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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ENPP7
Full Name:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 7
Alias:
Alkaline sphingomyelin phosphodiesterase;Intestinal alkaline sphingomyelinase
Type:
Mass (Da):
51494
Number AA:
458
UniProt ID:
Q6UWV6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S26
G
A
G
A
P
V
Q
S
Q
G
S
Q
N
K
L
Site 2
S29
A
P
V
Q
S
Q
G
S
Q
N
K
L
L
L
V
Site 3
S37
Q
N
K
L
L
L
V
S
F
D
G
F
R
W
N
Site 4
Y45
F
D
G
F
R
W
N
Y
D
Q
D
V
D
T
P
Site 5
T51
N
Y
D
Q
D
V
D
T
P
N
L
D
A
M
A
Site 6
Y66
R
D
G
V
K
A
R
Y
M
T
P
A
F
V
T
Site 7
Y98
H
G
V
V
H
N
M
Y
Y
N
T
T
S
K
V
Site 8
Y99
G
V
V
H
N
M
Y
Y
N
T
T
S
K
V
K
Site 9
Y109
T
S
K
V
K
L
P
Y
H
A
T
L
G
I
Q
Site 10
S139
R
Q
G
L
R
A
G
S
F
F
Y
P
G
G
N
Site 11
Y142
L
R
A
G
S
F
F
Y
P
G
G
N
V
T
Y
Site 12
S157
Q
G
V
A
V
T
R
S
R
K
E
G
I
A
H
Site 13
Y166
K
E
G
I
A
H
N
Y
K
N
E
T
E
W
R
Site 14
T192
E
E
D
L
D
L
V
T
L
Y
F
G
E
P
D
Site 15
Y194
D
L
D
L
V
T
L
Y
F
G
E
P
D
S
T
Site 16
S200
L
Y
F
G
E
P
D
S
T
G
H
R
Y
G
P
Site 17
T201
Y
F
G
E
P
D
S
T
G
H
R
Y
G
P
E
Site 18
Y205
P
D
S
T
G
H
R
Y
G
P
E
S
P
E
R
Site 19
S209
G
H
R
Y
G
P
E
S
P
E
R
R
E
M
V
Site 20
T222
M
V
R
Q
V
D
R
T
V
G
Y
L
R
E
S
Site 21
Y225
Q
V
D
R
T
V
G
Y
L
R
E
S
I
A
R
Site 22
S229
T
V
G
Y
L
R
E
S
I
A
R
N
H
L
T
Site 23
T251
T
S
D
H
G
M
T
T
V
D
K
R
A
G
D
Site 24
Y297
E
G
R
L
E
K
V
Y
D
A
L
K
D
A
H
Site 25
Y321
A
F
P
E
A
F
H
Y
A
N
N
P
R
V
T
Site 26
T328
Y
A
N
N
P
R
V
T
P
L
L
M
Y
S
D
Site 27
T364
N
K
D
M
D
M
K
T
I
F
R
A
V
G
P
Site 28
T426
L
P
P
D
G
R
P
T
L
L
P
K
G
R
S
Site 29
S433
T
L
L
P
K
G
R
S
A
L
P
P
S
S
R
Site 30
S438
G
R
S
A
L
P
P
S
S
R
P
L
L
V
M
Site 31
S439
R
S
A
L
P
P
S
S
R
P
L
L
V
M
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation