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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FBXW12
Full Name:
F-box/WD repeat-containing protein 12
Alias:
F-box and WD repeat domain containing 12; F-box and WD-40 domain-containing protein 12; F-box only protein 35; FBW12; FBXO35
Type:
Uncharacterized protein
Mass (Da):
53056
Number AA:
464
UniProt ID:
Q6X9E4
International Prot ID:
IPI00410182
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y40
N
R
I
A
D
S
D
Y
L
W
R
S
L
S
L
Site 2
S44
D
S
D
Y
L
W
R
S
L
S
L
Q
R
W
D
Site 3
S46
D
Y
L
W
R
S
L
S
L
Q
R
W
D
C
S
Site 4
Y89
A
Q
P
H
N
F
I
Y
K
V
T
K
N
I
A
Site 5
Y103
A
F
E
T
E
L
A
Y
L
S
G
N
R
L
T
Site 6
S105
E
T
E
L
A
Y
L
S
G
N
R
L
T
V
D
Site 7
T110
Y
L
S
G
N
R
L
T
V
D
E
Q
E
K
S
Site 8
S117
T
V
D
E
Q
E
K
S
I
I
C
S
V
S
P
Site 9
S121
Q
E
K
S
I
I
C
S
V
S
P
K
Q
E
L
Site 10
S150
P
V
Q
E
F
H
F
S
N
L
V
T
L
P
Q
Site 11
T154
F
H
F
S
N
L
V
T
L
P
Q
M
H
L
A
Site 12
Y196
P
C
Y
C
M
E
A
Y
L
T
K
D
G
P
F
Site 13
S225
L
P
G
L
R
D
V
S
K
V
T
A
F
Q
Y
Site 14
S264
P
Q
V
F
L
T
E
S
L
L
R
P
S
E
G
Site 15
S269
T
E
S
L
L
R
P
S
E
G
S
V
P
L
S
Site 16
S276
S
E
G
S
V
P
L
S
T
F
L
P
H
K
L
Site 17
T290
L
C
A
S
A
C
W
T
P
K
V
K
N
R
I
Site 18
T298
P
K
V
K
N
R
I
T
L
M
S
Q
S
S
T
Site 19
S301
K
N
R
I
T
L
M
S
Q
S
S
T
G
K
K
Site 20
S303
R
I
T
L
M
S
Q
S
S
T
G
K
K
T
E
Site 21
S304
I
T
L
M
S
Q
S
S
T
G
K
K
T
E
F
Site 22
T305
T
L
M
S
Q
S
S
T
G
K
K
T
E
F
I
Site 23
T313
G
K
K
T
E
F
I
T
F
D
L
T
T
K
K
Site 24
T317
E
F
I
T
F
D
L
T
T
K
K
T
G
G
Q
Site 25
Y392
N
F
W
V
D
P
C
Y
V
L
T
T
S
E
N
Site 26
T395
V
D
P
C
Y
V
L
T
T
S
E
N
S
V
H
Site 27
T396
D
P
C
Y
V
L
T
T
S
E
N
S
V
H
V
Site 28
Y404
S
E
N
S
V
H
V
Y
M
W
E
E
G
G
R
Site 29
Y414
E
E
G
G
R
H
P
Y
L
R
S
C
C
H
L
Site 30
T429
E
N
T
W
H
D
H
T
T
D
S
C
I
S
S
Site 31
S436
T
T
D
S
C
I
S
S
V
M
C
D
N
A
S
Site 32
S454
R
V
R
K
V
S
D
S
S
I
L
V
M
Y
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation