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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TMC5
Full Name:
Transmembrane channel-like protein 5
Alias:
Type:
Mass (Da):
114770
Number AA:
1006
UniProt ID:
Q6UXY8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y16
W
S
E
E
D
P
D
Y
P
D
Y
S
G
S
Q
Site 2
Y19
E
D
P
D
Y
P
D
Y
S
G
S
Q
N
R
T
Site 3
S20
D
P
D
Y
P
D
Y
S
G
S
Q
N
R
T
Q
Site 4
S22
D
Y
P
D
Y
S
G
S
Q
N
R
T
Q
G
Y
Site 5
T26
Y
S
G
S
Q
N
R
T
Q
G
Y
L
K
T
Q
Site 6
Y29
S
Q
N
R
T
Q
G
Y
L
K
T
Q
G
Y
P
Site 7
Y35
G
Y
L
K
T
Q
G
Y
P
D
V
P
G
P
L
Site 8
Y47
G
P
L
N
N
P
D
Y
P
G
T
R
S
N
P
Site 9
T50
N
N
P
D
Y
P
G
T
R
S
N
P
Y
S
V
Site 10
S52
P
D
Y
P
G
T
R
S
N
P
Y
S
V
A
S
Site 11
Y55
P
G
T
R
S
N
P
Y
S
V
A
S
R
T
R
Site 12
S56
G
T
R
S
N
P
Y
S
V
A
S
R
T
R
P
Site 13
S59
S
N
P
Y
S
V
A
S
R
T
R
P
D
Y
P
Site 14
T61
P
Y
S
V
A
S
R
T
R
P
D
Y
P
G
S
Site 15
Y65
A
S
R
T
R
P
D
Y
P
G
S
L
A
E
P
Site 16
S68
T
R
P
D
Y
P
G
S
L
A
E
P
N
Y
P
Site 17
Y74
G
S
L
A
E
P
N
Y
P
R
S
L
S
N
P
Site 18
S77
A
E
P
N
Y
P
R
S
L
S
N
P
D
Y
S
Site 19
S79
P
N
Y
P
R
S
L
S
N
P
D
Y
S
G
T
Site 20
Y83
R
S
L
S
N
P
D
Y
S
G
T
R
S
N
A
Site 21
S84
S
L
S
N
P
D
Y
S
G
T
R
S
N
A
Y
Site 22
S88
P
D
Y
S
G
T
R
S
N
A
Y
S
A
A
S
Site 23
Y91
S
G
T
R
S
N
A
Y
S
A
A
S
R
T
S
Site 24
S92
G
T
R
S
N
A
Y
S
A
A
S
R
T
S
P
Site 25
S95
S
N
A
Y
S
A
A
S
R
T
S
P
D
H
P
Site 26
S98
Y
S
A
A
S
R
T
S
P
D
H
P
T
S
L
Site 27
T103
R
T
S
P
D
H
P
T
S
L
P
E
P
D
Y
Site 28
S104
T
S
P
D
H
P
T
S
L
P
E
P
D
Y
S
Site 29
Y110
T
S
L
P
E
P
D
Y
S
E
F
Q
S
H
P
Site 30
S111
S
L
P
E
P
D
Y
S
E
F
Q
S
H
P
Y
Site 31
S115
P
D
Y
S
E
F
Q
S
H
P
Y
H
R
A
S
Site 32
Y118
S
E
F
Q
S
H
P
Y
H
R
A
S
S
R
Q
Site 33
S122
S
H
P
Y
H
R
A
S
S
R
Q
P
D
Y
P
Site 34
S123
H
P
Y
H
R
A
S
S
R
Q
P
D
Y
P
G
Site 35
Y128
A
S
S
R
Q
P
D
Y
P
G
S
Q
R
N
P
Site 36
S131
R
Q
P
D
Y
P
G
S
Q
R
N
P
D
F
A
Site 37
S140
R
N
P
D
F
A
G
S
S
S
S
G
N
Y
A
Site 38
S141
N
P
D
F
A
G
S
S
S
S
G
N
Y
A
G
Site 39
S142
P
D
F
A
G
S
S
S
S
G
N
Y
A
G
S
Site 40
S143
D
F
A
G
S
S
S
S
G
N
Y
A
G
S
R
Site 41
Y146
G
S
S
S
S
G
N
Y
A
G
S
R
T
H
P
Site 42
S149
S
S
G
N
Y
A
G
S
R
T
H
P
D
H
F
Site 43
S158
T
H
P
D
H
F
G
S
L
E
P
D
Y
P
G
Site 44
Y163
F
G
S
L
E
P
D
Y
P
G
A
Q
S
N
S
Site 45
S168
P
D
Y
P
G
A
Q
S
N
S
D
H
P
G
P
Site 46
S170
Y
P
G
A
Q
S
N
S
D
H
P
G
P
R
A
Site 47
S184
A
N
L
N
H
P
G
S
R
K
N
L
E
H
T
Site 48
T191
S
R
K
N
L
E
H
T
S
F
R
I
N
P
Y
Site 49
S192
R
K
N
L
E
H
T
S
F
R
I
N
P
Y
A
Site 50
Y198
T
S
F
R
I
N
P
Y
A
D
S
L
G
K
P
Site 51
S201
R
I
N
P
Y
A
D
S
L
G
K
P
D
Y
P
Site 52
Y207
D
S
L
G
K
P
D
Y
P
G
A
D
I
Q
P
Site 53
S216
G
A
D
I
Q
P
N
S
P
P
F
F
G
E
P
Site 54
Y225
P
F
F
G
E
P
D
Y
P
S
A
E
D
N
Q
Site 55
S227
F
G
E
P
D
Y
P
S
A
E
D
N
Q
N
L
Site 56
S236
E
D
N
Q
N
L
P
S
T
W
R
E
P
D
Y
Site 57
T237
D
N
Q
N
L
P
S
T
W
R
E
P
D
Y
S
Site 58
Y243
S
T
W
R
E
P
D
Y
S
D
A
E
N
G
H
Site 59
S244
T
W
R
E
P
D
Y
S
D
A
E
N
G
H
D
Site 60
Y252
D
A
E
N
G
H
D
Y
G
S
S
E
T
P
K
Site 61
T257
H
D
Y
G
S
S
E
T
P
K
M
T
R
G
V
Site 62
S266
K
M
T
R
G
V
L
S
R
T
S
S
I
Q
P
Site 63
T268
T
R
G
V
L
S
R
T
S
S
I
Q
P
S
F
Site 64
S269
R
G
V
L
S
R
T
S
S
I
Q
P
S
F
R
Site 65
S270
G
V
L
S
R
T
S
S
I
Q
P
S
F
R
H
Site 66
S274
R
T
S
S
I
Q
P
S
F
R
H
R
S
D
D
Site 67
S279
Q
P
S
F
R
H
R
S
D
D
P
V
G
S
L
Site 68
S285
R
S
D
D
P
V
G
S
L
W
G
E
N
D
Y
Site 69
Y292
S
L
W
G
E
N
D
Y
P
E
G
I
E
M
A
Site 70
S306
A
S
M
E
M
A
N
S
Y
G
H
S
L
P
G
Site 71
Y307
S
M
E
M
A
N
S
Y
G
H
S
L
P
G
A
Site 72
S310
M
A
N
S
Y
G
H
S
L
P
G
A
P
G
S
Site 73
S317
S
L
P
G
A
P
G
S
G
Y
V
N
P
A
Y
Site 74
Y319
P
G
A
P
G
S
G
Y
V
N
P
A
Y
V
G
Site 75
Y324
S
G
Y
V
N
P
A
Y
V
G
E
S
G
P
V
Site 76
Y334
E
S
G
P
V
H
A
Y
G
N
P
P
L
S
E
Site 77
S340
A
Y
G
N
P
P
L
S
E
C
D
W
H
K
S
Site 78
S347
S
E
C
D
W
H
K
S
P
Q
G
Q
K
L
I
Site 79
S356
Q
G
Q
K
L
I
A
S
L
I
P
M
T
S
R
Site 80
T361
I
A
S
L
I
P
M
T
S
R
D
R
I
K
A
Site 81
S362
A
S
L
I
P
M
T
S
R
D
R
I
K
A
I
Site 82
T375
A
I
R
N
Q
P
R
T
M
E
E
K
R
N
L
Site 83
S391
K
I
V
D
K
E
K
S
K
Q
T
H
R
I
L
Site 84
Y414
L
N
S
I
S
R
A
Y
R
R
S
K
N
S
L
Site 85
S417
I
S
R
A
Y
R
R
S
K
N
S
L
S
E
I
Site 86
S420
A
Y
R
R
S
K
N
S
L
S
E
I
L
N
S
Site 87
S422
R
R
S
K
N
S
L
S
E
I
L
N
S
I
S
Site 88
S427
S
L
S
E
I
L
N
S
I
S
L
W
Q
K
T
Site 89
S429
S
E
I
L
N
S
I
S
L
W
Q
K
T
L
K
Site 90
T434
S
I
S
L
W
Q
K
T
L
K
I
I
G
G
K
Site 91
S463
L
L
K
F
N
I
F
S
F
I
L
N
F
S
F
Site 92
Y504
Y
F
R
D
T
V
M
Y
Y
G
F
Y
T
N
S
Site 93
Y505
F
R
D
T
V
M
Y
Y
G
F
Y
T
N
S
T
Site 94
S518
S
T
I
Q
H
G
N
S
G
A
S
Y
N
M
Q
Site 95
Y522
H
G
N
S
G
A
S
Y
N
M
Q
L
A
Y
I
Site 96
S605
S
E
L
R
Q
E
N
S
K
L
T
F
N
Q
L
Site 97
T608
R
Q
E
N
S
K
L
T
F
N
Q
L
L
T
R
Site 98
T650
Y
N
L
E
F
L
K
T
H
S
N
P
G
A
V
Site 99
Y684
M
F
R
L
V
E
R
Y
E
M
P
R
H
E
V
Site 100
S873
G
P
F
R
G
L
P
S
F
I
Q
S
I
Y
S
Site 101
T884
S
I
Y
S
W
I
D
T
L
S
H
R
P
G
Y
Site 102
S968
E
K
K
A
N
P
S
S
L
V
L
E
R
R
E
Site 103
S990
H
L
G
E
H
D
G
S
L
D
L
R
S
R
R
Site 104
S995
D
G
S
L
D
L
R
S
R
R
S
V
Q
E
G
Site 105
S998
L
D
L
R
S
R
R
S
V
Q
E
G
N
P
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation