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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PCSK4
Full Name:
Proprotein convertase subtilisin/kexin type 4
Alias:
Proprotein convertase 4
Type:
Mass (Da):
82795
Number AA:
755
UniProt ID:
Q6UW60
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S43
S
S
W
A
V
Q
V
S
Q
G
N
R
E
V
E
Site 2
Y70
P
I
F
S
D
G
Q
Y
F
H
L
R
H
R
G
Site 3
T84
G
V
V
Q
Q
S
L
T
P
H
W
G
H
R
L
Site 4
S114
L
Q
R
R
V
K
R
S
V
V
V
P
T
D
P
Site 5
T119
K
R
S
V
V
V
P
T
D
P
W
F
S
K
Q
Site 6
S131
S
K
Q
W
Y
M
N
S
E
A
Q
P
D
L
S
Site 7
S138
S
E
A
Q
P
D
L
S
I
L
Q
A
W
S
Q
Site 8
S144
L
S
I
L
Q
A
W
S
Q
G
L
S
G
Q
G
Site 9
Y172
H
P
D
L
W
A
N
Y
D
P
L
A
S
Y
D
Site 10
Y183
A
S
Y
D
F
N
D
Y
D
P
D
P
Q
P
R
Site 11
Y191
D
P
D
P
Q
P
R
Y
T
P
S
K
E
N
R
Site 12
T192
P
D
P
Q
P
R
Y
T
P
S
K
E
N
R
H
Site 13
T201
S
K
E
N
R
H
G
T
R
C
A
G
E
V
A
Site 14
T237
R
M
L
D
G
T
I
T
D
V
I
E
A
Q
S
Site 15
S244
T
D
V
I
E
A
Q
S
L
S
L
Q
P
Q
H
Site 16
S246
V
I
E
A
Q
S
L
S
L
Q
P
Q
H
I
H
Site 17
Y255
Q
P
Q
H
I
H
I
Y
S
A
S
W
G
P
E
Site 18
T267
G
P
E
D
D
G
R
T
V
D
G
P
G
I
L
Site 19
T284
E
A
F
R
R
G
V
T
K
G
R
G
G
L
G
Site 20
Y305
S
G
N
G
G
L
H
Y
D
N
C
N
C
D
G
Site 21
Y313
D
N
C
N
C
D
G
Y
T
N
S
I
H
T
L
Site 22
T319
G
Y
T
N
S
I
H
T
L
S
V
G
S
T
T
Site 23
S321
T
N
S
I
H
T
L
S
V
G
S
T
T
Q
Q
Site 24
T325
H
T
L
S
V
G
S
T
T
Q
Q
G
R
V
P
Site 25
Y334
Q
Q
G
R
V
P
W
Y
S
E
A
C
A
S
T
Site 26
S335
Q
G
R
V
P
W
Y
S
E
A
C
A
S
T
L
Site 27
S347
S
T
L
T
T
T
Y
S
S
G
V
A
T
D
P
Site 28
T352
T
Y
S
S
G
V
A
T
D
P
Q
I
V
T
T
Site 29
T370
H
G
C
T
D
Q
H
T
G
T
S
A
S
A
P
Site 30
S406
Q
H
L
V
V
R
A
S
K
P
A
H
L
Q
A
Site 31
T418
L
Q
A
E
D
W
R
T
N
G
V
G
R
Q
V
Site 32
S426
N
G
V
G
R
Q
V
S
H
H
Y
G
Y
G
L
Site 33
T449
T
A
R
T
W
L
P
T
Q
P
Q
R
K
C
A
Site 34
S461
K
C
A
V
R
V
Q
S
R
P
T
P
I
L
P
Site 35
S488
G
L
H
N
S
I
R
S
L
E
H
V
Q
A
Q
Site 36
T497
E
H
V
Q
A
Q
L
T
L
S
Y
S
R
R
G
Site 37
S499
V
Q
A
Q
L
T
L
S
Y
S
R
R
G
D
L
Site 38
S501
A
Q
L
T
L
S
Y
S
R
R
G
D
L
E
I
Site 39
S509
R
R
G
D
L
E
I
S
L
T
S
P
M
G
T
Site 40
T511
G
D
L
E
I
S
L
T
S
P
M
G
T
R
S
Site 41
S512
D
L
E
I
S
L
T
S
P
M
G
T
R
S
T
Site 42
S529
A
I
R
P
L
D
V
S
T
E
G
Y
N
N
W
Site 43
Y533
L
D
V
S
T
E
G
Y
N
N
W
V
F
M
S
Site 44
Y561
L
G
L
E
N
K
G
Y
Y
F
N
T
G
T
L
Site 45
Y562
G
L
E
N
K
G
Y
Y
F
N
T
G
T
L
Y
Site 46
T567
G
Y
Y
F
N
T
G
T
L
Y
R
Y
T
L
L
Site 47
Y576
Y
R
Y
T
L
L
L
Y
G
T
A
E
D
M
T
Site 48
T583
Y
G
T
A
E
D
M
T
A
R
P
T
G
P
Q
Site 49
T587
E
D
M
T
A
R
P
T
G
P
Q
V
T
S
S
Site 50
S594
T
G
P
Q
V
T
S
S
A
C
V
Q
R
D
T
Site 51
T601
S
A
C
V
Q
R
D
T
E
G
L
C
Q
A
C
Site 52
T631
P
P
R
F
F
N
H
T
R
L
V
T
A
G
P
Site 53
T635
F
N
H
T
R
L
V
T
A
G
P
G
H
T
A
Site 54
T641
V
T
A
G
P
G
H
T
A
A
P
A
L
R
V
Site 55
Y657
S
S
C
H
A
S
C
Y
T
C
R
G
G
S
P
Site 56
T658
S
C
H
A
S
C
Y
T
C
R
G
G
S
P
R
Site 57
T668
G
G
S
P
R
D
C
T
S
C
P
P
S
S
T
Site 58
S669
G
S
P
R
D
C
T
S
C
P
P
S
S
T
L
Site 59
S673
D
C
T
S
C
P
P
S
S
T
L
D
Q
Q
Q
Site 60
S674
C
T
S
C
P
P
S
S
T
L
D
Q
Q
Q
G
Site 61
T675
T
S
C
P
P
S
S
T
L
D
Q
Q
Q
G
S
Site 62
T687
Q
G
S
C
M
G
P
T
T
P
D
S
R
P
R
Site 63
T688
G
S
C
M
G
P
T
T
P
D
S
R
P
R
L
Site 64
S691
M
G
P
T
T
P
D
S
R
P
R
L
R
A
A
Site 65
Y734
M
S
M
D
L
P
L
Y
A
W
L
S
R
A
R
Site 66
S738
L
P
L
Y
A
W
L
S
R
A
R
A
T
P
T
Site 67
T743
W
L
S
R
A
R
A
T
P
T
K
P
Q
V
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation