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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LRSAM1
Full Name:
E3 ubiquitin-protein ligase LRSAM1
Alias:
EC 6.3.2.-; Leucine rich repeat and sterile alpha motif containing 1; Leucine-rich repeat and sterile alpha motif-containing 1; Leucine-rich repeat and sterile alpha motif-containing protein 1; LRSM1; RIFLE; TAL; Tsg101-associated ligase
Type:
Ligase
Mass (Da):
83594
Number AA:
723
UniProt ID:
Q6UWE0
International Prot ID:
IPI00289113
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005576
GO:0044425
Uniprot
OncoNet
Molecular Function:
GO:0005179
GO:0004842
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0045806
GO:0046755
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
F
F
R
K
R
K
P
S
E
E
A
R
K
R
L
Site 2
Y20
E
A
R
K
R
L
E
Y
Q
M
C
L
A
K
E
Site 3
S69
V
H
T
N
H
L
T
S
L
L
P
K
S
C
S
Site 4
T94
D
L
H
D
N
Q
L
T
A
L
P
D
D
L
G
Site 5
S122
Q
L
M
Q
L
P
R
S
I
G
N
L
T
Q
L
Site 6
T127
P
R
S
I
G
N
L
T
Q
L
Q
T
L
N
V
Site 7
T131
G
N
L
T
Q
L
Q
T
L
N
V
K
D
N
K
Site 8
T145
K
L
K
E
L
P
D
T
V
G
E
L
R
S
L
Site 9
S151
D
T
V
G
E
L
R
S
L
R
T
L
N
I
S
Site 10
T154
G
E
L
R
S
L
R
T
L
N
I
S
G
N
E
Site 11
S158
S
L
R
T
L
N
I
S
G
N
E
I
Q
R
L
Site 12
S183
E
M
L
S
L
D
A
S
A
M
V
Y
P
P
R
Site 13
Y187
L
D
A
S
A
M
V
Y
P
P
R
E
V
C
G
Site 14
Y212
C
K
E
S
G
L
E
Y
Y
P
P
S
Q
Y
L
Site 15
Y213
K
E
S
G
L
E
Y
Y
P
P
S
Q
Y
L
L
Site 16
Y218
E
Y
Y
P
P
S
Q
Y
L
L
P
I
L
E
Q
Site 17
S234
G
I
E
N
S
R
D
S
P
D
G
P
T
D
R
Site 18
T239
R
D
S
P
D
G
P
T
D
R
F
S
R
E
E
Site 19
S243
D
G
P
T
D
R
F
S
R
E
E
L
E
W
Q
Site 20
S254
L
E
W
Q
N
R
F
S
D
Y
E
K
R
K
E
Site 21
Y256
W
Q
N
R
F
S
D
Y
E
K
R
K
E
Q
K
Site 22
T282
E
L
G
Q
R
E
H
T
Q
L
L
Q
Q
S
S
Site 23
S289
T
Q
L
L
Q
Q
S
S
S
Q
K
D
E
I
L
Site 24
S290
Q
L
L
Q
Q
S
S
S
Q
K
D
E
I
L
Q
Site 25
T298
Q
K
D
E
I
L
Q
T
V
K
E
E
Q
S
R
Site 26
S311
S
R
L
E
Q
G
L
S
E
H
Q
R
H
L
N
Site 27
S336
K
Q
T
E
Q
N
I
S
S
R
I
Q
K
L
L
Site 28
S337
Q
T
E
Q
N
I
S
S
R
I
Q
K
L
L
Q
Site 29
S352
D
N
Q
R
Q
K
K
S
S
E
I
L
K
S
L
Site 30
S353
N
Q
R
Q
K
K
S
S
E
I
L
K
S
L
E
Site 31
S358
K
S
S
E
I
L
K
S
L
E
N
E
R
I
R
Site 32
S371
I
R
M
E
Q
L
M
S
I
T
Q
E
E
T
E
Site 33
S379
I
T
Q
E
E
T
E
S
L
R
R
R
D
V
A
Site 34
S387
L
R
R
R
D
V
A
S
A
M
Q
Q
M
L
T
Site 35
T394
S
A
M
Q
Q
M
L
T
E
S
C
K
N
R
L
Site 36
Y406
N
R
L
I
Q
M
A
Y
E
S
Q
R
Q
N
L
Site 37
S408
L
I
Q
M
A
Y
E
S
Q
R
Q
N
L
V
Q
Site 38
S420
L
V
Q
Q
A
C
S
S
M
A
E
M
D
E
R
Site 39
S473
L
M
H
R
Q
I
R
S
Q
I
K
L
I
E
T
Site 40
S494
Q
L
E
L
K
R
K
S
L
D
T
E
S
L
Q
Site 41
T497
L
K
R
K
S
L
D
T
E
S
L
Q
E
M
I
Site 42
S499
R
K
S
L
D
T
E
S
L
Q
E
M
I
S
E
Site 43
S505
E
S
L
Q
E
M
I
S
E
Q
R
W
A
L
S
Site 44
S513
E
Q
R
W
A
L
S
S
L
L
Q
Q
L
L
K
Site 45
T534
E
E
L
R
E
I
L
T
E
L
E
A
K
S
E
Site 46
S540
L
T
E
L
E
A
K
S
E
T
R
Q
E
N
Y
Site 47
Y552
E
N
Y
W
L
I
Q
Y
Q
R
L
L
N
Q
K
Site 48
S562
L
L
N
Q
K
P
L
S
L
K
L
Q
E
E
G
Site 49
Y586
E
E
L
S
A
E
H
Y
L
P
I
F
A
H
H
Site 50
S601
R
L
S
L
D
L
L
S
Q
M
S
P
G
D
L
Site 51
S604
L
D
L
L
S
Q
M
S
P
G
D
L
A
K
V
Site 52
T648
P
P
M
G
E
V
V
T
P
T
A
P
Q
E
P
Site 53
S658
A
P
Q
E
P
P
E
S
V
R
P
S
A
P
P
Site 54
S662
P
P
E
S
V
R
P
S
A
P
P
A
E
L
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation