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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SPESP1
Full Name:
Sperm equatorial segment protein 1
Alias:
Equatorial segment; ESP; Glycosylated 38 kDa sperm protein C-7/8; Sperm equatorial segment 1; Sperm equatorial segment protein 1; SPESP; SP-ESP
Type:
Cytoskeletal protein
Mass (Da):
39003
Number AA:
350
UniProt ID:
Q6UW49
International Prot ID:
IPI00303075
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0001669
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y20
W
P
S
S
V
P
A
Y
P
S
I
T
V
T
P
Site 2
S22
S
S
V
P
A
Y
P
S
I
T
V
T
P
D
E
Site 3
T24
V
P
A
Y
P
S
I
T
V
T
P
D
E
E
Q
Site 4
T26
A
Y
P
S
I
T
V
T
P
D
E
E
Q
N
L
Site 5
Y36
E
E
Q
N
L
N
H
Y
I
Q
V
L
E
N
L
Site 6
S46
V
L
E
N
L
V
R
S
V
P
S
G
E
P
G
Site 7
S58
E
P
G
R
E
K
K
S
N
S
P
K
H
V
Y
Site 8
S60
G
R
E
K
K
S
N
S
P
K
H
V
Y
S
I
Site 9
Y65
S
N
S
P
K
H
V
Y
S
I
A
S
K
G
S
Site 10
S66
N
S
P
K
H
V
Y
S
I
A
S
K
G
S
K
Site 11
T85
V
T
H
G
D
A
S
T
E
N
D
V
L
T
N
Site 12
T91
S
T
E
N
D
V
L
T
N
P
I
S
E
E
T
Site 13
S95
D
V
L
T
N
P
I
S
E
E
T
T
T
F
P
Site 14
T99
N
P
I
S
E
E
T
T
T
F
P
T
G
G
F
Site 15
T100
P
I
S
E
E
T
T
T
F
P
T
G
G
F
T
Site 16
T107
T
F
P
T
G
G
F
T
P
E
I
G
K
K
K
Site 17
S118
G
K
K
K
H
T
E
S
T
P
F
W
S
I
K
Site 18
T119
K
K
K
H
T
E
S
T
P
F
W
S
I
K
P
Site 19
S123
T
E
S
T
P
F
W
S
I
K
P
N
N
V
S
Site 20
T156
P
E
P
A
A
K
Q
T
E
A
P
R
M
L
P
Site 21
T166
P
R
M
L
P
V
V
T
E
S
S
T
S
P
Y
Site 22
S169
L
P
V
V
T
E
S
S
T
S
P
Y
V
T
S
Site 23
S171
V
V
T
E
S
S
T
S
P
Y
V
T
S
Y
K
Site 24
Y173
T
E
S
S
T
S
P
Y
V
T
S
Y
K
S
P
Site 25
T175
S
S
T
S
P
Y
V
T
S
Y
K
S
P
V
T
Site 26
S176
S
T
S
P
Y
V
T
S
Y
K
S
P
V
T
T
Site 27
Y177
T
S
P
Y
V
T
S
Y
K
S
P
V
T
T
L
Site 28
S179
P
Y
V
T
S
Y
K
S
P
V
T
T
L
D
K
Site 29
T182
T
S
Y
K
S
P
V
T
T
L
D
K
S
T
G
Site 30
T183
S
Y
K
S
P
V
T
T
L
D
K
S
T
G
I
Site 31
S187
P
V
T
T
L
D
K
S
T
G
I
E
I
S
T
Site 32
S193
K
S
T
G
I
E
I
S
T
E
S
E
D
V
P
Site 33
S203
S
E
D
V
P
Q
L
S
G
E
T
A
I
E
K
Site 34
S235
K
K
I
L
D
I
N
S
Q
V
Q
Q
A
L
L
Site 35
S243
Q
V
Q
Q
A
L
L
S
D
T
S
N
P
A
Y
Site 36
T245
Q
Q
A
L
L
S
D
T
S
N
P
A
Y
R
E
Site 37
S246
Q
A
L
L
S
D
T
S
N
P
A
Y
R
E
D
Site 38
Y250
S
D
T
S
N
P
A
Y
R
E
D
I
E
A
S
Site 39
S264
S
K
D
H
L
K
R
S
L
A
L
A
A
A
A
Site 40
T277
A
A
E
H
K
L
K
T
M
Y
K
S
Q
L
L
Site 41
Y279
E
H
K
L
K
T
M
Y
K
S
Q
L
L
P
V
Site 42
S281
K
L
K
T
M
Y
K
S
Q
L
L
P
V
G
R
Site 43
S290
L
L
P
V
G
R
T
S
N
K
I
D
D
I
E
Site 44
Y313
S
R
S
K
L
Y
E
Y
L
D
I
K
C
V
P
Site 45
T329
E
M
R
E
K
A
A
T
V
F
N
T
L
K
N
Site 46
S340
T
L
K
N
M
C
R
S
R
R
V
T
A
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation