KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
CD109
Full Name:
CD109 antigen
Alias:
150 KDa TGF-beta-1-binding; 150 KDa TGF-beta-1-binding protein; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7; CD109 molecule; CPAMD7; DKFZp762L1111; FLJ38569; FLJ41966; P180; Platelet-specific Gov; Platelet-specific Gov antigen; R150; RP11-525G3.1
Type:
Mass (Da):
161671
Number AA:
1445
UniProt ID:
Q6YHK3
International Prot ID:
IPI00152540
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031225
GO:0005615
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004867
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T31
P
G
P
R
F
L
V
T
A
P
G
I
I
R
P
Site 2
S54
E
L
L
E
H
C
P
S
Q
V
T
V
K
A
E
Site 3
T57
E
H
C
P
S
Q
V
T
V
K
A
E
L
L
K
Site 4
S84
E
G
V
F
E
K
G
S
F
K
T
L
T
L
P
Site 5
T89
K
G
S
F
K
T
L
T
L
P
S
L
P
L
N
Site 6
Y102
L
N
S
A
D
E
I
Y
E
L
R
V
T
G
R
Site 7
T107
E
I
Y
E
L
R
V
T
G
R
T
Q
D
E
I
Site 8
T110
E
L
R
V
T
G
R
T
Q
D
E
I
L
F
S
Site 9
S117
T
Q
D
E
I
L
F
S
N
S
T
R
L
S
F
Site 10
S119
D
E
I
L
F
S
N
S
T
R
L
S
F
E
T
Site 11
S123
F
S
N
S
T
R
L
S
F
E
T
K
R
I
S
Site 12
T126
S
T
R
L
S
F
E
T
K
R
I
S
V
F
I
Site 13
S130
S
F
E
T
K
R
I
S
V
F
I
Q
T
D
K
Site 14
T162
S
D
F
K
P
Y
K
T
S
L
N
I
L
I
K
Site 15
S163
D
F
K
P
Y
K
T
S
L
N
I
L
I
K
D
Site 16
S181
N
L
I
Q
Q
W
L
S
Q
Q
S
D
L
G
V
Site 17
S190
Q
S
D
L
G
V
I
S
K
T
F
Q
L
S
S
Site 18
T192
D
L
G
V
I
S
K
T
F
Q
L
S
S
H
P
Site 19
S196
I
S
K
T
F
Q
L
S
S
H
P
I
L
G
D
Site 20
S197
S
K
T
F
Q
L
S
S
H
P
I
L
G
D
W
Site 21
Y215
V
Q
V
N
D
Q
T
Y
Y
Q
S
F
Q
V
S
Site 22
Y216
Q
V
N
D
Q
T
Y
Y
Q
S
F
Q
V
S
E
Site 23
Y224
Q
S
F
Q
V
S
E
Y
V
L
P
K
F
E
V
Site 24
T235
K
F
E
V
T
L
Q
T
P
L
Y
C
S
M
N
Site 25
Y238
V
T
L
Q
T
P
L
Y
C
S
M
N
S
K
H
Site 26
T251
K
H
L
N
G
T
I
T
A
K
Y
T
Y
G
K
Site 27
Y254
N
G
T
I
T
A
K
Y
T
Y
G
K
P
V
K
Site 28
Y256
T
I
T
A
K
Y
T
Y
G
K
P
V
K
G
D
Site 29
S272
T
L
T
F
L
P
L
S
F
W
G
K
K
K
N
Site 30
T283
K
K
K
N
I
T
K
T
F
K
I
N
G
S
A
Site 31
S289
K
T
F
K
I
N
G
S
A
N
F
S
F
N
D
Site 32
S293
I
N
G
S
A
N
F
S
F
N
D
E
E
M
K
Site 33
S305
E
M
K
N
V
M
D
S
S
N
G
L
S
E
Y
Site 34
S306
M
K
N
V
M
D
S
S
N
G
L
S
E
Y
L
Site 35
S310
M
D
S
S
N
G
L
S
E
Y
L
D
L
S
S
Site 36
Y312
S
S
N
G
L
S
E
Y
L
D
L
S
S
P
G
Site 37
S316
L
S
E
Y
L
D
L
S
S
P
G
P
V
E
I
Site 38
S317
S
E
Y
L
D
L
S
S
P
G
P
V
E
I
L
Site 39
S335
T
E
S
V
T
G
I
S
R
N
V
S
T
N
V
Site 40
S339
T
G
I
S
R
N
V
S
T
N
V
F
F
K
Q
Site 41
T367
L
K
P
S
L
N
F
T
A
T
V
K
V
T
R
Site 42
T369
P
S
L
N
F
T
A
T
V
K
V
T
R
A
D
Site 43
T381
R
A
D
G
N
Q
L
T
L
E
E
R
R
N
N
Site 44
T392
R
R
N
N
V
V
I
T
V
T
Q
R
N
Y
T
Site 45
T394
N
N
V
V
I
T
V
T
Q
R
N
Y
T
E
Y
Site 46
Y398
I
T
V
T
Q
R
N
Y
T
E
Y
W
S
G
S
Site 47
T399
T
V
T
Q
R
N
Y
T
E
Y
W
S
G
S
N
Site 48
Y401
T
Q
R
N
Y
T
E
Y
W
S
G
S
N
S
G
Site 49
S403
R
N
Y
T
E
Y
W
S
G
S
N
S
G
N
Q
Site 50
S407
E
Y
W
S
G
S
N
S
G
N
Q
K
M
E
A
Site 51
Y420
E
A
V
Q
K
I
N
Y
T
V
P
Q
S
G
T
Site 52
T421
A
V
Q
K
I
N
Y
T
V
P
Q
S
G
T
F
Site 53
S438
E
F
P
I
L
E
D
S
S
E
L
Q
L
K
A
Site 54
S439
F
P
I
L
E
D
S
S
E
L
Q
L
K
A
Y
Site 55
Y446
S
E
L
Q
L
K
A
Y
F
L
G
S
K
S
S
Site 56
S450
L
K
A
Y
F
L
G
S
K
S
S
M
A
V
H
Site 57
S458
K
S
S
M
A
V
H
S
L
F
K
S
P
S
K
Site 58
S462
A
V
H
S
L
F
K
S
P
S
K
T
Y
I
Q
Site 59
S464
H
S
L
F
K
S
P
S
K
T
Y
I
Q
L
K
Site 60
T466
L
F
K
S
P
S
K
T
Y
I
Q
L
K
T
R
Site 61
Y467
F
K
S
P
S
K
T
Y
I
Q
L
K
T
R
D
Site 62
S488
S
P
F
E
L
V
V
S
G
N
K
R
L
K
E
Site 63
S497
N
K
R
L
K
E
L
S
Y
M
V
V
S
R
G
Site 64
Y498
K
R
L
K
E
L
S
Y
M
V
V
S
R
G
Q
Site 65
S518
K
Q
N
S
T
M
F
S
L
T
P
E
N
S
W
Site 66
T520
N
S
T
M
F
S
L
T
P
E
N
S
W
T
P
Site 67
S524
F
S
L
T
P
E
N
S
W
T
P
K
A
C
V
Site 68
Y562
F
K
N
K
I
K
L
Y
W
S
K
V
K
A
E
Site 69
S564
N
K
I
K
L
Y
W
S
K
V
K
A
E
P
S
Site 70
S571
S
K
V
K
A
E
P
S
E
K
V
S
L
R
I
Site 71
S575
A
E
P
S
E
K
V
S
L
R
I
S
V
T
Q
Site 72
S579
E
K
V
S
L
R
I
S
V
T
Q
P
D
S
I
Site 73
S585
I
S
V
T
Q
P
D
S
I
V
G
I
V
A
V
Site 74
T606
M
N
A
S
N
D
I
T
M
E
N
V
V
H
E
Site 75
Y622
E
L
Y
N
T
G
Y
Y
L
G
M
F
M
N
S
Site 76
T642
E
C
G
L
W
V
L
T
D
A
N
L
T
K
D
Site 77
Y650
D
A
N
L
T
K
D
Y
I
D
G
V
Y
D
N
Site 78
Y655
K
D
Y
I
D
G
V
Y
D
N
A
E
Y
A
E
Site 79
Y660
G
V
Y
D
N
A
E
Y
A
E
R
F
M
E
E
Site 80
S683
H
D
F
S
L
G
S
S
P
H
V
R
K
H
F
Site 81
Y706
T
N
M
G
Y
R
I
Y
Q
E
F
E
V
T
V
Site 82
T712
I
Y
Q
E
F
E
V
T
V
P
D
S
I
T
S
Site 83
T802
T
S
N
E
I
N
A
T
G
H
Q
Q
T
L
L
Site 84
T833
H
L
G
E
I
P
I
T
V
T
A
L
S
P
T
Site 85
T840
T
V
T
A
L
S
P
T
A
S
D
A
V
T
Q
Site 86
S859
K
A
E
G
I
E
K
S
Y
S
Q
S
I
L
L
Site 87
S861
E
G
I
E
K
S
Y
S
Q
S
I
L
L
D
L
Site 88
S863
I
E
K
S
Y
S
Q
S
I
L
L
D
L
T
D
Site 89
T869
Q
S
I
L
L
D
L
T
D
N
R
L
Q
S
T
Site 90
S875
L
T
D
N
R
L
Q
S
T
L
K
T
L
S
F
Site 91
T876
T
D
N
R
L
Q
S
T
L
K
T
L
S
F
S
Site 92
T879
R
L
Q
S
T
L
K
T
L
S
F
S
F
P
P
Site 93
S881
Q
S
T
L
K
T
L
S
F
S
F
P
P
N
T
Site 94
T888
S
F
S
F
P
P
N
T
V
T
G
S
E
R
V
Site 95
S892
P
P
N
T
V
T
G
S
E
R
V
Q
I
T
A
Site 96
Y919
A
S
L
I
R
M
P
Y
G
C
G
E
Q
N
M
Site 97
Y938
P
N
I
Y
I
L
D
Y
L
T
K
K
K
Q
L
Site 98
T940
I
Y
I
L
D
Y
L
T
K
K
K
Q
L
T
D
Site 99
T946
L
T
K
K
K
Q
L
T
D
N
L
K
E
K
A
Site 100
S955
N
L
K
E
K
A
L
S
F
M
R
Q
G
Y
Q
Site 101
Y961
L
S
F
M
R
Q
G
Y
Q
R
E
L
L
Y
Q
Site 102
Y967
G
Y
Q
R
E
L
L
Y
Q
R
E
D
G
S
F
Site 103
S973
L
Y
Q
R
E
D
G
S
F
S
A
F
G
N
Y
Site 104
Y980
S
F
S
A
F
G
N
Y
D
P
S
G
S
T
W
Site 105
S983
A
F
G
N
Y
D
P
S
G
S
T
W
L
S
A
Site 106
S985
G
N
Y
D
P
S
G
S
T
W
L
S
A
F
V
Site 107
Y1002
C
F
L
E
A
D
P
Y
I
D
I
D
Q
N
V
Site 108
Y1014
Q
N
V
L
H
R
T
Y
T
W
L
K
G
H
Q
Site 109
T1015
N
V
L
H
R
T
Y
T
W
L
K
G
H
Q
K
Site 110
S1036
D
P
G
R
V
I
H
S
E
L
Q
G
G
N
K
Site 111
S1044
E
L
Q
G
G
N
K
S
P
V
T
L
T
A
Y
Site 112
Y1059
I
V
T
S
L
L
G
Y
R
K
Y
Q
P
N
I
Site 113
Y1062
S
L
L
G
Y
R
K
Y
Q
P
N
I
D
V
Q
Site 114
S1077
E
S
I
H
F
L
E
S
E
F
S
R
G
I
S
Site 115
S1080
H
F
L
E
S
E
F
S
R
G
I
S
D
N
Y
Site 116
S1084
S
E
F
S
R
G
I
S
D
N
Y
T
L
A
L
Site 117
Y1087
S
R
G
I
S
D
N
Y
T
L
A
L
I
T
Y
Site 118
S1101
Y
A
L
S
S
V
G
S
P
K
A
K
E
A
L
Site 119
T1112
K
E
A
L
N
M
L
T
W
R
A
E
Q
E
G
Site 120
S1126
G
G
M
Q
F
W
V
S
S
E
S
K
L
S
D
Site 121
S1127
G
M
Q
F
W
V
S
S
E
S
K
L
S
D
S
Site 122
S1129
Q
F
W
V
S
S
E
S
K
L
S
D
S
W
Q
Site 123
S1132
V
S
S
E
S
K
L
S
D
S
W
Q
P
R
S
Site 124
S1134
S
E
S
K
L
S
D
S
W
Q
P
R
S
L
D
Site 125
S1139
S
D
S
W
Q
P
R
S
L
D
I
E
V
A
A
Site 126
S1169
I
P
I
M
R
W
L
S
R
Q
R
N
S
L
G
Site 127
S1174
W
L
S
R
Q
R
N
S
L
G
G
F
A
S
T
Site 128
S1180
N
S
L
G
G
F
A
S
T
Q
D
T
T
V
A
Site 129
T1208
E
R
T
N
I
Q
V
T
V
T
G
P
S
S
P
Site 130
T1210
T
N
I
Q
V
T
V
T
G
P
S
S
P
S
P
Site 131
S1268
Y
N
V
K
A
S
G
S
S
R
R
R
R
S
I
Site 132
S1269
N
V
K
A
S
G
S
S
R
R
R
R
S
I
Q
Site 133
S1274
G
S
S
R
R
R
R
S
I
Q
N
Q
E
A
F
Site 134
S1304
V
D
L
N
V
C
T
S
F
S
G
P
G
R
S
Site 135
S1306
L
N
V
C
T
S
F
S
G
P
G
R
S
G
M
Site 136
S1332
M
V
P
S
E
A
I
S
L
S
E
T
V
K
K
Site 137
S1334
P
S
E
A
I
S
L
S
E
T
V
K
K
V
E
Site 138
T1336
E
A
I
S
L
S
E
T
V
K
K
V
E
Y
D
Site 139
Y1342
E
T
V
K
K
V
E
Y
D
H
G
K
L
N
L
Site 140
Y1350
D
H
G
K
L
N
L
Y
L
D
S
V
N
E
T
Site 141
S1353
K
L
N
L
Y
L
D
S
V
N
E
T
Q
F
C
Site 142
S1372
A
V
R
N
F
K
V
S
N
T
Q
D
A
S
V
Site 143
T1374
R
N
F
K
V
S
N
T
Q
D
A
S
V
S
I
Site 144
S1378
V
S
N
T
Q
D
A
S
V
S
I
V
D
Y
Y
Site 145
Y1384
A
S
V
S
I
V
D
Y
Y
E
P
R
R
Q
A
Site 146
Y1385
S
V
S
I
V
D
Y
Y
E
P
R
R
Q
A
V
Site 147
S1394
P
R
R
Q
A
V
R
S
Y
N
S
E
V
K
L
Site 148
Y1395
R
R
Q
A
V
R
S
Y
N
S
E
V
K
L
S
Site 149
S1397
Q
A
V
R
S
Y
N
S
E
V
K
L
S
S
C
Site 150
S1402
Y
N
S
E
V
K
L
S
S
C
D
L
C
S
D
Site 151
S1408
L
S
S
C
D
L
C
S
D
V
Q
G
C
R
P
Site 152
S1421
R
P
C
E
D
G
A
S
G
S
H
H
H
S
S
Site 153
S1423
C
E
D
G
A
S
G
S
H
H
H
S
S
V
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation