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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MEX3B
Full Name:
RNA-binding protein MEX3B
Alias:
DKFZp434J0617; Mex-3 B; RKHD3; RNF195
Type:
RNA binding protein
Mass (Da):
58830
Number AA:
UniProt ID:
Q6ZN04
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000932
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0005509
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0046777
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
P
S
S
L
F
A
D
L
E
R
Site 2
S14
A
D
L
E
R
N
G
S
G
G
G
G
G
G
S
Site 3
S21
S
G
G
G
G
G
G
S
S
G
G
G
E
T
L
Site 4
S22
G
G
G
G
G
G
S
S
G
G
G
E
T
L
D
Site 5
S53
L
D
S
D
E
G
A
S
L
Y
D
S
E
P
R
Site 6
Y55
S
D
E
G
A
S
L
Y
D
S
E
P
R
K
K
Site 7
S57
E
G
A
S
L
Y
D
S
E
P
R
K
K
S
V
Site 8
S63
D
S
E
P
R
K
K
S
V
N
M
T
E
C
V
Site 9
T67
R
K
K
S
V
N
M
T
E
C
V
P
V
P
S
Site 10
T96
I
K
A
L
R
A
K
T
N
T
Y
I
K
T
P
Site 11
T98
A
L
R
A
K
T
N
T
Y
I
K
T
P
V
R
Site 12
T102
K
T
N
T
Y
I
K
T
P
V
R
G
E
E
P
Site 13
S129
M
A
R
R
E
I
I
S
A
A
E
H
F
S
M
Site 14
S135
I
S
A
A
E
H
F
S
M
I
R
A
S
R
N
Site 15
S140
H
F
S
M
I
R
A
S
R
N
K
N
T
A
L
Site 16
T162
P
N
L
P
G
Q
T
T
I
Q
V
R
V
P
Y
Site 17
T190
I
K
R
I
Q
Q
Q
T
H
T
Y
I
V
T
P
Site 18
T192
R
I
Q
Q
Q
T
H
T
Y
I
V
T
P
S
R
Site 19
T196
Q
T
H
T
Y
I
V
T
P
S
R
D
K
E
P
Site 20
S198
H
T
Y
I
V
T
P
S
R
D
K
E
P
V
F
Site 21
T208
K
E
P
V
F
E
V
T
G
M
P
E
N
V
D
Site 22
T236
T
G
G
I
I
E
L
T
D
E
N
D
F
H
A
Site 23
S256
G
F
D
L
H
H
G
S
G
G
S
G
P
G
S
Site 24
S259
L
H
H
G
S
G
G
S
G
P
G
S
L
W
S
Site 25
S263
S
G
G
S
G
P
G
S
L
W
S
K
P
T
P
Site 26
S266
S
G
P
G
S
L
W
S
K
P
T
P
S
I
T
Site 27
T269
G
S
L
W
S
K
P
T
P
S
I
T
P
T
P
Site 28
S271
L
W
S
K
P
T
P
S
I
T
P
T
P
G
R
Site 29
T273
S
K
P
T
P
S
I
T
P
T
P
G
R
K
P
Site 30
T275
P
T
P
S
I
T
P
T
P
G
R
K
P
F
S
Site 31
S282
T
P
G
R
K
P
F
S
S
Y
R
N
D
S
S
Site 32
S283
P
G
R
K
P
F
S
S
Y
R
N
D
S
S
S
Site 33
Y284
G
R
K
P
F
S
S
Y
R
N
D
S
S
S
S
Site 34
S288
F
S
S
Y
R
N
D
S
S
S
S
L
G
S
A
Site 35
S289
S
S
Y
R
N
D
S
S
S
S
L
G
S
A
S
Site 36
S290
S
Y
R
N
D
S
S
S
S
L
G
S
A
S
T
Site 37
S291
Y
R
N
D
S
S
S
S
L
G
S
A
S
T
D
Site 38
S294
D
S
S
S
S
L
G
S
A
S
T
D
S
Y
F
Site 39
S296
S
S
S
L
G
S
A
S
T
D
S
Y
F
G
G
Site 40
T297
S
S
L
G
S
A
S
T
D
S
Y
F
G
G
G
Site 41
S299
L
G
S
A
S
T
D
S
Y
F
G
G
G
T
S
Site 42
Y300
G
S
A
S
T
D
S
Y
F
G
G
G
T
S
S
Site 43
S307
Y
F
G
G
G
T
S
S
S
A
A
A
T
Q
R
Site 44
S308
F
G
G
G
T
S
S
S
A
A
A
T
Q
R
L
Site 45
T312
T
S
S
S
A
A
A
T
Q
R
L
A
D
Y
S
Site 46
Y318
A
T
Q
R
L
A
D
Y
S
P
P
S
P
A
L
Site 47
S319
T
Q
R
L
A
D
Y
S
P
P
S
P
A
L
S
Site 48
S322
L
A
D
Y
S
P
P
S
P
A
L
S
F
A
H
Site 49
S326
S
P
P
S
P
A
L
S
F
A
H
N
G
N
N
Site 50
Y342
N
N
G
N
G
Y
T
Y
T
A
G
G
E
A
S
Site 51
S349
Y
T
A
G
G
E
A
S
V
P
S
P
D
G
C
Site 52
S352
G
G
E
A
S
V
P
S
P
D
G
C
P
E
L
Site 53
T362
G
C
P
E
L
Q
P
T
F
D
P
A
P
A
P
Site 54
S383
I
W
A
Q
F
E
R
S
P
G
G
G
P
A
A
Site 55
S393
G
G
P
A
A
P
V
S
S
S
C
S
S
S
A
Site 56
S394
G
P
A
A
P
V
S
S
S
C
S
S
S
A
S
Site 57
S395
P
A
A
P
V
S
S
S
C
S
S
S
A
S
S
Site 58
S397
A
P
V
S
S
S
C
S
S
S
A
S
S
S
A
Site 59
S398
P
V
S
S
S
C
S
S
S
A
S
S
S
A
S
Site 60
S399
V
S
S
S
C
S
S
S
A
S
S
S
A
S
S
Site 61
S401
S
S
C
S
S
S
A
S
S
S
A
S
S
S
S
Site 62
S402
S
C
S
S
S
A
S
S
S
A
S
S
S
S
V
Site 63
S403
C
S
S
S
A
S
S
S
A
S
S
S
S
V
V
Site 64
S405
S
S
A
S
S
S
A
S
S
S
S
V
V
F
P
Site 65
S406
S
A
S
S
S
A
S
S
S
S
V
V
F
P
G
Site 66
S408
S
S
S
A
S
S
S
S
V
V
F
P
G
G
G
Site 67
T436
H
R
R
L
H
P
G
T
S
C
P
R
L
S
P
Site 68
S437
R
R
L
H
P
G
T
S
C
P
R
L
S
P
P
Site 69
S442
G
T
S
C
P
R
L
S
P
P
L
H
M
A
P
Site 70
S462
H
L
A
R
R
V
R
S
D
P
G
G
G
G
L
Site 71
S488
Q
L
P
G
L
Q
P
S
D
T
S
G
S
S
S
Site 72
T490
P
G
L
Q
P
S
D
T
S
G
S
S
S
S
S
Site 73
S491
G
L
Q
P
S
D
T
S
G
S
S
S
S
S
S
Site 74
S493
Q
P
S
D
T
S
G
S
S
S
S
S
S
S
S
Site 75
S494
P
S
D
T
S
G
S
S
S
S
S
S
S
S
S
Site 76
S495
S
D
T
S
G
S
S
S
S
S
S
S
S
S
S
Site 77
S496
D
T
S
G
S
S
S
S
S
S
S
S
S
S
S
Site 78
S497
T
S
G
S
S
S
S
S
S
S
S
S
S
S
S
Site 79
S498
S
G
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 80
S499
G
S
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 81
S500
S
S
S
S
S
S
S
S
S
S
S
S
S
S
S
Site 82
S502
S
S
S
S
S
S
S
S
S
S
S
S
S
S
G
Site 83
S503
S
S
S
S
S
S
S
S
S
S
S
S
S
G
L
Site 84
S504
S
S
S
S
S
S
S
S
S
S
S
S
G
L
R
Site 85
S505
S
S
S
S
S
S
S
S
S
S
S
G
L
R
R
Site 86
S506
S
S
S
S
S
S
S
S
S
S
G
L
R
R
K
Site 87
S507
S
S
S
S
S
S
S
S
S
G
L
R
R
K
G
Site 88
S508
S
S
S
S
S
S
S
S
G
L
R
R
K
G
S
Site 89
S515
S
G
L
R
R
K
G
S
R
D
C
S
V
C
F
Site 90
S519
R
K
G
S
R
D
C
S
V
C
F
E
S
E
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation