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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TPTE2
Full Name:
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2
Alias:
Lipid phosphatase TPIP;TPTE and PTEN homologous inositol lipid phosphatase
Type:
Mass (Da):
61112
Number AA:
522
UniProt ID:
Q6XPS3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
N
E
S
P
Q
T
N
E
F
K
G
T
T
Site 2
T13
Q
T
N
E
F
K
G
T
T
E
E
A
P
A
K
Site 3
S22
E
E
A
P
A
K
E
S
P
H
T
S
E
F
K
Site 4
T25
P
A
K
E
S
P
H
T
S
E
F
K
G
A
A
Site 5
S26
A
K
E
S
P
H
T
S
E
F
K
G
A
A
L
Site 6
S40
L
V
S
P
I
S
K
S
M
L
E
R
L
S
K
Site 7
S46
K
S
M
L
E
R
L
S
K
F
E
V
E
D
A
Site 8
Y135
F
V
E
G
R
Q
Q
Y
F
S
D
L
F
N
I
Site 9
S137
E
G
R
Q
Q
Y
F
S
D
L
F
N
I
L
D
Site 10
T173
L
R
N
I
P
R
W
T
H
L
V
R
L
L
R
Site 11
S206
K
L
M
R
R
L
V
S
E
N
K
R
R
Y
T
Site 12
Y212
V
S
E
N
K
R
R
Y
T
R
D
G
F
D
L
Site 13
T213
S
E
N
K
R
R
Y
T
R
D
G
F
D
L
D
Site 14
S232
T
E
R
I
I
A
M
S
F
P
S
S
G
R
Q
Site 15
S236
I
A
M
S
F
P
S
S
G
R
Q
S
F
Y
R
Site 16
S240
F
P
S
S
G
R
Q
S
F
Y
R
N
P
I
E
Site 17
Y242
S
S
G
R
Q
S
F
Y
R
N
P
I
E
E
V
Site 18
Y261
D
K
K
H
R
N
H
Y
R
V
Y
N
L
C
S
Site 19
Y264
H
R
N
H
Y
R
V
Y
N
L
C
S
E
R
A
Site 20
Y272
N
L
C
S
E
R
A
Y
D
P
K
H
F
H
N
Site 21
S347
I
F
L
T
A
E
E
S
L
Y
Y
F
G
E
R
Site 22
Y349
L
T
A
E
E
S
L
Y
Y
F
G
E
R
R
T
Site 23
Y350
T
A
E
E
S
L
Y
Y
F
G
E
R
R
T
N
Site 24
T359
G
E
R
R
T
N
K
T
H
S
N
K
F
Q
G
Site 25
T369
N
K
F
Q
G
V
E
T
P
S
Q
N
R
Y
V
Site 26
S371
F
Q
G
V
E
T
P
S
Q
N
R
Y
V
G
Y
Site 27
Y375
E
T
P
S
Q
N
R
Y
V
G
Y
F
A
Q
V
Site 28
Y378
S
Q
N
R
Y
V
G
Y
F
A
Q
V
K
H
L
Site 29
Y386
F
A
Q
V
K
H
L
Y
N
W
N
L
P
P
R
Site 30
Y404
F
I
K
R
F
I
I
Y
S
I
R
G
D
V
C
Site 31
S427
E
K
K
V
V
F
S
S
T
S
L
G
N
C
S
Site 32
Y449
D
K
I
L
I
N
V
Y
D
G
P
P
L
Y
D
Site 33
Y455
V
Y
D
G
P
P
L
Y
D
D
V
K
V
Q
F
Site 34
S465
V
K
V
Q
F
F
S
S
N
L
P
K
Y
Y
D
Site 35
Y470
F
S
S
N
L
P
K
Y
Y
D
N
C
P
F
F
Site 36
Y471
S
S
N
L
P
K
Y
Y
D
N
C
P
F
F
F
Site 37
Y509
K
Q
K
A
W
K
I
Y
P
P
E
F
A
V
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation