
D
D
E
Site 41
T375
L
C
M
D
S
V
K
T
S
D
D
E
V
G
S
Site 42
S376
C
M
D
S
V
K
T
S
D
D
E
V
G
S
P
Site 43
S382
T
S
D
D
E
V
G
S
P
K
E
E
S
R
K
Site 44
S387
V
G
S
P
K
E
E
S
R
K
F
T
N
F
Q
Site 45
T391
K
E
E
S
R
K
F
T
N
F
Q
S
P
N
I
Site 46
S395
R
K
F
T
N
F
Q
S
P
N
I
D
P
T
E
Site 47
T401
Q
S
P
N
I
D
P
T
E
E
N
D
L
D
D
Site 48
S409
E
E
N
D
L
D
D
S
L
S
V
K
N
G
D
Site 49
S411
N
D
L
D
D
S
L
S
V
K
N
G
D
S
S
Site 50
S417
L
S
V
K
N
G
D
S
S
N
D
F
V
T
C
Site 51
S418
S
V
K
N
G
D
S
S
N
D
F
V
T
C
N
Site 52
T423
D
S
S
N
D
F
V
T
C
N
D
I
N
E
D
Site 53
S440
G
D
F
G
D
F
G
S
A
S
G
S
T
P
P
Site 54
S444
D
F
G
S
A
S
G
S
T
P
P
F
V
T
G
Site 55
T445
F
G
S
A
S
G
S
T
P
P
F
V
T
G
T
Site 56
T452
T
P
P
F
V
T
G
T
Q
D
S
M
S
D
A
Site 57
S455
F
V
T
G
T
Q
D
S
M
S
D
A
T
F
E
Site 58
S457
T
G
T
Q
D
S
M
S
D
A
T
F
E
E
S
Site 59
T460
Q
D
S
M
S
D
A
T
F
E
E
S
S
E
H
Site 60
S464
S
D
A
T
F
E
E
S
S
E
H
F
P
H
F
Site 61
S472
S
E
H
F
P
H
F
S
E
P
G
D
D
F
G
Site 62
T496
C
Q
E
E
T
I
L
T
K
S
D
L
K
Q
T
Site 63
S498
E
E
T
I
L
T
K
S
D
L
K
Q
T
S
D
Site 64
S504
K
S
D
L
K
Q
T
S
D
N
L
S
E
E
C
Site 65
S508
K
Q
T
S
D
N
L
S
E
E
C
Q
L
A
R
Site 66
S517
E
C
Q
L
A
R
K
S
S
G
T
G
T
E
P
Site 67
S518
C
Q
L
A
R
K
S
S
G
T
G
T
E
P
V
Site 68
T520
L
A
R
K
S
S
G
T
G
T
E
P
V
A
K
Site 69
T522
R
K
S
S
G
T
G
T
E
P
V
A
K
L
K
Site 70
S541
G
E
I
G
H
F
D
S
V
P
N
I
Q
D
D
Site 71
S555
D
C
N
G
F
Q
D
S
D
D
F
A
D
F
S
Site 72
S562
S
D
D
F
A
D
F
S
S
A
G
P
S
Q
V
Site 73
S563
D
D
F
A
D
F
S
S
A
G
P
S
Q
V
V
Site 74
S567
D
F
S
S
A
G
P
S
Q
V
V
D
W
N
A
Site 75
S584
D
E
Q
K
D
S
C
S
W
A
A
F
G
D
Q
Site 76
T614
R
T
D
E
N
I
D
T
P
G
T
P
K
T
H
Site 77
T617
E
N
I
D
T
P
G
T
P
K
T
H
S
V
P
Site 78
T620
D
T
P
G
T
P
K
T
H
S
V
P
S
A
T
Site 79
S622
P
G
T
P
K
T
H
S
V
P
S
A
T
S
K
Site 80
S625
P
K
T
H
S
V
P
S
A
T
S
K
G
A
V
Site 81
S640
A
S
G
H
L
Q
E
S
A
T
S
V
Q
T
A
Site 82
S643
H
L
Q
E
S
A
T
S
V
Q
T
A
L
L
N
Site 83
T673
P
D
A
E
E
E
V
T
S
L
K
H
L
L
E
Site 84
S674
D
A
E
E
E
V
T
S
L
K
H
L
L
E
T
Site 85
T683
K
H
L
L
E
T
S
T
L
P
I
K
T
R
E
Site 86
S695
T
R
E
A
L
P
E
S
G
E
L
L
D
V
W
Site 87
T703
G
E
L
L
D
V
W
T
E
L
Q
D
I
H
D
Site 88
Y716
H
D
A
H
G
L
R
Y
Q
W
G
G
S
H
S
Site 89
S723
Y
Q
W
G
G
S
H
S
N
K
K
L
L
S
S
Site 90
S729
H
S
N
K
K
L
L
S
S
L
G
I
D
T
R
Site 91
S730
S
N
K
K
L
L
S
S
L
G
I
D
T
R
N
Site 92
T735
L
S
S
L
G
I
D
T
R
N
I
L
F
T
G
Site 93
T741
D
T
R
N
I
L
F
T
G
N
K
K
Q
P
V
Site 94
T763
G
L
G
M
L
E
P
T
K
E
P
L
K
P
L
Site 95
S771
K
E
P
L
K
P
L
S
A
A
E
K
I
A
S
Site 96
T782
K
I
A
S
I
G
Q
T
A
T
M
S
P
D
M
Site 97
T793
S
P
D
M
N
T
C
T
S
D
Q
F
Q
E
S
Site 98
S794
P
D
M
N
T
C
T
S
D
Q
F
Q
E
S
L
Site 99
S800
T
S
D
Q
F
Q
E
S
L
P
P
V
Q
F
D
Site 100
S809
P
P
V
Q
F
D
W
S
S
S
G
L
T
N
P
Site 101
S810
P
V
Q
F
D
W
S
S
S
G
L
T
N
P
L
Site 102
S811
V
Q
F
D
W
S
S
S
G
L
T
N
P
L
D
Site 103
T814
D
W
S
S
S
G
L
T
N
P
L
D
A
S
G
Site 104
S820
L
T
N
P
L
D
A
S
G
G
S
T
L
L
N
Site 105
S837
F
F
G
P
V
D
D
S
S
S
S
S
S
T
T
Site 106
S838
F
G
P
V
D
D
S
S
S
S
S
S
T
T
I
Site 107
S839
G
P
V
D
D
S
S
S
S
S
S
T
T
I
P
Site 108
S840
P
V
D
D
S
S
S
S
S
S
T
T
I
P
G
Site 109
S841
V
D
D
S
S
S
S
S
S
T
T
I
P
G
V
Site 110
S842
D
D
S
S
S
S
S
S
T
T
I
P
G
V
D
Site 111
T843
D
S
S
S
S
S
S
T
T
I
P
G
V
D
P
Site 112
T844
S
S
S
S
S
S
T
T
I
P
G
V
D
P
E
Site 113
Y853
P
G
V
D
P
E
L
Y
E
L
T
T
S
K
L
Site 114
S858
E
L
Y
E
L
T
T
S
K
L
E
I
S
T
S
Site 115
S863
T
T
S
K
L
E
I
S
T
S
S
L
K
V
T
Site 116
S865
S
K
L
E
I
S
T
S
S
L
K
V
T
D
A
Site 117
S866
K
L
E
I
S
T
S
S
L
K
V
T
D
A
F
Site 118
S878
D
A
F
A
R
L
M
S
T
V
E
K
T
S
T
Site 119
T879
A
F
A
R
L
M
S
T
V
E
K
T
S
T
S
Site 120
S884
M
S
T
V
E
K
T
S
T
S
T
S
R
K
P
Site 121
T885
S
T
V
E
K
T
S
T
S
T
S
R
K
P
K
Site 122
S886
T
V
E
K
T
S
T
S
T
S
R
K
P
K
R
Site 123
S888
E
K
T
S
T
S
T
S
R
K
P
K
R
E
E
Site 124
S898
P
K
R
E
E
H
L
S
E
E
A
I
K
V
I
Site 125
T926
L
M
F
P
A
T
L
T
P
S
T
S
S
Q
E
Site 126
S928
F
P
A
T
L
T
P
S
T
S
S
Q
E
K
A
Site 127
S930
A
T
L
T
P
S
T
S
S
Q
E
K
A
D
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation