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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
THADA
Full Name:
Thyroid adenoma-associated protein
Alias:
GITA; KIAA1767
Type:
Uncharacterized protein
Mass (Da):
219607
Number AA:
1953
UniProt ID:
Q6YHU6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
I
C
H
Q
D
L
E
T
L
K
S
F
A
D
V
Site 2
S26
Q
D
L
E
T
L
K
S
F
A
D
V
E
G
K
Site 3
S50
V
Q
L
T
D
G
V
S
Q
I
H
Y
I
K
Q
Site 4
S90
A
G
I
Y
L
S
L
S
L
K
N
P
L
K
K
Site 5
S101
P
L
K
K
V
L
A
S
S
L
N
S
L
P
D
Site 6
T119
P
E
A
M
H
R
F
T
S
R
L
Q
E
E
L
Site 7
S120
E
A
M
H
R
F
T
S
R
L
Q
E
E
L
N
Site 8
T128
R
L
Q
E
E
L
N
T
T
D
L
Y
S
Y
R
Site 9
T129
L
Q
E
E
L
N
T
T
D
L
Y
S
Y
R
K
Site 10
Y132
E
L
N
T
T
D
L
Y
S
Y
R
K
V
T
D
Site 11
S133
L
N
T
T
D
L
Y
S
Y
R
K
V
T
D
N
Site 12
T138
L
Y
S
Y
R
K
V
T
D
N
I
S
S
C
M
Site 13
S154
N
F
N
L
G
R
A
S
V
N
N
L
L
K
N
Site 14
S239
S
I
F
T
K
V
L
S
D
D
D
L
L
Q
T
Site 15
T246
S
D
D
D
L
L
Q
T
V
Q
S
T
S
G
L
Site 16
S285
L
R
S
V
D
C
T
S
V
P
E
W
F
M
S
Site 17
S324
M
L
D
W
Q
N
G
S
M
G
R
S
G
E
A
Site 18
S328
Q
N
G
S
M
G
R
S
G
E
A
L
L
L
D
Site 19
T351
S
S
Q
I
K
E
P
T
L
E
M
F
L
S
R
Site 20
S373
S
A
I
Q
V
L
E
S
S
S
P
S
L
T
D
Site 21
S375
I
Q
V
L
E
S
S
S
P
S
L
T
D
S
L
Site 22
S377
V
L
E
S
S
S
P
S
L
T
D
S
L
N
G
Site 23
T379
E
S
S
S
P
S
L
T
D
S
L
N
G
N
S
Site 24
S381
S
S
P
S
L
T
D
S
L
N
G
N
S
S
I
Site 25
S387
D
S
L
N
G
N
S
S
I
V
G
R
L
L
E
Site 26
Y395
I
V
G
R
L
L
E
Y
V
Y
T
H
W
E
H
Site 27
Y397
G
R
L
L
E
Y
V
Y
T
H
W
E
H
P
L
Site 28
T411
L
D
A
L
R
H
Q
T
K
I
M
F
K
N
L
Site 29
S489
L
E
V
M
G
D
Q
S
L
V
P
Y
A
S
D
Site 30
Y493
G
D
Q
S
L
V
P
Y
A
S
D
L
L
E
T
Site 31
S507
T
M
F
R
N
H
K
S
H
L
K
S
Q
T
A
Site 32
S511
N
H
K
S
H
L
K
S
Q
T
A
E
S
S
W
Site 33
T513
K
S
H
L
K
S
Q
T
A
E
S
S
W
I
D
Site 34
Y544
G
N
L
D
Q
K
S
Y
V
I
D
Y
Y
L
P
Site 35
Y548
Q
K
S
Y
V
I
D
Y
Y
L
P
K
L
L
S
Site 36
Y549
K
S
Y
V
I
D
Y
Y
L
P
K
L
L
S
Y
Site 37
S555
Y
Y
L
P
K
L
L
S
Y
S
P
E
S
L
Q
Site 38
S557
L
P
K
L
L
S
Y
S
P
E
S
L
Q
Y
M
Site 39
Y563
Y
S
P
E
S
L
Q
Y
M
V
K
I
L
Q
T
Site 40
T576
Q
T
S
I
D
A
K
T
G
Q
E
Q
S
F
P
Site 41
S581
A
K
T
G
Q
E
Q
S
F
P
S
L
G
S
C
Site 42
S584
G
Q
E
Q
S
F
P
S
L
G
S
C
N
S
R
Site 43
S587
Q
S
F
P
S
L
G
S
C
N
S
R
G
A
L
Site 44
S612
R
A
H
G
H
L
Q
S
A
T
D
T
W
E
N
Site 45
T616
H
L
Q
S
A
T
D
T
W
E
N
L
V
S
D
Site 46
S622
D
T
W
E
N
L
V
S
D
A
R
I
K
Q
G
Site 47
S651
L
L
C
E
S
N
R
S
T
E
I
V
S
M
E
Site 48
T652
L
C
E
S
N
R
S
T
E
I
V
S
M
E
E
Site 49
Y669
W
I
Q
F
F
I
T
Y
N
L
N
S
Q
S
P
Site 50
S673
F
I
T
Y
N
L
N
S
Q
S
P
G
V
R
Q
Site 51
S675
T
Y
N
L
N
S
Q
S
P
G
V
R
Q
Q
I
Site 52
S696
L
F
C
R
I
Q
E
S
S
Q
V
L
Y
K
L
Site 53
S697
F
C
R
I
Q
E
S
S
Q
V
L
Y
K
L
E
Site 54
Y701
Q
E
S
S
Q
V
L
Y
K
L
E
Q
S
K
S
Site 55
S708
Y
K
L
E
Q
S
K
S
K
R
E
P
E
N
E
Site 56
T717
R
E
P
E
N
E
L
T
K
Q
H
P
S
V
S
Site 57
S724
T
K
Q
H
P
S
V
S
L
Q
Q
Y
K
N
F
Site 58
Y728
P
S
V
S
L
Q
Q
Y
K
N
F
M
S
S
I
Site 59
S747
F
E
A
L
F
P
G
S
S
Y
S
T
R
F
S
Site 60
S748
E
A
L
F
P
G
S
S
Y
S
T
R
F
S
A
Site 61
S750
L
F
P
G
S
S
Y
S
T
R
F
S
A
L
T
Site 62
T751
F
P
G
S
S
Y
S
T
R
F
S
A
L
T
I
Site 63
Y774
H
V
P
E
G
R
I
Y
T
V
Y
Q
L
S
H
Site 64
T775
V
P
E
G
R
I
Y
T
V
Y
Q
L
S
H
D
Site 65
Y777
E
G
R
I
Y
T
V
Y
Q
L
S
H
D
I
D
Site 66
T816
L
L
M
K
L
S
K
T
A
V
H
F
Q
D
S
Site 67
S837
F
Q
A
A
L
E
L
S
T
S
T
K
P
Y
D
Site 68
S839
A
A
L
E
L
S
T
S
T
K
P
Y
D
C
V
Site 69
Y843
L
S
T
S
T
K
P
Y
D
C
V
T
A
S
Y
Site 70
S864
W
Q
D
A
L
P
S
S
L
S
A
Y
L
T
Q
Site 71
S866
D
A
L
P
S
S
L
S
A
Y
L
T
Q
Q
V
Site 72
T870
S
S
L
S
A
Y
L
T
Q
Q
V
A
C
D
N
Site 73
S905
E
N
L
E
E
E
V
S
Q
A
E
N
S
L
L
Site 74
S938
L
Q
K
L
S
L
N
S
L
Q
L
V
S
E
W
Site 75
S943
L
N
S
L
Q
L
V
S
E
W
R
P
V
V
E
Site 76
S964
Y
R
L
S
T
V
V
S
P
V
I
Q
S
S
S
Site 77
S971
S
P
V
I
Q
S
S
S
P
E
G
L
I
P
M
Site 78
T980
E
G
L
I
P
M
D
T
D
S
E
S
A
S
R
Site 79
S982
L
I
P
M
D
T
D
S
E
S
A
S
R
L
Q
Site 80
S984
P
M
D
T
D
S
E
S
A
S
R
L
Q
M
I
Site 81
S986
D
T
D
S
E
S
A
S
R
L
Q
M
I
L
N
Site 82
T1000
N
E
I
Q
P
R
D
T
N
D
Y
F
N
Q
A
Site 83
Y1003
Q
P
R
D
T
N
D
Y
F
N
Q
A
K
I
L
Site 84
S1015
K
I
L
K
E
H
D
S
F
D
M
K
D
L
N
Site 85
S1024
D
M
K
D
L
N
A
S
V
V
N
I
D
T
S
Site 86
S1031
S
V
V
N
I
D
T
S
T
E
I
K
G
K
E
Site 87
T1041
I
K
G
K
E
V
K
T
C
D
V
T
A
Q
M
Site 88
S1079
P
M
Q
P
V
P
E
S
S
D
G
L
L
T
V
Site 89
T1085
E
S
S
D
G
L
L
T
V
E
Q
V
K
E
I
Site 90
Y1095
Q
V
K
E
I
G
D
Y
F
K
Q
H
L
L
Q
Site 91
S1103
F
K
Q
H
L
L
Q
S
R
H
R
G
A
F
E
Site 92
S1130
L
N
R
C
P
N
V
S
L
Q
K
L
P
E
Q
Site 93
S1149
V
L
E
E
I
K
C
S
D
P
S
S
K
L
C
Site 94
S1153
I
K
C
S
D
P
S
S
K
L
C
A
T
R
R
Site 95
T1158
P
S
S
K
L
C
A
T
R
R
S
A
G
I
P
Site 96
S1161
K
L
C
A
T
R
R
S
A
G
I
P
F
Y
I
Site 97
S1174
Y
I
Q
A
L
L
A
S
E
P
K
K
G
R
M
Site 98
S1203
G
P
T
D
D
I
Q
S
T
V
P
Q
V
H
A
Site 99
T1204
P
T
D
D
I
Q
S
T
V
P
Q
V
H
A
L
Site 100
T1221
L
R
A
L
F
R
D
T
R
L
G
E
N
I
I
Site 101
Y1230
L
G
E
N
I
I
P
Y
V
A
D
G
A
K
A
Site 102
S1275
K
R
A
K
D
E
H
S
K
T
N
R
M
T
G
Site 103
T1277
A
K
D
E
H
S
K
T
N
R
M
T
G
R
E
Site 104
T1281
H
S
K
T
N
R
M
T
G
R
E
F
F
S
R
Site 105
S1309
T
V
A
N
T
V
D
S
D
M
G
E
P
N
R
Site 106
S1333
V
L
E
R
L
Y
A
S
P
M
D
G
T
S
S
Site 107
S1339
A
S
P
M
D
G
T
S
S
A
L
S
M
G
P
Site 108
S1340
S
P
M
D
G
T
S
S
A
L
S
M
G
P
F
Site 109
Y1360
R
C
G
H
S
P
V
Y
H
S
R
E
M
A
A
Site 110
S1388
N
T
I
R
T
L
L
S
T
L
P
S
C
T
D
Site 111
T1389
T
I
R
T
L
L
S
T
L
P
S
C
T
D
Q
Site 112
S1418
F
H
L
L
Q
A
Y
S
D
S
K
H
G
T
N
Site 113
S1420
L
L
Q
A
Y
S
D
S
K
H
G
T
N
S
D
Site 114
T1424
Y
S
D
S
K
H
G
T
N
S
D
F
Q
H
E
Site 115
S1426
D
S
K
H
G
T
N
S
D
F
Q
H
E
L
T
Site 116
T1433
S
D
F
Q
H
E
L
T
D
I
T
V
C
T
K
Site 117
T1436
Q
H
E
L
T
D
I
T
V
C
T
K
A
K
L
Site 118
Y1515
K
V
P
G
L
P
Q
Y
L
Q
S
L
T
R
L
Site 119
S1534
V
W
A
A
A
A
K
S
G
E
R
E
T
N
V
Site 120
T1539
A
K
S
G
E
R
E
T
N
V
P
I
S
F
S
Site 121
S1544
R
E
T
N
V
P
I
S
F
S
Q
L
L
E
S
Site 122
S1551
S
F
S
Q
L
L
E
S
A
F
P
E
V
R
S
Site 123
T1630
T
E
H
C
V
H
L
T
P
K
E
F
L
I
W
Site 124
S1647
D
I
A
S
N
E
R
S
E
I
Q
S
V
A
L
Site 125
S1651
N
E
R
S
E
I
Q
S
V
A
L
R
L
A
S
Site 126
T1667
V
I
S
H
H
M
Q
T
C
V
E
N
R
E
L
Site 127
T1696
S
C
E
D
H
L
P
T
E
S
R
L
A
V
V
Site 128
T1715
S
T
T
P
L
F
L
T
N
P
H
P
I
L
E
Site 129
T1751
V
R
D
A
A
T
E
T
V
T
T
A
M
S
Q
Site 130
T1754
A
A
T
E
T
V
T
T
A
M
S
Q
E
N
T
Site 131
S1757
E
T
V
T
T
A
M
S
Q
E
N
T
C
Q
S
Site 132
T1761
T
A
M
S
Q
E
N
T
C
Q
S
T
E
F
A
Site 133
Y1827
M
H
Q
V
E
E
D
Y
L
F
E
K
A
E
V
Site 134
S1856
K
H
L
F
C
L
L
S
K
S
G
W
R
P
P
Site 135
S1858
L
F
C
L
L
S
K
S
G
W
R
P
P
S
P
Site 136
S1864
K
S
G
W
R
P
P
S
P
E
M
L
C
H
L
Site 137
S1883
S
E
Q
C
H
L
L
S
Q
F
F
R
E
L
P
Site 138
T1898
P
A
A
E
F
V
K
T
V
E
F
T
R
L
R
Site 139
T1929
E
G
K
E
G
E
D
T
L
V
L
S
V
W
D
Site 140
S1933
G
E
D
T
L
V
L
S
V
W
D
S
Y
A
E
Site 141
S1937
L
V
L
S
V
W
D
S
Y
A
E
S
R
Q
L
Site 142
Y1938
V
L
S
V
W
D
S
Y
A
E
S
R
Q
L
T
Site 143
S1941
V
W
D
S
Y
A
E
S
R
Q
L
T
L
P
R
Site 144
T1945
Y
A
E
S
R
Q
L
T
L
P
R
T
E
A
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation