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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MPRIP
Full Name:
Myosin phosphatase Rho-interacting protein
Alias:
MRIP; M-RIP; Myosin phosphatase Rho interacting protein; P116Rip; Rho interacting protein 3; Rho-interacting protein 3; RHOIP3
Type:
GTPase activating protein, Rac/Rho
Mass (Da):
116533
Number AA:
1025
UniProt ID:
Q6WCQ1
International Prot ID:
IPI00295457
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S31
N
C
F
K
P
R
E
S
H
L
L
N
D
E
D
Site 2
T40
L
L
N
D
E
D
L
T
Q
A
K
P
I
Y
G
Site 3
T57
L
L
L
A
P
D
G
T
D
F
D
N
P
V
H
Site 4
Y77
Q
R
R
F
F
I
L
Y
E
H
G
L
L
R
Y
Site 5
T91
Y
A
L
D
E
M
P
T
T
L
P
Q
G
T
I
Site 6
T92
A
L
D
E
M
P
T
T
L
P
Q
G
T
I
N
Site 7
S118
G
R
T
G
Q
K
F
S
L
C
I
L
T
P
E
Site 8
T134
E
H
F
I
R
A
E
T
K
E
I
V
S
G
W
Site 9
Y148
W
L
E
M
L
M
V
Y
P
R
T
N
K
Q
N
Site 10
T166
K
R
K
V
E
P
P
T
P
Q
E
P
G
P
A
Site 11
T178
G
P
A
K
V
A
V
T
S
S
S
S
S
S
S
Site 12
S179
P
A
K
V
A
V
T
S
S
S
S
S
S
S
S
Site 13
S180
A
K
V
A
V
T
S
S
S
S
S
S
S
S
S
Site 14
S181
K
V
A
V
T
S
S
S
S
S
S
S
S
S
S
Site 15
S182
V
A
V
T
S
S
S
S
S
S
S
S
S
S
S
Site 16
S183
A
V
T
S
S
S
S
S
S
S
S
S
S
S
I
Site 17
S184
V
T
S
S
S
S
S
S
S
S
S
S
S
I
P
Site 18
S185
T
S
S
S
S
S
S
S
S
S
S
S
I
P
S
Site 19
S186
S
S
S
S
S
S
S
S
S
S
S
I
P
S
A
Site 20
S187
S
S
S
S
S
S
S
S
S
S
I
P
S
A
E
Site 21
S188
S
S
S
S
S
S
S
S
S
I
P
S
A
E
K
Site 22
S189
S
S
S
S
S
S
S
S
I
P
S
A
E
K
V
Site 23
S192
S
S
S
S
S
I
P
S
A
E
K
V
P
T
T
Site 24
T198
P
S
A
E
K
V
P
T
T
K
S
T
L
W
Q
Site 25
S201
E
K
V
P
T
T
K
S
T
L
W
Q
E
E
M
Site 26
T210
L
W
Q
E
E
M
R
T
K
D
Q
P
D
G
S
Site 27
S217
T
K
D
Q
P
D
G
S
S
L
S
P
A
Q
S
Site 28
S218
K
D
Q
P
D
G
S
S
L
S
P
A
Q
S
P
Site 29
S220
Q
P
D
G
S
S
L
S
P
A
Q
S
P
S
Q
Site 30
S224
S
S
L
S
P
A
Q
S
P
S
Q
S
Q
P
P
Site 31
S226
L
S
P
A
Q
S
P
S
Q
S
Q
P
P
A
A
Site 32
S228
P
A
Q
S
P
S
Q
S
Q
P
P
A
A
S
S
Site 33
S234
Q
S
Q
P
P
A
A
S
S
L
R
E
P
G
L
Site 34
S235
S
Q
P
P
A
A
S
S
L
R
E
P
G
L
E
Site 35
S243
L
R
E
P
G
L
E
S
K
E
E
E
S
A
M
Site 36
S248
L
E
S
K
E
E
E
S
A
M
S
S
D
R
M
Site 37
S251
K
E
E
E
S
A
M
S
S
D
R
M
D
C
G
Site 38
S252
E
E
E
S
A
M
S
S
D
R
M
D
C
G
R
Site 39
S265
G
R
K
V
R
V
E
S
G
Y
F
S
L
E
K
Site 40
Y267
K
V
R
V
E
S
G
Y
F
S
L
E
K
T
K
Site 41
S269
R
V
E
S
G
Y
F
S
L
E
K
T
K
Q
D
Site 42
T273
G
Y
F
S
L
E
K
T
K
Q
D
L
K
A
E
Site 43
S289
Q
Q
L
P
P
P
L
S
P
P
S
P
S
T
P
Site 44
S292
P
P
P
L
S
P
P
S
P
S
T
P
N
H
R
Site 45
S294
P
L
S
P
P
S
P
S
T
P
N
H
R
R
S
Site 46
T295
L
S
P
P
S
P
S
T
P
N
H
R
R
S
Q
Site 47
S301
S
T
P
N
H
R
R
S
Q
V
I
E
K
F
E
Site 48
T320
E
K
A
E
H
M
E
T
N
A
V
G
P
S
P
Site 49
S326
E
T
N
A
V
G
P
S
P
S
S
D
T
R
Q
Site 50
S329
A
V
G
P
S
P
S
S
D
T
R
Q
G
R
S
Site 51
T348
F
P
R
K
R
D
F
T
N
E
A
P
P
A
P
Site 52
S360
P
A
P
L
P
D
A
S
A
S
P
L
S
P
H
Site 53
S362
P
L
P
D
A
S
A
S
P
L
S
P
H
R
R
Site 54
S365
D
A
S
A
S
P
L
S
P
H
R
R
A
K
S
Site 55
S372
S
P
H
R
R
A
K
S
L
D
R
R
S
T
E
Site 56
S377
A
K
S
L
D
R
R
S
T
E
P
S
V
T
P
Site 57
T378
K
S
L
D
R
R
S
T
E
P
S
V
T
P
D
Site 58
S381
D
R
R
S
T
E
P
S
V
T
P
D
L
L
N
Site 59
T383
R
S
T
E
P
S
V
T
P
D
L
L
N
F
K
Site 60
Y398
K
G
W
L
T
K
Q
Y
E
D
G
Q
W
K
K
Site 61
Y417
L
A
D
Q
S
L
R
Y
Y
R
D
S
V
A
E
Site 62
Y418
A
D
Q
S
L
R
Y
Y
R
D
S
V
A
E
E
Site 63
S421
S
L
R
Y
Y
R
D
S
V
A
E
E
A
A
D
Site 64
S436
L
D
G
E
I
D
L
S
A
C
Y
D
V
T
E
Site 65
Y439
E
I
D
L
S
A
C
Y
D
V
T
E
Y
P
V
Site 66
T442
L
S
A
C
Y
D
V
T
E
Y
P
V
Q
R
N
Site 67
Y444
A
C
Y
D
V
T
E
Y
P
V
Q
R
N
Y
G
Site 68
Y450
E
Y
P
V
Q
R
N
Y
G
F
Q
I
H
T
K
Site 69
T462
H
T
K
E
G
E
F
T
L
S
A
M
T
S
G
Site 70
S464
K
E
G
E
F
T
L
S
A
M
T
S
G
I
R
Site 71
T486
M
K
H
V
H
P
T
T
A
P
D
V
T
S
S
Site 72
S493
T
A
P
D
V
T
S
S
L
P
E
E
K
N
K
Site 73
S501
L
P
E
E
K
N
K
S
S
C
S
F
E
T
C
Site 74
S502
P
E
E
K
N
K
S
S
C
S
F
E
T
C
P
Site 75
S504
E
K
N
K
S
S
C
S
F
E
T
C
P
R
P
Site 76
T512
F
E
T
C
P
R
P
T
E
K
Q
E
A
E
L
Site 77
S529
P
D
P
E
Q
K
R
S
R
A
R
E
R
R
R
Site 78
S540
E
R
R
R
E
G
R
S
K
T
F
D
W
A
E
Site 79
T542
R
R
E
G
R
S
K
T
F
D
W
A
E
F
R
Site 80
T568
G
G
V
G
P
A
D
T
H
E
P
L
R
P
E
Site 81
T602
R
F
G
M
L
D
A
T
D
G
P
G
T
E
D
Site 82
S619
L
R
M
E
V
D
R
S
P
G
L
P
M
S
D
Site 83
S625
R
S
P
G
L
P
M
S
D
L
K
T
H
N
V
Site 84
T629
L
P
M
S
D
L
K
T
H
N
V
H
V
E
I
Site 85
T646
R
W
H
Q
V
E
T
T
P
L
R
E
E
K
Q
Site 86
S662
P
I
A
P
V
H
L
S
S
E
D
G
G
D
R
Site 87
S663
I
A
P
V
H
L
S
S
E
D
G
G
D
R
L
Site 88
S671
E
D
G
G
D
R
L
S
T
H
E
L
T
S
L
Site 89
T672
D
G
G
D
R
L
S
T
H
E
L
T
S
L
L
Site 90
S677
L
S
T
H
E
L
T
S
L
L
E
K
E
L
E
Site 91
S686
L
E
K
E
L
E
Q
S
Q
K
E
A
S
D
L
Site 92
S691
E
Q
S
Q
K
E
A
S
D
L
L
E
Q
N
R
Site 93
S713
V
A
L
G
R
E
Q
S
A
R
E
G
Y
V
L
Site 94
Y718
E
Q
S
A
R
E
G
Y
V
L
Q
A
T
C
E
Site 95
T765
D
R
L
L
A
E
E
T
A
A
T
I
S
A
I
Site 96
S790
M
E
R
E
L
E
K
S
Q
R
S
Q
I
S
S
Site 97
S793
E
L
E
K
S
Q
R
S
Q
I
S
S
V
N
S
Site 98
S796
K
S
Q
R
S
Q
I
S
S
V
N
S
D
V
E
Site 99
S797
S
Q
R
S
Q
I
S
S
V
N
S
D
V
E
A
Site 100
S800
S
Q
I
S
S
V
N
S
D
V
E
A
L
R
R
Site 101
Y809
V
E
A
L
R
R
Q
Y
L
E
E
L
Q
S
V
Site 102
S815
Q
Y
L
E
E
L
Q
S
V
Q
R
E
L
E
V
Site 103
S824
Q
R
E
L
E
V
L
S
E
Q
Y
S
Q
K
C
Site 104
S828
E
V
L
S
E
Q
Y
S
Q
K
C
L
E
N
A
Site 105
T878
A
E
I
T
R
L
R
T
L
L
T
G
D
G
G
Site 106
T881
T
R
L
R
T
L
L
T
G
D
G
G
G
E
A
Site 107
T889
G
D
G
G
G
E
A
T
G
S
P
L
A
Q
G
Site 108
S891
G
G
G
E
A
T
G
S
P
L
A
Q
G
K
D
Site 109
Y900
L
A
Q
G
K
D
A
Y
E
L
E
V
L
L
R
Site 110
S911
V
L
L
R
V
K
E
S
E
I
Q
Y
L
K
Q
Site 111
Y915
V
K
E
S
E
I
Q
Y
L
K
Q
E
I
S
S
Site 112
S921
Q
Y
L
K
Q
E
I
S
S
L
K
D
E
L
Q
Site 113
S922
Y
L
K
Q
E
I
S
S
L
K
D
E
L
Q
T
Site 114
Y936
T
A
L
R
D
K
K
Y
A
S
D
K
Y
K
D
Site 115
S938
L
R
D
K
K
Y
A
S
D
K
Y
K
D
I
Y
Site 116
Y941
K
K
Y
A
S
D
K
Y
K
D
I
Y
T
E
L
Site 117
Y945
S
D
K
Y
K
D
I
Y
T
E
L
S
I
A
K
Site 118
T946
D
K
Y
K
D
I
Y
T
E
L
S
I
A
K
A
Site 119
S960
A
K
A
D
C
D
I
S
R
L
K
E
Q
L
K
Site 120
S977
T
E
A
L
G
E
K
S
P
D
S
A
T
V
S
Site 121
S980
L
G
E
K
S
P
D
S
A
T
V
S
G
Y
D
Site 122
T982
E
K
S
P
D
S
A
T
V
S
G
Y
D
I
M
Site 123
S984
S
P
D
S
A
T
V
S
G
Y
D
I
M
K
S
Site 124
Y986
D
S
A
T
V
S
G
Y
D
I
M
K
S
K
S
Site 125
S991
S
G
Y
D
I
M
K
S
K
S
N
P
D
F
L
Site 126
S993
Y
D
I
M
K
S
K
S
N
P
D
F
L
K
K
Site 127
S1003
D
F
L
K
K
D
R
S
C
V
T
R
Q
L
R
Site 128
S1014
R
Q
L
R
N
I
R
S
K
S
V
I
E
Q
V
Site 129
S1016
L
R
N
I
R
S
K
S
V
I
E
Q
V
S
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation