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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TSRC1
Full Name:
ADAMTS-like protein 4
Alias:
ADAMTSL-4; ADAMTS-like 4; ATL4; DKFZP434K1772; Thrombospondin repeat containing 1
Type:
Unknown function
Mass (Da):
116545
Number AA:
877
UniProt ID:
Q6UY14
International Prot ID:
IPI00374068
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031012
Uniprot
OncoNet
Molecular Function:
GO:0004222
GO:0002020
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0043065
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
C
L
D
Q
E
V
L
S
G
H
S
L
Q
T
P
Site 2
T35
L
S
G
H
S
L
Q
T
P
T
E
E
G
Q
G
Site 3
S68
G
V
G
V
Q
R
R
S
R
T
C
Q
L
P
T
Site 4
T70
G
V
Q
R
R
S
R
T
C
Q
L
P
T
V
Q
Site 5
T75
S
R
T
C
Q
L
P
T
V
Q
L
H
P
S
L
Site 6
S81
P
T
V
Q
L
H
P
S
L
P
L
P
P
R
P
Site 7
T106
G
Q
G
P
R
P
Q
T
S
P
E
T
L
P
L
Site 8
S107
Q
G
P
R
P
Q
T
S
P
E
T
L
P
L
Y
Site 9
Y114
S
P
E
T
L
P
L
Y
R
T
Q
S
R
G
R
Site 10
T116
E
T
L
P
L
Y
R
T
Q
S
R
G
R
G
G
Site 11
S118
L
P
L
Y
R
T
Q
S
R
G
R
G
G
P
L
Site 12
S130
G
P
L
R
G
P
A
S
H
L
G
R
E
E
T
Site 13
T137
S
H
L
G
R
E
E
T
Q
E
I
R
A
A
R
Site 14
S146
E
I
R
A
A
R
R
S
R
L
R
D
P
I
K
Site 15
Y159
I
K
P
G
M
F
G
Y
G
R
V
P
F
A
L
Site 16
S177
R
N
R
R
H
P
R
S
P
P
R
S
E
L
S
Site 17
S181
H
P
R
S
P
P
R
S
E
L
S
L
I
S
S
Site 18
S184
S
P
P
R
S
E
L
S
L
I
S
S
R
G
E
Site 19
S187
R
S
E
L
S
L
I
S
S
R
G
E
E
A
I
Site 20
S188
S
E
L
S
L
I
S
S
R
G
E
E
A
I
P
Site 21
S196
R
G
E
E
A
I
P
S
P
T
P
R
A
E
P
Site 22
T198
E
E
A
I
P
S
P
T
P
R
A
E
P
F
S
Site 23
S205
T
P
R
A
E
P
F
S
A
N
G
S
P
Q
T
Site 24
S209
E
P
F
S
A
N
G
S
P
Q
T
E
L
P
P
Site 25
T212
S
A
N
G
S
P
Q
T
E
L
P
P
T
E
L
Site 26
T217
P
Q
T
E
L
P
P
T
E
L
S
V
H
T
P
Site 27
S220
E
L
P
P
T
E
L
S
V
H
T
P
S
P
Q
Site 28
T223
P
T
E
L
S
V
H
T
P
S
P
Q
A
E
P
Site 29
S225
E
L
S
V
H
T
P
S
P
Q
A
E
P
L
S
Site 30
S232
S
P
Q
A
E
P
L
S
P
E
T
A
Q
T
E
Site 31
T238
L
S
P
E
T
A
Q
T
E
V
A
P
R
T
R
Site 32
S258
H
H
P
R
A
Q
A
S
G
T
E
P
P
S
P
Site 33
T260
P
R
A
Q
A
S
G
T
E
P
P
S
P
T
H
Site 34
S264
A
S
G
T
E
P
P
S
P
T
H
S
L
G
E
Site 35
S268
E
P
P
S
P
T
H
S
L
G
E
G
G
F
F
Site 36
S278
E
G
G
F
F
R
A
S
P
Q
P
R
R
P
S
Site 37
S285
S
P
Q
P
R
R
P
S
S
Q
G
W
A
S
P
Site 38
S286
P
Q
P
R
R
P
S
S
Q
G
W
A
S
P
Q
Site 39
S291
P
S
S
Q
G
W
A
S
P
Q
V
A
G
R
R
Site 40
S304
R
R
P
D
P
F
P
S
V
P
R
G
R
G
Q
Site 41
T322
G
P
W
G
T
G
G
T
P
H
G
P
R
L
E
Site 42
S343
G
A
W
L
P
L
L
S
N
G
P
H
A
S
S
Site 43
S350
S
N
G
P
H
A
S
S
L
W
S
L
F
A
P
Site 44
S353
P
H
A
S
S
L
W
S
L
F
A
P
S
S
P
Site 45
S359
W
S
L
F
A
P
S
S
P
I
P
R
C
S
G
Site 46
S365
S
S
P
I
P
R
C
S
G
E
S
E
Q
L
R
Site 47
S368
I
P
R
C
S
G
E
S
E
Q
L
R
A
C
S
Site 48
S375
S
E
Q
L
R
A
C
S
Q
A
P
C
P
P
E
Site 49
Y404
Q
E
F
M
G
Q
L
Y
Q
W
E
P
F
T
E
Site 50
T410
L
Y
Q
W
E
P
F
T
E
V
Q
G
S
Q
R
Site 51
S415
P
F
T
E
V
Q
G
S
Q
R
C
E
L
N
C
Site 52
Y430
R
P
R
G
F
R
F
Y
V
R
H
T
E
K
V
Site 53
T434
F
R
F
Y
V
R
H
T
E
K
V
Q
D
G
T
Site 54
T441
T
E
K
V
Q
D
G
T
L
C
Q
P
G
A
P
Site 55
S467
G
C
D
G
I
L
G
S
G
R
R
P
D
G
C
Site 56
S482
G
V
C
G
G
D
D
S
T
C
R
L
V
S
G
Site 57
T483
V
C
G
G
D
D
S
T
C
R
L
V
S
G
N
Site 58
S488
D
S
T
C
R
L
V
S
G
N
L
T
D
R
G
Site 59
T492
R
L
V
S
G
N
L
T
D
R
G
G
P
L
G
Site 60
S521
Q
I
A
Q
L
R
P
S
S
N
Y
L
A
L
R
Site 61
S522
I
A
Q
L
R
P
S
S
N
Y
L
A
L
R
G
Site 62
Y524
Q
L
R
P
S
S
N
Y
L
A
L
R
G
P
G
Site 63
S547
W
A
V
D
P
P
G
S
Y
R
A
G
G
T
V
Site 64
Y557
A
G
G
T
V
F
R
Y
N
R
P
P
R
E
E
Site 65
S569
R
E
E
G
K
G
E
S
L
S
A
E
G
P
T
Site 66
S571
E
G
K
G
E
S
L
S
A
E
G
P
T
T
Q
Site 67
T577
L
S
A
E
G
P
T
T
Q
P
V
D
V
Y
M
Site 68
Y583
T
T
Q
P
V
D
V
Y
M
I
F
Q
E
E
N
Site 69
Y595
E
E
N
P
G
V
F
Y
Q
Y
V
I
S
S
P
Site 70
Y597
N
P
G
V
F
Y
Q
Y
V
I
S
S
P
P
P
Site 71
S601
F
Y
Q
Y
V
I
S
S
P
P
P
I
L
E
N
Site 72
T610
P
P
I
L
E
N
P
T
P
E
P
P
V
P
Q
Site 73
T638
P
A
P
R
P
A
R
T
P
G
T
L
Q
R
Q
Site 74
T641
R
P
A
R
T
P
G
T
L
Q
R
Q
V
R
I
Site 75
T659
P
A
P
P
H
P
R
T
P
L
G
S
P
A
A
Site 76
S663
H
P
R
T
P
L
G
S
P
A
A
Y
W
K
R
Site 77
Y667
P
L
G
S
P
A
A
Y
W
K
R
V
G
H
S
Site 78
S677
R
V
G
H
S
A
C
S
A
S
C
G
K
G
V
Site 79
S679
G
H
S
A
C
S
A
S
C
G
K
G
V
W
R
Site 80
S693
R
P
I
F
L
C
I
S
R
E
S
G
E
E
L
Site 81
S696
F
L
C
I
S
R
E
S
G
E
E
L
D
E
R
Site 82
S714
A
G
A
R
P
P
A
S
P
E
P
C
H
G
T
Site 83
T721
S
P
E
P
C
H
G
T
P
C
P
P
Y
W
E
Site 84
S736
A
G
E
W
T
S
C
S
R
S
C
G
P
G
T
Site 85
S738
E
W
T
S
C
S
R
S
C
G
P
G
T
Q
H
Site 86
T743
S
R
S
C
G
P
G
T
Q
H
R
Q
L
Q
C
Site 87
S760
E
F
G
G
G
G
S
S
V
P
P
E
R
C
G
Site 88
S777
P
R
P
N
I
T
Q
S
C
Q
L
R
L
C
G
Site 89
S796
G
S
P
W
S
Q
C
S
V
R
C
G
R
G
Q
Site 90
S805
R
C
G
R
G
Q
R
S
R
Q
V
R
C
V
G
Site 91
S819
G
N
N
G
D
E
V
S
E
Q
E
C
A
S
G
Site 92
S825
V
S
E
Q
E
C
A
S
G
P
P
Q
P
P
S
Site 93
S832
S
G
P
P
Q
P
P
S
R
E
A
C
D
M
G
Site 94
S855
S
D
W
S
S
K
C
S
A
E
C
G
T
G
I
Site 95
S890
A
G
A
G
T
G
Q
S
C
P
T
G
S
R
P
Site 96
T893
G
T
G
Q
S
C
P
T
G
S
R
P
P
D
M
Site 97
S895
G
Q
S
C
P
T
G
S
R
P
P
D
M
R
A
Site 98
S904
P
P
D
M
R
A
C
S
L
G
P
C
E
R
T
Site 99
S923
T
G
P
W
G
E
C
S
S
E
C
G
S
G
T
Site 100
S924
G
P
W
G
E
C
S
S
E
C
G
S
G
T
Q
Site 101
S928
E
C
S
S
E
C
G
S
G
T
Q
R
R
D
I
Site 102
T930
S
S
E
C
G
S
G
T
Q
R
R
D
I
I
C
Site 103
S939
R
R
D
I
I
C
V
S
K
L
G
T
E
F
N
Site 104
T948
L
G
T
E
F
N
V
T
S
P
S
N
C
S
H
Site 105
S949
G
T
E
F
N
V
T
S
P
S
N
C
S
H
L
Site 106
S951
E
F
N
V
T
S
P
S
N
C
S
H
L
P
R
Site 107
S954
V
T
S
P
S
N
C
S
H
L
P
R
P
P
A
Site 108
S983
S
T
P
W
S
P
C
S
R
S
C
Q
G
G
T
Site 109
S985
P
W
S
P
C
S
R
S
C
Q
G
G
T
Q
T
Site 110
S999
T
R
E
V
Q
C
L
S
T
N
Q
T
L
S
T
Site 111
T1003
Q
C
L
S
T
N
Q
T
L
S
T
R
C
P
P
Site 112
S1005
L
S
T
N
Q
T
L
S
T
R
C
P
P
Q
L
Site 113
T1006
S
T
N
Q
T
L
S
T
R
C
P
P
Q
L
R
Site 114
S1015
C
P
P
Q
L
R
P
S
R
K
R
P
C
N
S
Site 115
S1022
S
R
K
R
P
C
N
S
Q
P
C
S
Q
R
P
Site 116
S1036
P
D
D
Q
C
K
D
S
S
P
H
C
P
L
V
Site 117
S1037
D
D
Q
C
K
D
S
S
P
H
C
P
L
V
V
Site 118
Y1054
R
L
C
V
Y
P
Y
Y
T
A
T
C
C
R
S
Site 119
S1069
C
A
H
V
L
E
R
S
P
Q
D
P
S
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation