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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
C14orf49
Full Name:
Nesprin-3
Alias:
Chromosome 14 open reading frame 49; FLJ25605; NET53; SYNE3
Type:
Mass (Da):
112216
Number AA:
975
UniProt ID:
Q6ZMZ3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
P
Q
D
D
F
D
R
S
V
E
D
A
Q
A
W
Site 2
T33
Q
L
Q
V
N
D
N
T
Q
G
P
R
A
A
L
Site 3
Y118
V
W
L
H
W
S
E
Y
L
L
A
R
D
E
F
Site 4
Y126
L
L
A
R
D
E
F
Y
R
W
F
Q
K
M
M
Site 5
S179
R
L
L
E
E
A
A
S
L
F
N
R
I
G
D
Site 6
S188
F
N
R
I
G
D
P
S
V
D
E
D
A
Q
K
Site 7
Y201
Q
K
R
M
K
A
E
Y
D
A
V
K
A
K
A
Site 8
Y225
V
A
R
E
H
E
E
Y
Q
A
G
V
D
E
F
Site 9
T256
R
N
C
K
L
P
I
T
Q
R
L
S
T
L
Q
Site 10
S260
L
P
I
T
Q
R
L
S
T
L
Q
D
I
A
K
Site 11
T261
P
I
T
Q
R
L
S
T
L
Q
D
I
A
K
D
Site 12
S275
D
F
P
R
G
E
E
S
L
E
T
L
E
E
Q
Site 13
T278
R
G
E
E
S
L
E
T
L
E
E
Q
S
A
G
Site 14
T290
S
A
G
V
I
R
N
T
S
P
L
G
A
E
K
Site 15
S291
A
G
V
I
R
N
T
S
P
L
G
A
E
K
I
Site 16
S329
R
L
R
G
L
L
R
S
R
G
A
W
E
Q
Q
Site 17
S345
K
Q
L
E
A
E
L
S
E
F
R
M
V
L
Q
Site 18
Y378
L
V
A
H
W
R
R
Y
S
A
T
R
A
A
L
Site 19
S379
V
A
H
W
R
R
Y
S
A
T
R
A
A
L
A
Site 20
T381
H
W
R
R
Y
S
A
T
R
A
A
L
A
S
E
Site 21
S387
A
T
R
A
A
L
A
S
E
E
P
R
V
D
R
Site 22
S415
N
L
K
P
L
S
D
S
V
I
A
T
I
Q
E
Site 23
S425
A
T
I
Q
E
Y
Q
S
L
K
V
K
S
A
R
Site 24
S430
Y
Q
S
L
K
V
K
S
A
R
L
R
N
A
A
Site 25
T477
P
D
L
P
S
L
H
T
F
L
P
Q
I
E
A
Site 26
T497
S
R
L
K
E
L
L
T
M
L
Q
L
K
K
D
Site 27
S525
L
L
E
Q
V
A
G
S
M
R
D
R
D
L
L
Site 28
S535
D
R
D
L
L
H
N
S
L
L
Q
R
K
S
K
Site 29
S541
N
S
L
L
Q
R
K
S
K
L
Q
S
L
L
A
Site 30
S545
Q
R
K
S
K
L
Q
S
L
L
A
Q
H
K
D
Site 31
S589
P
G
K
Q
A
Q
L
S
R
L
Q
G
L
Q
E
Site 32
S627
H
K
M
D
Q
L
S
S
D
F
Q
A
L
Q
R
Site 33
S635
D
F
Q
A
L
Q
R
S
L
E
D
L
V
D
R
Site 34
T652
Q
S
V
Q
E
H
C
T
F
S
H
Q
L
L
E
Site 35
S685
A
G
P
G
D
A
E
S
Q
E
A
E
F
E
R
Site 36
S705
P
E
K
E
A
Q
L
S
L
V
E
A
Q
G
W
Site 37
S718
G
W
L
V
M
E
K
S
S
P
E
G
A
A
V
Site 38
S736
E
L
R
E
L
A
E
S
W
R
A
L
R
L
L
Site 39
S763
L
Q
R
M
E
V
D
S
G
K
K
M
V
F
T
Site 40
T770
S
G
K
K
M
V
F
T
N
N
I
P
K
S
G
Site 41
S802
L
L
Q
E
E
E
G
S
H
E
D
F
S
Q
L
Site 42
S807
E
G
S
H
E
D
F
S
Q
L
L
R
N
F
G
Site 43
S833
R
I
I
A
M
R
T
S
T
A
E
D
L
R
T
Site 44
T834
I
I
A
M
R
T
S
T
A
E
D
L
R
T
R
Site 45
T840
S
T
A
E
D
L
R
T
R
K
S
K
L
Q
E
Site 46
S843
E
D
L
R
T
R
K
S
K
L
Q
E
L
E
A
Site 47
T871
R
L
G
P
A
R
G
T
S
D
E
L
E
D
L
Site 48
S872
L
G
P
A
R
G
T
S
D
E
L
E
D
L
R
Site 49
Y880
D
E
L
E
D
L
R
Y
Q
W
M
L
Y
K
S
Site 50
Y885
L
R
Y
Q
W
M
L
Y
K
S
K
L
K
D
S
Site 51
S892
Y
K
S
K
L
K
D
S
G
H
L
L
T
Q
S
Site 52
T897
K
D
S
G
H
L
L
T
Q
S
S
P
G
E
P
Site 53
S899
S
G
H
L
L
T
Q
S
S
P
G
E
P
T
G
Site 54
S900
G
H
L
L
T
Q
S
S
P
G
E
P
T
G
F
Site 55
T910
E
P
T
G
F
Q
K
T
R
R
W
R
G
L
G
Site 56
S918
R
R
W
R
G
L
G
S
L
F
R
R
A
C
C
Site 57
S952
P
I
R
E
E
D
R
S
C
T
L
A
N
N
F
Site 58
T954
R
E
E
D
R
S
C
T
L
A
N
N
F
A
R
Site 59
T964
N
N
F
A
R
S
F
T
L
M
L
R
Y
N
G
Site 60
Y969
S
F
T
L
M
L
R
Y
N
G
P
P
P
T
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation