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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IGSF10
Full Name:
Immunoglobulin superfamily member 10
Alias:
Calvaria mechanical force protein 608; CMF608; FLJ25972; IGS10; Immunoglobulin superfamily 10; Immunoglobulin superfamily, member 10
Type:
Mass (Da):
290840
Number AA:
UniProt ID:
Q6WRI0
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0001503
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y47
E
V
H
C
T
F
R
Y
L
T
S
I
P
D
S
Site 2
T49
H
C
T
F
R
Y
L
T
S
I
P
D
S
I
P
Site 3
S50
C
T
F
R
Y
L
T
S
I
P
D
S
I
P
P
Site 4
S54
Y
L
T
S
I
P
D
S
I
P
P
N
V
E
R
Site 5
S68
R
I
N
L
G
Y
N
S
L
V
R
L
M
E
T
Site 6
S78
R
L
M
E
T
D
F
S
G
L
T
K
L
E
L
Site 7
T100
I
H
T
I
P
D
K
T
F
S
D
L
Q
A
L
Site 8
T124
V
R
K
L
Q
K
D
T
F
Y
G
L
R
S
L
Site 9
Y126
K
L
Q
K
D
T
F
Y
G
L
R
S
L
T
R
Site 10
S130
D
T
F
Y
G
L
R
S
L
T
R
L
H
M
D
Site 11
T132
F
Y
G
L
R
S
L
T
R
L
H
M
D
H
N
Site 12
S199
L
S
D
N
F
L
T
S
L
P
Q
E
M
V
S
Site 13
S206
S
L
P
Q
E
M
V
S
Y
M
P
D
L
D
S
Site 14
Y207
L
P
Q
E
M
V
S
Y
M
P
D
L
D
S
L
Site 15
S213
S
Y
M
P
D
L
D
S
L
Y
L
H
G
N
P
Site 16
Y215
M
P
D
L
D
S
L
Y
L
H
G
N
P
W
T
Site 17
S248
I
K
C
K
K
D
R
S
P
S
S
A
Q
Q
C
Site 18
S250
C
K
K
D
R
S
P
S
S
A
Q
Q
C
P
L
Site 19
S251
K
K
D
R
S
P
S
S
A
Q
Q
C
P
L
C
Site 20
T263
P
L
C
M
N
P
R
T
S
K
G
K
P
L
A
Site 21
S264
L
C
M
N
P
R
T
S
K
G
K
P
L
A
M
Site 22
T283
A
F
Q
C
A
K
P
T
I
D
S
S
L
K
S
Site 23
S286
C
A
K
P
T
I
D
S
S
L
K
S
K
S
L
Site 24
S287
A
K
P
T
I
D
S
S
L
K
S
K
S
L
T
Site 25
S290
T
I
D
S
S
L
K
S
K
S
L
T
I
L
E
Site 26
S292
D
S
S
L
K
S
K
S
L
T
I
L
E
D
S
Site 27
T294
S
L
K
S
K
S
L
T
I
L
E
D
S
S
S
Site 28
S301
T
I
L
E
D
S
S
S
A
F
I
S
P
Q
G
Site 29
S305
D
S
S
S
A
F
I
S
P
Q
G
F
M
A
P
Site 30
T317
M
A
P
F
G
S
L
T
L
N
M
T
D
Q
S
Site 31
T321
G
S
L
T
L
N
M
T
D
Q
S
G
N
E
A
Site 32
S341
I
Q
K
P
S
R
T
S
P
I
A
F
T
E
E
Site 33
Y351
A
F
T
E
E
N
D
Y
I
V
L
N
T
S
F
Site 34
S391
S
P
L
I
L
E
R
S
H
L
L
S
E
T
P
Site 35
S395
L
E
R
S
H
L
L
S
E
T
P
Q
L
Y
Y
Site 36
T397
R
S
H
L
L
S
E
T
P
Q
L
Y
Y
K
Y
Site 37
Y401
L
S
E
T
P
Q
L
Y
Y
K
Y
K
Q
V
A
Site 38
Y404
T
P
Q
L
Y
Y
K
Y
K
Q
V
A
P
K
P
Site 39
T416
P
K
P
E
D
I
F
T
N
I
E
A
D
L
R
Site 40
S427
A
D
L
R
A
D
P
S
W
L
M
Q
D
Q
I
Site 41
T444
Q
L
N
R
T
A
T
T
F
S
T
L
Q
I
Q
Site 42
T447
R
T
A
T
T
F
S
T
L
Q
I
Q
Y
S
S
Site 43
S453
S
T
L
Q
I
Q
Y
S
S
D
A
Q
I
T
L
Site 44
T486
N
N
T
K
L
E
H
T
V
L
V
G
G
T
V
Site 45
T504
C
P
G
Q
G
D
P
T
P
H
V
D
W
L
L
Site 46
S515
D
W
L
L
A
D
G
S
K
V
R
A
P
Y
V
Site 47
Y521
G
S
K
V
R
A
P
Y
V
S
E
D
G
R
I
Site 48
S523
K
V
R
A
P
Y
V
S
E
D
G
R
I
L
I
Site 49
S533
G
R
I
L
I
D
K
S
G
K
L
E
L
Q
M
Site 50
S543
L
E
L
Q
M
A
D
S
F
D
T
G
V
Y
H
Site 51
Y549
D
S
F
D
T
G
V
Y
H
C
I
S
S
N
Y
Site 52
T563
Y
D
D
A
D
I
L
T
Y
R
I
T
V
V
E
Site 53
Y576
V
E
P
L
V
E
A
Y
Q
E
N
G
I
H
H
Site 54
T584
Q
E
N
G
I
H
H
T
V
F
I
G
E
T
L
Site 55
Y616
I
P
G
N
N
V
L
Y
Q
S
S
R
D
K
K
Site 56
S618
G
N
N
V
L
Y
Q
S
S
R
D
K
K
V
L
Site 57
T636
T
L
R
I
L
Q
V
T
P
K
D
Q
G
Y
Y
Site 58
Y642
V
T
P
K
D
Q
G
Y
Y
R
C
V
A
A
N
Site 59
S661
D
F
L
I
F
Q
V
S
V
K
M
K
G
Q
R
Site 60
T676
P
L
E
H
D
G
E
T
E
G
S
G
L
D
E
Site 61
S679
H
D
G
E
T
E
G
S
G
L
D
E
S
N
P
Site 62
S684
E
G
S
G
L
D
E
S
N
P
I
A
H
L
K
Site 63
S701
P
G
A
Q
L
R
T
S
A
L
M
E
A
E
V
Site 64
S713
A
E
V
G
K
H
T
S
S
T
S
K
R
H
N
Site 65
S714
E
V
G
K
H
T
S
S
T
S
K
R
H
N
Y
Site 66
S716
G
K
H
T
S
S
T
S
K
R
H
N
Y
R
E
Site 67
Y721
S
T
S
K
R
H
N
Y
R
E
L
T
L
Q
R
Site 68
T725
R
H
N
Y
R
E
L
T
L
Q
R
R
G
D
S
Site 69
S732
T
L
Q
R
R
G
D
S
T
H
R
R
F
R
E
Site 70
T733
L
Q
R
R
G
D
S
T
H
R
R
F
R
E
N
Site 71
S747
N
R
R
H
F
P
P
S
A
R
R
I
D
P
Q
Site 72
T775
M
P
D
K
R
E
N
T
T
V
S
P
P
P
V
Site 73
T776
P
D
K
R
E
N
T
T
V
S
P
P
P
V
V
Site 74
S778
K
R
E
N
T
T
V
S
P
P
P
V
V
T
Q
Site 75
S796
I
P
G
E
E
D
D
S
S
G
M
L
A
L
H
Site 76
S797
P
G
E
E
D
D
S
S
G
M
L
A
L
H
E
Site 77
T822
N
L
P
A
R
T
V
T
A
D
S
R
T
I
S
Site 78
S825
A
R
T
V
T
A
D
S
R
T
I
S
D
S
P
Site 79
T827
T
V
T
A
D
S
R
T
I
S
D
S
P
M
T
Site 80
S829
T
A
D
S
R
T
I
S
D
S
P
M
T
N
I
Site 81
S831
D
S
R
T
I
S
D
S
P
M
T
N
I
N
Y
Site 82
Y838
S
P
M
T
N
I
N
Y
G
T
E
F
S
P
V
Site 83
S843
I
N
Y
G
T
E
F
S
P
V
V
N
S
Q
I
Site 84
S848
E
F
S
P
V
V
N
S
Q
I
L
P
P
E
E
Site 85
S862
E
P
T
D
F
K
L
S
T
A
I
K
T
T
A
Site 86
T867
K
L
S
T
A
I
K
T
T
A
M
S
K
N
I
Site 87
S880
N
I
N
P
T
M
S
S
Q
I
Q
G
T
T
N
Site 88
T886
S
S
Q
I
Q
G
T
T
N
Q
H
S
S
T
V
Site 89
S906
G
A
T
E
F
Q
D
S
D
Q
M
G
R
G
R
Site 90
S918
R
G
R
E
H
F
Q
S
R
P
P
I
T
V
R
Site 91
T923
F
Q
S
R
P
P
I
T
V
R
T
M
I
K
D
Site 92
S947
T
N
K
L
L
L
E
S
V
N
T
T
N
S
H
Site 93
T950
L
L
L
E
S
V
N
T
T
N
S
H
Q
T
S
Site 94
T951
L
L
E
S
V
N
T
T
N
S
H
Q
T
S
V
Site 95
S953
E
S
V
N
T
T
N
S
H
Q
T
S
V
R
E
Site 96
S957
T
T
N
S
H
Q
T
S
V
R
E
V
S
E
P
Site 97
S962
Q
T
S
V
R
E
V
S
E
P
R
H
N
H
F
Site 98
Y970
E
P
R
H
N
H
F
Y
S
H
T
T
Q
I
L
Site 99
S978
S
H
T
T
Q
I
L
S
T
S
T
F
P
S
D
Site 100
S980
T
T
Q
I
L
S
T
S
T
F
P
S
D
P
H
Site 101
T981
T
Q
I
L
S
T
S
T
F
P
S
D
P
H
T
Site 102
S984
L
S
T
S
T
F
P
S
D
P
H
T
A
A
H
Site 103
T988
T
F
P
S
D
P
H
T
A
A
H
S
Q
F
P
Site 104
S992
D
P
H
T
A
A
H
S
Q
F
P
I
P
R
N
Site 105
S1000
Q
F
P
I
P
R
N
S
T
V
N
I
P
L
F
Site 106
T1001
F
P
I
P
R
N
S
T
V
N
I
P
L
F
R
Site 107
S1024
G
G
R
G
R
I
I
S
P
Y
R
T
P
V
L
Site 108
Y1026
R
G
R
I
I
S
P
Y
R
T
P
V
L
R
R
Site 109
T1028
R
I
I
S
P
Y
R
T
P
V
L
R
R
H
R
Site 110
Y1036
P
V
L
R
R
H
R
Y
S
I
F
R
S
T
T
Site 111
S1037
V
L
R
R
H
R
Y
S
I
F
R
S
T
T
R
Site 112
S1041
H
R
Y
S
I
F
R
S
T
T
R
G
S
S
E
Site 113
T1042
R
Y
S
I
F
R
S
T
T
R
G
S
S
E
K
Site 114
T1043
Y
S
I
F
R
S
T
T
R
G
S
S
E
K
S
Site 115
S1046
F
R
S
T
T
R
G
S
S
E
K
S
T
T
A
Site 116
S1047
R
S
T
T
R
G
S
S
E
K
S
T
T
A
F
Site 117
S1050
T
R
G
S
S
E
K
S
T
T
A
F
S
A
T
Site 118
T1051
R
G
S
S
E
K
S
T
T
A
F
S
A
T
V
Site 119
T1052
G
S
S
E
K
S
T
T
A
F
S
A
T
V
L
Site 120
T1076
R
E
R
L
T
T
A
T
A
A
L
S
F
P
S
Site 121
S1099
A
D
I
A
R
V
P
S
E
E
S
T
T
L
V
Site 122
T1103
R
V
P
S
E
E
S
T
T
L
V
Q
N
P
L
Site 123
T1104
V
P
S
E
E
S
T
T
L
V
Q
N
P
L
L
Site 124
S1118
L
L
L
E
N
K
P
S
V
E
K
T
T
P
T
Site 125
T1122
N
K
P
S
V
E
K
T
T
P
T
I
K
Y
F
Site 126
T1123
K
P
S
V
E
K
T
T
P
T
I
K
Y
F
R
Site 127
Y1128
K
T
T
P
T
I
K
Y
F
R
T
E
I
S
Q
Site 128
S1134
K
Y
F
R
T
E
I
S
Q
V
T
P
T
G
A
Site 129
T1137
R
T
E
I
S
Q
V
T
P
T
G
A
V
M
T
Site 130
T1155
T
S
I
P
M
E
K
T
H
K
V
N
A
S
Y
Site 131
S1161
K
T
H
K
V
N
A
S
Y
P
R
V
S
S
T
Site 132
Y1162
T
H
K
V
N
A
S
Y
P
R
V
S
S
T
N
Site 133
S1166
N
A
S
Y
P
R
V
S
S
T
N
E
A
K
R
Site 134
S1167
A
S
Y
P
R
V
S
S
T
N
E
A
K
R
D
Site 135
S1175
T
N
E
A
K
R
D
S
V
I
T
S
S
L
S
Site 136
S1179
K
R
D
S
V
I
T
S
S
L
S
G
A
I
T
Site 137
S1180
R
D
S
V
I
T
S
S
L
S
G
A
I
T
K
Site 138
T1191
A
I
T
K
P
P
M
T
I
I
A
I
T
R
F
Site 139
S1226
L
R
N
Q
H
K
V
S
L
Q
K
S
T
A
V
Site 140
S1230
H
K
V
S
L
Q
K
S
T
A
V
M
L
P
K
Site 141
T1238
T
A
V
M
L
P
K
T
S
P
A
L
P
R
D
Site 142
S1239
A
V
M
L
P
K
T
S
P
A
L
P
R
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T
L
V
I
Q
N
P
Q
Site 295
T2597
L
V
I
Q
N
P
Q
T
S
D
S
G
I
Y
K
Site 296
S2600
Q
N
P
Q
T
S
D
S
G
I
Y
K
C
T
A
Site 297
Y2603
Q
T
S
D
S
G
I
Y
K
C
T
A
K
N
P
Site 298
S2613
T
A
K
N
P
L
G
S
D
Y
A
A
T
Y
I
Site 299
Y2615
K
N
P
L
G
S
D
Y
A
A
T
Y
I
Q
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation