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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KSR2
Full Name:
Kinase suppressor of Ras 2
Alias:
FLJ25965
Type:
Protein kinase, Ser/Thr (non-receptor);
TKL
group; RAF family
Mass (Da):
107632
Number AA:
950
UniProt ID:
Q6VAB6
International Prot ID:
IPI00167121
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Kinase suppressor of Ras 2 S490 phosphosite-specific antibody AB-PK676#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK676#Kinase suppressor of Ras 2 (P487-H493, human) pS490 phosphopeptide - Powder PE-04ANF95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ANF95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
D
E
E
N
M
T
K
S
E
E
Q
Q
P
Site 2
S9
D
E
E
N
M
T
K
S
E
E
Q
Q
P
L
S
Site 3
S16
S
E
E
Q
Q
P
L
S
L
Q
K
A
L
Q
Q
Site 4
S34
V
Q
N
M
I
D
L
S
I
S
N
L
E
G
L
Site 5
S36
N
M
I
D
L
S
I
S
N
L
E
G
L
R
T
Site 6
T43
S
N
L
E
G
L
R
T
K
C
A
T
S
N
D
Site 7
T47
G
L
R
T
K
C
A
T
S
N
D
L
T
Q
K
Site 8
T52
C
A
T
S
N
D
L
T
Q
K
E
I
R
T
L
Site 9
Y66
L
E
S
K
L
V
K
Y
F
S
R
Q
L
S
C
Site 10
S68
S
K
L
V
K
Y
F
S
R
Q
L
S
C
K
K
Site 11
S72
K
Y
F
S
R
Q
L
S
C
K
K
K
V
A
L
Site 12
S110
K
E
V
L
E
E
I
S
P
G
Q
L
S
L
E
Site 13
S115
E
I
S
P
G
Q
L
S
L
E
D
L
L
E
M
Site 14
T130
T
D
E
Q
V
C
E
T
V
E
K
Y
G
A
N
Site 15
Y134
V
C
E
T
V
E
K
Y
G
A
N
R
E
E
C
Site 16
S157
C
L
R
N
V
H
M
S
G
G
N
L
S
K
Q
Site 17
T188
P
V
C
P
P
E
P
T
P
W
I
R
T
H
L
Site 18
S196
P
W
I
R
T
H
L
S
Q
S
P
R
V
P
S
Site 19
S198
I
R
T
H
L
S
Q
S
P
R
V
P
S
K
C
Site 20
S203
S
Q
S
P
R
V
P
S
K
C
V
Q
H
Y
C
Site 21
Y209
P
S
K
C
V
Q
H
Y
C
H
T
S
P
T
P
Site 22
S213
V
Q
H
Y
C
H
T
S
P
T
P
G
A
P
V
Site 23
T215
H
Y
C
H
T
S
P
T
P
G
A
P
V
Y
T
Site 24
Y221
P
T
P
G
A
P
V
Y
T
H
V
D
R
L
T
Site 25
T228
Y
T
H
V
D
R
L
T
V
D
A
Y
P
G
L
Site 26
Y232
D
R
L
T
V
D
A
Y
P
G
L
C
P
P
P
Site 27
S243
C
P
P
P
P
L
E
S
G
H
R
S
L
P
P
Site 28
S247
P
L
E
S
G
H
R
S
L
P
P
S
P
R
Q
Site 29
S251
G
H
R
S
L
P
P
S
P
R
Q
R
H
A
V
Site 30
T260
R
Q
R
H
A
V
R
T
P
P
R
T
P
N
I
Site 31
T264
A
V
R
T
P
P
R
T
P
N
I
V
T
T
V
Site 32
T269
P
R
T
P
N
I
V
T
T
V
T
P
P
G
T
Site 33
T270
R
T
P
N
I
V
T
T
V
T
P
P
G
T
P
Site 34
T272
P
N
I
V
T
T
V
T
P
P
G
T
P
P
M
Site 35
T276
T
T
V
T
P
P
G
T
P
P
M
R
K
K
N
Site 36
T290
N
K
L
K
P
P
G
T
P
P
P
S
S
R
K
Site 37
S294
P
P
G
T
P
P
P
S
S
R
K
L
I
H
L
Site 38
S295
P
G
T
P
P
P
S
S
R
K
L
I
H
L
I
Site 39
T306
I
H
L
I
P
G
F
T
A
L
H
R
S
K
S
Site 40
S311
G
F
T
A
L
H
R
S
K
S
H
E
F
Q
L
Site 41
S313
T
A
L
H
R
S
K
S
H
E
F
Q
L
G
H
Site 42
T327
H
R
V
D
E
A
H
T
P
K
A
K
K
K
S
Site 43
S343
P
L
N
L
K
I
H
S
S
V
G
S
C
E
N
Site 44
S344
L
N
L
K
I
H
S
S
V
G
S
C
E
N
I
Site 45
S347
K
I
H
S
S
V
G
S
C
E
N
I
P
S
Q
Site 46
S353
G
S
C
E
N
I
P
S
Q
Q
R
S
P
L
L
Site 47
S357
N
I
P
S
Q
Q
R
S
P
L
L
S
E
R
S
Site 48
S361
Q
Q
R
S
P
L
L
S
E
R
S
L
R
S
F
Site 49
S364
S
P
L
L
S
E
R
S
L
R
S
F
F
V
G
Site 50
S367
L
S
E
R
S
L
R
S
F
F
V
G
H
A
P
Site 51
S378
G
H
A
P
F
L
P
S
T
P
P
V
H
T
E
Site 52
T379
H
A
P
F
L
P
S
T
P
P
V
H
T
E
A
Site 53
T384
P
S
T
P
P
V
H
T
E
A
N
F
S
A
N
Site 54
S389
V
H
T
E
A
N
F
S
A
N
T
L
S
V
P
Site 55
S394
N
F
S
A
N
T
L
S
V
P
R
W
S
P
Q
Site 56
S399
T
L
S
V
P
R
W
S
P
Q
I
P
R
R
D
Site 57
S410
P
R
R
D
L
G
N
S
I
K
H
R
F
S
T
Site 58
T472
D
P
A
R
L
V
R
T
E
S
V
P
C
D
I
Site 59
S474
A
R
L
V
R
T
E
S
V
P
C
D
I
N
N
Site 60
Y489
P
L
R
K
P
P
R
Y
S
D
L
H
I
S
Q
Site 61
S490
L
R
K
P
P
R
Y
S
D
L
H
I
S
Q
T
Kinase suppressor of Ras 2 S490 phosphosite-specific antibody AB-PK676#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK676#Kinase suppressor of Ras 2 (P487-H493, human) pS490 phosphopeptide - Powder PE-04ANF95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ANF95
Site 62
S495
R
Y
S
D
L
H
I
S
Q
T
L
P
K
T
N
Site 63
T497
S
D
L
H
I
S
Q
T
L
P
K
T
N
K
I
Site 64
T501
I
S
Q
T
L
P
K
T
N
K
I
N
K
D
H
Site 65
Y513
K
D
H
I
P
V
P
Y
Q
P
D
S
S
S
N
Site 66
S517
P
V
P
Y
Q
P
D
S
S
S
N
P
S
S
T
Site 67
S518
V
P
Y
Q
P
D
S
S
S
N
P
S
S
T
T
Site 68
S519
P
Y
Q
P
D
S
S
S
N
P
S
S
T
T
S
Site 69
S522
P
D
S
S
S
N
P
S
S
T
T
S
S
T
P
Site 70
S523
D
S
S
S
N
P
S
S
T
T
S
S
T
P
S
Site 71
T524
S
S
S
N
P
S
S
T
T
S
S
T
P
S
S
Site 72
T525
S
S
N
P
S
S
T
T
S
S
T
P
S
S
P
Site 73
S526
S
N
P
S
S
T
T
S
S
T
P
S
S
P
A
Site 74
S527
N
P
S
S
T
T
S
S
T
P
S
S
P
A
P
Site 75
T528
P
S
S
T
T
S
S
T
P
S
S
P
A
P
P
Site 76
S530
S
T
T
S
S
T
P
S
S
P
A
P
P
L
P
Site 77
S531
T
T
S
S
T
P
S
S
P
A
P
P
L
P
P
Site 78
S539
P
A
P
P
L
P
P
S
A
T
P
P
S
P
L
Site 79
T541
P
P
L
P
P
S
A
T
P
P
S
P
L
H
P
Site 80
S544
P
P
S
A
T
P
P
S
P
L
H
P
S
P
Q
Site 81
S549
P
P
S
P
L
H
P
S
P
Q
C
T
R
Q
Q
Site 82
Y566
F
N
L
P
A
S
H
Y
Y
K
Y
K
Q
Q
F
Site 83
Y569
P
A
S
H
Y
Y
K
Y
K
Q
Q
F
I
F
P
Site 84
T584
D
V
V
P
V
P
E
T
P
T
R
A
P
Q
V
Site 85
T615
L
Q
I
E
V
E
P
T
S
E
N
E
E
V
H
Site 86
S616
Q
I
E
V
E
P
T
S
E
N
E
E
V
H
D
Site 87
S628
V
H
D
E
A
E
E
S
E
D
D
F
E
E
M
Site 88
S638
D
F
E
E
M
N
L
S
L
L
S
A
R
S
F
Site 89
S641
E
M
N
L
S
L
L
S
A
R
S
F
P
R
K
Site 90
S644
L
S
L
L
S
A
R
S
F
P
R
K
A
S
Q
Site 91
S650
R
S
F
P
R
K
A
S
Q
T
S
I
F
L
Q
Site 92
T652
F
P
R
K
A
S
Q
T
S
I
F
L
Q
E
W
Site 93
Y681
K
G
R
F
G
Q
V
Y
H
G
R
W
H
G
E
Site 94
Y714
F
K
R
E
V
M
A
Y
R
Q
T
R
H
E
N
Site 95
T717
E
V
M
A
Y
R
Q
T
R
H
E
N
V
V
L
Site 96
Y748
L
C
K
G
R
T
L
Y
S
V
V
R
D
A
K
Site 97
S749
C
K
G
R
T
L
Y
S
V
V
R
D
A
K
I
Site 98
S841
P
E
I
I
R
Q
L
S
P
D
T
E
E
D
K
Site 99
T844
I
R
Q
L
S
P
D
T
E
E
D
K
L
P
F
Site 100
S852
E
E
D
K
L
P
F
S
K
H
S
D
V
F
A
Site 101
S855
K
L
P
F
S
K
H
S
D
V
F
A
L
G
T
Site 102
T876
A
R
E
W
P
F
K
T
Q
P
A
E
A
I
I
Site 103
S895
T
G
M
K
P
N
L
S
Q
I
G
M
G
K
E
Site 104
T920
F
E
Q
E
E
R
P
T
F
T
K
L
M
D
M
Site 105
S939
P
K
R
N
R
R
L
S
H
P
G
H
F
W
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation