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Updated November 2019
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Protein Info
Short Name:
EML6
Full Name:
Echinoderm microtubule-associated protein-like 6
Alias:
Echinoderm microtubule-associated protein-like 6: Echinoderm microtubule-associated protein-like 5-like: Echinoderm microtubule-associated protein-like 6: Echinoderm microtubule-associated protein-like 5-like
Type:
Mass (Da):
217881
Number AA:
1958
UniProt ID:
Q6ZMW3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005874
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y17
Q
L
R
L
E
W
V
Y
G
Y
R
G
H
Q
C
Site 2
Y29
H
Q
C
R
N
N
L
Y
Y
T
A
G
K
E
V
Site 3
Y30
Q
C
R
N
N
L
Y
Y
T
A
G
K
E
V
V
Site 4
Y47
V
A
G
V
G
V
V
Y
N
T
R
E
H
S
Q
Site 5
S66
G
H
N
D
D
I
I
S
L
A
L
H
P
D
K
Site 6
Y86
G
Q
V
G
K
E
P
Y
I
C
I
W
D
S
Y
Site 7
S99
S
Y
N
V
Q
T
V
S
L
L
K
D
V
H
T
Site 8
S123
S
D
G
Q
R
L
A
S
V
G
L
D
A
K
N
Site 9
S145
R
K
G
K
L
L
A
S
A
T
G
H
S
D
R
Site 10
S150
L
A
S
A
T
G
H
S
D
R
I
F
D
I
S
Site 11
Y161
F
D
I
S
W
D
P
Y
Q
P
N
R
V
V
S
Site 12
T178
V
K
H
I
K
F
W
T
L
C
G
N
A
L
T
Site 13
T185
T
L
C
G
N
A
L
T
A
K
R
G
I
F
G
Site 14
T211
A
C
A
K
E
D
I
T
Y
S
G
A
L
N
G
Site 15
Y212
C
A
K
E
D
I
T
Y
S
G
A
L
N
G
D
Site 16
T231
K
G
L
N
L
V
R
T
I
Q
G
A
H
S
A
Site 17
S237
R
T
I
Q
G
A
H
S
A
G
I
F
S
M
Y
Site 18
T252
A
C
E
E
G
F
A
T
G
G
R
D
G
C
I
Site 19
T264
G
C
I
R
L
W
D
T
D
F
K
P
I
T
K
Site 20
T277
T
K
I
D
L
R
E
T
E
Q
G
Y
K
G
L
Site 21
S285
E
Q
G
Y
K
G
L
S
I
R
S
V
C
W
K
Site 22
T300
A
D
R
L
L
A
G
T
Q
D
S
E
I
F
E
Site 23
S344
K
P
L
A
V
T
G
S
D
D
R
S
V
R
L
Site 24
S348
V
T
G
S
D
D
R
S
V
R
L
W
S
L
A
Site 25
S353
D
R
S
V
R
L
W
S
L
A
D
H
A
L
I
Site 26
S371
N
M
E
E
A
V
R
S
V
A
F
S
P
D
G
Site 27
S379
V
A
F
S
P
D
G
S
Q
L
A
L
G
M
K
Site 28
S389
A
L
G
M
K
D
G
S
F
I
V
L
R
V
R
Site 29
T399
V
L
R
V
R
D
M
T
E
V
V
H
I
K
D
Site 30
S417
V
I
H
E
M
K
F
S
P
D
G
S
Y
L
A
Site 31
S421
M
K
F
S
P
D
G
S
Y
L
A
V
G
S
N
Site 32
Y422
K
F
S
P
D
G
S
Y
L
A
V
G
S
N
D
Site 33
Y435
N
D
G
P
V
D
V
Y
A
V
A
Q
R
Y
K
Site 34
S448
Y
K
K
I
G
E
C
S
K
S
L
S
F
I
T
Site 35
S452
G
E
C
S
K
S
L
S
F
I
T
H
I
D
W
Site 36
T455
S
K
S
L
S
F
I
T
H
I
D
W
S
L
D
Site 37
Y465
D
W
S
L
D
S
K
Y
L
Q
T
N
D
G
A
Site 38
Y478
G
A
G
E
R
L
F
Y
R
M
P
S
G
K
P
Site 39
S482
R
L
F
Y
R
M
P
S
G
K
P
L
T
S
K
Site 40
Y515
V
S
G
I
W
P
K
Y
T
E
V
T
D
I
N
Site 41
T516
S
G
I
W
P
K
Y
T
E
V
T
D
I
N
S
Site 42
S530
S
V
D
A
N
Y
N
S
S
V
L
V
S
G
D
Site 43
S531
V
D
A
N
Y
N
S
S
V
L
V
S
G
D
D
Site 44
Y559
R
G
A
K
F
R
K
Y
V
G
H
S
A
H
V
Site 45
T567
V
G
H
S
A
H
V
T
N
V
R
W
S
H
D
Site 46
S580
H
D
F
Q
W
V
L
S
T
G
G
A
D
H
S
Site 47
S614
P
Q
E
G
G
A
D
S
Y
S
E
E
S
D
S
Site 48
Y615
Q
E
G
G
A
D
S
Y
S
E
E
S
D
S
D
Site 49
S616
E
G
G
A
D
S
Y
S
E
E
S
D
S
D
L
Site 50
S619
A
D
S
Y
S
E
E
S
D
S
D
L
S
D
V
Site 51
S621
S
Y
S
E
E
S
D
S
D
L
S
D
V
P
E
Site 52
S624
E
E
S
D
S
D
L
S
D
V
P
E
L
D
S
Site 53
S631
S
D
V
P
E
L
D
S
D
I
E
Q
E
A
Q
Site 54
Y641
E
Q
E
A
Q
I
N
Y
D
R
Q
V
Y
K
E
Site 55
Y646
I
N
Y
D
R
Q
V
Y
K
E
D
L
P
Q
L
Site 56
S676
R
E
K
A
P
E
D
S
L
K
L
Q
F
I
H
Site 57
Y688
F
I
H
G
Y
R
G
Y
D
C
R
N
N
L
F
Site 58
Y696
D
C
R
N
N
L
F
Y
T
Q
A
G
E
V
V
Site 59
Y713
I
A
A
V
A
V
V
Y
N
R
Q
Q
H
S
Q
Site 60
Y723
Q
Q
H
S
Q
R
L
Y
L
G
H
D
D
D
I
Site 61
S732
G
H
D
D
D
I
L
S
L
T
I
H
P
V
K
Site 62
T734
D
D
D
I
L
S
L
T
I
H
P
V
K
D
Y
Site 63
Y741
T
I
H
P
V
K
D
Y
V
A
T
G
Q
V
G
Site 64
S765
T
Q
T
L
K
C
L
S
L
L
K
G
Q
H
Q
Site 65
T811
K
K
G
E
K
I
A
T
T
R
G
H
K
D
K
Site 66
T834
H
H
V
D
K
L
V
T
V
G
I
K
H
I
K
Site 67
S852
Q
A
G
G
G
F
T
S
K
R
G
T
F
G
S
Site 68
T856
G
F
T
S
K
R
G
T
F
G
S
V
G
K
L
Site 69
S859
S
K
R
G
T
F
G
S
V
G
K
L
E
T
M
Site 70
T898
K
D
I
L
L
L
K
T
V
K
A
H
D
G
P
Site 71
Y939
F
E
R
C
L
K
T
Y
A
I
K
R
S
A
L
Site 72
S944
K
T
Y
A
I
K
R
S
A
L
S
T
S
S
K
Site 73
S947
A
I
K
R
S
A
L
S
T
S
S
K
G
L
L
Site 74
S949
K
R
S
A
L
S
T
S
S
K
G
L
L
L
E
Site 75
S950
R
S
A
L
S
T
S
S
K
G
L
L
L
E
D
Site 76
T1021
A
T
V
S
D
D
K
T
L
R
I
W
E
L
S
Site 77
S1028
T
L
R
I
W
E
L
S
A
Q
H
R
M
L
A
Site 78
S1086
H
H
R
K
E
M
I
S
D
I
K
F
S
K
D
Site 79
S1091
M
I
S
D
I
K
F
S
K
D
T
G
K
Y
L
Site 80
T1094
D
I
K
F
S
K
D
T
G
K
Y
L
A
V
A
Site 81
Y1097
F
S
K
D
T
G
K
Y
L
A
V
A
S
H
D
Site 82
Y1110
H
D
N
F
V
D
I
Y
N
V
L
T
S
K
R
Site 83
T1129
K
G
A
S
S
Y
I
T
H
I
D
W
D
S
R
Site 84
S1144
G
K
L
L
Q
V
N
S
G
A
R
E
Q
L
F
Site 85
S1165
K
R
H
I
I
R
P
S
E
I
E
K
I
E
W
Site 86
S1191
E
G
I
W
P
A
H
S
D
I
T
D
V
N
A
Site 87
T1194
W
P
A
H
S
D
I
T
D
V
N
A
A
S
L
Site 88
S1206
A
S
L
T
K
D
C
S
L
L
A
T
G
D
D
Site 89
Y1222
G
F
V
K
L
F
S
Y
P
V
K
G
Q
H
A
Site 90
Y1234
Q
H
A
R
F
K
K
Y
V
G
H
S
A
H
V
Site 91
T1242
V
G
H
S
A
H
V
T
N
V
R
W
L
H
N
Site 92
T1273
W
T
R
E
F
V
G
T
Q
E
S
K
L
V
D
Site 93
T1286
V
D
S
E
E
S
D
T
D
V
E
E
D
G
G
Site 94
Y1294
D
V
E
E
D
G
G
Y
D
S
D
V
A
R
E
Site 95
S1296
E
E
D
G
G
Y
D
S
D
V
A
R
E
K
A
Site 96
Y1306
A
R
E
K
A
I
D
Y
T
T
K
I
Y
A
V
Site 97
T1307
R
E
K
A
I
D
Y
T
T
K
I
Y
A
V
S
Site 98
Y1311
I
D
Y
T
T
K
I
Y
A
V
S
I
R
E
M
Site 99
S1314
T
T
K
I
Y
A
V
S
I
R
E
M
E
G
T
Site 100
T1321
S
I
R
E
M
E
G
T
K
P
H
Q
Q
L
K
Site 101
S1331
H
Q
Q
L
K
E
V
S
V
E
E
R
P
P
V
Site 102
Y1382
D
C
R
N
N
L
H
Y
L
N
D
G
A
D
I
Site 103
S1403
A
G
I
V
Q
N
L
S
T
G
S
Q
S
F
Y
Site 104
S1406
V
Q
N
L
S
T
G
S
Q
S
F
Y
L
E
H
Site 105
S1408
N
L
S
T
G
S
Q
S
F
Y
L
E
H
T
D
Site 106
Y1410
S
T
G
S
Q
S
F
Y
L
E
H
T
D
D
I
Site 107
T1421
T
D
D
I
L
C
L
T
V
N
Q
H
P
K
Y
Site 108
Y1428
T
V
N
Q
H
P
K
Y
R
N
V
V
A
T
S
Site 109
T1434
K
Y
R
N
V
V
A
T
S
Q
I
G
T
T
P
Site 110
S1435
Y
R
N
V
V
A
T
S
Q
I
G
T
T
P
S
Site 111
T1440
A
T
S
Q
I
G
T
T
P
S
I
H
I
W
D
Site 112
Y1467
F
H
S
K
G
V
N
Y
I
N
F
S
A
T
G
Site 113
S1518
V
V
E
F
R
P
D
S
D
T
Q
F
V
S
V
Site 114
T1520
E
F
R
P
D
S
D
T
Q
F
V
S
V
G
V
Site 115
S1524
D
S
D
T
Q
F
V
S
V
G
V
K
H
M
K
Site 116
S1549
Y
K
K
G
V
I
G
S
L
G
A
A
K
M
Q
Site 117
T1619
T
G
G
K
E
R
P
T
K
E
G
G
A
V
K
Site 118
S1651
Q
L
V
E
C
V
R
S
V
C
R
G
K
G
K
Site 119
S1678
V
G
E
K
N
A
A
S
N
I
L
I
D
G
H
Site 120
S1704
P
S
K
D
L
F
I
S
A
S
N
D
G
T
A
Site 121
S1706
K
D
L
F
I
S
A
S
N
D
G
T
A
R
I
Site 122
T1710
I
S
A
S
N
D
G
T
A
R
I
W
D
L
A
Site 123
S1726
K
K
L
L
N
K
V
S
L
G
H
A
A
R
C
Site 124
S1771
G
K
K
R
D
R
K
S
A
I
Q
D
I
R
I
Site 125
S1779
A
I
Q
D
I
R
I
S
P
D
N
R
F
L
A
Site 126
S1790
R
F
L
A
V
G
S
S
E
H
T
V
D
F
Y
Site 127
T1793
A
V
G
S
S
E
H
T
V
D
F
Y
D
L
T
Site 128
Y1797
S
E
H
T
V
D
F
Y
D
L
T
Q
G
T
N
Site 129
T1800
T
V
D
F
Y
D
L
T
Q
G
T
N
L
N
R
Site 130
Y1810
T
N
L
N
R
I
G
Y
C
K
D
I
P
S
F
Site 131
Y1829
D
F
S
A
D
G
K
Y
I
Q
V
S
T
G
A
Site 132
Y1837
I
Q
V
S
T
G
A
Y
K
R
Q
V
H
E
V
Site 133
Y1923
K
F
A
K
H
K
R
Y
F
G
H
S
A
H
V
Site 134
T1931
F
G
H
S
A
H
V
T
N
I
R
F
S
Y
D
Site 135
Y1937
V
T
N
I
R
F
S
Y
D
D
K
Y
V
V
S
Site 136
Y1941
R
F
S
Y
D
D
K
Y
V
V
S
T
G
G
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation