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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GIGYF2
Full Name:
PERQ amino acid-rich with GYF domain-containing protein 2
Alias:
GFY2; Grb10-interacting GYF 2; GRB10-interacting GYF protein 2; KIAA0642; PERQ2; Trinucleotide repeat-containing 15
Type:
Unknown function
Mass (Da):
150070
Number AA:
1299
UniProt ID:
Q6Y7W6
International Prot ID:
IPI00784233
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
P
E
W
L
R
A
L
S
S
G
G
S
I
T
S
Site 2
S20
E
W
L
R
A
L
S
S
G
G
S
I
T
S
P
Site 3
S23
R
A
L
S
S
G
G
S
I
T
S
P
P
L
S
Site 4
T25
L
S
S
G
G
S
I
T
S
P
P
L
S
P
A
Site 5
S26
S
S
G
G
S
I
T
S
P
P
L
S
P
A
L
Site 6
S30
S
I
T
S
P
P
L
S
P
A
L
P
K
Y
K
Site 7
Y36
L
S
P
A
L
P
K
Y
K
L
A
D
Y
R
Y
Site 8
Y41
P
K
Y
K
L
A
D
Y
R
Y
G
R
E
E
M
Site 9
Y43
Y
K
L
A
D
Y
R
Y
G
R
E
E
M
L
A
Site 10
S60
L
K
D
N
K
I
P
S
D
L
L
D
K
E
F
Site 11
T85
P
L
A
L
V
P
F
T
E
E
E
Q
R
N
F
Site 12
S93
E
E
E
Q
R
N
F
S
M
S
V
N
S
A
A
Site 13
S95
E
Q
R
N
F
S
M
S
V
N
S
A
A
V
L
Site 14
T112
T
G
R
G
G
G
G
T
V
V
G
A
P
R
G
Site 15
S121
V
G
A
P
R
G
R
S
S
S
R
G
R
G
R
Site 16
S122
G
A
P
R
G
R
S
S
S
R
G
R
G
R
G
Site 17
S123
A
P
R
G
R
S
S
S
R
G
R
G
R
G
R
Site 18
Y136
G
R
G
E
C
G
F
Y
Q
R
S
F
D
E
V
Site 19
S139
E
C
G
F
Y
Q
R
S
F
D
E
V
E
G
V
Site 20
S158
G
G
R
E
M
H
R
S
Q
S
W
E
E
R
G
Site 21
S160
R
E
M
H
R
S
Q
S
W
E
E
R
G
D
R
Site 22
T188
N
F
E
E
G
G
P
T
S
V
G
R
K
H
E
Site 23
S189
F
E
E
G
G
P
T
S
V
G
R
K
H
E
F
Site 24
S199
R
K
H
E
F
I
R
S
E
S
E
N
W
R
I
Site 25
S201
H
E
F
I
R
S
E
S
E
N
W
R
I
F
R
Site 26
S225
G
G
W
R
L
A
G
S
R
R
D
G
E
R
W
Site 27
S236
G
E
R
W
R
P
H
S
P
D
G
P
R
S
A
Site 28
S242
H
S
P
D
G
P
R
S
A
G
W
R
E
H
M
Site 29
Y268
D
R
D
D
E
R
G
Y
R
R
V
R
S
G
S
Site 30
S273
R
G
Y
R
R
V
R
S
G
S
G
S
I
D
D
Site 31
S275
Y
R
R
V
R
S
G
S
G
S
I
D
D
D
R
Site 32
S277
R
V
R
S
G
S
G
S
I
D
D
D
R
D
S
Site 33
S284
S
I
D
D
D
R
D
S
L
P
E
W
C
L
E
Site 34
T299
D
A
E
E
E
M
G
T
F
D
S
S
G
A
F
Site 35
S302
E
E
M
G
T
F
D
S
S
G
A
F
L
S
L
Site 36
S303
E
M
G
T
F
D
S
S
G
A
F
L
S
L
K
Site 37
S308
D
S
S
G
A
F
L
S
L
K
K
V
Q
K
E
Site 38
S335
V
D
E
G
E
E
C
S
D
S
E
G
S
H
N
Site 39
S337
E
G
E
E
C
S
D
S
E
G
S
H
N
E
E
Site 40
T351
E
A
K
E
P
D
K
T
N
K
K
E
G
E
K
Site 41
T359
N
K
K
E
G
E
K
T
D
R
V
G
V
E
A
Site 42
T370
G
V
E
A
S
E
E
T
P
Q
T
S
S
S
S
Site 43
T373
A
S
E
E
T
P
Q
T
S
S
S
S
A
R
P
Site 44
S374
S
E
E
T
P
Q
T
S
S
S
S
A
R
P
G
Site 45
S376
E
T
P
Q
T
S
S
S
S
A
R
P
G
T
P
Site 46
S377
T
P
Q
T
S
S
S
S
A
R
P
G
T
P
S
Site 47
T382
S
S
S
A
R
P
G
T
P
S
D
H
Q
S
Q
Site 48
S384
S
A
R
P
G
T
P
S
D
H
Q
S
Q
E
A
Site 49
S388
G
T
P
S
D
H
Q
S
Q
E
A
S
Q
F
E
Site 50
S392
D
H
Q
S
Q
E
A
S
Q
F
E
R
K
D
E
Site 51
S438
A
D
V
Q
Q
P
L
S
Q
I
P
S
D
T
A
Site 52
S442
Q
P
L
S
Q
I
P
S
D
T
A
S
P
L
L
Site 53
S459
P
P
P
V
P
N
P
S
P
T
L
R
P
V
E
Site 54
T461
P
V
P
N
P
S
P
T
L
R
P
V
E
T
P
Site 55
S477
V
G
A
P
G
M
G
S
V
S
T
E
P
D
D
Site 56
S479
A
P
G
M
G
S
V
S
T
E
P
D
D
E
E
Site 57
Y501
Q
A
E
K
M
V
A
Y
L
Q
D
S
A
L
D
Site 58
S514
L
D
D
E
R
L
A
S
K
L
Q
E
H
R
A
Site 59
S525
E
H
R
A
K
G
V
S
I
P
L
M
H
E
A
Site 60
Y538
E
A
M
Q
K
W
Y
Y
K
D
P
Q
G
E
I
Site 61
S576
V
K
R
A
C
D
E
S
F
Q
P
L
G
D
I
Site 62
S593
M
W
G
R
V
P
F
S
P
G
P
A
P
P
P
Site 63
T611
E
L
D
Q
E
R
L
T
R
Q
Q
E
L
T
A
Site 64
T617
L
T
R
Q
Q
E
L
T
A
L
Y
Q
M
Q
H
Site 65
Y620
Q
Q
E
L
T
A
L
Y
Q
M
Q
H
L
Q
Y
Site 66
Y636
Q
F
L
I
Q
Q
Q
Y
A
Q
V
L
A
Q
Q
Site 67
S650
Q
Q
K
A
A
L
S
S
Q
Q
Q
Q
Q
L
A
Site 68
T665
L
L
L
Q
Q
F
Q
T
L
K
M
R
I
S
D
Site 69
S671
Q
T
L
K
M
R
I
S
D
Q
N
I
I
P
S
Site 70
S678
S
D
Q
N
I
I
P
S
V
T
R
S
V
S
V
Site 71
T680
Q
N
I
I
P
S
V
T
R
S
V
S
V
P
D
Site 72
S684
P
S
V
T
R
S
V
S
V
P
D
T
G
S
I
Site 73
T688
R
S
V
S
V
P
D
T
G
S
I
W
E
L
Q
Site 74
T697
S
I
W
E
L
Q
P
T
A
S
Q
P
T
V
W
Site 75
S699
W
E
L
Q
P
T
A
S
Q
P
T
V
W
E
G
Site 76
T702
Q
P
T
A
S
Q
P
T
V
W
E
G
G
S
V
Site 77
S708
P
T
V
W
E
G
G
S
V
W
D
L
P
L
D
Site 78
T718
D
L
P
L
D
T
T
T
P
G
P
A
L
E
Q
Site 79
S925
L
A
Q
M
K
L
P
S
S
S
T
W
G
Q
Q
Site 80
S926
A
Q
M
K
L
P
S
S
S
T
W
G
Q
Q
S
Site 81
S927
Q
M
K
L
P
S
S
S
T
W
G
Q
Q
S
N
Site 82
S933
S
S
T
W
G
Q
Q
S
N
T
T
A
C
Q
S
Site 83
T936
W
G
Q
Q
S
N
T
T
A
C
Q
S
Q
A
T
Site 84
S940
S
N
T
T
A
C
Q
S
Q
A
T
L
S
L
A
Site 85
S945
C
Q
S
Q
A
T
L
S
L
A
E
I
Q
K
L
Site 86
S993
L
S
G
W
G
N
V
S
K
P
S
G
T
T
K
Site 87
S996
W
G
N
V
S
K
P
S
G
T
T
K
S
L
L
Site 88
S1001
K
P
S
G
T
T
K
S
L
L
E
I
Q
Q
E
Site 89
T1033
P
N
R
A
R
N
N
T
H
S
N
L
H
T
S
Site 90
S1035
R
A
R
N
N
T
H
S
N
L
H
T
S
I
G
Site 91
T1039
N
T
H
S
N
L
H
T
S
I
G
N
S
V
W
Site 92
S1040
T
H
S
N
L
H
T
S
I
G
N
S
V
W
G
Site 93
S1044
L
H
T
S
I
G
N
S
V
W
G
S
I
N
T
Site 94
S1048
I
G
N
S
V
W
G
S
I
N
T
G
P
P
N
Site 95
S1059
G
P
P
N
Q
W
A
S
D
L
V
S
S
I
W
Site 96
S1063
Q
W
A
S
D
L
V
S
S
I
W
S
N
A
D
Site 97
S1067
D
L
V
S
S
I
W
S
N
A
D
T
K
N
S
Site 98
S1091
K
E
V
G
P
R
N
S
T
N
K
N
K
N
N
Site 99
T1092
E
V
G
P
R
N
S
T
N
K
N
K
N
N
A
Site 100
S1100
N
K
N
K
N
N
A
S
L
S
K
S
V
G
V
Site 101
S1102
N
K
N
N
A
S
L
S
K
S
V
G
V
S
N
Site 102
S1104
N
N
A
S
L
S
K
S
V
G
V
S
N
R
Q
Site 103
S1108
L
S
K
S
V
G
V
S
N
R
Q
N
K
K
V
Site 104
S1166
S
F
L
K
E
V
E
S
P
Y
E
V
H
D
Y
Site 105
Y1168
L
K
E
V
E
S
P
Y
E
V
H
D
Y
I
R
Site 106
Y1173
S
P
Y
E
V
H
D
Y
I
R
A
Y
L
G
D
Site 107
Y1177
V
H
D
Y
I
R
A
Y
L
G
D
T
S
E
A
Site 108
S1182
R
A
Y
L
G
D
T
S
E
A
K
E
F
A
K
Site 109
S1241
M
N
H
S
T
L
H
S
V
F
Q
T
N
Q
S
Site 110
T1245
T
L
H
S
V
F
Q
T
N
Q
S
N
N
Q
Q
Site 111
S1260
S
N
F
E
A
V
Q
S
G
K
K
K
K
K
Q
Site 112
S1275
K
M
V
R
A
D
P
S
L
L
G
F
S
V
N
Site 113
S1280
D
P
S
L
L
G
F
S
V
N
A
S
S
E
R
Site 114
S1284
L
G
F
S
V
N
A
S
S
E
R
L
N
M
G
Site 115
S1285
G
F
S
V
N
A
S
S
E
R
L
N
M
G
E
Site 116
Y1299
E
I
E
T
L
D
D
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation