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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Death domain-containing protein 1
Full Name:
Death domain-containing protein 1
Alias:
Type:
Mass (Da):
101549
Number AA:
901
UniProt ID:
Q6ZMT9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S61
H
Q
L
L
E
H
T
S
G
T
L
R
S
T
C
Site 2
T63
L
L
E
H
T
S
G
T
L
R
S
T
C
Q
Q
Site 3
S66
H
T
S
G
T
L
R
S
T
C
Q
Q
L
H
V
Site 4
T67
T
S
G
T
L
R
S
T
C
Q
Q
L
H
V
L
Site 5
S103
K
I
T
E
H
L
G
S
T
A
A
L
L
K
K
Site 6
T137
T
M
S
S
I
Q
D
T
K
A
A
D
I
A
A
Site 7
T153
G
E
L
N
V
I
E
T
A
T
V
S
P
T
N
Site 8
T155
L
N
V
I
E
T
A
T
V
S
P
T
N
G
E
Site 9
S157
V
I
E
T
A
T
V
S
P
T
N
G
E
E
S
Site 10
T159
E
T
A
T
V
S
P
T
N
G
E
E
S
H
Y
Site 11
Y166
T
N
G
E
E
S
H
Y
T
N
Q
V
Q
L
E
Site 12
T167
N
G
E
E
S
H
Y
T
N
Q
V
Q
L
E
K
Site 13
T177
V
Q
L
E
K
N
K
T
H
M
S
S
A
L
V
Site 14
S191
V
E
K
E
N
N
T
S
L
N
G
R
V
L
G
Site 15
S202
R
V
L
G
Q
E
E
S
Q
N
K
M
F
P
D
Site 16
T234
I
N
G
N
R
E
E
T
H
G
I
I
Q
T
T
Site 17
S249
E
T
E
I
Q
E
T
S
E
S
P
R
E
E
M
Site 18
S251
E
I
Q
E
T
S
E
S
P
R
E
E
M
T
T
Site 19
T257
E
S
P
R
E
E
M
T
T
S
S
I
I
C
D
Site 20
T258
S
P
R
E
E
M
T
T
S
S
I
I
C
D
I
Site 21
Y269
I
C
D
I
S
K
K
Y
I
N
S
T
L
P
N
Site 22
S272
I
S
K
K
Y
I
N
S
T
L
P
N
D
S
E
Site 23
T273
S
K
K
Y
I
N
S
T
L
P
N
D
S
E
N
Site 24
Y292
N
N
I
M
E
K
E
Y
L
D
V
L
S
D
D
Site 25
S297
K
E
Y
L
D
V
L
S
D
D
T
G
P
Q
V
Site 26
T300
L
D
V
L
S
D
D
T
G
P
Q
V
S
C
Y
Site 27
S305
D
D
T
G
P
Q
V
S
C
Y
I
T
A
P
S
Site 28
S328
R
I
I
N
H
M
S
S
L
I
V
G
D
N
E
Site 29
S339
G
D
N
E
E
L
V
S
N
V
I
T
I
E
C
Site 30
T343
E
L
V
S
N
V
I
T
I
E
C
S
D
K
E
Site 31
Y371
T
A
R
Y
R
G
N
Y
R
D
I
M
V
K
V
Site 32
S385
V
C
D
I
N
L
Q
S
S
Y
L
N
P
N
S
Site 33
Y387
D
I
N
L
Q
S
S
Y
L
N
P
N
S
L
E
Site 34
S392
S
S
Y
L
N
P
N
S
L
E
G
M
K
G
G
Site 35
S406
G
Y
K
G
T
C
A
S
V
K
V
Y
K
L
G
Site 36
S425
V
S
C
L
K
K
E
S
F
T
V
T
K
K
G
Site 37
T429
K
K
E
S
F
T
V
T
K
K
G
L
A
L
K
Site 38
S437
K
K
G
L
A
L
K
S
S
M
D
S
R
I
S
Site 39
S438
K
G
L
A
L
K
S
S
M
D
S
R
I
S
L
Site 40
S441
A
L
K
S
S
M
D
S
R
I
S
L
N
Y
P
Site 41
S444
S
S
M
D
S
R
I
S
L
N
Y
P
P
G
V
Site 42
Y447
D
S
R
I
S
L
N
Y
P
P
G
V
F
T
S
Site 43
T479
H
L
K
A
Q
Q
D
T
F
Y
S
V
Q
S
T
Site 44
Y481
K
A
Q
Q
D
T
F
Y
S
V
Q
S
T
S
P
Site 45
S482
A
Q
Q
D
T
F
Y
S
V
Q
S
T
S
P
L
Site 46
S485
D
T
F
Y
S
V
Q
S
T
S
P
L
I
H
I
Site 47
T486
T
F
Y
S
V
Q
S
T
S
P
L
I
H
I
Q
Site 48
S487
F
Y
S
V
Q
S
T
S
P
L
I
H
I
Q
H
Site 49
T497
I
H
I
Q
H
P
S
T
Y
P
F
Q
K
P
V
Site 50
Y498
H
I
Q
H
P
S
T
Y
P
F
Q
K
P
V
T
Site 51
S511
V
T
L
F
L
P
C
S
P
Y
L
D
K
N
N
Site 52
Y513
L
F
L
P
C
S
P
Y
L
D
K
N
N
L
G
Site 53
S530
I
D
H
K
R
R
A
S
A
T
I
N
R
I
T
Site 54
T532
H
K
R
R
A
S
A
T
I
N
R
I
T
P
S
Site 55
T537
S
A
T
I
N
R
I
T
P
S
Y
F
N
R
T
Site 56
Y540
I
N
R
I
T
P
S
Y
F
N
R
T
K
I
A
Site 57
S548
F
N
R
T
K
I
A
S
I
R
K
P
R
K
N
Site 58
S557
R
K
P
R
K
N
A
S
E
C
L
K
L
L
G
Site 59
S567
L
K
L
L
G
F
R
S
Q
D
S
G
W
C
G
Site 60
S570
L
G
F
R
S
Q
D
S
G
W
C
G
L
D
D
Site 61
S604
R
F
I
V
L
H
L
S
S
T
M
D
N
S
H
Site 62
S610
L
S
S
T
M
D
N
S
H
L
V
T
F
V
K
Site 63
T614
M
D
N
S
H
L
V
T
F
V
K
S
L
E
E
Site 64
S653
V
V
P
S
K
D
L
S
Q
V
L
K
D
L
H
Site 65
S694
T
G
N
I
F
A
S
S
N
G
K
D
Y
G
K
Site 66
Y699
A
S
S
N
G
K
D
Y
G
K
D
Y
T
L
I
Site 67
Y703
G
K
D
Y
G
K
D
Y
T
L
I
F
H
L
Q
Site 68
T704
K
D
Y
G
K
D
Y
T
L
I
F
H
L
Q
R
Site 69
Y728
E
V
D
E
F
G
N
Y
S
C
P
H
Y
K
G
Site 70
Y733
G
N
Y
S
C
P
H
Y
K
G
T
I
V
V
Y
Site 71
Y740
Y
K
G
T
I
V
V
Y
K
V
P
K
G
K
I
Site 72
S785
K
L
I
N
R
P
Q
S
T
K
R
V
S
K
D
Site 73
T786
L
I
N
R
P
Q
S
T
K
R
V
S
K
D
P
Site 74
S790
P
Q
S
T
K
R
V
S
K
D
P
V
E
A
L
Site 75
S810
H
W
L
A
E
E
L
S
E
E
N
A
E
S
L
Site 76
S816
L
S
E
E
N
A
E
S
L
S
S
T
L
P
L
Site 77
S819
E
N
A
E
S
L
S
S
T
L
P
L
R
R
S
Site 78
T820
N
A
E
S
L
S
S
T
L
P
L
R
R
S
T
Site 79
T827
T
L
P
L
R
R
S
T
I
Q
L
I
K
L
K
Site 80
T840
L
K
N
P
D
D
L
T
E
Q
I
H
E
F
L
Site 81
T856
F
W
K
K
S
L
P
T
F
T
D
K
L
R
L
Site 82
S874
H
L
R
K
I
G
R
S
D
L
A
E
E
L
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation