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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDZRN4
Full Name:
PDZ domain-containing RING finger protein 4
Alias:
Ligand of Numb protein X 4;SEMACAP3-like protein
Type:
Mass (Da):
117103
Number AA:
1036
UniProt ID:
Q6ZMN7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y83
K
L
R
V
Q
C
D
Y
R
A
R
G
C
G
H
Site 2
S91
R
A
R
G
C
G
H
S
V
R
L
H
E
L
E
Site 3
S114
G
P
A
R
R
L
R
S
R
G
G
C
A
S
G
Site 4
S120
R
S
R
G
G
C
A
S
G
L
G
G
G
E
V
Site 5
T136
A
R
G
G
C
G
P
T
P
R
A
G
R
G
G
Site 6
T188
L
Q
G
E
V
Q
L
T
A
R
R
Y
Q
E
K
Site 7
Y192
V
Q
L
T
A
R
R
Y
Q
E
K
F
T
Q
Y
Site 8
Y199
Y
Q
E
K
F
T
Q
Y
M
A
H
V
R
N
F
Site 9
T224
D
G
E
H
K
P
F
T
I
V
L
E
R
E
N
Site 10
T233
V
L
E
R
E
N
D
T
L
G
F
N
I
I
G
Site 11
T253
N
N
Q
E
G
T
S
T
E
G
I
Y
V
S
K
Site 12
Y257
G
T
S
T
E
G
I
Y
V
S
K
I
L
E
N
Site 13
S259
S
T
E
G
I
Y
V
S
K
I
L
E
N
G
P
Site 14
S288
E
V
N
G
K
D
L
S
K
A
T
H
E
E
A
Site 15
T314
V
V
Q
V
L
R
R
T
P
L
S
R
P
A
Y
Site 16
S317
V
L
R
R
T
P
L
S
R
P
A
Y
G
M
A
Site 17
Y321
T
P
L
S
R
P
A
Y
G
M
A
S
E
V
Q
Site 18
T353
L
A
K
L
R
P
P
T
P
P
V
P
D
I
C
Site 19
S370
L
L
S
D
S
C
H
S
L
H
P
M
E
H
E
Site 20
Y379
H
P
M
E
H
E
F
Y
E
D
N
E
Y
I
S
Site 21
Y384
E
F
Y
E
D
N
E
Y
I
S
S
L
P
A
D
Site 22
S387
E
D
N
E
Y
I
S
S
L
P
A
D
A
D
R
Site 23
T395
L
P
A
D
A
D
R
T
E
D
F
E
Y
E
E
Site 24
Y400
D
R
T
E
D
F
E
Y
E
E
V
E
L
C
R
Site 25
S409
E
V
E
L
C
R
V
S
S
Q
E
K
L
G
L
Site 26
S410
V
E
L
C
R
V
S
S
Q
E
K
L
G
L
T
Site 27
T417
S
Q
E
K
L
G
L
T
V
C
Y
R
T
D
D
Site 28
T428
R
T
D
D
E
E
D
T
G
I
Y
V
S
E
V
Site 29
Y431
D
E
E
D
T
G
I
Y
V
S
E
V
D
P
N
Site 30
S433
E
D
T
G
I
Y
V
S
E
V
D
P
N
S
I
Site 31
S439
V
S
E
V
D
P
N
S
I
A
A
K
D
G
R
Site 32
S472
E
E
A
V
A
L
L
S
N
D
E
C
K
R
I
Site 33
T538
K
Q
E
E
E
E
G
T
T
D
T
A
T
S
S
Site 34
T539
Q
E
E
E
E
G
T
T
D
T
A
T
S
S
S
Site 35
T541
E
E
E
G
T
T
D
T
A
T
S
S
S
N
N
Site 36
T543
E
G
T
T
D
T
A
T
S
S
S
N
N
H
E
Site 37
S561
G
V
G
R
T
D
E
S
L
R
N
D
E
S
S
Site 38
S567
E
S
L
R
N
D
E
S
S
E
Q
E
N
A
A
Site 39
S568
S
L
R
N
D
E
S
S
E
Q
E
N
A
A
E
Site 40
S579
N
A
A
E
D
P
N
S
T
S
L
K
S
K
R
Site 41
S581
A
E
D
P
N
S
T
S
L
K
S
K
R
D
L
Site 42
S584
P
N
S
T
S
L
K
S
K
R
D
L
G
Q
S
Site 43
S591
S
K
R
D
L
G
Q
S
Q
D
T
L
G
S
V
Site 44
T594
D
L
G
Q
S
Q
D
T
L
G
S
V
E
L
Q
Site 45
Y602
L
G
S
V
E
L
Q
Y
N
E
S
L
V
S
G
Site 46
S605
V
E
L
Q
Y
N
E
S
L
V
S
G
E
Y
I
Site 47
S608
Q
Y
N
E
S
L
V
S
G
E
Y
I
D
S
D
Site 48
S614
V
S
G
E
Y
I
D
S
D
C
I
G
N
P
D
Site 49
Y643
K
I
R
N
H
G
E
Y
D
L
Y
Y
S
S
S
Site 50
Y646
N
H
G
E
Y
D
L
Y
Y
S
S
S
T
I
E
Site 51
Y647
H
G
E
Y
D
L
Y
Y
S
S
S
T
I
E
C
Site 52
S650
Y
D
L
Y
Y
S
S
S
T
I
E
C
N
Q
G
Site 53
Y696
L
Q
K
V
T
D
Q
Y
G
D
I
W
T
L
H
Site 54
Y710
H
D
G
G
F
R
N
Y
N
T
S
I
D
M
Q
Site 55
S731
I
M
E
H
P
E
K
S
D
K
D
S
S
S
A
Site 56
S735
P
E
K
S
D
K
D
S
S
S
A
Y
N
T
A
Site 57
S737
K
S
D
K
D
S
S
S
A
Y
N
T
A
E
S
Site 58
Y739
D
K
D
S
S
S
A
Y
N
T
A
E
S
C
R
Site 59
T741
D
S
S
S
A
Y
N
T
A
E
S
C
R
S
T
Site 60
S744
S
A
Y
N
T
A
E
S
C
R
S
T
P
L
T
Site 61
T748
T
A
E
S
C
R
S
T
P
L
T
V
D
R
S
Site 62
T751
S
C
R
S
T
P
L
T
V
D
R
S
P
D
S
Site 63
S755
T
P
L
T
V
D
R
S
P
D
S
S
L
P
R
Site 64
S758
T
V
D
R
S
P
D
S
S
L
P
R
V
I
N
Site 65
S759
V
D
R
S
P
D
S
S
L
P
R
V
I
N
L
Site 66
T767
L
P
R
V
I
N
L
T
N
K
K
N
L
R
S
Site 67
T775
N
K
K
N
L
R
S
T
M
A
A
T
Q
S
S
Site 68
T779
L
R
S
T
M
A
A
T
Q
S
S
S
G
Q
S
Site 69
S781
S
T
M
A
A
T
Q
S
S
S
G
Q
S
S
K
Site 70
S782
T
M
A
A
T
Q
S
S
S
G
Q
S
S
K
E
Site 71
S783
M
A
A
T
Q
S
S
S
G
Q
S
S
K
E
S
Site 72
S786
T
Q
S
S
S
G
Q
S
S
K
E
S
T
S
T
Site 73
S787
Q
S
S
S
G
Q
S
S
K
E
S
T
S
T
K
Site 74
S790
S
G
Q
S
S
K
E
S
T
S
T
K
A
K
T
Site 75
T793
S
S
K
E
S
T
S
T
K
A
K
T
T
E
Q
Site 76
S803
K
T
T
E
Q
G
C
S
A
E
S
K
E
K
V
Site 77
S806
E
Q
G
C
S
A
E
S
K
E
K
V
L
E
G
Site 78
S824
P
D
Q
E
K
A
V
S
E
H
I
P
Y
L
S
Site 79
Y829
A
V
S
E
H
I
P
Y
L
S
P
Y
H
S
S
Site 80
S831
S
E
H
I
P
Y
L
S
P
Y
H
S
S
S
Y
Site 81
Y833
H
I
P
Y
L
S
P
Y
H
S
S
S
Y
R
Y
Site 82
S835
P
Y
L
S
P
Y
H
S
S
S
Y
R
Y
A
N
Site 83
S837
L
S
P
Y
H
S
S
S
Y
R
Y
A
N
I
P
Site 84
Y840
Y
H
S
S
S
Y
R
Y
A
N
I
P
A
H
A
Site 85
Y850
I
P
A
H
A
R
H
Y
Q
S
Y
M
Q
L
I
Site 86
Y853
H
A
R
H
Y
Q
S
Y
M
Q
L
I
Q
Q
K
Site 87
S861
M
Q
L
I
Q
Q
K
S
A
V
E
Y
A
Q
S
Site 88
Y865
Q
Q
K
S
A
V
E
Y
A
Q
S
Q
L
S
L
Site 89
S871
E
Y
A
Q
S
Q
L
S
L
V
S
M
C
K
E
Site 90
S874
Q
S
Q
L
S
L
V
S
M
C
K
E
S
Q
K
Site 91
S879
L
V
S
M
C
K
E
S
Q
K
C
S
E
P
K
Site 92
Y900
I
R
S
D
G
T
R
Y
I
T
K
R
P
V
R
Site 93
T902
S
D
G
T
R
Y
I
T
K
R
P
V
R
D
R
Site 94
S923
L
K
I
K
E
E
R
S
G
M
T
T
D
D
D
Site 95
T927
E
E
R
S
G
M
T
T
D
D
D
T
M
S
E
Site 96
T931
G
M
T
T
D
D
D
T
M
S
E
M
K
M
G
Site 97
S933
T
T
D
D
D
T
M
S
E
M
K
M
G
R
Y
Site 98
Y940
S
E
M
K
M
G
R
Y
W
S
K
E
E
R
K
Site 99
S974
R
L
E
C
L
K
E
S
P
Q
S
G
S
E
G
Site 100
S977
C
L
K
E
S
P
Q
S
G
S
E
G
K
K
E
Site 101
S979
K
E
S
P
Q
S
G
S
E
G
K
K
E
I
N
Site 102
S1020
L
M
T
H
G
A
K
S
P
D
G
T
R
V
H
Site 103
T1024
G
A
K
S
P
D
G
T
R
V
H
N
A
F
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation