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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIAA1718
Full Name:
Lysine-specific demethylase 7
Alias:
JHD1D
Type:
Uncharacterized protein
Mass (Da):
106557
Number AA:
941
UniProt ID:
Q6ZMT4
International Prot ID:
IPI00418567
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S30
V
A
A
P
G
R
A
S
A
P
P
P
P
P
P
Site 2
Y39
P
P
P
P
P
P
V
Y
C
V
C
R
Q
P
Y
Site 3
Y105
R
N
W
H
R
H
D
Y
T
E
I
D
D
G
S
Site 4
T106
N
W
H
R
H
D
Y
T
E
I
D
D
G
S
K
Site 5
S112
Y
T
E
I
D
D
G
S
K
P
V
Q
A
G
T
Site 6
T119
S
K
P
V
Q
A
G
T
R
T
F
I
K
E
L
Site 7
T121
P
V
Q
A
G
T
R
T
F
I
K
E
L
R
S
Site 8
S128
T
F
I
K
E
L
R
S
R
V
F
P
S
A
D
Site 9
T147
K
M
H
G
S
Q
L
T
Q
R
Y
L
E
K
H
Site 10
Y150
G
S
Q
L
T
Q
R
Y
L
E
K
H
G
F
D
Site 11
S178
R
L
P
S
P
T
F
S
V
M
D
V
E
R
Y
Site 12
S203
D
V
A
R
Q
A
D
S
K
M
T
L
H
N
Y
Site 13
Y210
S
K
M
T
L
H
N
Y
V
K
Y
F
M
N
P
Site 14
Y213
T
L
H
N
Y
V
K
Y
F
M
N
P
N
R
P
Site 15
S227
P
K
V
L
N
V
I
S
L
E
F
S
D
T
K
Site 16
S231
N
V
I
S
L
E
F
S
D
T
K
M
S
E
L
Site 17
T233
I
S
L
E
F
S
D
T
K
M
S
E
L
V
E
Site 18
S236
E
F
S
D
T
K
M
S
E
L
V
E
V
P
D
Site 19
Y269
P
K
P
F
V
Q
K
Y
C
L
M
G
V
Q
D
Site 20
Y278
L
M
G
V
Q
D
S
Y
T
D
F
H
I
D
F
Site 21
Y292
F
G
G
T
S
V
W
Y
H
V
L
W
G
E
K
Site 22
Y302
L
W
G
E
K
I
F
Y
L
I
K
P
T
D
E
Site 23
Y314
T
D
E
N
L
A
R
Y
E
S
W
S
S
S
V
Site 24
S316
E
N
L
A
R
Y
E
S
W
S
S
S
V
T
Q
Site 25
S318
L
A
R
Y
E
S
W
S
S
S
V
T
Q
S
E
Site 26
S319
A
R
Y
E
S
W
S
S
S
V
T
Q
S
E
V
Site 27
S320
R
Y
E
S
W
S
S
S
V
T
Q
S
E
V
F
Site 28
T322
E
S
W
S
S
S
V
T
Q
S
E
V
F
F
G
Site 29
S324
W
S
S
S
V
T
Q
S
E
V
F
F
G
D
K
Site 30
Y336
G
D
K
V
D
K
C
Y
K
C
V
V
K
Q
G
Site 31
Y382
I
G
M
Q
L
R
C
Y
E
M
E
K
R
L
K
Site 32
T390
E
M
E
K
R
L
K
T
P
D
L
F
K
F
P
Site 33
T426
E
D
G
F
Q
P
Q
T
Y
L
V
Q
G
V
K
Site 34
Y427
D
G
F
Q
P
Q
T
Y
L
V
Q
G
V
K
A
Site 35
T437
Q
G
V
K
A
L
H
T
A
L
K
L
W
M
K
Site 36
S485
E
N
G
K
P
V
K
S
Q
G
I
P
I
V
C
Site 37
S497
I
V
C
P
V
S
R
S
S
N
E
A
T
S
P
Site 38
S498
V
C
P
V
S
R
S
S
N
E
A
T
S
P
Y
Site 39
T502
S
R
S
S
N
E
A
T
S
P
Y
H
S
R
R
Site 40
S503
R
S
S
N
E
A
T
S
P
Y
H
S
R
R
K
Site 41
Y505
S
N
E
A
T
S
P
Y
H
S
R
R
K
M
R
Site 42
S507
E
A
T
S
P
Y
H
S
R
R
K
M
R
K
L
Site 43
T521
L
R
D
H
N
V
R
T
P
S
N
L
D
I
L
Site 44
S523
D
H
N
V
R
T
P
S
N
L
D
I
L
E
L
Site 45
T532
L
D
I
L
E
L
H
T
R
E
V
L
K
R
L
Site 46
S550
P
W
E
E
D
I
L
S
S
K
L
N
G
K
F
Site 47
S565
N
K
H
L
Q
P
S
S
T
V
P
E
W
R
A
Site 48
T566
K
H
L
Q
P
S
S
T
V
P
E
W
R
A
K
Site 49
T582
N
D
L
R
L
L
L
T
N
G
R
I
I
K
D
Site 50
S598
R
Q
P
F
A
D
Q
S
L
Y
T
A
D
S
E
Site 51
Y600
P
F
A
D
Q
S
L
Y
T
A
D
S
E
N
E
Site 52
S604
Q
S
L
Y
T
A
D
S
E
N
E
E
D
K
R
Site 53
T613
N
E
E
D
K
R
R
T
K
K
A
K
M
K
I
Site 54
S634
E
G
V
E
H
E
E
S
Q
K
P
L
N
G
F
Site 55
T643
K
P
L
N
G
F
F
T
R
V
K
S
E
L
R
Site 56
S647
G
F
F
T
R
V
K
S
E
L
R
S
R
S
S
Site 57
S651
R
V
K
S
E
L
R
S
R
S
S
G
Y
S
D
Site 58
S653
K
S
E
L
R
S
R
S
S
G
Y
S
D
I
S
Site 59
S654
S
E
L
R
S
R
S
S
G
Y
S
D
I
S
E
Site 60
S657
R
S
R
S
S
G
Y
S
D
I
S
E
S
E
D
Site 61
S660
S
S
G
Y
S
D
I
S
E
S
E
D
S
G
P
Site 62
S662
G
Y
S
D
I
S
E
S
E
D
S
G
P
E
C
Site 63
S665
D
I
S
E
S
E
D
S
G
P
E
C
T
A
L
Site 64
S674
P
E
C
T
A
L
K
S
I
F
T
T
E
E
S
Site 65
T677
T
A
L
K
S
I
F
T
T
E
E
S
E
S
S
Site 66
T678
A
L
K
S
I
F
T
T
E
E
S
E
S
S
G
Site 67
S681
S
I
F
T
T
E
E
S
E
S
S
G
D
E
K
Site 68
S684
T
T
E
E
S
E
S
S
G
D
E
K
K
Q
E
Site 69
S694
E
K
K
Q
E
I
T
S
N
F
K
E
E
S
N
Site 70
S710
M
R
N
F
L
Q
K
S
Q
K
P
S
R
S
E
Site 71
S714
L
Q
K
S
Q
K
P
S
R
S
E
I
P
I
K
Site 72
S716
K
S
Q
K
P
S
R
S
E
I
P
I
K
R
E
Site 73
S727
I
K
R
E
C
P
T
S
T
S
T
E
E
E
A
Site 74
S729
R
E
C
P
T
S
T
S
T
E
E
E
A
I
Q
Site 75
S756
C
L
Q
R
Q
I
Q
S
T
D
C
S
G
E
R
Site 76
T757
L
Q
R
Q
I
Q
S
T
D
C
S
G
E
R
N
Site 77
S760
Q
I
Q
S
T
D
C
S
G
E
R
N
S
L
Q
Site 78
S765
D
C
S
G
E
R
N
S
L
Q
D
P
S
S
C
Site 79
S770
R
N
S
L
Q
D
P
S
S
C
H
G
S
N
H
Site 80
S771
N
S
L
Q
D
P
S
S
C
H
G
S
N
H
E
Site 81
S775
D
P
S
S
C
H
G
S
N
H
E
V
R
Q
L
Site 82
Y783
N
H
E
V
R
Q
L
Y
R
Y
D
K
P
V
E
Site 83
Y785
E
V
R
Q
L
Y
R
Y
D
K
P
V
E
C
G
Site 84
T797
E
C
G
Y
H
V
K
T
E
D
P
D
L
R
T
Site 85
S805
E
D
P
D
L
R
T
S
S
W
I
K
Q
F
D
Site 86
S806
D
P
D
L
R
T
S
S
W
I
K
Q
F
D
T
Site 87
S822
R
F
H
P
Q
D
L
S
R
S
Q
K
C
I
R
Site 88
S824
H
P
Q
D
L
S
R
S
Q
K
C
I
R
K
E
Site 89
S833
K
C
I
R
K
E
G
S
S
E
I
S
Q
R
V
Site 90
S834
C
I
R
K
E
G
S
S
E
I
S
Q
R
V
Q
Site 91
S837
K
E
G
S
S
E
I
S
Q
R
V
Q
S
R
N
Site 92
S842
E
I
S
Q
R
V
Q
S
R
N
Y
V
D
S
S
Site 93
Y845
Q
R
V
Q
S
R
N
Y
V
D
S
S
G
S
S
Site 94
S848
Q
S
R
N
Y
V
D
S
S
G
S
S
L
Q
N
Site 95
S849
S
R
N
Y
V
D
S
S
G
S
S
L
Q
N
G
Site 96
S852
Y
V
D
S
S
G
S
S
L
Q
N
G
K
Y
M
Site 97
Y858
S
S
L
Q
N
G
K
Y
M
Q
N
S
N
L
T
Site 98
S866
M
Q
N
S
N
L
T
S
G
A
C
Q
I
S
N
Site 99
S872
T
S
G
A
C
Q
I
S
N
G
S
L
S
P
E
Site 100
S875
A
C
Q
I
S
N
G
S
L
S
P
E
R
P
V
Site 101
S877
Q
I
S
N
G
S
L
S
P
E
R
P
V
G
E
Site 102
T885
P
E
R
P
V
G
E
T
S
F
S
V
P
L
H
Site 103
S886
E
R
P
V
G
E
T
S
F
S
V
P
L
H
P
Site 104
S888
P
V
G
E
T
S
F
S
V
P
L
H
P
T
K
Site 105
T894
F
S
V
P
L
H
P
T
K
R
P
A
S
N
P
Site 106
S899
H
P
T
K
R
P
A
S
N
P
P
P
I
S
N
Site 107
S905
A
S
N
P
P
P
I
S
N
Q
A
T
K
G
K
Site 108
T909
P
P
I
S
N
Q
A
T
K
G
K
R
P
K
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation