KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CRTC3
Full Name:
CREB-regulated transcription coactivator 3
Alias:
CREB-regulated transcription coactivator 3: Transducer of regulated cAMP response element-binding protein 3: CREB-regulated transcription coactivator 3: Transducer of regulated cAMP response element-binding protein 3; TORC-3; Transducer of CREB protein 3; Transducer of regulated cAMP response element-binding protein (CREB) 3
Type:
Transcription, coactivator/corepressor
Mass (Da):
66959
Number AA:
619
UniProt ID:
Q6UUV7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0044419
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
A
A
S
P
G
S
G
S
A
N
Site 2
S7
_
M
A
A
S
P
G
S
G
S
A
N
P
R
K
Site 3
S9
A
A
S
P
G
S
G
S
A
N
P
R
K
F
S
Site 4
S16
S
A
N
P
R
K
F
S
E
K
I
A
L
H
T
Site 5
T30
T
Q
R
Q
A
E
E
T
R
A
F
E
Q
L
M
Site 6
T38
R
A
F
E
Q
L
M
T
D
L
T
L
S
R
V
Site 7
T41
E
Q
L
M
T
D
L
T
L
S
R
V
Q
F
Q
Site 8
T56
K
L
Q
Q
L
R
L
T
Q
Y
H
G
G
S
L
Site 9
Y58
Q
Q
L
R
L
T
Q
Y
H
G
G
S
L
P
N
Site 10
S62
L
T
Q
Y
H
G
G
S
L
P
N
V
S
Q
L
Site 11
S67
G
G
S
L
P
N
V
S
Q
L
R
S
S
A
S
Site 12
S71
P
N
V
S
Q
L
R
S
S
A
S
E
F
Q
P
Site 13
S72
N
V
S
Q
L
R
S
S
A
S
E
F
Q
P
S
Site 14
S74
S
Q
L
R
S
S
A
S
E
F
Q
P
S
F
H
Site 15
S79
S
A
S
E
F
Q
P
S
F
H
Q
A
D
N
V
Site 16
T89
Q
A
D
N
V
R
G
T
R
H
H
G
L
V
E
Site 17
S99
H
G
L
V
E
R
P
S
R
N
R
F
H
P
L
Site 18
S110
F
H
P
L
H
R
R
S
G
D
K
P
G
R
Q
Site 19
S121
P
G
R
Q
F
D
G
S
A
F
G
A
N
Y
S
Site 20
S128
S
A
F
G
A
N
Y
S
S
Q
P
L
D
E
S
Site 21
S129
A
F
G
A
N
Y
S
S
Q
P
L
D
E
S
W
Site 22
S135
S
S
Q
P
L
D
E
S
W
P
R
Q
Q
P
P
Site 23
T154
K
H
P
G
F
R
L
T
S
A
L
N
R
T
N
Site 24
S155
H
P
G
F
R
L
T
S
A
L
N
R
T
N
S
Site 25
T160
L
T
S
A
L
N
R
T
N
S
D
S
A
L
H
Site 26
S162
S
A
L
N
R
T
N
S
D
S
A
L
H
T
S
Site 27
S164
L
N
R
T
N
S
D
S
A
L
H
T
S
A
L
Site 28
T168
N
S
D
S
A
L
H
T
S
A
L
S
T
K
P
Site 29
T173
L
H
T
S
A
L
S
T
K
P
Q
D
P
Y
G
Site 30
Y179
S
T
K
P
Q
D
P
Y
G
G
G
G
Q
S
A
Site 31
S207
N
G
H
G
E
V
A
S
F
P
G
P
L
K
E
Site 32
S236
W
E
T
K
E
I
Q
S
L
S
G
R
P
R
S
Site 33
S238
T
K
E
I
Q
S
L
S
G
R
P
R
S
C
D
Site 34
S243
S
L
S
G
R
P
R
S
C
D
V
G
G
G
N
Site 35
S262
N
G
Q
N
L
G
L
S
P
F
L
G
T
L
N
Site 36
S273
G
T
L
N
T
G
G
S
L
P
D
L
T
N
L
Site 37
T278
G
G
S
L
P
D
L
T
N
L
H
Y
S
T
P
Site 38
Y282
P
D
L
T
N
L
H
Y
S
T
P
L
P
A
S
Site 39
S283
D
L
T
N
L
H
Y
S
T
P
L
P
A
S
L
Site 40
T284
L
T
N
L
H
Y
S
T
P
L
P
A
S
L
D
Site 41
S289
Y
S
T
P
L
P
A
S
L
D
T
T
D
H
H
Site 42
T293
L
P
A
S
L
D
T
T
D
H
H
F
G
S
M
Site 43
S299
T
T
D
H
H
F
G
S
M
S
V
G
N
S
V
Site 44
S301
D
H
H
F
G
S
M
S
V
G
N
S
V
N
N
Site 45
S305
G
S
M
S
V
G
N
S
V
N
N
I
P
A
A
Site 46
S320
M
T
H
L
G
I
R
S
S
S
G
L
Q
S
S
Site 47
S321
T
H
L
G
I
R
S
S
S
G
L
Q
S
S
R
Site 48
S322
H
L
G
I
R
S
S
S
G
L
Q
S
S
R
S
Site 49
S326
R
S
S
S
G
L
Q
S
S
R
S
N
P
S
I
Site 50
S327
S
S
S
G
L
Q
S
S
R
S
N
P
S
I
Q
Site 51
S329
S
G
L
Q
S
S
R
S
N
P
S
I
Q
A
T
Site 52
S332
Q
S
S
R
S
N
P
S
I
Q
A
T
L
N
K
Site 53
T336
S
N
P
S
I
Q
A
T
L
N
K
T
V
L
S
Site 54
S343
T
L
N
K
T
V
L
S
S
S
L
N
N
H
P
Site 55
S344
L
N
K
T
V
L
S
S
S
L
N
N
H
P
Q
Site 56
S345
N
K
T
V
L
S
S
S
L
N
N
H
P
Q
T
Site 57
T352
S
L
N
N
H
P
Q
T
S
V
P
N
A
S
A
Site 58
S358
Q
T
S
V
P
N
A
S
A
L
H
P
S
L
R
Site 59
S363
N
A
S
A
L
H
P
S
L
R
L
F
S
L
S
Site 60
S368
H
P
S
L
R
L
F
S
L
S
N
P
S
L
S
Site 61
S370
S
L
R
L
F
S
L
S
N
P
S
L
S
T
T
Site 62
S373
L
F
S
L
S
N
P
S
L
S
T
T
N
L
S
Site 63
S375
S
L
S
N
P
S
L
S
T
T
N
L
S
G
P
Site 64
T376
L
S
N
P
S
L
S
T
T
N
L
S
G
P
S
Site 65
T377
S
N
P
S
L
S
T
T
N
L
S
G
P
S
R
Site 66
S380
S
L
S
T
T
N
L
S
G
P
S
R
R
R
Q
Site 67
S383
T
T
N
L
S
G
P
S
R
R
R
Q
P
P
V
Site 68
S391
R
R
R
Q
P
P
V
S
P
L
T
L
S
P
G
Site 69
T394
Q
P
P
V
S
P
L
T
L
S
P
G
P
E
A
Site 70
S396
P
V
S
P
L
T
L
S
P
G
P
E
A
H
Q
Site 71
S406
P
E
A
H
Q
G
F
S
R
Q
L
S
S
T
S
Site 72
S410
Q
G
F
S
R
Q
L
S
S
T
S
P
L
A
P
Site 73
S411
G
F
S
R
Q
L
S
S
T
S
P
L
A
P
Y
Site 74
T412
F
S
R
Q
L
S
S
T
S
P
L
A
P
Y
P
Site 75
S413
S
R
Q
L
S
S
T
S
P
L
A
P
Y
P
T
Site 76
Y418
S
T
S
P
L
A
P
Y
P
T
S
Q
M
V
S
Site 77
T420
S
P
L
A
P
Y
P
T
S
Q
M
V
S
S
D
Site 78
S421
P
L
A
P
Y
P
T
S
Q
M
V
S
S
D
R
Site 79
S425
Y
P
T
S
Q
M
V
S
S
D
R
S
Q
L
S
Site 80
S426
P
T
S
Q
M
V
S
S
D
R
S
Q
L
S
F
Site 81
S429
Q
M
V
S
S
D
R
S
Q
L
S
F
L
P
T
Site 82
S432
S
S
D
R
S
Q
L
S
F
L
P
T
E
A
Q
Site 83
T436
S
Q
L
S
F
L
P
T
E
A
Q
A
Q
V
S
Site 84
S443
T
E
A
Q
A
Q
V
S
P
P
P
P
Y
P
A
Site 85
Y448
Q
V
S
P
P
P
P
Y
P
A
P
Q
E
L
T
Site 86
S477
Q
Q
P
Q
A
A
S
S
L
P
Q
S
D
F
Q
Site 87
S506
D
V
G
F
D
Q
Q
S
M
R
P
G
P
A
F
Site 88
S524
V
P
L
V
Q
Q
G
S
R
E
L
Q
D
S
F
Site 89
S530
G
S
R
E
L
Q
D
S
F
H
L
R
P
S
P
Site 90
S536
D
S
F
H
L
R
P
S
P
Y
S
N
C
G
S
Site 91
Y538
F
H
L
R
P
S
P
Y
S
N
C
G
S
L
P
Site 92
S539
H
L
R
P
S
P
Y
S
N
C
G
S
L
P
N
Site 93
S543
S
P
Y
S
N
C
G
S
L
P
N
T
I
L
P
Site 94
T547
N
C
G
S
L
P
N
T
I
L
P
E
D
S
S
Site 95
S554
T
I
L
P
E
D
S
S
T
S
L
F
K
D
L
Site 96
T555
I
L
P
E
D
S
S
T
S
L
F
K
D
L
N
Site 97
S556
L
P
E
D
S
S
T
S
L
F
K
D
L
N
S
Site 98
T577
E
V
S
L
N
V
D
T
P
F
P
L
E
E
E
Site 99
S609
S
M
G
L
L
D
P
S
V
E
E
T
F
R
A
Site 100
T613
L
D
P
S
V
E
E
T
F
R
A
D
R
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation